Gene Overview
Target Gene: MAT2A
NCBI Official Symbol: MAT2A
Entrez ID: 4144
Ensembl ID: ENSG00000168906
Gene Full Name: methionine adenosyltransferase 2A
Strand: +
Gene Locus: 2p11.2
External Links:

MAT2A Significantly Regulated by These T(co)Fs

T(co)Fs that Activate MAT2A   
T(co)Fs that Repress MAT2A
The Intensity of the Gene Regulated by T(co)Fs:
MAT2A-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
MAT2A HNF1B shRNA Ovary RMG2 1.77932 0.83133 4.00753e-09 1.2814e-07 DataSet_01_103
MAT2A FOXA1 shRNA Prostate 22RV1 0.60319 -0.72931 - - DataSet_01_105
MAT2A ZIC2 siRNA Pancreas PANC1 1.60282 0.68061 - - DataSet_01_121
MAT2A IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 0.65799 -0.60386 0.29083 0.99993 DataSet_01_137
MAT2A TAL1 shRNA Umbilical_cord_blood ECFCs 0.64429 -0.63421 0.03567 0.46435 DataSet_01_152
MAT2A JUN siRNA Peripheral_blood CD4+ T cells 0.59949 -0.73819 0.1556 0.37822 DataSet_01_164
MAT2A MAF siRNA Peripheral_blood CD4+ T cells 0.4099 -1.28667 0.10742 0.40307 DataSet_01_165
MAT2A NFATC3 siRNA Peripheral_blood CD4+ T cells 0.00277 -8.49514 0.00737 0.07685 DataSet_01_166
MAT2A STAT3 siRNA Peripheral_blood CD4+ T cells 0.00212 -8.88321 0.00531 0.99183 DataSet_01_168
MAT2A HOXB7 siRNA Pancreas MIA PaCa-2 0.56889 -0.81378 0.01893 0.57972 DataSet_01_169
MAT2A XBP1 shRNA Mammary_gland MDA-MB-231 1.54601 0.62855 6e-04 0.01323 DataSet_01_204
MAT2A LIN28A siRNA Embryo H9 0.58809 -0.76589 0.01029 0.05015 DataSet_01_215
MAT2A TWIST1 shRNA Stomach CAF32 0.56764 -0.81695 0.00174 0.02318 DataSet_01_253
MAT2A SALL4 shRNA Lung H661 1.93714 0.95393 0.00316 0.07251 DataSet_01_277
MAT2A POSTN shRNA Brain GSC272 1.65152 0.7238 0.26586 0.63175 DataSet_01_293
MAT2A TFAP4 siRNA Brain BE(2)-C 0.13569 -2.88161 0.25433 0.51625 DataSet_01_295
MAT2A MYC siRNA Colon HCT116 0.51755 -0.95024 1.42423e-06 1.13754e-05 DataSet_01_324
MAT2A ETV4 shRNA Prostate PC3 1.61757 0.69383 - - DataSet_01_356
MAT2A U2AF2 shRNA Liver HepG2 0.60791 -0.71806 0.00636 0.06107 DataSet_02_105
MAT2A TAF15 shRNA Liver HepG2 2.28487 1.19211 0.00068 0.01075 DataSet_02_106
MAT2A ZNF622 shRNA Liver HepG2 0.51246 -0.96448 0.00136 0.00953 DataSet_02_108
MAT2A RBM39 shRNA Liver HepG2 0.66341 -0.59203 0.12063 0.35543 DataSet_02_111
MAT2A BCLAF1 shRNA Liver HepG2 0.64645 -0.6294 0.00296 0.02973 DataSet_02_112
MAT2A U2AF2 shRNA Liver HepG2 0.34875 -1.51975 0.00546 0.06011 DataSet_02_113
MAT2A PCBP1 shRNA Liver HepG2 1.66126 0.73228 0.00088 0.0135 DataSet_02_115
MAT2A PTBP1 shRNA Liver HepG2 1.91562 0.93781 8e-04 0.00669 DataSet_02_120
MAT2A HNRNPLL shRNA Liver HepG2 0.53255 -0.90901 0.00118 0.01333 DataSet_02_125
MAT2A RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 0.65419 -0.61222 0.04324 0.24786 DataSet_02_151
MAT2A TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 1.52271 0.60664 0.24316 0.48112 DataSet_02_163
MAT2A RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 0.56534 -0.82282 0.51208 1 DataSet_02_190
MAT2A ATF4 siRNA Skin A375 0.580753 -0.784004 0.221811406365669 0.775512819201899 DataSet_03_018
MAT2A BRCA1 siRNA Mammary_gland MCF7 2.39599 1.26062 0.0143967603977244 0.999850583334387 DataSet_03_028
MAT2A CEBPA siRNA Mammary_gland MCF7 0.642106 -0.639116 0.140350998871551 0.999962793175751 DataSet_03_047
MAT2A CEBPB siRNA Mammary_gland MCF7 2.13004 1.09088 0.0261827463304953 0.993756826434039 DataSet_03_048
MAT2A CHEK1 siRNA Mammary_gland MCF7 0.664452 -0.589762 0.168500650098297 0.999587656258211 DataSet_03_053
MAT2A E2F7 siRNA Upper_aerodigestive_tract SCC25 0.618782 -0.692497 7.16602632888805e-05 0.000871509704673204 DataSet_03_063
MAT2A ESRRA siRNA Mammary_gland MCF7 2.21175 1.14519 0.0215598275707539 0.999964003642835 DataSet_03_072
MAT2A GATA3 siRNA Mammary_gland MCF7 0.509094 -0.973997 0.0138264617574221 0.109502955781686 DataSet_03_103
MAT2A HES6 siRNA Brain A172 1.85932 0.894777 0.00111748058615329 0.844497726481877 DataSet_03_116
MAT2A HES6 siRNA Brain LN405 1.79341 0.842702 0.00738411107661125 0.959972868676594 DataSet_03_117
MAT2A HOXB7 siRNA Mammary_gland MCF7 2.247 1.168 0.0198860949053384 0.999977683706165 DataSet_03_127
MAT2A KDM3A siRNA Mammary_gland MCF7 0.652131 -0.616765 0.00044761072436382 0.0109826071224034 DataSet_03_146
MAT2A Klf4 siRNA Skin Primary neonatal keratinocytes 0.319783 -1.64483 0.000246675252266885 0.00380381205563561 DataSet_03_147
MAT2A MITF siRNA Skin Ma-Mel-15 0.603292 -0.729073 0.00212770156875534 0.0501368591126684 DataSet_03_167
MAT2A MITF siRNA Skin SK-MEL-5 0.469938 -1.08946 3.13129979680841e-06 3.76927589556667e-05 DataSet_03_168
MAT2A MYB siRNA Prostate VCaP 1.84293 0.882 0.00155187080953446 0.0549041778282522 DataSet_03_174
MAT2A MYC siRNA Central_nervous_system DAOY M2.1 0.506369 -0.98174 8.2661119255527e-08 1.40946971454995e-06 DataSet_03_178
MAT2A MYC siRNA Haematopoietic_and_lymphoid_tissue B-cell lymphoma cell line BL41 0.584389 -0.775 0.00192538497169429 0.599669640585273 DataSet_03_179
MAT2A MYCN CRISPR Neuroblastoma CHP-134 0.477119 -1.06758 1.99764075652157e-07 4.54498691271006e-05 DataSet_03_183
MAT2A MYCN CRISPR Neuroblastoma CHP-134 0.477119 -1.06758 1.99764075652157e-07 4.54498691271006e-05 DataSet_03_184
MAT2A NMI siRNA Mammary_gland MCF7 1.61687 0.693207 0.114667805392214 0.711644471873432 DataSet_03_199
MAT2A PHB shRNA Embryo Embryonic stem cells (ESCs) 0.591663 -0.757152 0.000137377682449999 0.00154223527634436 DataSet_03_211
MAT2A POLR2A siRNA Mammary_gland MCF7 0.61522 -0.700825 0.0377708998529362 0.999513313282531 DataSet_03_213
MAT2A PRRX1 CRISPR Neuroblastoma 691-MES 1.64456 0.717699 0.136478636436796 0.89189998148014 DataSet_03_217
MAT2A SOX2 siRNA Lung LK2 1.64042 0.714069 - - DataSet_03_241
MAT2A SOX9 knockdown Liver HepG2 0.641264 -0.64101 0.00251265867190517 0.0226007600835202 DataSet_03_248
MAT2A SP1 siRNA Cervix HeLa 1.70345 0.768457 5.74595433878667e-05 0.00129883759088127 DataSet_03_249
MAT2A SP1 siRNA Mammary_gland MDA-MB-231 8.35941 3.0634 0.0763146134187709 0.413972819854456 DataSet_03_250
MAT2A SP100 siRNA Mammary_gland MCF7 2.61005 1.38408 0.00948632980502662 0.999952086018951 DataSet_03_252
MAT2A STAT3 CRISPR Embryo hESC 2.09129 1.06439 0.00377311099055146 0.0436364999938631 DataSet_03_258
MAT2A TP63 siRNA Skin Primary neonatal keratinocytes 2.29135 1.1962 3.9234708558533e-05 0.00198048394833341 DataSet_03_281
MAT2A ZNF750 siRNA Skin Primary neonatal keratinocytes 0.557803 -0.842173 0.00210372022674195 0.0392698709966477 DataSet_03_294
MAT2A MARK2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.433295 -1.20658 0.00220650251625688 0.0144267408178244 DataSet_04_012
MAT2A NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 0.326547 -1.61464 0.0746590909982356 0.177639500793791 DataSet_04_014
MAT2A NUP35 shRNA Haematopoietic_and_lymphoid_tissue K562 0.549161 -0.8647 0.00440576224828795 0.0211064392370052 DataSet_04_015
MAT2A SMAD4 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.64211 0.71555 0.00243028980001146 0.0979887211869635 DataSet_04_019
MAT2A ABT1 shRNA Liver HepG2 0.658691 -0.602326 0.000882994548193686 0.00770542431380138 DataSet_04_052
MAT2A CALR shRNA Liver HepG2 0.653699 -0.613302 0.000489238724910819 0.007146367171992 DataSet_04_053
MAT2A NPM1 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.52076 0.604788 0.000197939826375922 0.0340600577442938 DataSet_04_046
MAT2A DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.24075 1.16398 0.000365566309281221 0.00765628183537773 DataSet_02_14
MAT2A ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.30425 1.2043 5.72635680115742e-05 0.0105020352197014 DataSet_02_34
MAT2A HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.64341 0.716696 0.0523191558184898 0.502319332676611 DataSet_02_45
MAT2A NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.0664 1.04712 0.00581355474997604 0.249809726688677 DataSet_02_32
MAT2A SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.80868 0.854937 0.000257153117575157 0.00993467045008745 DataSet_02_47
MAT2A TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.62347 0.699082 0.00073078466950195 0.0200892037693997 DataSet_02_43
MAT2A TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.65159 0.723855 0.000602155275868026 0.00865416948146593 DataSet_02_33
MAT2A HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 0.588214 -0.765588 0.00220429106705638 0.0108480660889293 DataSet_04_059
MAT2A SMARCA4 siRNA Colon HCT116 1.76168 0.816952 5.569236e-03 0.1306486 DataSet_03_302
MAT2A EZH2 knockdown Colon HCT116 2.22101 1.15121 0.044981363 0.8488990 DataSet_03_334
MAT2A ARID3B CRISPR Colon HCT15 0.271211 -1.88251 - - DataSet_03_335
MAT2A CREBBP CRISPR Brain U5-NPC 1.62044 0.696386 0.3840115254 0.7490853 DataSet_03_356
MAT2A TP53 CRISPR Brain U5-NPC 2.07183 1.0509 3.403175e-02 1.684526e-01 DataSet_03_358
MAT2A DNMT3A knockout Embryo_kidney HEK293T 2.12177 1.08527 - - DataSet_03_369
MAT2A ZFP36L1 siRNA Urinary_bladder J82 2.05876 1.04178 - - DataSet_03_371
MAT2A YY1 knockdown Liver HepG2 1.57638 0.656617 6.136422e-06 6.798802e-05 DataSet_03_390
MAT2A ILF2 siRNA Stomach SGC-7901 2.86999 1.52105 0.0162909138 0.06732667 DataSet_03_393
MAT2A MAP3K7 shRNA Prostate LNCaP 0.62701 -0.67344 1.316911e-03 2.385543e-02 DataSet_03_408
MAT2A SIRT1 siRNA Pancreas PANC1 0.447153 -1.16116 3.195513e-05 0.008076714 DataSet_03_410
MAT2A FOXP3 CRISPR Peripheral_blood Naive Treg 1.58628 0.665651 6.619167e-01 0.836007687 DataSet_03_427
MAT2A USP7 shRNA Skin xenograft cells 0.455881 -1.13327 0.26715041 0.4348960 DataSet_03_431
MAT2A PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.645555 -0.631388 - - DataSet_03_432
MAT2A IRF2 shRNA Cord_Blood CD34+ cells 1.85864 0.894246 - - DataSet_03_460
MAT2A TXNIP shRNA Cord_Blood CD34+ cells 2.24173 1.16461 - - DataSet_03_461
MAT2A TXNIP shRNA Cord_blood ST3 1.52313 0.607041 6.793259e-02 0.3288521925 DataSet_03_462
MAT2A SMARCA1 Cas13 Embryo_kidney HEK293T 0.303308 -1.72115 - - DataSet_03_466
MAT2A SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.78103 0.832716 - - DataSet_03_467
MAT2A SMARCA1 shRNA Embryo_kidney HEK293T 0.617621 -0.695205 - - DataSet_03_468
Regulation Region
 
T(co)Fs that significantly regulate SP100 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of MAT2A
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines