Gene Overview
Target Gene: SERPINA5
NCBI Official Symbol: SERPINA5
Entrez ID: 5104
Ensembl ID: ENSG00000188488
Gene Full Name: serpin family A member 5
Strand: +
Gene Locus: 14q32.13
External Links:

SERPINA5 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate SERPINA5   
T(co)Fs that Repress SERPINA5
The Intensity of the Gene Regulated by T(co)Fs:
SERPINA5-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
SERPINA5 SPDEF shRNA Mammary_gland MCF7 0.39651 -1.33458 0.61334 0.99999 DataSet_01_107
SERPINA5 ID1 siRNA Lung A549 0.27004 -1.88878 0.04138 0.22468 DataSet_01_117
SERPINA5 ID1 siRNA Lung H1650 1.54436 0.62701 0.03606 0.35366 DataSet_01_118
SERPINA5 ZIC2 siRNA Pancreas PANC1 1.65039 0.7228 - - DataSet_01_121
SERPINA5 FOXM1 siRNA Central_nervous_system U87 0.16848 -2.56938 - - DataSet_01_122
SERPINA5 POLR3A siRNA Mammary_gland MCF7 0.63014 -0.66626 - - DataSet_01_139
SERPINA5 SF1 siRNA Adrenal_gland H295R/TR 0.5057 -0.98365 1.10262e-06 0.00014 DataSet_01_146
SERPINA5 STAT1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 2.02506 1.01796 0.26281 0.57408 DataSet_01_154
SERPINA5 HSF1 shRNA Skin A375 0.51423 -0.95953 1.99364e-05 0.00068 DataSet_01_155
SERPINA5 NR2F2 siRNA Ovary ES2 1.87028 0.90326 0.01475 0.55224 DataSet_01_177
SERPINA5 HSF1 shRNA Liver KYN2 2.1939 1.1335 - - DataSet_01_178
SERPINA5 TCF4 siRNA Autonomic_ganglia SH-SY5Y 0.56501 -0.82365 0.00275 0.04719 DataSet_01_185
SERPINA5 SPDEF siRNA Mammary_gland MCF7 1.89537 0.92248 0.00521 0.14514 DataSet_01_189
SERPINA5 GATA2 siRNA Prostate LNCaP 0.50172 -0.99504 0.01906 0.05685 DataSet_01_193
SERPINA5 TP63 siRNA Head_and_neck SCC-012 1.66975 0.73963 - - DataSet_01_201
SERPINA5 HIC1 shRNA Mammary_gland HBL100 1.94397 0.95901 - - DataSet_01_205
SERPINA5 MITF shRNA Skin COLO829 1.86837 0.90178 2.2884e-05 0.00241 DataSet_01_207
SERPINA5 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 2.05943 1.04225 - - DataSet_01_208
SERPINA5 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.3394 -1.55895 - - DataSet_01_209
SERPINA5 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.2399 -2.05951 - - DataSet_01_210
SERPINA5 LIN28A siRNA Embryo H9 1.84807 0.88602 0.0026 0.0219 DataSet_01_215
SERPINA5 PTEN shRNA Mammary_gland MCF10A 3.7573 1.9097 2.66619e-09 4.12798e-07 DataSet_01_218
SERPINA5 SNAI2 shRNA Skin Primary human keratinocytes 1.60951 0.68662 0.11094 0.22332 DataSet_01_225
SERPINA5 IRX1 shRNA Bone_marrow 143B 0.13479 -2.89118 0.05693 0.24639 DataSet_01_227
SERPINA5 FOXA1 siRNA Prostate LNCaP 2.59086 1.37343 0.03155 0.2714 DataSet_01_233
SERPINA5 TWIST1 shRNA Stomach CAF14 3.11728 1.64029 0.05239 0.99996 DataSet_01_252
SERPINA5 TWIST1 shRNA Stomach CAF32 0.54465 -0.87659 0.42319 0.57532 DataSet_01_253
SERPINA5 SF1 siRNA Endometrial_tissue OsisHESC 0.39039 -1.35701 0.00943 0.05439 DataSet_01_271
SERPINA5 ESRRA shRNA Embryo_kidney 293T 0.37756 -1.40522 0.26411 0.79327 DataSet_01_280
SERPINA5 MSX1 siRNA Tooth Dental Pulp Cells 0.41953 -1.25315 0.07324 0.14804 DataSet_01_281
SERPINA5 SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.9158 0.93795 0.05266 0.82552 DataSet_01_290
SERPINA5 POSTN shRNA Brain GSC272 0.44408 -1.17111 0.07592 0.54319 DataSet_01_293
SERPINA5 TFAP4 siRNA Brain BE(2)-C 0.1218 -3.03736 0.22728 0.51625 DataSet_01_295
SERPINA5 PTEN shRNA Mammary_gland SKBR3 4.96293 2.31119 0.00341 0.425 DataSet_01_303
SERPINA5 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 2.23684 1.16146 0.0363 0.30112 DataSet_01_313
SERPINA5 HIF1A siRNA Oral_cavity OEC-M1 2.42712 1.27925 0.12941 0.85151 DataSet_01_348
SERPINA5 CDX2 siRNA Colon COLO320 4.62381 2.20908 - - DataSet_01_357
SERPINA5 HOXA10 siRNA Uterus Endometrial stromal cells 0.6399 -0.64407 - - DataSet_01_358
SERPINA5 PAX3 shRNA Soft_tissue Rh30 0.45484 -1.13656 - - DataSet_01_359
SERPINA5 FIP1L1 shRNA Liver HepG2 0.55187 -0.85759 0.00364 0.02527 DataSet_02_103
SERPINA5 XRCC5 shRNA Liver HepG2 0.65424 -0.61211 0.00708 0.14276 DataSet_02_114
SERPINA5 FUS shRNA Liver HepG2 1.55815 0.63984 0.00452 0.06726 DataSet_02_124
SERPINA5 SRSF3 shRNA Liver HepG2 0.46286 -1.11136 0.00434 0.07178 DataSet_02_127
SERPINA5 AR siRNA Prostate abl cells 3.80303 1.92715 0.125032974120846 0.999852161656754 DataSet_03_004
SERPINA5 AR siRNA Prostate LNCaP 2.19048 1.13125 0.0802984054273219 1 DataSet_03_005
SERPINA5 BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.655911 -0.608428 0.202986746232498 0.812924622042657 DataSet_03_025
SERPINA5 CREBBP siRNA Mammary_gland MCF7 0.517372 -0.950725 0.00087060791034727 0.963067261754673 DataSet_03_055
SERPINA5 ESR1 siRNA Mammary_gland MCF7 0.660024 -0.599409 0.00258708546009334 0.999753934970283 DataSet_03_068
SERPINA5 FOXA1 siRNA Mammary_gland MCF7 0.397575 -1.3307 8.06561948266664e-08 1.21664609709407e-05 DataSet_03_080
SERPINA5 FOXA1 siRNA Prostate LNCaP 2.20221 1.13895 0.0070807824730718 0.0665496918413427 DataSet_03_083
SERPINA5 FOXF2 siRNA Mammary_gland MCF10A 1.92736 0.946629 - - DataSet_03_086
SERPINA5 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.495259 -1.01374 - - DataSet_03_096
SERPINA5 GATA2 siRNA Uterus Decidual stromal cells 0.363503 -1.45996 0.0592806145585934 0.658810167437737 DataSet_03_100
SERPINA5 GATA4 siRNA Stomach KatoIII 1.78213 0.833605 0.215117843135444 0.914759953395016 DataSet_03_106
SERPINA5 GATA4 siRNA Stomach YCC3 1.98058 0.985922 0.282683309955631 0.780312330141814 DataSet_03_107
SERPINA5 GATA6 siRNA Stomach AGS 0.583578 -0.777003 0.370346943001357 0.807869464166796 DataSet_03_108
SERPINA5 GATA6 siRNA Stomach KatoIII 1.67194 0.741527 0.477356334970432 0.856554057834032 DataSet_03_109
SERPINA5 GATA6 siRNA Stomach YCC3 1.81079 0.85662 0.0674398638669106 0.671804406967076 DataSet_03_110
SERPINA5 HIC1 CRISPR Prostate PC3 1.74073 0.79969 - - DataSet_03_118
SERPINA5 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.5028 0.587653 0.546930895555006 0.999948959532916 DataSet_03_134
SERPINA5 JARID1A siRNA Brain NB1691 2.36297 1.2406 0.00394271368424972 0.295853725064195 DataSet_03_136
SERPINA5 KDM3A siRNA Mammary_gland MCF7 0.409515 -1.28801 2.16428758252037e-06 0.000548086083123809 DataSet_03_146
SERPINA5 KLF5 siRNA Stomach KatoIII 0.498022 -1.00572 0.152533607054225 0.598522039439239 DataSet_03_150
SERPINA5 KLF5 siRNA Stomach YCC3 1.50263 0.587486 0.157860385170917 0.519761844218324 DataSet_03_151
SERPINA5 MAX siRNA Mammary_gland MCF7 1.64083 0.714428 0.00396724481615852 0.999907009675999 DataSet_03_158
SERPINA5 MEF2D shRNA Liver HuH7 0.570115 -0.810676 - - DataSet_03_162
SERPINA5 MYC siRNA Colon HT29 3.19602 1.67628 - - DataSet_03_177
SERPINA5 NR2F2 siRNA Uterus Primary eutopic stromal cells 2.34641 1.23045 0.050787647251811 0.99947668859931 DataSet_03_202
SERPINA5 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.630153 -0.666225 0.209729424790436 0.34196903048241 DataSet_03_211
SERPINA5 SOX2 CRISPR Seminoma-like TCam-2 2.29306 1.19727 0.276730292475143 0.999580851453413 DataSet_03_244
SERPINA5 SP1 siRNA Ovary OVSAYO 0.273 -1.87303 0.00160100781233252 0.0753028885209158 DataSet_03_251
SERPINA5 STAT3 CRISPR Embryo hESC 0.0579254 -4.10966 0.0139210201745909 0.0726694998030357 DataSet_03_258
SERPINA5 STAT6 siRNA Umbilical_vein HUVEC 4.93548 2.30319 0.411818707856821 0.896395898147886 DataSet_03_264
SERPINA5 TFE3 siRNA Kidney UOK257-2 0.61136 -0.709906 - - DataSet_03_275
SERPINA5 NFX1 CRISPR Liver HepG2 1.51227 0.596718 0.00277589887953014 0.0192313080438846 DataSet_04_032
SERPINA5 CCAR1 shRNA Liver HepG2 1.67211 0.741673 0.00043343679638296 0.0132011207020191 DataSet_04_054
SERPINA5 CNOT7 shRNA Liver HepG2 0.542934 -0.881152 0.000319769437972152 0.00406184029269598 DataSet_04_051
SERPINA5 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.0952381 -3.39232 0.0955147889112542 0.489929409877901 DataSet_02_49
SERPINA5 SMARCA4 siRNA Colon HCT116 0.433037 -1.20744 8.917573e-03 0.1352359 DataSet_03_302
SERPINA5 ELF3 CRISPR Bile_duct HBDEC2 9.2605 3.21109 7.007802e-06 2.853235e-04 DataSet_03_304
SERPINA5 ELF3 knockdown Bile_duct HBDEC2 1.60538 0.682916 1.824824e-02 1.089866e-01 DataSet_03_305
SERPINA5 SNAI2 shRNA Pancreas pancreatic cancer stem cells 1.90657 0.930977 3.547766e-01 0.6793886 DataSet_03_306
SERPINA5 ACTR5 siRNA Muscle RD 0.628783 -0.669365 - - DataSet_03_343
SERPINA5 INO80 siRNA Muscle RD 0.514091 -0.959904 - - DataSet_03_344
SERPINA5 BRCA1 siRNA Mammary_gland MCF7 1.71334 0.776815 4.264968e-02 0.9999931 DataSet_03_308
SERPINA5 EZH2 knockdown Colon HCT116 0.378319 -1.40232 0.013375096 0.8488990 DataSet_03_334
SERPINA5 TET1 CRISPR Mammary_gland MDA-MB-231 0.0345572 -4.85487 6.125914e-09 5.370644e-06 DataSet_03_347
SERPINA5 EZH2 shRNA Mammary_gland LM2 2.72136 1.44433 1.479780e-02 1.919120e-01 DataSet_03_350
SERPINA5 ETV5 knockdown Colon HT29 0.264568 -1.91829 1.152285e-03 0.047368168 DataSet_03_353
SERPINA5 CREBBP CRISPR Brain U5-NPC 0.129284 -2.95138 0.0045167080 0.7490853 DataSet_03_356
SERPINA5 PTPN14 CRISPR Brain U5-NPC 0.447072 -1.16142 1.779241e-01 0.41313722 DataSet_03_357
SERPINA5 TP53 CRISPR Brain U5-NPC 0.203848 -2.29443 2.129631e-02 1.643609e-01 DataSet_03_358
SERPINA5 NCOA2 siRNA Uterus endometrial stromal cells 0.454545 -1.1375 0.2596036972 1 DataSet_03_360
SERPINA5 TP53 knockout Stomach SNU1 5.31744 2.41073 0.1079189773 0.9301241 DataSet_03_365
SERPINA5 ZNF148 shRNA Mammary_gland MDA-MB-231 0.584231 -0.77539 2.069648e-01 0.425622041 DataSet_03_366
SERPINA5 ABL1 shRNA Liver HuH7 0.581996 -0.78092 3.741715e-06 0.0005194034 DataSet_03_367
SERPINA5 TPR shRNA Bone_marrow U2OS 2.18295 1.12628 3.830276e-03 8.235824e-02 DataSet_03_370
SERPINA5 E2F1 siRNA Nasopharynx HK1 0.166667 -2.58496 1.881906e-02 1.761987e-01 DataSet_03_373
SERPINA5 GLI1 siRNA Skeletal_muscle RMS13 0.0614368 -4.02475 3.049374e-04 0.011441677 DataSet_03_375
SERPINA5 EZH2 CRISPR Ovary SKOV3 2.28571 1.19265 1.350950e-01 0.3331947069 DataSet_03_378
SERPINA5 DNMT1 siRNA Skin Human melanoma cells 2.37116 1.24559 6.864203e-06 8.190469e-05 DataSet_03_382
SERPINA5 TCF19 CRISPR Oral_squamous CAL27 2.11514 1.08075 6.407343e-05 0.0053187239 DataSet_03_383
SERPINA5 YY1 shRNA Brain GSC1517 3.59992 1.84796 - - DataSet_03_384
SERPINA5 NFKBIA shRNA Bone_marrow U2OS 0.0079766 -6.97001 8.859676e-01 0.95150329 DataSet_03_389
SERPINA5 YY1 knockdown Liver HepG2 1.89703 0.923745 2.141221e-10 1.138610e-08 DataSet_03_390
SERPINA5 ASXL1 CRISPR Embryo iPSC 2.83013 1.50087 0.1979732971 0.8187866 DataSet_03_394
SERPINA5 BMI1 shRNA Bile_duct QBC-939 0.650931 -0.619424 2.263142e-03 0.0131329620 DataSet_03_395
SERPINA5 RELA CRISPR Brain T30 0.0189134 -5.72445 0.3036697662 0.8400824 DataSet_03_399
SERPINA5 HMGA1 shRNA Bile_duct HUCCT1 0.615385 -0.70044 3.147133e-01 0.543358550 DataSet_03_400
SERPINA5 EHF shRNA Stomach MKN7 0.123857 -3.01325 - - DataSet_03_402
SERPINA5 TFAP2A knockout Embryo H9 0.122318 -3.0313 5.286570e-03 0.05065014 DataSet_03_405
SERPINA5 SATB2 CRISPR Colon Colon organoid 2.49153 1.31703 7.819984e-02 0.95735254 DataSet_03_406
SERPINA5 CHD1 shRNA Prostate LNCaP 0.37037 -1.43296 1.807945e-02 3.036572e-01 DataSet_03_407
SERPINA5 SIRT1 siRNA Pancreas PANC1 0.357143 -1.48543 1.207190e-01 0.250466384 DataSet_03_410
SERPINA5 E2F6 shRNA Liver HuH7 0.644952 -0.632737 - - DataSet_03_412
SERPINA5 E2F1 siRNA Prostate LNCaP 2 1 4.309967e-01 0.7642299494 DataSet_03_413
SERPINA5 E2F2 siRNA Prostate LNCaP 0.5 -1 5.292141e-01 6.889215e-01 DataSet_03_414
SERPINA5 ZKSCAN3 CRISPR Colon HCT116 0.498912 -1.00314 6.860773e-03 0.194572063 DataSet_03_415
SERPINA5 FOXK2 shRNA Ovary OVCAR-5 0.0978934 -3.35264 9.637805e-03 0.09617284 DataSet_03_419
SERPINA5 FOXQ1 CRISPR Lymph Primary CD4+ T cells 2 1 - - DataSet_03_422
SERPINA5 STAT5B CRISPR Embryo_kidney HEK293 2 1 7.241027e-01 0.913907731 DataSet_03_424
SERPINA5 USP7 shRNA Skin xenograft cells 0.366994 -1.44617 0.29393765 0.4402595 DataSet_03_431
SERPINA5 EP300 knockout Pancreas HPAF-II orthotopic cells 0.588067 -0.765948 1.669045e-03 1.135324e-02 DataSet_03_436
SERPINA5 SUFU shRNA Mammary_gland HCC1954 cells 3.4104 1.76994 0.0042405887 0.2904148 DataSet_03_437
SERPINA5 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 9.35794 3.22619 6.516433e-04 0.18694722 DataSet_03_439
SERPINA5 DAXX shRNA Mammary_gland MDA-MB-231 7.78675 2.96102 5.105186e-03 0.08605633 DataSet_03_441
SERPINA5 HMG20A siRNA Mammary_gland MDA-MB-231 0.424242 -1.23704 0.1684814860 0.4301846 DataSet_03_442
SERPINA5 PHF14 siRNA Mammary_gland MDA-MB-231 0.272727 -1.87447 0.0524370577 0.4369198 DataSet_03_443
SERPINA5 FOSL1 siRNA Prostate MSKPCa3 1.75 0.807355 0.3075217310 0.5297688 DataSet_03_445
SERPINA5 RELB CRISPR Colon SW480 3.6 1.848 9.843513e-05 6.813209e-03 DataSet_03_449
SERPINA5 CBX2 siRNA Mammary_gland MDA-MB-231 2.9065 1.53928 9.962563e-02 2.443241e-01 DataSet_03_450
SERPINA5 CBX2 siRNA Mammary_gland MCF7 0.634878 -0.655449 2.837630e-01 0.4386775294 DataSet_03_451
SERPINA5 SREBF2 siRNA Umbilical_vein HUVEC 2.19194 1.13221 2.511293e-03 7.500869e-02 DataSet_03_457
SERPINA5 ARID1A shRNA Bile_duct MMNK1 0.361866 -1.46647 1.513587e-01 0.432374863 DataSet_03_458
SERPINA5 SOX9 knockout Liver HuH7 3.06193 1.61444 2.171420e-05 9.993572e-04 DataSet_03_463
SERPINA5 PARP1 knockout Embryo_kidney HEK293a 0.153398 -2.70465 1.833946e-08 5.060595e-07 DataSet_03_464
SERPINA5 SMARCA1 Cas13 Embryo_kidney HEK293T 3 1.58496 - - DataSet_03_466
SERPINA5 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 3 1.58496 - - DataSet_03_467
SERPINA5 WHSC1 siRNA Prostate PC3 0.659574 -0.600393 5.679772e-01 0.73858213 DataSet_03_471
Regulation Region
 
T(co)Fs that significantly regulate SPDEF by the evidences of both expression and ChIP-seq/motif
Expression Atlas of SERPINA5
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines