Gene Overview
Target Gene: PPBP
NCBI Official Symbol: PPBP
Entrez ID: 5473
Ensembl ID: ENSG00000163736
Gene Full Name: pro-platelet basic protein
Strand: -
Gene Locus: 4q13.3
External Links:

PPBP Significantly Regulated by These T(co)Fs

T(co)Fs that Activate PPBP   
T(co)Fs that Repress PPBP
The Intensity of the Gene Regulated by T(co)Fs:
PPBP-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
PPBP IRF6 shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 0.55366 -0.85294 0.01959 0.10856 DataSet_01_101
PPBP HNF1B shRNA Ovary RMG2 1.84582 0.88426 0.01494 0.03545 DataSet_01_103
PPBP SPDEF shRNA Mammary_gland MCF7 0.3618 -1.46673 0.41134 0.99999 DataSet_01_107
PPBP ID1 siRNA Lung A549 12.7585 3.67338 4.58248e-05 0.08908 DataSet_01_117
PPBP ID1 siRNA Lung H1650 1.9841 0.98849 0.47823 0.76186 DataSet_01_118
PPBP ZIC2 siRNA Pancreas PANC1 1.54685 0.62933 - - DataSet_01_121
PPBP FOXM1 siRNA Central_nervous_system U87 49.7408 5.63636 - - DataSet_01_122
PPBP POLR3A siRNA Mammary_gland MCF7 7.81967 2.96711 - - DataSet_01_139
PPBP MYBL2 shRNA Bone_marrow CD34+ BM cells 0.64495 -0.63273 0.01168 0.20765 DataSet_01_148
PPBP TP53 siRNA Lung SAECs 3.61111 1.85244 0.04505 0.39147 DataSet_01_175
PPBP TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.50887 -0.97463 - - DataSet_01_196
PPBP FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 1.70111 0.76648 - - DataSet_01_208
PPBP FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 2.68694 1.42597 - - DataSet_01_209
PPBP FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.19475 -2.36034 - - DataSet_01_210
PPBP LIN28A siRNA Embryo H9 1.65472 0.72659 0.01408 0.06076 DataSet_01_215
PPBP SNAI2 shRNA Skin Primary human keratinocytes 66.1887 6.04851 9.44926e-07 0.00444 DataSet_01_225
PPBP ZIC5 siRNA Skin SK-MEL-28 1.66607 0.73645 - - DataSet_01_285
PPBP SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.60359 0.6813 0.55238 0.94809 DataSet_01_290
PPBP TFAP4 siRNA Brain BE(2)-C 0.27459 -1.86465 0.43276 0.51625 DataSet_01_295
PPBP SOX7 siRNA Umbilical_vein HUVEC 4.7791 2.25674 0.25211 0.89788 DataSet_01_299
PPBP SOX17 siRNA Umbilical_vein HUVEC 6.24288 2.64221 0.12711 0.99998 DataSet_01_300
PPBP PTEN shRNA Skin A431 0.37882 -1.40043 0.50527 0.68215 DataSet_01_301
PPBP PTEN shRNA Lung HCC827 3.74708 1.90577 0.14622 0.63682 DataSet_01_302
PPBP PTEN shRNA Mammary_gland SKBR3 2.36009 1.23884 0.23899 0.6983 DataSet_01_303
PPBP SOX9 siRNA Prostate VCaP 0.5 -1 0.27895 0.93253 DataSet_01_308
PPBP SOX9 siRNA Prostate VCaP 0.5 -1 0.27895 0.93253 DataSet_01_309
PPBP TFAP2C siRNA Lung NCI-H292 1.67554 0.74463 - - DataSet_01_312
PPBP ARNT siRNA Upper_aerodigestive_tract HSC3 0.60833 -0.71706 - - DataSet_01_315
PPBP HOXC6 siRNA Prostate LNCaP 9.42188 3.23601 0.00233 0.9106 DataSet_01_333
PPBP KLF4 siRNA Embryo HCE 1.52124 0.60525 0.07724 0.54259 DataSet_01_341
PPBP ETV4 shRNA Prostate PC3 0.63543 -0.65419 - - DataSet_01_356
PPBP GTF2B siRNA Cervix HeLa 0.58621 -0.77052 - - DataSet_01_362
PPBP AR siRNA Prostate abl cells 0.472973 -1.08017 0.424928866383373 0.999852161656754 DataSet_03_004
PPBP ARID1A siRNA Mammary_gland MDA-MB-157 0.664379 -0.589921 - - DataSet_03_014
PPBP ASCL1 siRNA Lung DMS79 1.56757 0.648528 0.792159330949694 0.964261400321283 DataSet_03_016
PPBP ATF4 siRNA Skin A375 0.651181 -0.618869 0.265191776253159 0.775512819201899 DataSet_03_018
PPBP BCL6 siRNA Lymph OCI-Ly7 DLBCL 3.66166 1.8725 0.189594138484114 0.805330711214399 DataSet_03_025
PPBP BCL6 siRNA Lymph Pfeiffer DLBCL 1.89252 0.920313 0.134187306859622 0.609571246076173 DataSet_03_026
PPBP FLI1 siRNA Haematopoietic_and_lymphoid_tissue THP-1 1.81891 0.863073 0.0810160820034829 0.460465733362931 DataSet_03_078
PPBP GATA2 siRNA Uterus Decidual stromal cells 0.239941 -2.05925 0.0597271039362224 0.660869177403836 DataSet_03_100
PPBP GATA4 siRNA Stomach AGS 2.37564 1.24832 0.505010802668212 0.927617141201533 DataSet_03_105
PPBP GATA4 siRNA Stomach KatoIII 0.533055 -0.907645 0.448246474085211 0.952969829738916 DataSet_03_106
PPBP GATA6 siRNA Stomach AGS 1.98428 0.988615 0.534186385365644 0.879279885610597 DataSet_03_108
PPBP GATA6 siRNA Stomach KatoIII 0.63219 -0.661569 0.472669727797769 0.854752647637635 DataSet_03_109
PPBP GATA6 siRNA Stomach YCC3 1.53943 0.622395 0.033822424759052 0.5672562713455 DataSet_03_110
PPBP Klf4 siRNA Skin Primary neonatal keratinocytes 0.131199 -2.93017 4.80445865989021e-05 0.00143504210041272 DataSet_03_147
PPBP KLF5 siRNA Stomach AGS 0.39137 -1.35339 0.284454234306966 0.737125177538138 DataSet_03_149
PPBP KLF5 siRNA Stomach YCC3 0.218308 -2.19556 0.0588883444591755 0.354994316080533 DataSet_03_151
PPBP MEF2D shRNA Liver HuH7 1.63531 0.70956 - - DataSet_03_162
PPBP MYB siRNA Cord_Blood CD34+ progenitor cells 5.61052 2.48813 - - DataSet_03_170
PPBP MYC siRNA Colon HT29 0.645549 -0.631401 - - DataSet_03_177
PPBP MYCN siRNA Brain BE(2)C cells 0.600235 -0.7364 - - DataSet_03_187
PPBP MYCN siRNA Brain BE(2)C cells 0.539764 -0.8896 - - DataSet_03_188
PPBP NR2F2 siRNA Uterus Primary eutopic stromal cells 2.10138 1.07134 0.308179845892732 0.99947668859931 DataSet_03_202
PPBP RELB siRNA Immortalized_keratinocyte HaCaT 1.54975 0.632034 0.00568979958740189 0.0355761556420817 DataSet_03_227
PPBP SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.047619 -4.39232 - - DataSet_03_246
PPBP SP1 siRNA Ovary OVSAYO 1.70162 0.766911 0.119884257139143 0.410470560721383 DataSet_03_251
PPBP STAT3 CRISPR Embryo hESC 2.21089 1.14463 0.195888093390947 0.265736441982206 DataSet_03_258
PPBP STAT6 siRNA Umbilical_vein HUVEC 1.52174 0.605721 0.977821770609793 0.997470019683329 DataSet_03_264
PPBP TFAP2C siRNA Mammary_gland MCF7 0.216771 -2.20576 0.289792483144106 0.62492095424075 DataSet_03_274
PPBP ZNF750 siRNA Skin Primary neonatal keratinocytes 0.0927471 -3.43055 3.40530408962947e-05 0.0136073386888985 DataSet_03_294
PPBP CNOT3 shRNA Lung A549 6.33841 2.66412 1.804269e-01 0.8830540 DataSet_03_340
PPBP NFKBIZ knockout Colon Colon organoid 0.323824 -1.62672 7.403088e-02 0.662436134 DataSet_03_323
PPBP ELF3 knockdown Bile_duct HBDEC2 1.6703 0.740107 2.075815e-04 9.702967e-03 DataSet_03_305
PPBP HDAC4 siRNA Liver human hepatocytes 1.99522 0.99655 2.260377e-02 1.419076e-01 DataSet_03_345
PPBP HDAC5 siRNA Liver human hepatocytes 1.87138 0.9041 3.469024e-02 1.180679e-01 DataSet_03_346
PPBP SNAI2 shRNA Pancreas pancreatic cancer stem cells 0.602769 -0.730323 1.459153e-01 0.6510154 DataSet_03_306
PPBP ACTR5 siRNA Muscle RD 0.346774 -1.52793 - - DataSet_03_343
PPBP INO80 siRNA Muscle RD 0.287448 -1.79863 - - DataSet_03_344
PPBP AEBP1 siRNA Central_nervous_system U87MG 1.50618 0.59089 1.750031e-01 0.9999434 DataSet_03_338
PPBP BRCA1 siRNA Mammary_gland MCF7 1.63039 0.705214 2.116187e-01 0.9999931 DataSet_03_308
PPBP RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 0.0227616 -5.45725 3.043199e-02 2.068626e-01 DataSet_03_359
PPBP EP300 shRNA Mammary_gland MCF10AT 3.5 1.80736 2.229447e-02 0.113641895 DataSet_03_364
PPBP ZNF148 shRNA Mammary_gland MDA-MB-231 0.0569408 -4.13439 2.317722e-01 0.455697259 DataSet_03_366
PPBP USP22 shRNA Liver PLC_PRF_5 cells 0.0322581 -4.9542 1.099523e-03 0.06354719 DataSet_03_368
PPBP SMARCA2 shRNA Lung NCI-H1944 2.96154 1.56635 1.131994e-02 2.331415e-01 DataSet_03_377
PPBP NFKB2 siRNA Bone_marrow U2OS 0.5 -1 7.185697e-01 0.86784391 DataSet_03_381
PPBP NFKBIA shRNA Bone_marrow U2OS 0.0402685 -4.63421 7.282950e-01 0.88617932 DataSet_03_389
PPBP EHF shRNA Stomach MKN7 35.3066 5.14187 - - DataSet_03_402
PPBP SATB2 CRISPR Colon Colon organoid 0.644068 -0.634716 2.021963e-01 0.95735254 DataSet_03_406
PPBP FOXP3 CRISPR Peripheral_blood Naive Treg 14 3.80735 2.540100e-01 0.611870317 DataSet_03_427
PPBP STAT3 siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 0.333333 -1.58496 0.5235513025 1 DataSet_03_430
PPBP PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.0838428 -3.57617 - - DataSet_03_432
PPBP FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 0.25 -2 5.784533e-01 0.96654605 DataSet_03_439
PPBP HAND1 siRNA Placenta HPMVEC 0.340909 -1.55254 8.900518e-02 0.9463341 DataSet_03_459
PPBP TXNIP shRNA Cord_Blood CD34+ cells 1.81937 0.863437 - - DataSet_03_461
PPBP WHSC1 siRNA Prostate PC3 0.554688 -0.850253 2.962358e-01 0.52788011 DataSet_03_471
Regulation Region
 
T(co)Fs that significantly regulate HOXC6 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of PPBP
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines