Gene Overview
Target Gene: PLCB2
NCBI Official Symbol: PLCB2
Entrez ID: 5330
Ensembl ID: ENSG00000137841
Gene Full Name: phospholipase C beta 2
Strand: -
Gene Locus: 15q15.1
External Links:

PLCB2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate PLCB2   
T(co)Fs that Repress PLCB2
The Intensity of the Gene Regulated by T(co)Fs:
PLCB2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
PLCB2 HOXA1 siRNA Lung_fibroblast IMR-90 0.58489 -0.77376 0.01951 0.14748 DataSet_01_110
PLCB2 ID1 siRNA Lung A549 0.53764 -0.89529 0.0543 0.24788 DataSet_01_117
PLCB2 ZIC2 siRNA Pancreas PANC1 3.2947 1.72015 - - DataSet_01_121
PLCB2 FOXM1 siRNA Central_nervous_system U87 2.86715 1.51962 - - DataSet_01_122
PLCB2 RUNX1 siRNA Haematopoietic_and_lymphoid_tissue Kasumi-1 0.58032 -0.78508 4.20918e-06 0.00099 DataSet_01_159
PLCB2 ELK1 siRNA Peripheral_blood CD4+ T cells 3.11659 1.63997 9.57653e-05 0.00243 DataSet_01_162
PLCB2 GATA3 siRNA Peripheral_blood CD4+ T cells 273.928 8.09765 0.23877 0.58185 DataSet_01_163
PLCB2 JUN siRNA Peripheral_blood CD4+ T cells 2.57981 1.36726 0.00018 0.00528 DataSet_01_164
PLCB2 MAF siRNA Peripheral_blood CD4+ T cells 2.39272 1.25865 0.00033 0.0122 DataSet_01_165
PLCB2 NFATC3 siRNA Peripheral_blood CD4+ T cells 937 9.87191 0.05548 0.24712 DataSet_01_166
PLCB2 GATA2 siRNA Prostate LNCaP 0.52041 -0.94228 0.10666 0.20491 DataSet_01_193
PLCB2 CREB1 shRNA Parotid_gland H3118 MEC 0.35396 -1.49833 0.28644 0.64867 DataSet_01_194
PLCB2 TP63 siRNA Head_and_neck SCC-1 0.60959 -0.71409 - - DataSet_01_198
PLCB2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 2.67584 1.41999 - - DataSet_01_209
PLCB2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 2.13386 1.09347 - - DataSet_01_210
PLCB2 REST siRNA Prostate LNCaP 1.59982 0.67791 0.05592 0.28042 DataSet_01_211
PLCB2 LIN28A siRNA Embryo H9 0.45965 -1.12139 0.00089 0.01143 DataSet_01_215
PLCB2 STAT5 shRNA Haematopoietic_and_lymphoid_tissue K562 0.55086 -0.86025 0.00099 0.00714 DataSet_01_239
PLCB2 TWIST1 shRNA Stomach CAF14 0.65082 -0.61967 0.27053 0.99996 DataSet_01_252
PLCB2 TWIST1 shRNA Stomach CAF32 0.33324 -1.58536 0.00945 0.05045 DataSet_01_253
PLCB2 TWIST1 shRNA Stomach CAF 0.4657 -1.10251 0.06666 0.56583 DataSet_01_254
PLCB2 FOXO1 siRNA Umbilical_vein HUVEC 0.62084 -0.6877 0.00868 0.06293 DataSet_01_270
PLCB2 MSX1 siRNA Tooth Dental Pulp Cells 0.64278 -0.6376 0.02232 0.05634 DataSet_01_281
PLCB2 SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 0.45203 -1.14551 0.01369 0.77909 DataSet_01_290
PLCB2 POSTN shRNA Brain GSC272 2.23974 1.16333 0.13229 0.56076 DataSet_01_293
PLCB2 TFAP4 siRNA Brain BE(2)-C 0.22944 -2.1238 0.43447 0.51625 DataSet_01_295
PLCB2 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 0.62353 -0.68146 0.20298 0.42139 DataSet_01_313
PLCB2 GATA3 siRNA Oral_cavity OEC-M1 1.79879 0.84703 0.08374 0.99787 DataSet_01_347
PLCB2 HIF1A siRNA Oral_cavity OEC-M1 2.36623 1.24259 0.10695 0.85151 DataSet_01_348
PLCB2 CDX2 siRNA Colon COLO320 0.56853 -0.8147 - - DataSet_01_357
PLCB2 GTF2B siRNA Cervix HeLa 0.5639 -0.8265 - - DataSet_01_362
PLCB2 RBFOX2 shRNA Liver HepG2 0.04167 -4.58496 0.00492 0.65168 DataSet_02_101
PLCB2 SAFB2 shRNA Liver HepG2 0.04167 -4.58496 0.13408 0.21573 DataSet_02_102
PLCB2 FIP1L1 shRNA Liver HepG2 4.10526 2.03747 0.07741 0.14706 DataSet_02_103
PLCB2 HDGF shRNA Liver HepG2 7.42857 2.89308 0.02619 0.13005 DataSet_02_104
PLCB2 U2AF2 shRNA Liver HepG2 0.64706 -0.62803 0.41595 0.56307 DataSet_02_105
PLCB2 TAF15 shRNA Liver HepG2 3.83333 1.9386 0.02677 0.05676 DataSet_02_106
PLCB2 HNRNPUL1 shRNA Liver HepG2 2.70833 1.43741 0.16376 0.24883 DataSet_02_109
PLCB2 BCLAF1 shRNA Liver HepG2 0.44444 -1.16993 0.52203 0.62767 DataSet_02_112
PLCB2 XRCC5 shRNA Liver HepG2 0.05882 -4.08746 0.00525 0.13784 DataSet_02_114
PLCB2 TARDBP shRNA Liver HepG2 0.56604 -0.82103 0.41794 0.51436 DataSet_02_116
PLCB2 CEBPZ shRNA Liver HepG2 0.31579 -1.66297 0.43184 1 DataSet_02_118
PLCB2 RBM25 shRNA Liver HepG2 0.04167 -4.58496 0.01145 0.04301 DataSet_02_119
PLCB2 RBM34 shRNA Liver HepG2 0.33333 -1.58496 0.1814 0.52787 DataSet_02_121
PLCB2 EWSR1 shRNA Liver HepG2 4.85714 2.28011 0.3094 0.43662 DataSet_02_122
PLCB2 PCBP2 shRNA Liver HepG2 0.23529 -2.08746 0.00414 0.05922 DataSet_02_123
PLCB2 FUS shRNA Liver HepG2 0.37255 -1.4245 0.14165 0.31485 DataSet_02_124
PLCB2 HNRNPLL shRNA Liver HepG2 0.0566 -4.14296 0.06905 0.12263 DataSet_02_125
PLCB2 SNRNP70 shRNA Liver HepG2 0.43396 -1.20436 0.20122 0.31176 DataSet_02_126
PLCB2 PRPF4 shRNA Liver HepG2 0.62069 -0.68806 0.1853 0.30152 DataSet_02_128
PLCB2 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.2509 -1.99484 0.00093 0.02779 DataSet_02_131
PLCB2 AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.32006 -1.6436 0.03156 0.1483 DataSet_02_132
PLCB2 SRSF7 shRNA Haematopoietic_and_lymphoid_tissue K562 0.48817 -1.03454 0.00859 0.22541 DataSet_02_133
PLCB2 PCBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.26595 -1.91077 0.01854 0.21523 DataSet_02_137
PLCB2 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.54772 -0.8685 0.00123 0.02038 DataSet_02_143
PLCB2 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.34139 -1.55049 0.05511 0.25367 DataSet_02_144
PLCB2 SAFB2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.66635 -0.58564 0.1464 0.5886 DataSet_02_150
PLCB2 YBX3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.65604 -0.60814 0.02478 0.43734 DataSet_02_153
PLCB2 FUS shRNA Haematopoietic_and_lymphoid_tissue K562 0.48214 -1.05247 0.0133 0.22852 DataSet_02_155
PLCB2 PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.02869 1.02055 0.00384 0.0795 DataSet_02_158
PLCB2 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 2.22615 1.15455 0.48495 0.67546 DataSet_02_163
PLCB2 U2AF1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.54688 -0.87072 0.00281 0.13212 DataSet_02_165
PLCB2 U2AF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.48713 -1.03761 0.04029 0.12087 DataSet_02_170
PLCB2 CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.64261 -0.63799 0.22458 1 DataSet_02_187
PLCB2 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 1.86556 0.89961 0.53979 1 DataSet_02_190
PLCB2 MAZ siRNA Haematopoietic_and_lymphoid_tissue K562 0.63864 -0.64691 0.16456 1 DataSet_02_199
PLCB2 ZFX siRNA Mammary_gland MCF7 0.17308 -2.53051 0.05338 0.2107 DataSet_02_206
PLCB2 CEBPB siRNA Embryo hESC 0.521868 -0.938244 0.0795659864261317 0.432540019163026 DataSet_03_049
PLCB2 FOXO1 shRNA Haematopoietic_and_lymphoid_tissue BL41 1.50438 0.589172 0.0018932463771373 0.186224998419857 DataSet_03_094
PLCB2 GATA4 siRNA Stomach YCC3 1.63047 0.705285 0.190453668842741 0.723556876980623 DataSet_03_107
PLCB2 HIC1 CRISPR Prostate PC3 15.8464 3.98608 - - DataSet_03_118
PLCB2 MITF siRNA Skin SK-MEL-5 0.610852 -0.711106 0.00195825813741954 0.00579414383326293 DataSet_03_168
PLCB2 MYB siRNA Cord_Blood CD34+ progenitor cells 3.19507 1.67585 - - DataSet_03_170
PLCB2 MYCN CRISPR Neuroblastoma CHP-134 0.541922 -0.883842 6.86665885535215e-05 0.00191106442622656 DataSet_03_183
PLCB2 MYCN CRISPR Neuroblastoma CHP-134 0.541922 -0.883842 6.86665885535215e-05 0.00191106442622656 DataSet_03_184
PLCB2 SOX11 siRNA Lung_fibroblast NHLF 0.326664 -1.61412 0.00471624420319694 0.304507242190339 DataSet_03_237
PLCB2 SOX11 siRNA Lung_fibroblast NHLF 0.327617 -1.60992 0.0084944455607489 0.194079691413854 DataSet_03_238
PLCB2 SOX2 siRNA Mammary_gland GSC-11 0.619025 -0.691931 0.072975906221863 0.253232105850334 DataSet_03_245
PLCB2 STAT3 CRISPR Embryo hESC 3.64129 1.86445 0.0219506250980263 0.0861005947317821 DataSet_03_258
PLCB2 TP63 siRNA Foreskin Neonatal foreskin keratinocytes 0.491503 -1.02473 0.0109270704962178 0.729684006943091 DataSet_03_282
PLCB2 MARK2 shRNA Haematopoietic_and_lymphoid_tissue K562 3.26201 1.70576 0.006928909887466 0.0240943631200024 DataSet_04_012
PLCB2 NUP35 shRNA Haematopoietic_and_lymphoid_tissue K562 1.60925 0.686386 0.0685220748476006 0.120240843138472 DataSet_04_015
PLCB2 ZNF574 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.607054 -0.720103 0.0193030383285176 0.127458695109974 DataSet_04_023
PLCB2 CTCF CRISPR Liver HepG2 1.66667 0.736966 0.328268567500791 0.887740925820345 DataSet_04_027
PLCB2 FUBP1 shRNA Liver HepG2 0.4 -1.32193 0.0992439740152278 0.468353491102494 DataSet_04_030
PLCB2 MECP2 CRISPR Liver HepG2 0.433333 -1.20645 0.193157378380394 0.4762293472573 DataSet_04_031
PLCB2 SMAD2 CRISPR Liver HepG2 0.428571 -1.22239 0.085253033057118 0.629342048902149 DataSet_04_034
PLCB2 SMAD4 CRISPR Liver HepG2 2.68421 1.4245 0.31897974301675 0.474728913914055 DataSet_04_035
PLCB2 SMAD5 CRISPR Liver HepG2 0.08 -3.64386 0.00182870900584175 0.367798690114644 DataSet_04_036
PLCB2 SRPK2 CRISPR Liver HepG2 0.533333 -0.906891 0.30735019769812 0.506270288293308 DataSet_04_037
PLCB2 WRN shRNA Liver HepG2 0.433333 -1.20645 0.0739474825494444 0.279284151244226 DataSet_04_038
PLCB2 ZNF574 CRISPR Liver HepG2 0.12 -3.05889 0.0114224247212356 0.074853798505892 DataSet_04_041
PLCB2 APTX CRISPR Liver HepG2 1.66667 0.736966 0.493872126771506 0.929956813680557 DataSet_04_069
PLCB2 CHCHD3 CRISPR Liver HepG2 7.66667 2.9386 0.319438662732238 0.653166604128214 DataSet_04_067
PLCB2 CNOT7 CRISPR Liver HepG2 0.357143 -1.48543 0.222249094544263 0.37548945328112 DataSet_04_045
PLCB2 DNMT3B CRISPR Liver HepG2 19 4.24793 0.221264780858175 0.487472400510306 DataSet_04_044
PLCB2 PAN2 CRISPR Liver HepG2 2.68421 1.4245 0.258129320957616 0.43258720947027 DataSet_04_066
PLCB2 RIOK2 CRISPR Liver HepG2 10.75 3.42626 0.0530518191033308 0.944114636228534 DataSet_04_070
PLCB2 SEPT11 CRISPR Liver HepG2 5.16667 2.36923 0.0690462967330587 0.257810069972861 DataSet_04_068
PLCB2 CCAR1 shRNA Liver HepG2 7.375 2.88264 0.0389972665950901 0.109671244232735 DataSet_04_054
PLCB2 CNOT7 shRNA Liver HepG2 9.58823 3.26127 0.00124186485772014 0.007713635005299 DataSet_04_051
PLCB2 DDX1 shRNA Liver HepG2 0.0416667 -4.58496 0.192880809741936 0.422020876373387 DataSet_04_057
PLCB2 NPM1 shRNA Liver HepG2 0.520833 -0.941106 0.390922717885213 0.787578281024645 DataSet_04_058
PLCB2 PRPF6 shRNA Liver HepG2 0.156863 -2.67243 0.0411409212938335 0.154416000044184 DataSet_04_056
PLCB2 YBX3 shRNA Liver HepG2 0.25 -2 0.298473050935798 0.491876454560664 DataSet_02_98
PLCB2 RIOK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.604478 -0.726239 0.040872339915307 0.541705789458807 DataSet_04_076
PLCB2 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.651639 -0.617854 0.0434048376967811 0.369827837546894 DataSet_02_32
PLCB2 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.10981 1.07711 0.00127462801309912 0.0233610049739588 DataSet_04_060
PLCB2 DDX1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.572433 -0.804822 0.00435154889267746 0.374619201786221 DataSet_04_063
PLCB2 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 1.88667 0.915844 0.00656525183114528 0.0219497711684891 DataSet_04_059
PLCB2 SMARCA4 siRNA Colon HCT116 1.95791 0.969312 5.779553e-02 7.987421e-01 DataSet_03_301
PLCB2 ELF3 knockdown Bile_duct HBDEC2 0.528424 -0.920233 2.882130e-05 4.119192e-03 DataSet_03_305
PLCB2 SNAI2 shRNA Pancreas pancreatic cancer stem cells 0.509426 -0.973056 8.783577e-02 0.6510154 DataSet_03_306
PLCB2 INO80 siRNA Muscle RD 0.602969 -0.729845 - - DataSet_03_344
PLCB2 EZH2 knockdown Colon HCT116 1.72845 0.789478 0.073941645 0.8488990 DataSet_03_334
PLCB2 ESR1 siRNA Mammary_gland MCF7 0.502753 -0.992077 1.852343e-03 0.0257343334 DataSet_03_352
PLCB2 TET1 CRISPR Mammary_gland Hs578T 0.47724 -1.06721 1.334593e-02 5.881892e-02 DataSet_03_355
PLCB2 CREBBP CRISPR Brain U5-NPC 1.62857 0.703607 0.8339396397 0.8992456 DataSet_03_356
PLCB2 PTPN14 CRISPR Brain U5-NPC 0.157895 -2.66297 1.189171e-03 0.15389182 DataSet_03_357
PLCB2 TP53 CRISPR Brain U5-NPC 0.4 -1.32193 5.889813e-01 6.704468e-01 DataSet_03_358
PLCB2 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 1.57261 0.653161 1.084167e-02 1.463542e-01 DataSet_03_359
PLCB2 NCOA3 siRNA Mammary_gland MDA-MB-231 1.5114 0.595886 5.477844e-01 0.9194402 DataSet_03_361
PLCB2 DNMT3A knockout Embryo_kidney HEK293T 13.8337 3.79012 - - DataSet_03_369
PLCB2 E2F1 siRNA Nasopharynx HK1 9.03073 3.17484 2.176272e-01 8.531523e-01 DataSet_03_373
PLCB2 GLI1 siRNA Skeletal_muscle RMS13 0.211019 -2.24455 1.287496e-02 0.086820447 DataSet_03_375
PLCB2 ZNF213 siRNA Mammary_gland MCF7 0.450599 -1.15008 3.145795e-02 3.258922e-01 DataSet_03_376
PLCB2 DNMT1 siRNA Skin Human melanoma cells 0.448388 -1.15718 1.423092e-05 1.344076e-04 DataSet_03_382
PLCB2 ILF2 siRNA Stomach SGC-7901 2.20408 1.14018 0.1555066009 0.33266775 DataSet_03_393
PLCB2 BMI1 shRNA Bile_duct QBC-939 0.637173 -0.650244 4.307278e-02 0.1218848322 DataSet_03_395
PLCB2 RELA CRISPR Brain T30 1.64867 0.721306 0.2946879507 0.8400824 DataSet_03_399
PLCB2 EHF shRNA Stomach MKN7 0.0469703 -4.41211 - - DataSet_03_402
PLCB2 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 2.39726 1.26139 2.800853e-03 0.3239928 DataSet_03_403
PLCB2 TFAP2A knockout Embryo H9 0.312395 -1.67856 4.241280e-04 0.02106303 DataSet_03_405
PLCB2 MAP3K7 shRNA Prostate LNCaP 0.45283 -1.14296 2.915327e-03 3.876631e-02 DataSet_03_408
PLCB2 STRAP knockout Nerve SK-N-AS 2.02365 1.01696 - - DataSet_03_409
PLCB2 SIRT1 siRNA Pancreas PANC1 1.54717 0.629632 1.799766e-01 0.331296332 DataSet_03_410
PLCB2 E2F1 siRNA Prostate LNCaP 0.621622 -0.685891 5.323378e-01 0.8203267443 DataSet_03_413
PLCB2 ZKSCAN3 CRISPR Colon HCT116 0.635821 -0.653308 7.324078e-02 0.440051674 DataSet_03_415
PLCB2 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 2.50757 1.32629 9.515930e-03 0.054270238 DataSet_03_418
PLCB2 FOXK2 shRNA Ovary OVCAR-5 2.66667 1.41504 1.602060e-02 0.10942311 DataSet_03_419
PLCB2 FOXP3 CRISPR Peripheral_blood Naive Treg 0.612204 -0.707916 1.088570e-01 0.435630334 DataSet_03_427
PLCB2 USP7 shRNA Skin xenograft cells 0.455208 -1.1354 0.26236801 0.4348960 DataSet_03_431
PLCB2 POU2AF1 CRISPR Lymph SUDHL4 2.33652 1.22436 1.196904e-04 0.005917891 DataSet_03_435
PLCB2 SUFU shRNA Mammary_gland HCC1954 cells 0.259259 -1.94753 0.3264285651 0.6455297 DataSet_03_437
PLCB2 CIC knockout Brain Immortalized Astrocyte Cells 0.533113 -0.907488 1.221179e-02 2.102299e-01 DataSet_03_438
PLCB2 SETDB1 shRNA Colon HCT116 0.490738 -1.02697 - - DataSet_03_440
PLCB2 FOSL1 siRNA Prostate MSKPCa3 0.47619 -1.07039 0.0670058961 0.4620050 DataSet_03_445
PLCB2 CAMTA1 knockout Embryo_kidney HEK293T 2.23529 1.16047 2.747358e-02 0.14738195 DataSet_03_448
PLCB2 CBX2 siRNA Mammary_gland MCF7 0.323714 -1.62721 6.651928e-02 0.1368643691 DataSet_03_451
PLCB2 ZFP36L1 CRISPR Lung NCI-H1876 0.347053 -1.52677 3.060054e-01 0.992381486 DataSet_03_454
PLCB2 ARID1A shRNA Bile_duct MMNK1 0.610971 -0.710823 3.409369e-01 0.563578466 DataSet_03_458
PLCB2 SOX9 knockout Liver HuH7 0.166667 -2.58496 3.247524e-02 1.022292e-01 DataSet_03_463
PLCB2 STAT3 shRNA Liver HepG2 1.77821 0.830426 2.827621e-02 0.2667824543 DataSet_03_465
PLCB2 SMARCA1 Cas13 Embryo_kidney HEK293T 0.375 -1.41504 - - DataSet_03_466
PLCB2 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 2.3125 1.20945 - - DataSet_03_467
PLCB2 SMARCA1 shRNA Embryo_kidney HEK293T 0.583333 -0.777608 - - DataSet_03_468
PLCB2 WHSC1 siRNA Prostate PC3 1.53488 0.618129 1.706558e-01 0.39710238 DataSet_03_471
PLCB2 CREBBP CRISPR Lymph U2932 1.55952 0.641106 3.903060e-01 1.0000000 DataSet_03_474
Regulation Region
 
T(co)Fs that significantly regulate SMAD5 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of PLCB2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines