Gene Overview
Target Gene: NAPSA
NCBI Official Symbol: NAPSA
Entrez ID: 9476
Ensembl ID: ENSG00000131400
Gene Full Name: napsin A aspartic peptidase
Strand: -
Gene Locus: 19q13.33
External Links:

NAPSA Significantly Regulated by These T(co)Fs

T(co)Fs that Activate NAPSA   
T(co)Fs that Repress NAPSA
The Intensity of the Gene Regulated by T(co)Fs:
NAPSA-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
NAPSA HOXA1 siRNA Lung_fibroblast IMR-90 2.09525 1.06712 0.14676 0.41415 DataSet_01_110
NAPSA ZIC2 siRNA Pancreas PANC1 2.17544 1.12131 - - DataSet_01_121
NAPSA FOXM1 siRNA Central_nervous_system U87 0.23498 -2.08939 - - DataSet_01_122
NAPSA ZNF85 siRNA Gastrointestinal_tissue GIST-T1 1.61432 0.69093 0.00017 0.00431 DataSet_01_126
NAPSA HSF1 shRNA Skin A375 0.60211 -0.73189 0.14169 0.37071 DataSet_01_155
NAPSA ELK1 siRNA Peripheral_blood CD4+ T cells 533.757 9.06004 0.02148 0.08722 DataSet_01_162
NAPSA JUN siRNA Peripheral_blood CD4+ T cells 2.24465 1.16649 0.00426 0.03944 DataSet_01_164
NAPSA MAF siRNA Peripheral_blood CD4+ T cells 2.10633 1.07473 0.00601 0.07814 DataSet_01_165
NAPSA NFATC3 siRNA Peripheral_blood CD4+ T cells 1.77054 0.82419 0.0401 0.20775 DataSet_01_166
NAPSA STAT3 siRNA Peripheral_blood CD4+ T cells 0.6317 -0.66268 0.16523 0.99183 DataSet_01_168
NAPSA CREB1 shRNA Parotid_gland HSY 0.59116 -0.75838 0.9111 0.99108 DataSet_01_195
NAPSA TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.75844 0.8143 - - DataSet_01_197
NAPSA TP63 siRNA Head_and_neck SCC-6 1.9383 0.95479 - - DataSet_01_202
NAPSA FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 0.61308 -0.70586 - - DataSet_01_208
NAPSA FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.32097 -1.63949 - - DataSet_01_209
NAPSA STAT5 shRNA Haematopoietic_and_lymphoid_tissue K562 1.98111 0.98631 2.10876e-05 0.00067 DataSet_01_239
NAPSA SIX4 siRNA Ovary PEO1 0.58639 -0.77006 0.01238 0.07873 DataSet_01_269
NAPSA STAT5 shRNA Prostate CWR22Pc 1.52759 0.61126 0.16933 0.33607 DataSet_01_279
NAPSA POSTN shRNA Brain GSC272 2.51386 1.3299 0.05395 0.53645 DataSet_01_293
NAPSA TFAP4 siRNA Brain BE(2)-C 0.158 -2.66204 0.28634 0.51625 DataSet_01_295
NAPSA PTEN shRNA Mammary_gland SKBR3 7.8245 2.968 0.01513 0.47085 DataSet_01_303
NAPSA TOX shRNA Haematopoietic_and_lymphoid_tissue HPB-ALL 0.65914 -0.60133 0.09048 0.7327 DataSet_01_332
NAPSA KLF4 siRNA Embryo HCE 1.99688 0.99775 0.0755 0.54086 DataSet_01_341
NAPSA KLF7 siRNA Embryo HCE 2.44275 1.28851 0.002 0.99985 DataSet_01_342
NAPSA GATA3 siRNA Oral_cavity OEC-M1 0.66387 -0.59103 0.19326 0.99787 DataSet_01_347
NAPSA TAF15 shRNA Liver HepG2 2.75 1.45943 0.04115 0.07708 DataSet_02_106
NAPSA SSB shRNA Liver HepG2 5 2.32193 0.02307 0.04803 DataSet_02_107
NAPSA BCLAF1 shRNA Liver HepG2 2.25 1.16993 0.00127 0.02531 DataSet_02_112
NAPSA XRCC5 shRNA Liver HepG2 0.57143 -0.80735 0.10138 0.27978 DataSet_02_114
NAPSA FUS shRNA Liver HepG2 0.35714 -1.48543 0.04496 0.16582 DataSet_02_124
NAPSA TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 1.53704 0.62015 0.16547 0.45475 DataSet_02_129
NAPSA POLR2G shRNA Haematopoietic_and_lymphoid_tissue K562 0.51515 -0.95693 0.19686 0.7289 DataSet_02_130
NAPSA RBM17 shRNA Haematopoietic_and_lymphoid_tissue K562 0.66286 -0.59323 0.05495 0.31815 DataSet_02_138
