Gene Overview
Target Gene: IL5
NCBI Official Symbol: IL5
Entrez ID: 3567
Ensembl ID: ENSG00000113525
Gene Full Name: interleukin 5
Strand: -
Gene Locus: 5q31.1
External Links:

IL5 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate IL5   
T(co)Fs that Repress IL5
The Intensity of the Gene Regulated by T(co)Fs:
IL5-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
IL5 ID1 siRNA Lung H1650 0.62634 -0.67499 0.9148 0.96646 DataSet_01_118
IL5 ZIC2 siRNA Pancreas PANC1 1.73057 0.79125 - - DataSet_01_121
IL5 FOXM1 siRNA Central_nervous_system U87 0.49557 -1.01285 - - DataSet_01_122
IL5 SOX4 shRNA Parotid_gland ACC3 1.765 0.81967 0.48598 0.9882 DataSet_01_140
IL5 ELK1 siRNA Peripheral_blood CD4+ T cells 2.14149 1.09861 0.0284 0.10628 DataSet_01_162
IL5 GATA3 siRNA Peripheral_blood CD4+ T cells 0.59009 -0.761 0.45374 0.75537 DataSet_01_163
IL5 JUN siRNA Peripheral_blood CD4+ T cells 1.51059 0.59511 0.12717 0.33431 DataSet_01_164
IL5 MAF siRNA Peripheral_blood CD4+ T cells 1.8783 0.90943 0.04614 0.25868 DataSet_01_165
IL5 NFATC3 siRNA Peripheral_blood CD4+ T cells 2.45721 1.29702 0.01487 0.11434 DataSet_01_166
IL5 HOXB7 siRNA Pancreas MIA PaCa-2 1.60818 0.68543 0.25244 0.69672 DataSet_01_169
IL5 HOXB7 siRNA Pancreas Capan-1 0.45854 -1.12487 0.0883 0.56934 DataSet_01_170
IL5 GABPA shRNA Prostate C4-2B 789.787 9.62532 0.23427 0.43934 DataSet_01_190
IL5 GABPA shRNA Prostate LNCaP 819.273 9.6782 0.46237 0.7048 DataSet_01_191
IL5 CREB1 shRNA Parotid_gland H3118 MEC 2.93458 1.55315 0.57019 0.82805 DataSet_01_194
IL5 TP63 siRNA Immortalized_keratinocyte HaCaT RG 3.02151 1.59527 - - DataSet_01_196
IL5 TP63 siRNA Immortalized_keratinocyte HaCaT 0.48415 -1.04647 - - DataSet_01_200
IL5 TP63 siRNA Head_and_neck SCC-012 4.57025 2.19227 - - DataSet_01_201
IL5 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 1.59718 0.67553 - - DataSet_01_208
IL5 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.64994 -0.62162 - - DataSet_01_210
IL5 SNAI2 shRNA Skin Primary human keratinocytes 1.51597 0.60024 0.51649 0.64146 DataSet_01_225
IL5 TWIST1 shRNA Stomach CAF32 1.62127 0.69712 0.28756 0.44591 DataSet_01_253
IL5 ESRRA shRNA Embryo_kidney 293T 2.14637 1.1019 0.08972 0.69763 DataSet_01_280
IL5 POSTN shRNA Brain GSC272 2.1437 1.10011 0.25894 0.62903 DataSet_01_293
IL5 TFAP4 siRNA Brain BE(2)-C 0.18536 -2.43157 0.30936 0.51625 DataSet_01_295
IL5 SOX7 siRNA Umbilical_vein HUVEC 0.45277 -1.14316 0.04759 0.89788 DataSet_01_299
IL5 SOX17 siRNA Umbilical_vein HUVEC 0.57709 -0.79314 0.15629 0.99998 DataSet_01_300
IL5 PTEN shRNA Skin A431 0.32987 -1.60004 0.13207 0.31057 DataSet_01_301
IL5 PTEN shRNA Mammary_gland SKBR3 0.17452 -2.51856 0.5803 0.85484 DataSet_01_303
IL5 SOX9 siRNA Prostate VCaP 0.57233 -0.80509 0.2795 0.93253 DataSet_01_308
IL5 SOX9 siRNA Prostate VCaP 0.57233 -0.80509 0.2795 0.93253 DataSet_01_309
IL5 ARNT siRNA Upper_aerodigestive_tract HSC3 1.62465 0.70013 - - DataSet_01_315
IL5 HOXC6 siRNA Prostate LNCaP 3.18621 1.67184 0.28169 0.99927 DataSet_01_333
IL5 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 3.88889 1.95936 0.75555 0.87446 DataSet_02_140
IL5 BCLAF1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.12593 -2.98935 0.22145 0.39867 DataSet_02_142
IL5 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 5.66667 2.5025 0.02712 0.06628 DataSet_02_143
IL5 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.41176 -1.28011 0.49772 0.63088 DataSet_02_147
IL5 SAFB2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.35294 -1.5025 0.26273 0.68821 DataSet_02_150
IL5 RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 0.30769 -1.70044 0.05074 0.25582 DataSet_02_151
IL5 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.57143 -0.80735 0.64445 0.8431 DataSet_02_152
IL5 SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 5.3 2.40599 0.02914 0.37594 DataSet_02_154
IL5 FUS shRNA Haematopoietic_and_lymphoid_tissue K562 0.23404 -2.09516 0.02902 0.24051 DataSet_02_155
IL5 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 20.25 4.33985 0.03597 0.16938 DataSet_02_160
IL5 AGO1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.19149 -2.38466 0.02911 0.53443 DataSet_02_162
IL5 SSB shRNA Haematopoietic_and_lymphoid_tissue K562 0.19149 -2.38466 0.03008 0.21826 DataSet_02_164
IL5 ZFX siRNA Prostate C4-2B 4.88889 2.28951 0.15538 0.25069 DataSet_02_172
IL5 ZMIZ1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.55556 -0.848 0.23313 1 DataSet_02_181
IL5 CTCF siRNA Haematopoietic_and_lymphoid_tissue K562 2.15385 1.10692 0.23945 1 DataSet_02_185
IL5 BRCA1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.13636 -2.87447 0.03808 1 DataSet_02_202
IL5 ASCL1 siRNA Lung DMS79 0.208333 -2.26303 0.0988979785986005 0.765964136821421 DataSet_03_016
IL5 BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.49416 -1.01695 0.515171238183524 0.917357745690599 DataSet_03_025
IL5 CEBPB siRNA Embryo hESC 0.576437 -0.794764 0.0887798153769444 0.447065347141895 DataSet_03_049
IL5 FOXM1 siRNA Mammary_gland BT-20 cells 0.6 -0.736966 0.0871164351263946 0.50033384521145 DataSet_03_091
IL5 GATA2 siRNA Uterus Decidual stromal cells 1.6514 0.723694 0.250540593521785 0.841421007103421 DataSet_03_100
IL5 GATA3 siRNA Mammary_gland MCF7 1.57125 0.651915 0.0131197682263912 0.999831535534034 DataSet_03_102
IL5 GATA4 siRNA Stomach AGS 3.78306 1.91955 0.141351038375898 0.79562735665868 DataSet_03_105
IL5 GATA4 siRNA Stomach KatoIII 0.38364 -1.38218 0.0405054051365727 0.863208745436085 DataSet_03_106
IL5 GATA4 siRNA Stomach YCC3 0.42556 -1.23257 0.297003019734453 0.786220811473778 DataSet_03_107
IL5 GATA6 siRNA Stomach AGS 2.08777 1.06196 0.418030584258334 0.830805093806372 DataSet_03_108
IL5 GRHL3 siRNA Skin Primary neonatal keratinocytes 0.605994 -0.722625 0.000611897002052007 0.10859593984353 DataSet_03_113
IL5 HNF4a siRNA Liver HepG2 0.461538 -1.11548 0.798933998056128 0.973139196414395 DataSet_03_126
IL5 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 0.341435 -1.55032 0.670266417697464 0.999948959532916 DataSet_03_134
IL5 KLF5 siRNA Stomach AGS 2.02851 1.02042 0.481239967130399 0.835246661830343 DataSet_03_149
IL5 KLF5 siRNA Stomach KatoIII 0.631969 -0.662074 0.524726744214395 0.840118303742618 DataSet_03_150
IL5 MEF2D shRNA Liver HuH7 1.60197 0.679848 - - DataSet_03_162
IL5 MTA2 siRNA Stomach SGC-7901 1.61164 0.688529 - - DataSet_03_169
IL5 MYB siRNA Cord_Blood CD34+ progenitor cells 1.6475 0.720276 - - DataSet_03_170
IL5 MYC siRNA Colon HT29 0.319563 -1.64583 - - DataSet_03_177
IL5 NR2F2 siRNA Uterus Primary eutopic stromal cells 2.09812 1.0691 0.19637169774324 0.99947668859931 DataSet_03_202
IL5 PHB shRNA Embryo Embryonic stem cells (ESCs) 2.66736 1.41541 0.0988067810607149 0.192070093704648 DataSet_03_211
IL5 SATB1 siRNA Peripheral_blood CD4+ T cells 2.57895 1.36678 0.179080957885718 0.999998339488038 DataSet_03_230
IL5 SOX11 siRNA Lung_fibroblast NHLF 2.45882 1.29796 0.0030673807534046 0.304507242190339 DataSet_03_237
IL5 SOX11 siRNA Lung_fibroblast NHLF 2.04006 1.02861 0.0892311371951196 0.416988601456255 DataSet_03_238
IL5 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.142857 -2.80735 - - DataSet_03_246
IL5 TFE3 siRNA Kidney UOK257-2 72.6476 6.18284 - - DataSet_03_275
IL5 ZNF746 siRNA Colon HCT116 0.138312 -2.854 - - DataSet_03_293
IL5 CTCF CRISPR Haematopoietic_and_lymphoid_tissue K562 2 1 0.35137945997919 0.652897117611272 DataSet_04_005
IL5 SMAD5 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.6 -0.736966 0.405254464541062 0.701818484371431 DataSet_04_020
IL5 APTX CRISPR Liver HepG2 0.4 -1.32193 0.118761261449958 0.534000424612069 DataSet_04_025
IL5 MECP2 CRISPR Liver HepG2 2.36364 1.24101 0.222383536649273 0.506634775246218 DataSet_04_031
IL5 SMAD4 CRISPR Liver HepG2 0.166667 -2.58496 0.335018723747926 0.490031578323664 DataSet_04_035
IL5 SMAD5 CRISPR Liver HepG2 0.0769231 -3.70044 0.00110578852179396 0.348373279896866 DataSet_04_036
IL5 DDX20 CRISPR Liver HepG2 1.63636 0.710493 0.339517135299075 0.486649093702164 DataSet_04_043
IL5 DNMT3B CRISPR Liver HepG2 0.285714 -1.80735 0.410345254175815 0.672028073782985 DataSet_04_044
IL5 PAN2 CRISPR Liver HepG2 0.166667 -2.58496 0.266094177467043 0.441837475439307 DataSet_04_066
IL5 ACTN4 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.508646464231333 0.707589143367921 DataSet_04_048
IL5 DDX17 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.764286366274978 0.968114061978831 DataSet_04_047
IL5 DDX20 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.428571 -1.22239 0.581997983991922 0.860140566043122 DataSet_04_050
IL5 SEPT11 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.3125 -1.67807 0.432875702819889 1 DataSet_04_077
IL5 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.4375 -1.19265 0.471506728466 0.63963710605471 DataSet_04_049
IL5 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.33333 1.22239 0.58709904993641 0.852167446592096 DataSet_02_75
IL5 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 9 3.16992 0.192112327071255 0.338607248293543 DataSet_04_060
IL5 AEBP1 siRNA Umbilical_vein HUVEC 0.659353 -0.600877 5.605744e-01 0.999982779 DataSet_03_300
IL5 SMARCA4 siRNA Colon HCT116 1.60582 0.683312 3.032634e-01 9.892536e-01 DataSet_03_301
IL5 INO80 siRNA Muscle RD 0.666365 -0.585615 - - DataSet_03_344
IL5 EZH2 knockdown Colon HCT116 0.579186 -0.787902 0.273250680 0.9137200 DataSet_03_334
IL5 ESR1 siRNA Mammary_gland MCF7 5.2931 2.40411 2.397148e-02 0.1172555877 DataSet_03_352
IL5 MYC siRNA Peripheral_blood T lymphocyte 1.63529 0.709543 6.551551e-01 0.831289491 DataSet_03_363
IL5 TP53 knockout Stomach SNU1 0.575628 -0.796791 0.5184049458 0.9473503 DataSet_03_365
IL5 TPR shRNA Bone_marrow U2OS 76.4055 6.2556 6.834928e-02 3.919369e-01 DataSet_03_370
IL5 SMARCA2 shRNA Lung NCI-H1944 1.57143 0.652077 3.225472e-01 6.547888e-01 DataSet_03_377
IL5 TCF19 CRISPR Oral_squamous CAL27 0.482496 -1.05141 8.008215e-01 0.9190809990 DataSet_03_383
IL5 NFKBIA shRNA Bone_marrow U2OS 0.009375 -6.73697 5.089995e-01 0.87005461 DataSet_03_389
IL5 KDM5A CRISPR Lung GLC16 0.565555 -0.822261 7.026807e-01 0.823162920 DataSet_03_392
IL5 BMI1 shRNA Bile_duct QBC-939 0.416371 -1.26406 5.310574e-01 0.7143013979 DataSet_03_395
IL5 RELA CRISPR Brain T30 0.408449 -1.29177 0.6383106652 0.8934353 DataSet_03_399
IL5 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 0.5 -1 7.554749e-01 0.8347154 DataSet_03_403
IL5 SATB2 CRISPR Colon Colon organoid 3 1.58496 4.125112e-01 0.95735254 DataSet_03_406
IL5 ZKSCAN3 CRISPR Colon HCT116 2.75 1.45943 3.701224e-01 0.657114841 DataSet_03_415
IL5 BRD4 CRISPR Lymph CD8+ T cells 3.18349 1.67061 - - DataSet_03_420
IL5 FOXQ1 CRISPR Lymph Primary CD4+ T cells 0.195991 -2.35114 - - DataSet_03_422
IL5 FOXP3 CRISPR Peripheral_blood Naive Treg 2.20204 1.13884 2.593850e-02 0.244311551 DataSet_03_427
IL5 IKZF2 shRNA Lymph Hut78 0.306755 -1.70484 2.684006e-01 0.73609286 DataSet_03_429
IL5 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 5 2.32193 2.848603e-01 0.574894029 DataSet_03_434
IL5 FOSL1 siRNA Prostate MSKPCa3 4 2 0.5529219693 0.7399105 DataSet_03_445
IL5 OGT siRNA Embryo BeWo cells 0.6 -0.736966 2.729156e-01 0.66237450 DataSet_03_453
IL5 PARP1 knockout Embryo_kidney HEK293a 2.125 1.08746 1.663645e-02 4.813468e-02 DataSet_03_464
Regulation Region
 
T(co)Fs that significantly regulate SMAD5 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of IL5
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines