Gene Overview
| Target Gene: | Thbs2 |
| NCBI Official Symbol: | Thbs2 |
| Entrez ID: | 21826 |
| Ensembl ID: | ENSMUSG00000023885 |
| Gene Full Name: | thrombospondin 2 |
| Strand: | - |
| Gene Locus: | 17 A2|17 8.95 cM |
| External Links: |
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Thbs2 Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate Thbs2
T(co)Fs
that Repress Thbs2
The Intensity of the Gene Regulated by T(co)Fs:
Thbs2-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| Thbs2 | Adnp | knockout | Embryo | Whole embryonic body | 0.413203 | -1.27508 | 0.00899777978659076 | 0.298825811229323 | DataSet_11_001 |
| Thbs2 | Bhlha9 | knockout | Limb | Whole limb bud | 2.21531 | 1.14751 | - | - | DataSet_11_016 |
| Thbs2 | Cebpb | knockout | Mammary_gland | Mammary epithlial cells (MECs) | 0.443396 | -1.17333 | 0.433275210652152 | 0.999788745984441 | DataSet_11_020 |
| Thbs2 | Dmrt1 | knockout | Testis | Testes | 0.648864 | -0.624012 | 0.119178704998406 | 0.8012876826985 | DataSet_11_024 |
| Thbs2 | E2f4 | knockout | Brain | Forebrain | 2.18803 | 1.12963 | - | - | DataSet_11_034 |
| Thbs2 | Elf5 | knockout | Mammary_gland | Mammary gland | 2.84723 | 1.50956 | 0.00752265034023673 | 0.199357152238597 | DataSet_11_035 |
| Thbs2 | Foxk1 | shRNA | Embryo | MEFs | 1.52311 | 0.607016 | 7.01173352856267e-05 | 0.00719952302554051 | DataSet_11_042 |
| Thbs2 | Gata4 | siRNA | Testis | TM4 | 0.645032 | -0.632558 | 3.34356216548791e-06 | 0.000668935337241947 | DataSet_11_050 |
| Thbs2 | Hsf4 | knockout | Eye | Lens | 0.400163 | -1.32134 | 0.326178918855318 | 0.987999303842427 | DataSet_11_058 |
| Thbs2 | Klf17 | shRNA | Mammary_gland | 168FARN | 0.129013 | -2.95441 | 7.23620582482823e-08 | 0.000365725245004299 | DataSet_11_066 |
| Thbs2 | Mafg | knockout | Embryo | Whole embryo | 0.608321 | -0.717094 | 0.372800550662665 | 1 | DataSet_11_073 |
| Thbs2 | Mef2b | shRNA | Muscle | C2C12 | 0.65707 | -0.605881 | 7.73698576258942e-05 | 0.00284841690670236 | DataSet_11_078 |
| Thbs2 | Mef2c | shRNA | Muscle | C2C12 | 0.598174 | -0.741363 | 2.03306563601143e-05 | 0.00140472048246356 | DataSet_11_079 |
| Thbs2 | Neurod1 | knockout | Eye | Retina | 2.08624 | 1.0609 | 0.00624358274536332 | 0.0444247511909367 | DataSet_11_088 |
| Thbs2 | Nrf1 | knockdown | Liver | Liver | 3.65322 | 1.86917 | 0.00325210264956805 | 0.0320271166635451 | DataSet_11_096 |
| Thbs2 | Pitx2 | knockout | Eye | Cornea | 2.89065 | 1.53139 | 0.267006678681927 | 0.662866780745032 | DataSet_11_103 |
| Thbs2 | Prdm2 | shRNA | Muscle | C2C12 | 0.637429 | -0.649663 | 0.0668233376053448 | 0.823100428615999 | DataSet_11_108 |
| Thbs2 | Prox1 | knockout | Liver | Liver | 2.87204 | 1.52207 | - | - | DataSet_11_109 |
| Thbs2 | Rest | knockout | Brain | Brain | 2.13645 | 1.09521 | 0.712291810082527 | 1 | DataSet_11_113 |
| Thbs2 | Runx1 | knockout | Lymph | ProB cells | 8.30192 | 3.05345 | 0.000130699993575121 | 0.007050483113976 | DataSet_11_116 |
| Thbs2 | Runx2 | knockout | Humeri | Embryonic humeri | 0.552832 | -0.855087 | 0.0414265452122036 | 0.371647154810165 | DataSet_11_120 |
| Thbs2 | Sall4 | shRNA | Embryo | ES cells | 1.55761 | 0.639329 | 0.883128318695087 | 0.999840995136314 | DataSet_11_123 |
| Thbs2 | Smad4 | siRNA | Brain | bEnd3 | 34.168 | 5.09458 | - | - | DataSet_11_127 |
| Thbs2 | Smad4 | knockout | Aorta | Aortic arteries | 2.81213 | 1.49166 | 0.00838679464106258 | 0.148675647564341 | DataSet_11_128 |
| Thbs2 | Snai1 | knockout | Embryo | Teratoma | 0.622007 | -0.684997 | - | - | DataSet_11_130 |
| Thbs2 | Snai1 | knockout | Embryo | Embryonic stem cells (ESCs) | 0.591622 | -0.757252 | 0.0459273817512892 | 0.247874011164062 | DataSet_11_131 |
| Thbs2 | Sohlh1 | knockout | Ovary | Ovary | 1.72758 | 0.78875 | 4.88930119676082e-05 | 0.000993322536173642 | DataSet_11_134 |
| Thbs2 | Sohlh2 | knockout | Ovary | Ovary | 1.73458 | 0.794583 | 3.72150087184781e-05 | 0.000602292517834414 | DataSet_11_135 |
| Thbs2 | Sox9 | knockout | Lung | Trachea | 0.456927 | -1.12997 | 5.26361037927057e-05 | 0.0142353164287138 | DataSet_11_144 |
| Thbs2 | Spdef | knockout | Stomach | Stomach | 1.50261 | 0.587474 | 0.110977922793441 | 0.871950375651701 | DataSet_11_147 |
| Thbs2 | Stat6 | knockout | Bone_marrow | Bone marrow-derived macrophages | 2.73436 | 1.4512 | 0.255572068860815 | 0.463966764134981 | DataSet_11_153 |
| Thbs2 | Tsc22d4 | shRNA | Adipose_tissue | Abdominal fat | 0.631383 | -0.663412 | 6.20403939708802e-05 | 0.0188765029989291 | DataSet_11_170 |
| Thbs2 | Wt1 | knockout | Oviduct | Oviduct | 1.5105 | 0.595026 | 0.00312027914606365 | 0.51929206106762 | DataSet_11_180 |
| Thbs2 | Yy1 | knockout | White_adipose_tissue | Visceral white adipose tissue | 0.277213 | -1.85093 | 0.00233137457813991 | 0.0312922810266709 | DataSet_11_185 |
| Thbs2 | Mapk9 | knockout | Hip | Mouse Hip Cartilage | 0.376554 | -1.40907 | 3.273955e-06 | 5.518489e-05 | DataSet_11_236 |
| Thbs2 | Kdm5b | knockout | Heart | left ventricles | 0.427094 | -1.22737 | 0.4365264320 | 0.9999827 | DataSet_11_210 |
| Thbs2 | Dnmt1 | knockout | Embryo | Embryonic fibroblasts | 0.0440282 | -4.50543 | 5.784784e-06 | 6.162748e-04 | DataSet_11_192 |
| Thbs2 | Dnmt1 | shRNA | Embryo | Embryonic fibroblasts | 1.50199 | 0.586877 | - | - | DataSet_11_196 |
| Thbs2 | Ezh2 | knockdown | Brain | Brain | 0.30308 | -1.72223 | 5.891937e-05 | 0.0066866986 | DataSet_11_221 |
| Thbs2 | Dnmt1 | knockout | Liver | Liver | 1.79 | 0.839964 | 9.609864e-04 | 2.462254e-02 | DataSet_11_232 |
| Thbs2 | Bptf | shRNA | Mammary_gland | 4T1 cells | 0.484645 | -1.045 | 7.709318e-04 | 0.077472761 | DataSet_11_223 |
| Thbs2 | Smarca4 | shRNA | Embryo | ES cells | 0.291082 | -1.7805 | - | - | DataSet_11_224 |
| Thbs2 | Smarca4 | shRNA | Embryo | ES cells | 0.291082 | -1.7805 | - | - | DataSet_11_225 |
| Thbs2 | Rag1 | knockout | Bone | Mice fractured callus | 1.53937 | 0.622341 | 8.604316e-04 | 7.077177e-03 | DataSet_11_230 |
| Thbs2 | Dnmt3b | siRNA | Embryo | iPSC | 0.590538 | -0.759898 | - | - | DataSet_11_242 |
| Thbs2 | Lin28a | knockout | Heart | Heart | 0.60884 | -0.715865 | 0.0164254749 | 0.8777652 | DataSet_11_243 |
| Thbs2 | Twist1 | knockout | Bone_marrow | stromal cells | 1.3515e-20 | -66.004 | - | - | DataSet_11_244 |
| Thbs2 | Kat6a | knockout | Embryo | Embryonic fibroblasts | 0.223468 | -2.16186 | 9.556630e-04 | 0.0235309830 | DataSet_11_245 |
| Thbs2 | Fubp1 | shRNA | Brain | brain neural progenitors | 0.041507 | -4.5905 | 0.3001168638 | 1 | DataSet_11_246 |
| Thbs2 | Dnmt1 | siRNA | Embryo | Embryo | 10 | 3.32193 | - | - | DataSet_11_248 |
| Thbs2 | Kmt2d | knockout | Skin | iBiP melanoma mouse model tumor cell | 3.0834 | 1.62452 | 5.193540e-04 | 5.478850e-03 | DataSet_11_250 |
| Thbs2 | Kdm2a | CRISPR | Embryo | ES cells | 7.75 | 2.9542 | 0.0463156675 | 1.0000000 | DataSet_11_251 |
| Thbs2 | Nsd2 | shRNA | Prostate | NPK | 0.537219 | -0.896417 | 3.745737e-07 | 3.262277e-05 | DataSet_11_257 |
| Thbs2 | Eed | knockout | Brain | Forebrain | 1.68537 | 0.75307 | 3.227964e-01 | 7.492072e-01 | DataSet_11_258 |
| Thbs2 | Eed | knockout | Brain | hindbrain | 1.5042 | 0.588994 | 1.819122e-01 | 9.999914e-01 | DataSet_11_259 |
| Thbs2 | Eed | knockout | Brain | midbrain | 1.7825 | 0.833904 | 6.152622e-02 | 7.978124e-01 | DataSet_11_260 |
| Thbs2 | Arhgap35 | knockout | Ventral_spinal_cord | Ventral spinal cord | 1.50847 | 0.59309 | 1.511427e-01 | 1.000000000 | DataSet_11_264 |
| Thbs2 | Dux | knockout | Embryo | Embryo | 0.159182 | -2.65125 | 6.107233e-01 | 7.451531e-01 | DataSet_11_269 |
| Thbs2 | Dux | knockout | Embryo | Embryo | 0.159182 | -2.65125 | 6.107239e-01 | 7.451698e-01 | DataSet_11_273 |
| Thbs2 | Usp7 | knockout | Embryo | ES cells | 1.95 | 0.963474 | 5.928962e-01 | 0.8146516 | DataSet_11_279 |
| Thbs2 | Dnmt1 | knockout | Cortex | mature Pvergic cortical interneurons | 2.15054 | 1.1047 | 8.375019e-02 | 0.6936949 | DataSet_11_283 |
| Thbs2 | Setd2 | knockout | Kidney | primary renal tubular epithelial (RTE) cells | 1.61111 | 0.688056 | - | - | DataSet_11_285 |
| Thbs2 | Pdx1 | CRISPR | Liver | Liver | 0.386921 | -1.36989 | 2.108587e-02 | 0.320198855 | DataSet_11_286 |
| Thbs2 | Usp7 | siRNA | Embryo | ES cells | 2.0625 | 1.04439 | 2.390612e-01 | 0.6667924 | DataSet_11_287 |
| Thbs2 | Med19 | knockout | White_adipose_tissue | Gonadal white adipose tissue | 0.448555 | -1.15664 | 4.972663e-03 | 8.321130e-02 | DataSet_11_289 |
| Thbs2 | Mkl1 | knockout | Bone_marrow | Bone marrow differentiated macrophages | 11.9259 | 3.57603 | 6.942617e-02 | 0.4700473002 | DataSet_11_294 |
| Thbs2 | Phf8 | knockout | prostate | Prostate | 2.39848 | 1.26212 | 0.2728131804 | 0.5247280 | DataSet_11_298 |
| Thbs2 | Arid2 | knockout | Muscle | LSK | 0.0571429 | -4.12928 | 4.413181e-08 | 3.038855e-05 | DataSet_11_301 |
| Thbs2 | Dnmt1 | knockout | Skin | Keratinocytes | 2.00384 | 1.00277 | 5.404628e-01 | 0.7867139414 | DataSet_11_303 |
| Thbs2 | Satb2 | CRISPR | Colon | Colon organoid | 0.333333 | -1.58496 | 3.419267e-01 | 0.6518149 | DataSet_11_304 |
| Thbs2 | Foxp3 | CRISPR | Spleens_and_lymphnodes | CD4+ Th0 cells | 0.343137 | -1.54314 | - | - | DataSet_11_305 |
| Thbs2 | Jmjd6 | knockout | Bone_marrow | Lin-Sca1+Kit+ (LSK) haematopoietic stem and progenitor cells | 1.71429 | 0.777608 | - | - | DataSet_11_306 |
| Thbs2 | Cited2 | knockout | Haematopoietic_and_lymphoid_tissue | Hematopoietic stem cell (HSC) | 0.414634 | -1.27009 | - | - | DataSet_11_308 |
| Thbs2 | Myc | CRISPR | Skeletal_muscle | quiescent muscle stem cell | 48.5678 | 5.60193 | 1.771811e-01 | 0.80359421 | DataSet_11_310 |
| Thbs2 | Irf7 | knockout | Bone_marrow | c-kit+ leukemic cells | 0.571429 | -0.807355 | - | - | DataSet_11_313 |
| Thbs2 | Arid1b | knockout | Bone_marrow | bone marrow leukemia cells | 0.133333 | -2.90689 | 3.336531e-02 | 0.2389285646 | DataSet_11_317 |
| Thbs2 | Arid2 | knockout | Bone_marrow | bone marrow leukemia cells | 0.25 | -2 | 6.445815e-02 | 0.7021662 | DataSet_11_318 |
| Thbs2 | Kat7 | knockout | Thymic_lobes | Thymic epithelial cells | 1.7201 | 0.782492 | 1.509699e-02 | 1.038872e-01 | DataSet_11_320 |
| Thbs2 | Bud31 | knockout | Testis | Spermatogonial stem cells | 0.373164 | -1.42212 | 9.337976e-02 | 0.8600602 | DataSet_11_321 |
| Thbs2 | Tet1 | siRNA | Embryo | Embryonic fibroblasts | 2.24164 | 1.16455 | 1.830383e-01 | 0.9609895 | DataSet_11_327 |
| Thbs2 | Kdm5b | siRNA | Embryo | ES cells | 0.253834 | -1.97804 | 0.5727437703 | 0.9056999 | DataSet_11_331 |
| Thbs2 | Ezh2 | knockout | Eye | Retina | 0.492063 | -1.02308 | 1.884097e-02 | 1.881629e-01 | DataSet_11_333 |
| Thbs2 | Atrx | knockout | Embryo | ES cells | 3 | 1.58496 | - | - | DataSet_11_335 |
| Thbs2 | Dnmt3a | knockout | Peritoneum | peritoneal macrophages | 0.580754 | -0.784001 | - | - | DataSet_11_336 |
| Thbs2 | Dnmt1 | siRNA | Heart | embryonic cardiomyocytes | 0.462854 | -1.11137 | 3.799115e-03 | 0.013283501 | DataSet_11_340 |
| Thbs2 | Ezh2 | knockout | Small_intestinal_crypts | small intestinal crypts | 0.00174956 | -9.15879 | 0.0318894004 | 0.1712697 | DataSet_11_341 |
| Thbs2 | Hnrnpk | siRNA | Embryo | ES cells | 0.484081 | -1.04668 | 1.633834e-02 | 0.039236387 | DataSet_11_342 |
| Thbs2 | Pcbp1 | shRNA | Thymus | Th1 | 1.88235 | 0.912537 | 5.800784e-03 | 0.06997712 | DataSet_11_343 |
| Thbs2 | Dnmt1 | knockout | Kidney | kidney Cap Mesenchyme | 2.83899 | 1.50538 | 1.167583e-01 | 3.578822e-01 | DataSet_11_344 |
Regulation Region
Expression Atlas of Thbs2