NAPSA TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 1.57438 0.65478 0.04352 0.23158 DataSet_02_140
NAPSA FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.35593 -1.49033 0.06589 0.17656 DataSet_02_147
NAPSA ILF3 shRNA Haematopoietic_and_lymphoid_tissue K562 2.28671 1.19328 0.00524 0.2373 DataSet_02_148
NAPSA RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 1.77451 0.82742 0.12366 0.32154 DataSet_02_151
NAPSA ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.54839 0.63077 0.09206 0.37586 DataSet_02_152
NAPSA XRCC5 shRNA Haematopoietic_and_lymphoid_tissue K562 0.60104 -0.73448 0.14735 0.71227 DataSet_02_159
NAPSA TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.31818 -1.65208 0.2543 0.49184 DataSet_02_163
NAPSA SSB shRNA Haematopoietic_and_lymphoid_tissue K562 0.63636 -0.65208 0.46204 0.65155 DataSet_02_164
NAPSA U2AF1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.54132 -0.88544 0.41128 0.58063 DataSet_02_165
NAPSA RBM25 shRNA Haematopoietic_and_lymphoid_tissue K562 0.52479 -0.93018 0.39105 0.60101 DataSet_02_166
NAPSA TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.40321 0.50985 DataSet_02_169
NAPSA U2AF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.49587 -1.01197 0.32995 0.46109 DataSet_02_170
NAPSA RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 1.74 0.79909 0.24148 1 DataSet_02_190
NAPSA AR siRNA Prostate abl cells 1.52068 0.604718 0.245624084323296 0.999852161656754 DataSet_03_004
NAPSA ASCL1 siRNA Lung DMS79 0.509901 -0.971711 0.0488949337033735 0.67028012814667 DataSet_03_016
NAPSA FOXO1 shRNA Haematopoietic_and_lymphoid_tissue BL41 1.61741 0.693685 0.00174021136122033 0.17946507166355 DataSet_03_094
NAPSA FOXO1 shRNA Haematopoietic_and_lymphoid_tissue Namalwa 1.58056 0.660439 0.000696754313982332 0.0611591103809688 DataSet_03_095
NAPSA GRHL3 siRNA Skin Primary neonatal keratinocytes 1.5705 0.651227 0.00358305163649239 0.173720753983663 DataSet_03_113
NAPSA HNF4a siRNA Liver HepG2 0.541203 -0.885759 0.322945983157804 0.861371985158337 DataSet_03_126
NAPSA KLF5 siRNA Stomach YCC3 0.527423 -0.922967 0.353770931400251 0.702836524926916 DataSet_03_151
NAPSA MITF siRNA Skin SK-MEL-5 0.600487 -0.735794 0.0014549536385728 0.00458188889355745 DataSet_03_168
NAPSA MYB siRNA Prostate DU145 2.18909 1.13033 2.61516960023333e-05 0.00838125943263224 DataSet_03_171
NAPSA NR2F2 siRNA Uterus Primary eutopic stromal cells 1.57665 0.656861 0.255293618270119 0.99947668859931 DataSet_03_202
NAPSA PHB shRNA Embryo Embryonic stem cells (ESCs) 1.90529 0.930008 0.136695895867563 0.246822614783119 DataSet_03_211
NAPSA SOX11 siRNA Lung_fibroblast NHLF 1.79103 0.840792 0.147758897724519 0.561917112421014 DataSet_03_237
NAPSA SOX11 siRNA Lung_fibroblast NHLF 1.89488 0.922108 0.0271138095908982 0.260392760840558 DataSet_03_238
NAPSA SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.197183 -2.34239 - - DataSet_03_246
NAPSA SP1 siRNA Ovary OVSAYO 0.201576 -2.31061 0.00031253699134392 0.0593489715581834 DataSet_03_251
NAPSA STAT3 siRNA Prostate DU145 0.589886 -0.761491 9.55761532608467e-05 0.00888283948010143 DataSet_03_260
NAPSA TFE3 siRNA Kidney UOK257-2 1.50445 0.589237 - - DataSet_03_275
NAPSA APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 0.604563 -0.726036 0.00726529514442743 0.415700541355058 DataSet_04_001
NAPSA ERN1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.561702 -0.832123 0.0741266020102601 0.707544492138917 DataSet_04_009
NAPSA FUBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.16129 1.11189 0.0468714246163915 0.127942698650418 DataSet_04_010
NAPSA NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 25.3775 4.66548 0.311012827112096 0.460376218934875 DataSet_04_014
NAPSA NUP35 shRNA Haematopoietic_and_lymphoid_tissue K562 0.468208 -1.09478 0.200319792483858 0.279186050844023 DataSet_04_015
NAPSA SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.487879 -1.03541 0.0160610630440359 0.096044009095471 DataSet_04_018
NAPSA ZNF574 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.587859 -0.766457 0.0503454260935389 0.172184231476255 DataSet_04_023
NAPSA DNMT3B CRISPR Liver HepG2 0.166667 -2.58496 0.583858629051633 0.802288889311392 DataSet_04_044
NAPSA CCAR1 shRNA Liver HepG2 0.5 -1 0.93045824620379 0.965821784874108 DataSet_04_054
NAPSA PRPF6 shRNA Liver HepG2 0.642857 -0.63743 0.778543163084551 0.899779595335502 DataSet_04_056
NAPSA SMG7 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.66482 -0.588964 0.0229356766036971 0.36988468995597 DataSet_04_075
NAPSA DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.59158 0.670459 0.112709710355283 0.220902108056461 DataSet_02_14
NAPSA ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 3.68548 1.88185 0.00238015221205429 0.0287952160283423 DataSet_04_060
NAPSA CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 2.49194 1.31727 0.0513827734382855 0.173761844957449 DataSet_04_061
NAPSA DDX1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.38732 1.25539 0.0031314625658289 0.367854001139043 DataSet_04_063
NAPSA HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 0.358382 -1.48043 0.00463647341120034 0.0173662144343019 DataSet_04_059
NAPSA PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 1.6943 0.76069 0.0499968951732639 0.354058442830134 DataSet_04_065
NAPSA ACTR5 siRNA Muscle RD 0.656175 -0.607848 - - DataSet_03_343
NAPSA TET1 CRISPR Mammary_gland Hs578T 2.74922 1.45902 2.404955e-01 4.297396e-01 DataSet_03_355
NAPSA ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 0.620986 -0.687367 7.578411e-01 8.167511e-01 DataSet_03_362
NAPSA MYC siRNA Peripheral_blood T lymphocyte 1.57972 0.659664 8.358206e-03 0.067633922 DataSet_03_363
NAPSA USP22 shRNA Liver PLC_PRF_5 cells 0.248201 -2.01042 1.164727e-01 0.31961143 DataSet_03_368
NAPSA DNMT3A knockout Embryo_kidney HEK293T 0.391872 -1.35155 - - DataSet_03_369
NAPSA ZFP36L1 siRNA Urinary_bladder J82 4 2 - - DataSet_03_371
NAPSA E2F1 siRNA Nasopharynx HK1 4 2 4.618097e-01 1.000000e+00 DataSet_03_373
NAPSA ZNF213 siRNA Mammary_gland MCF7 2.24701 1.168 1.066575e-01 5.247077e-01 DataSet_03_376
NAPSA DNMT1 siRNA Skin Human melanoma cells 2.58265 1.36885 1.008957e-01 1.613594e-01 DataSet_03_382
NAPSA NFKBIA shRNA Bone_marrow U2OS 0.133882 -2.90097 8.130091e-01 0.92151588 DataSet_03_389
NAPSA KDM5A CRISPR Lung GLC16 2.71083 1.43874 1.992411e-01 0.337336938 DataSet_03_392
NAPSA ILF2 siRNA Stomach SGC-7901 1.75 0.807355 0.5815873053 0.66041517 DataSet_03_393
NAPSA RELA CRISPR Brain T30 0.107048 -3.22366 0.3563906268 0.8400824 DataSet_03_399
NAPSA SUMO1 CRISPR Bone_marrow U2OS 1.81633 0.861024 9.904363e-03 5.535671e-02 DataSet_03_401
NAPSA JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 2.07143 1.05063 1.194914e-01 0.3395398 DataSet_03_403
NAPSA CDK7 shRNA Bone_marrow D458 10 3.32193 3.948102e-01 0.66962085 DataSet_03_404
NAPSA TFAP2A knockout Embryo H9 1.57627 0.656516 1.305399e-01 0.26450551 DataSet_03_405
NAPSA CHD1 shRNA Prostate LNCaP 2.5 1.32193 2.916005e-02 3.829517e-01 DataSet_03_407
NAPSA MAP3K7 shRNA Prostate LNCaP 2.25 1.16992 1.214613e-01 3.328411e-01 DataSet_03_408
NAPSA STRAP knockout Nerve SK-N-AS 0.414419 -1.27084 - - DataSet_03_409
NAPSA SIRT1 siRNA Pancreas PANC1 4.6579 2.21968 7.595576e-03 0.043387092 DataSet_03_410
NAPSA E2F1 siRNA Prostate LNCaP 1.88889 0.917538 9.592633e-02 0.6731381120 DataSet_03_413
NAPSA NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 2 1 5.378509e-01 0.674304555 DataSet_03_418
NAPSA PRDM1 CRISPR Lymph CD8+ T cells 1.84783 0.885829 - - DataSet_03_421
NAPSA MAEL CRISPR Liver Alexander cells 0.175824 -2.50779 - - DataSet_03_423
NAPSA USP7 shRNA Skin xenograft cells 0.458333 -1.12553 0.22931005 0.4348960 DataSet_03_431
NAPSA POU2AF1 CRISPR Lymph SUDHL4 1.99005 0.992805 1.564324e-02 0.055746525 DataSet_03_435
NAPSA EP300 knockout Pancreas HPAF-II orthotopic cells 1.64757 0.720342 3.398618e-03 1.897745e-02 DataSet_03_436
NAPSA FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 2 1 4.087473e-02 0.77151037 DataSet_03_439
NAPSA SETDB1 shRNA Colon HCT116 0.466201 -1.10098 - - DataSet_03_440
NAPSA DAXX shRNA Mammary_gland MDA-MB-231 0.590887 -0.759047 3.707345e-01 0.67626284 DataSet_03_441
NAPSA CAMTA1 knockout Embryo_kidney HEK293T 1.65517 0.726982 2.937295e-01 0.44365395 DataSet_03_448
NAPSA RELB CRISPR Colon SW480 2.19298 1.13289 1.001166e-02 7.851197e-02 DataSet_03_449
NAPSA CBX2 siRNA Mammary_gland MDA-MB-231 2.25539 1.17338 1.988628e-02 7.700811e-02 DataSet_03_450
NAPSA PPARG siRNA Aortic_valve Valvular endothelial cell 1.72632 0.787696 1.762929e-01 6.136283e-01 DataSet_03_456
NAPSA SREBF2 siRNA Umbilical_vein HUVEC 0.644127 -0.634582 1.689905e-01 6.047474e-01 DataSet_03_457
NAPSA ARID1A shRNA Bile_duct MMNK1 1.58759 0.666838 4.721855e-01 0.669282925 DataSet_03_458
NAPSA SOX9 knockout Liver HuH7 2.5 1.32193 2.585507e-01 4.338812e-01 DataSet_03_463
NAPSA PARP1 knockout Embryo_kidney HEK293a 3.72388 1.89681 1.889696e-07 3.508998e-06 DataSet_03_464
NAPSA SMARCA1 Cas13 Embryo_kidney HEK293T 0.153846 -2.70044 - - DataSet_03_466
NAPSA SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.75 0.807355 - - DataSet_03_467
NAPSA SMARCA1 shRNA Embryo_kidney HEK293T 0.403846 -1.30812 - - DataSet_03_468
NAPSA WHSC1 siRNA Prostate PC3 0.641026 -0.641546 7.511002e-01 0.86065555 DataSet_03_471
NAPSA EZH2 siRNA Umbilical_vein HUVEC 0.647059 -0.628031 2.463913e-01 0.517968113 DataSet_03_473
NAPSA EZH2 siRNA Prostate LNCaP 1.91667 0.9386 5.558302e-01 1.0000000 DataSet_03_475
NAPSA HMGB2 knockdown Umbilical_vein HUVEC 1.73333 0.793549 3.638746e-02 0.13632533 DataSet_03_476
NAPSA APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 0.604563 -0.726036 0.006293796 0.3637527 DataSet_04_072
Regulation Region
 
T(co)Fs that significantly regulate BCL11A by the evidences of both expression and ChIP-seq/motif
Expression Atlas of NAPSA
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines