Gene Overview
Target Gene: NHSL1
NCBI Official Symbol: NHSL1
Entrez ID: 57224
Ensembl ID: ENSG00000135540
Gene Full Name: NHS like 1
Strand: -
Gene Locus: 6q24.1
External Links:

NHSL1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate NHSL1   
T(co)Fs that Repress NHSL1
The Intensity of the Gene Regulated by T(co)Fs:
NHSL1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
NHSL1 ZIC2 siRNA Pancreas PANC1 0.28462 -1.81291 - - DataSet_01_121
NHSL1 FOXM1 siRNA Central_nervous_system U87 0.20713 -2.27137 - - DataSet_01_122
NHSL1 IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 2.46126 1.2994 0.00971 0.29708 DataSet_01_137
NHSL1 IKZF1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.7653 0.81992 0.10802 0.99993 DataSet_01_138
NHSL1 NR3C1 siRNA Uterus Endometrial stromal cells 1.52626 0.61 0.07899 0.99972 DataSet_01_141
NHSL1 RUNX1 siRNA Haematopoietic_and_lymphoid_tissue Kasumi-1 0.35402 -1.49811 1.95684e-05 0.00231 DataSet_01_159
NHSL1 GATA2 siRNA Prostate LNCaP 0.43688 -1.19468 0.00198 0.00993 DataSet_01_193
NHSL1 HIC1 shRNA Mammary_gland HBL100 0.41713 -1.26143 - - DataSet_01_205
NHSL1 MITF shRNA Skin COLO829 0.51636 -0.95354 0.02785 0.14194 DataSet_01_207
NHSL1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 0.53032 -0.91506 - - DataSet_01_208
NHSL1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 1.65967 0.7309 - - DataSet_01_209
NHSL1 REST siRNA Prostate LNCaP 1.53027 0.61378 0.30646 0.61002 DataSet_01_211
NHSL1 TWIST1 shRNA Stomach CAF32 1.81545 0.86033 0.0048 0.03545 DataSet_01_253
NHSL1 STAT5 shRNA Prostate CWR22Pc 1.94974 0.96328 0.00879 0.04907 DataSet_01_279
NHSL1 MSX1 siRNA Tooth Dental Pulp Cells 2.1355 1.09457 4e-04 0.00259 DataSet_01_281
NHSL1 ZIC5 siRNA Skin A375 1.7279 0.78902 - - DataSet_01_284
NHSL1 TFAP4 siRNA Brain BE(2)-C 0.2072 -2.27094 0.37166 0.51625 DataSet_01_295
NHSL1 ARID1B shRNA Liver IRM90 1.59215 0.67097 0.00033 0.00653 DataSet_01_298
NHSL1 RUNX1 shRNA Embryo H9 0.65653 -0.60707 0.04459 0.18661 DataSet_01_314
NHSL1 ELK3 shRNA Mammary_gland MDA-MB-231 2.28849 1.19439 0.00011 0.00063 DataSet_01_318
NHSL1 FOXO1 shRNA Haematopoietic_and_lymphoid_tissue 018Z 0.65462 -0.61126 0.06463 0.93203 DataSet_01_322
NHSL1 MYC siRNA Colon HCT116 1.61462 0.69119 4.81202e-06 3.19251e-05 DataSet_01_324
NHSL1 SOX17 siRNA Umbilical_vein HUVEC 0.62806 -0.67103 - - DataSet_01_360
NHSL1 RBFOX2 shRNA Liver HepG2 0.65414 -0.61234 0.06108 0.65168 DataSet_02_101
NHSL1 U2AF2 shRNA Liver HepG2 1.84162 0.88098 0.01312 0.07704 DataSet_02_105
NHSL1 TAF15 shRNA Liver HepG2 1.58487 0.66436 0.00202 0.01374 DataSet_02_106
NHSL1 U2AF2 shRNA Liver HepG2 1.75399 0.81064 0.00228 0.05145 DataSet_02_113
NHSL1 PCBP1 shRNA Liver HepG2 1.52315 0.60705 0.00335 0.01933 DataSet_02_115
NHSL1 PTBP1 shRNA Liver HepG2 1.6217 0.69751 0.00202 0.00909 DataSet_02_120
NHSL1 SNRNP70 shRNA Liver HepG2 0.59098 -0.75883 0.00655 0.04414 DataSet_02_126
NHSL1 POLR2G shRNA Haematopoietic_and_lymphoid_tissue K562 9.5 3.24793 0.01881 0.69659 DataSet_02_130
NHSL1 AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.03125 -5 0.02102 0.12935 DataSet_02_132
NHSL1 RBM17 shRNA Haematopoietic_and_lymphoid_tissue K562 5 2.32193 0.03143 0.27846 DataSet_02_138
NHSL1 RBFOX2 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.08688 0.48912 DataSet_02_139
NHSL1 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.33076 0.41774 DataSet_02_143
NHSL1 DROSHA shRNA Haematopoietic_and_lymphoid_tissue K562 2.88889 1.53051 0.4619 0.71623 DataSet_02_145
NHSL1 NONO shRNA Haematopoietic_and_lymphoid_tissue K562 20 4.32193 0.01195 0.19424 DataSet_02_149
NHSL1 RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 6.44444 2.68806 0.06801 0.26996 DataSet_02_151
NHSL1 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.02174 -5.52356 0.00061 0.23369 DataSet_02_152
NHSL1 YBX3 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 1 1 DataSet_02_153
NHSL1 SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 3.63636 1.8625 0.1893 0.49732 DataSet_02_154
NHSL1 HNRNPUL1 shRNA Haematopoietic_and_lymphoid_tissue K562 3.44444 1.78427 0.43017 0.70572 DataSet_02_156
NHSL1 GTF2F1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.09091 -3.45943 0.01409 0.7666 DataSet_02_157
NHSL1 PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.125 1.08746 0.69755 0.78856 DataSet_02_158
NHSL1 XRCC5 shRNA Haematopoietic_and_lymphoid_tissue K562 0.27273 -1.87447 0.02466 0.59238 DataSet_02_159
NHSL1 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 0.05556 -4.16993 0.00385 0.11802 DataSet_02_160
NHSL1 SUB1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.09091 -3.45943 0.01662 0.66851 DataSet_02_161
NHSL1 EWSR1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.3913 -1.35364 0.21158 0.43959 DataSet_02_167
NHSL1 ZFX siRNA Prostate C4-2B 0.6566 -0.60692 0.00035 0.00335 DataSet_02_172
NHSL1 MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 3.70588 1.88982 0.13019 1 DataSet_02_173
NHSL1 NFE2L2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.05882 -4.08746 0.01156 1 DataSet_02_174
NHSL1 LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 0.43182 -1.2115 0.17601 1 DataSet_02_175
NHSL1 VEZF1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.14286 -2.80735 0.01705 1 DataSet_02_179
NHSL1 ZMIZ1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.08696 -3.52356 0.11018 1 DataSet_02_181
NHSL1 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 0.05556 -4.16993 0.0483 1 DataSet_02_182
NHSL1 MAFK siRNA Haematopoietic_and_lymphoid_tissue K562 0.30303 -1.72247 0.12046 1 DataSet_02_183
NHSL1 KAT2B siRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.48412 1 DataSet_02_184
NHSL1 BHLHE40 siRNA Haematopoietic_and_lymphoid_tissue K562 0.04762 -4.39232 0.01595 1 DataSet_02_186
NHSL1 CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.14286 -2.80735 0.0077 1 DataSet_02_187
NHSL1 LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 1.61364 0.69032 0.69362 1 DataSet_02_191
NHSL1 MAX siRNA Haematopoietic_and_lymphoid_tissue K562 0.44444 -1.16993 0.77727 1 DataSet_02_192
NHSL1 ARID3A siRNA Haematopoietic_and_lymphoid_tissue K562 1.52174 0.60572 0.30594 1 DataSet_02_193
NHSL1 TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.02994 1 DataSet_02_194
NHSL1 LMNB1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.61111 0.68806 0.61312 1 DataSet_02_195
NHSL1 CHD2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.40625 -1.29956 0.00466 0.12618 DataSet_02_196
NHSL1 CDAN1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.61111 -0.71049 0.60119 1 DataSet_02_197
NHSL1 TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.85714 0.89308 0.84692 1 DataSet_02_201
NHSL1 RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.2008 1 DataSet_02_204
NHSL1 E2F6 siRNA Haematopoietic_and_lymphoid_tissue K562 2.33333 1.22239 0.75735 1 DataSet_02_205
NHSL1 GATA6 siRNA Stomach YCC3 1.64158 0.715083 0.0623284280064046 0.656479624746445 DataSet_03_110
NHSL1 KLF5 siRNA Stomach YCC3 1.50008 0.585037 0.235468060319711 0.603327406899026 DataSet_03_151
NHSL1 MEF2D siRNA Liver HuH7 1.6177 0.693941 - - DataSet_03_163
NHSL1 MITF siRNA Skin SK-MEL-5 0.565629 -0.822072 0.000412379623668883 0.00167226260083614 DataSet_03_168
NHSL1 MTA2 siRNA Stomach SGC-7901 2.17507 1.12106 - - DataSet_03_169
NHSL1 SOX11 siRNA Lung_fibroblast NHLF 0.602148 -0.731811 0.101033614889786 0.440074915249862 DataSet_03_238
NHSL1 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.648256 -0.625365 - - DataSet_03_246
NHSL1 TP53 siRNA Foreskin Neonatal foreskin keratinocytes 1.56154 0.642973 0.209259232008711 0.999791649573014 DataSet_03_278
NHSL1 CIZ1 CRISPR Haematopoietic_and_lymphoid_tissue K562 4.85714 2.28011 0.05337905008821 0.112996135478111 DataSet_04_004
NHSL1 CTCF CRISPR Haematopoietic_and_lymphoid_tissue K562 1.52174 0.605721 0.0395919713889727 0.355044357932884 DataSet_04_005
NHSL1 EIF2AK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.67647 0.745427 0.774387254777812 0.906975666200048 DataSet_04_008
NHSL1 MECP2 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.04348 1.03103 0.291930280881533 0.848572146483105 DataSet_04_013
NHSL1 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 53.7353 5.7478 0.0873628509106752 0.196193449920235 DataSet_04_014
NHSL1 RPS3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.0217951108795282 0.387731141877528 DataSet_04_017
NHSL1 XRCC5 CRISPR Haematopoietic_and_lymphoid_tissue K562 4.14286 2.05063 0.00102945798390441 0.136850345610058 DataSet_04_021
NHSL1 ABT1 shRNA Liver HepG2 0.548378 -0.866758 0.000427747553479773 0.0052899773534195 DataSet_04_052
NHSL1 DDX17 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.139535 -2.8413 0.035319513223659 0.560950203494295 DataSet_04_047
NHSL1 DDX20 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.125 -3 0.496730791232565 0.81388268115171 DataSet_04_050
NHSL1 NPM1 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.86957 1.52083 0.0693373853436912 0.196234312277707 DataSet_04_046
NHSL1 SEPT11 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.0434783 -4.52356 0.175548741466379 1 DataSet_04_077
NHSL1 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.565217 -0.823122 0.499299045256855 0.665072439743366 DataSet_04_049
NHSL1 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.470588 -1.08746 0.610571127205224 0.761931196554418 DataSet_02_34
NHSL1 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.380952 -1.39232 0.0771765469914413 0.454270082358651 DataSet_02_75
NHSL1 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 10.3529 3.37197 0.147481891759632 0.641456443990014 DataSet_02_45
NHSL1 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.05882 1.04182 0.328949707972119 0.509561186914737 DataSet_02_35
NHSL1 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.41176 1.77052 0.232060123755378 0.508338094559482 DataSet_02_32
NHSL1 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.235294 -2.08746 0.407464210699556 0.568512582154711 DataSet_02_47
NHSL1 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.82759 1.49957 0.434512697654656 0.796520915383835 DataSet_02_49
NHSL1 TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.17647 1.12199 0.537595606229493 0.712654855459341 DataSet_02_43
NHSL1 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.235294 -2.08746 0.418680991914878 0.579398884208444 DataSet_02_33
NHSL1 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.88235 0.912537 0.364528243190841 0.535694923165177 DataSet_02_53
NHSL1 CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 0.0217391 -5.52356 0.0230695037048707 0.115104134507164 DataSet_04_061
NHSL1 PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 3.54545 1.82597 0.433556289704689 0.768095733868235 DataSet_04_065
NHSL1 UBE2L3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.3125 -1.67807 0.228102810652072 0.477924260749796 DataSet_04_062
NHSL1 EZH2 knockdown Uterus Ishikawa (ISK) cell 0.604299 -0.726667 - - DataSet_03_324
NHSL1 SMARCA4 siRNA Colon HCT116 0.435163 -1.20037 1.905879e-02 4.694409e-01 DataSet_03_301
NHSL1 SMARCA4 siRNA Colon HCT116 1.54451 0.627149 1.263925e-02 0.1428389 DataSet_03_302
NHSL1 ACTR5 siRNA Muscle RD 0.635775 -0.653411 - - DataSet_03_343
NHSL1 INO80 siRNA Muscle RD 1.61243 0.689235 - - DataSet_03_344
NHSL1 TET1 CRISPR Mammary_gland MDA-MB-231 2.17629 1.12187 7.508437e-03 5.033852e-02 DataSet_03_347
NHSL1 TET1 CRISPR Mammary_gland Hs578T 1.67376 0.743095 3.687305e-02 1.172474e-01 DataSet_03_355
NHSL1 PTPN14 CRISPR Brain U5-NPC 0.489705 -1.03002 1.306156e-02 0.23456001 DataSet_03_357
NHSL1 TP53 CRISPR Brain U5-NPC 1.50918 0.593765 1.831360e-01 3.168014e-01 DataSet_03_358
NHSL1 DNMT3A knockout Embryo_kidney HEK293T 2.61561 1.38715 - - DataSet_03_369
NHSL1 ZFP36L1 siRNA Urinary_bladder J82 2.25778 1.17491 - - DataSet_03_371
NHSL1 ZNF213 siRNA Mammary_gland MCF7 0.475648 -1.07203 1.689287e-01 6.571458e-01 DataSet_03_376
NHSL1 EZH2 CRISPR Ovary SKOV3 2.1864 1.12856 1.179140e-03 0.0230729921 DataSet_03_378
NHSL1 DDX5 shRNA Stomach HGC-27 1.96657 0.975684 - - DataSet_03_379
NHSL1 TCF19 CRISPR Oral_squamous CAL27 0.581724 -0.781594 1.334723e-04 0.0071427422 DataSet_03_383
NHSL1 YY1 shRNA Brain GSC1517 1.55935 0.640947 - - DataSet_03_384
NHSL1 NFKBIA shRNA Bone_marrow U2OS 0.390127 -1.35799 3.190483e-01 0.87005461 DataSet_03_389
NHSL1 ILF2 siRNA Stomach SGC-7901 1.64583 0.718818 0.1013289097 0.25676939 DataSet_03_393
NHSL1 BMI1 shRNA Bile_duct QBC-939 0.652152 -0.616721 2.920141e-03 0.0157238833 DataSet_03_395
NHSL1 IKZF2 CRISPR Lymph CAR T Cell 0.415659 -1.26653 4.198858e-01 0.786889949 DataSet_03_397
NHSL1 TLE4 CRISPR Lymph CAR T Cell 0.399188 -1.32486 3.851757e-01 0.69129108 DataSet_03_398
NHSL1 HMGA1 shRNA Bile_duct HUCCT1 1.78362 0.834806 6.344331e-03 0.096367000 DataSet_03_400
NHSL1 EHF shRNA Stomach MKN7 0.189842 -2.39713 - - DataSet_03_402
NHSL1 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.56033 0.641849 4.505370e-02 0.3239928 DataSet_03_403
NHSL1 CDK7 shRNA Bone_marrow D458 0.50712 -0.979602 3.609369e-02 0.27753676 DataSet_03_404
NHSL1 E2F2 siRNA Prostate LNCaP 0.573944 -0.801019 8.599745e-05 3.253313e-03 DataSet_03_414
NHSL1 RUNX2 shRNA Cord_blood Natural Killer Cell 0.245283 -2.02748 4.043222e-01 0.793390621 DataSet_03_416
NHSL1 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 4.7619 2.25154 4.004018e-04 0.007086598 DataSet_03_418
NHSL1 FOXK2 shRNA Ovary OVCAR-5 1.55969 0.641256 1.595346e-01 0.38406165 DataSet_03_419
NHSL1 PRDM1 CRISPR Lymph CD8+ T cells 1.81481 0.859822 - - DataSet_03_421
NHSL1 FOXQ1 CRISPR Lymph Primary CD4+ T cells 0.475 -1.074 - - DataSet_03_422
NHSL1 FOXP3 CRISPR Peripheral_blood Naive Treg 1.64356 0.716828 3.608330e-01 0.684249468 DataSet_03_427
NHSL1 USP7 shRNA Skin xenograft cells 0.37219 -1.42589 0.26752604 0.4348960 DataSet_03_431
NHSL1 CIC knockout Brain Immortalized Astrocyte Cells 1.59271 0.671484 1.894406e-03 8.283092e-02 DataSet_03_438
NHSL1 SETDB1 shRNA Colon HCT116 0.384857 -1.37761 - - DataSet_03_440
NHSL1 DAXX shRNA Mammary_gland MDA-MB-231 1.54241 0.625188 7.076920e-01 0.88673164 DataSet_03_441
NHSL1 CBX2 siRNA Mammary_gland MDA-MB-231 1.53662 0.619761 7.672770e-03 3.872344e-02 DataSet_03_450
NHSL1 CBX2 siRNA Mammary_gland MCF7 1.7138 0.777196 3.330955e-05 0.0008146265 DataSet_03_451
NHSL1 SMARCA2 shRNA Lung HCC2302 2.24677 1.16786 1.398435e-09 7.957387e-09 DataSet_03_455
NHSL1 IRF2 shRNA Cord_Blood CD34+ cells 0.230769 -2.11548 - - DataSet_03_460
NHSL1 SOX9 knockout Liver HuH7 1.94674 0.961059 2.256181e-04 3.527523e-03 DataSet_03_463
NHSL1 SMARCA1 Cas13 Embryo_kidney HEK293T 0.202498 -2.30402 - - DataSet_03_466
NHSL1 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 2.06575 1.04666 - - DataSet_03_467
NHSL1 CHCHD3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.0465116 -4.42626 0.03107414 0.8431706 DataSet_04_071
Regulation Region
 
T(co)Fs that significantly regulate NONO by the evidences of both expression and ChIP-seq/motif
Expression Atlas of NHSL1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines