Gene Overview
Target Gene: SMOC1
NCBI Official Symbol: SMOC1
Entrez ID: 64093
Ensembl ID: ENSG00000198732
Gene Full Name: SPARC related modular calcium binding 1
Strand: +
Gene Locus: 14q24.2
External Links:

SMOC1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate SMOC1   
T(co)Fs that Repress SMOC1
The Intensity of the Gene Regulated by T(co)Fs:
SMOC1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
SMOC1 HOXA1 siRNA Lung_fibroblast IMR-90 1.97719 0.98345 0.01714 0.13724 DataSet_01_110
SMOC1 TCF3 shRNA Mammary_gland MDA-MB468 1.85918 0.89466 6.91938e-05 0.00191 DataSet_01_116
SMOC1 ID1 siRNA Lung A549 1.70102 0.7664 0.00588 0.12148 DataSet_01_117
SMOC1 FOXM1 siRNA Central_nervous_system U87 1.9896 0.99248 - - DataSet_01_122
SMOC1 ID1 shRNA Neuroepithelium GSC2 0.30372 -1.71919 1.36109e-13 1.64862e-11 DataSet_01_133
SMOC1 ID1 shRNA Neuroepithelium GSC8 1.66313 0.7339 2.68443e-09 9.36241e-09 DataSet_01_134
SMOC1 POLR3A siRNA Mammary_gland MCF7 1.54299 0.62573 - - DataSet_01_139
SMOC1 HSF1 shRNA Skin A375 0.53489 -0.90269 0.00229 0.02283 DataSet_01_155
SMOC1 GABPA shRNA Prostate C4-2B 671.184 9.39056 0.23906 0.43934 DataSet_01_190
SMOC1 GABPA shRNA Prostate LNCaP 855.696 9.74096 0.46336 0.7048 DataSet_01_191
SMOC1 CREB1 shRNA Parotid_gland H3118 MEC 0.43695 -1.19445 0.04287 0.30622 DataSet_01_194
SMOC1 TP63 siRNA Immortalized_keratinocyte HaCaT RG 4.07698 2.0275 - - DataSet_01_197
SMOC1 TP63 siRNA Head_and_neck SCC-012 0.3689 -1.43872 - - DataSet_01_201
SMOC1 HIC1 shRNA Mammary_gland HBL100 1.62808 0.70318 - - DataSet_01_205
SMOC1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 3.98547 1.99475 - - DataSet_01_208
SMOC1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.58096 -0.78349 - - DataSet_01_210
SMOC1 LIN28A siRNA Embryo H9 3.42679 1.77686 0.00024 0.00514 DataSet_01_215
SMOC1 PTEN shRNA Mammary_gland MCF10A 0.6188 -0.69244 1.92143e-06 5.33299e-05 DataSet_01_218
SMOC1 ATM shRNA Mammary_gland MCF10A 0.66327 -0.59232 1.37984e-07 5.09003e-06 DataSet_01_219
SMOC1 KLF2 shRNA Bone_marrow RPMI8226 2.10283 1.07233 0.00453 0.41961 DataSet_01_226
SMOC1 MYC siRNA White_adipose_tissue Adipose stem cells 0.42027 -1.2506 1.89125e-06 0.00028 DataSet_01_231
SMOC1 TWIST1 shRNA Stomach CAF32 1.50326 0.58809 0.05083 0.1393 DataSet_01_253
SMOC1 MYT1L shRNA Fetal_spinal_cord SPC04 0.63361 -0.65833 0.00604 0.14246 DataSet_01_264
SMOC1 MSX1 siRNA Tooth Dental Pulp Cells 0.62014 -0.68934 0.00024 0.00182 DataSet_01_281
SMOC1 JUN siRNA Mammary_gland BT549 0.66239 -0.59425 0.00014 0.00222 DataSet_01_291
SMOC1 POSTN shRNA Brain GSC272 4.27354 2.09543 0.01712 0.48721 DataSet_01_293
SMOC1 TFAP4 siRNA Brain BE(2)-C 0.16308 -2.61634 0.30379 0.51625 DataSet_01_295
SMOC1 ELK3 shRNA Mammary_gland MDA-MB-231 5.48513 2.45553 7.40508e-05 0.00048 DataSet_01_318
SMOC1 ZNF25 siRNA Bone_marrow hMSC-TERT4 3.15352 1.65696 0.12238 0.63688 DataSet_01_319
SMOC1 GRHL3 siRNA Skin NHEK 1.86937 0.90255 0.00091 0.13736 DataSet_01_336
SMOC1 CDX2 siRNA Colon COLO320 0.48223 -1.05222 - - DataSet_01_357
SMOC1 GTF2B siRNA Cervix HeLa 0.57296 -0.80349 - - DataSet_01_362
SMOC1 ZNF622 shRNA Liver HepG2 0.66003 -0.59939 0.00196 0.01117 DataSet_02_108
SMOC1 PTBP1 shRNA Liver HepG2 0.59413 -0.75114 0.00076 0.00659 DataSet_02_120
SMOC1 AR siRNA Prostate abl cells 2.7 1.43296 0.0469665989448367 0.999852161656754 DataSet_03_004
SMOC1 BCL6 siRNA Lymph Pfeiffer DLBCL 0.609971 -0.713188 0.0330158800719229 0.454194857102278 DataSet_03_026
SMOC1 CASP8AP2 siRNA Bone_marrow U2OS 1.83497 0.875757 0.00460858341118786 0.0544854134208168 DataSet_03_031
SMOC1 GATA2 siRNA Lymph Lymphatic endothelial cells 5.46433 2.45004 2.2732003308612e-08 3.78655261314306e-06 DataSet_03_101
SMOC1 GATA3 siRNA Mammary_gland MCF7 0.246089 -2.02275 1.38484122220885e-06 0.00238139928745718 DataSet_03_103
SMOC1 GATA4 siRNA Stomach KatoIII 0.640074 -0.643688 0.302343736017966 0.934564887474274 DataSet_03_106
SMOC1 HINFP siRNA Bone_marrow U2OS 2.70608 1.43621 0.000127803965910553 0.0119701614309133 DataSet_03_123
SMOC1 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 0.469328 -1.09133 0.589503360690567 0.999948959532916 DataSet_03_134
SMOC1 JUN siRNA Fibroblasts WI38 0.618627 -0.692857 0.00141653286857042 0.0188698167349385 DataSet_03_140
SMOC1 JUN siRNA Fibroblasts WI38 0.618627 -0.692857 0.00141519850792933 0.0187485705812239 DataSet_03_141
SMOC1 Klf4 siRNA Skin Primary neonatal keratinocytes 0.190404 -2.39286 7.72648618208318e-05 0.00188740914195243 DataSet_03_147
SMOC1 KLF5 siRNA Colon SW480 1.50746 0.592123 0.000838463598709614 0.0649365396506516 DataSet_03_148
SMOC1 MEF2D siRNA Liver HuH7 0.614979 -0.701392 - - DataSet_03_163
SMOC1 PRRX1 CRISPR Neuroblastoma 691-MES 0.535058 -0.902232 0.00439888709711081 0.89189998148014 DataSet_03_217
SMOC1 RELA siRNA Fibroblasts WI38 0.629441 -0.667857 0.00848854649022822 0.0556586917462051 DataSet_03_222
SMOC1 RELA siRNA Fibroblasts WI38 0.622211 -0.684524 0.0012079108059031 0.00870586960705232 DataSet_03_223
SMOC1 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.280992 -1.8314 - - DataSet_03_246
SMOC1 SOX9 knockdown Liver HepG2 0.594227 -0.750913 6.13718185603252e-06 0.000587655925116094 DataSet_03_248
SMOC1 SP1 siRNA Mammary_gland MDA-MB-231 0.644795 -0.633088 0.128173403036726 0.413972819854456 DataSet_03_250
SMOC1 STAT3 CRISPR Embryo hESC 2.24537 1.16695 0.101497810452217 0.188523170131278 DataSet_03_258
SMOC1 TFE3 siRNA Kidney UOK257-2 2.05297 1.03772 - - DataSet_03_275
SMOC1 ZNF165 siRNA Mammary_gland SUM159 1.51536 0.599658 0.789557291258038 0.999998167536832 DataSet_03_288
SMOC1 ZNF750 siRNA Skin Primary neonatal keratinocytes 0.348252 -1.5218 0.00169706959865216 0.036836598193796 DataSet_03_294
SMOC1 CNOT7 shRNA Liver HepG2 0.411728 -1.28024 0.00013326411261934 0.00297803504609268 DataSet_04_051
SMOC1 YBX3 shRNA Liver HepG2 1.57254 0.653094 0.00169014237797521 0.0449593293234035 DataSet_02_98
SMOC1 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2 1 0.852616758179449 0.947662743608659 DataSet_02_38
SMOC1 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.711482528108772 0.916364799847791 DataSet_02_75
SMOC1 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.5 1.80735 0.824555093508511 0.966610805974383 DataSet_02_45
SMOC1 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 9.5 3.24793 0.3749974003555 0.617744880416236 DataSet_02_32
SMOC1 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2 1 0.844911861851982 0.916364064021578 DataSet_02_47
SMOC1 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 5.5 2.45943 0.426228240500505 0.595514727693198 DataSet_02_53
SMOC1 SMARCA4 siRNA Colon HCT116 0.251217 -1.99299 1.515703e-04 1.601831e-02 DataSet_03_301
SMOC1 ELF3 CRISPR Bile_duct HBDEC2 2.02634 1.01888 2.942257e-06 1.991902e-04 DataSet_03_304
SMOC1 PRMT1 shRNA Lung A549 3.11344 1.63851 - - DataSet_03_342
SMOC1 AEBP1 siRNA Central_nervous_system U87MG 0.598363 -0.740906 6.747234e-02 0.9999434 DataSet_03_338
SMOC1 SKI CRISPR Blood HL60 0.2 -2.32193 2.296282e-02 0.269756947 DataSet_03_351
SMOC1 ESR1 siRNA Mammary_gland MCF7 2.02511 1.018 9.634532e-03 0.0672197296 DataSet_03_352
SMOC1 ETV5 knockdown Colon HT29 2 1 5.461014e-01 0.722069294 DataSet_03_353
SMOC1 TET1 CRISPR Mammary_gland Hs578T 10.0101 3.32339 1.772917e-01 3.508606e-01 DataSet_03_355
SMOC1 CREBBP CRISPR Brain U5-NPC 45.4546 5.50635 0.0057540626 0.7490853 DataSet_03_356
SMOC1 PTPN14 CRISPR Brain U5-NPC 0.135294 -2.88583 1.895355e-02 0.24988386 DataSet_03_357
SMOC1 TP53 CRISPR Brain U5-NPC 2.72727 1.44746 1.026125e-01 2.387636e-01 DataSet_03_358
SMOC1 NCOA2 siRNA Uterus endometrial stromal cells 0.454545 -1.1375 0.1570757964 1 DataSet_03_360
SMOC1 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 0.454677 -1.13709 5.150669e-07 2.079807e-05 DataSet_03_362
SMOC1 EP300 shRNA Mammary_gland MCF10AT 0.213362 -2.22862 2.250109e-04 0.014110412 DataSet_03_364
SMOC1 DNMT3A knockout Embryo_kidney HEK293T 15.8533 3.98671 - - DataSet_03_369
SMOC1 BHLHE40 shRNA Cervix HeLaS3 1.6475 0.720282 2.570021e-01 0.84447131 DataSet_03_372
SMOC1 GLI1 siRNA Skeletal_muscle RMS13 0.598049 -0.741665 4.831532e-03 0.049223944 DataSet_03_375
SMOC1 ZNF213 siRNA Mammary_gland MCF7 0.578602 -0.789357 3.817413e-01 6.625333e-01 DataSet_03_376
SMOC1 SMARCA2 shRNA Lung NCI-H1944 0.476091 -1.07069 1.379572e-04 6.678769e-02 DataSet_03_377
SMOC1 EZH2 CRISPR Ovary SKOV3 17.0312 4.09011 3.143680e-06 0.0008444251 DataSet_03_378
SMOC1 NFKB2 siRNA Bone_marrow U2OS 0.598015 -0.741747 3.945835e-02 0.26136390 DataSet_03_381
SMOC1 DNMT1 siRNA Skin Human melanoma cells 1.74583 0.80391 4.257801e-03 1.051293e-02 DataSet_03_382
SMOC1 YY1 shRNA Brain GSC1517 0.659574 -0.600393 - - DataSet_03_384
SMOC1 TRIM8 siRNA Mammary_gland MCF7 0.26 -1.94342 5.560646e-04 0.0096629362 DataSet_03_388
SMOC1 NFKBIA shRNA Bone_marrow U2OS 0.536161 -0.899261 5.721138e-02 0.87005461 DataSet_03_389
SMOC1 IKZF2 CRISPR Lymph CAR T Cell 0.59957 -0.737999 5.231571e-01 0.847824801 DataSet_03_397
SMOC1 RELA CRISPR Brain T30 0.381781 -1.38918 0.1669898315 0.8400824 DataSet_03_399
SMOC1 HMGA1 shRNA Bile_duct HUCCT1 1.65655 0.728181 2.336393e-03 0.057723172 DataSet_03_400
SMOC1 CDK7 shRNA Bone_marrow D458 58 5.85798 6.633303e-05 0.03240403 DataSet_03_404
SMOC1 TFAP2A knockout Embryo H9 0.0295868 -5.0789 7.047449e-05 0.01552045 DataSet_03_405
SMOC1 CHD1 shRNA Prostate LNCaP 0.5 -1 7.104709e-02 5.430070e-01 DataSet_03_407
SMOC1 MAP3K7 shRNA Prostate LNCaP 0.277778 -1.848 1.083949e-02 8.535775e-02 DataSet_03_408
SMOC1 STRAP knockout Nerve SK-N-AS 15.615 3.96486 - - DataSet_03_409
SMOC1 FOXQ1 CRISPR Lymph Primary CD4+ T cells 0.333333 -1.58496 - - DataSet_03_422
SMOC1 MAEL CRISPR Liver Alexander cells 0.277937 -1.84717 - - DataSet_03_423
SMOC1 FOXP3 CRISPR Peripheral_blood Naive Treg 0.214286 -2.22239 4.177057e-01 0.727167419 DataSet_03_427
SMOC1 USP7 shRNA Skin xenograft cells 0.480769 -1.05658 0.25033281 0.4348960 DataSet_03_431
SMOC1 EP300 knockout Pancreas HPAF-II orthotopic cells 0.0145269 -6.10512 3.933522e-06 2.126626e-04 DataSet_03_436
SMOC1 SUFU shRNA Mammary_gland HCC1954 cells 0.491525 -1.02466 0.3418004254 0.6601538 DataSet_03_437
SMOC1 CIC knockout Brain Immortalized Astrocyte Cells 4.86539 2.28255 2.017439e-01 6.421568e-01 DataSet_03_438
SMOC1 CAMTA1 knockout Embryo_kidney HEK293T 0.644407 -0.633955 5.025260e-03 0.09316750 DataSet_03_448
SMOC1 RELB CRISPR Colon SW480 0.4 -1.32193 2.288393e-01 4.604547e-01 DataSet_03_449
SMOC1 CBX2 siRNA Mammary_gland MCF7 3.87959 1.9559 9.706316e-02 0.1849950485 DataSet_03_451
SMOC1 ZFP36L1 CRISPR Lung NCI-H1876 3.71062 1.89166 4.987752e-05 0.078861351 DataSet_03_454
SMOC1 SMARCA2 shRNA Lung HCC2302 0.222615 -2.16738 9.216089e-13 1.555718e-11 DataSet_03_455
SMOC1 ARID1A shRNA Bile_duct MMNK1 0.210054 -2.25117 4.337683e-03 0.062860919 DataSet_03_458
SMOC1 HAND1 siRNA Placenta HPMVEC 0.647727 -0.626542 1.718833e-01 0.9463341 DataSet_03_459
SMOC1 SOX9 knockout Liver HuH7 3.43373 1.77978 7.520023e-05 1.845231e-03 DataSet_03_463
SMOC1 SMARCA1 Cas13 Embryo_kidney HEK293T 0.459906 -1.12059 - - DataSet_03_466
SMOC1 LIN28A siRNA Mammary_gland MCF7M 2.22459 1.15354 8.508672e-01 0.9847589 DataSet_03_469
SMOC1 LIN28A siRNA Mammary_gland MCF7M 2.22459 1.15354 8.508672e-01 0.9847589 DataSet_03_470
SMOC1 WHSC1 siRNA Prostate PC3 8.2 3.03562 5.981277e-02 0.22706607 DataSet_03_471
SMOC1 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 16 4 0.3535321 0.7749238 DataSet_04_072
Regulation Region
 
T(co)Fs that significantly regulate CDK7 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of SMOC1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines