Gene Overview
Target Gene: AGR3
NCBI Official Symbol: AGR3
Entrez ID: 155465
Ensembl ID: ENSG00000173467
Gene Full Name: anterior gradient 3, protein disulphide isomerase family member
Strand: -
Gene Locus: 7p21.1
External Links:

AGR3 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate AGR3   
T(co)Fs that Repress AGR3
The Intensity of the Gene Regulated by T(co)Fs:
AGR3-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
AGR3 ESR1 siRNA Mammary_gland MCF7 0.40992 -1.28657 3.2859e-08 7.78992e-05 DataSet_01_111
AGR3 GABPA siRNA Lung A549 1.88125 0.91169 0.00171 0.00515 DataSet_01_113
AGR3 ID1 siRNA Lung A549 2.96789 1.56944 0.11219 0.33002 DataSet_01_117
AGR3 ID1 siRNA Lung H1650 0.55888 -0.8394 0.23901 0.58565 DataSet_01_118
AGR3 FOXM1 siRNA Central_nervous_system U87 1.53832 0.62136 - - DataSet_01_122
AGR3 EGR4 siRNA Lung SBC-5 1.68415 0.75202 0.06539 0.38512 DataSet_01_132
AGR3 SPDEF shRNA Mammary_gland MCF7 0.18171 -2.46027 0.00191 0.06668 DataSet_01_135
AGR3 POLR3A siRNA Mammary_gland MCF7 0.47525 -1.07325 - - DataSet_01_139
AGR3 TFAP2C shRNA Mammary_gland MCF7 0.4935 -1.01889 1.02486e-12 5.38922e-11 DataSet_01_150
AGR3 STAT1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 0.6198 -0.69012 0.1088 0.38556 DataSet_01_154
AGR3 HSF1 shRNA Skin A375 0.19266 -2.37587 0.12472 0.34393 DataSet_01_155
AGR3 ELK1 siRNA Peripheral_blood CD4+ T cells 0.49275 -1.02108 0.61137 0.7906 DataSet_01_162
AGR3 GATA3 siRNA Peripheral_blood CD4+ T cells 0.51604 -0.95445 0.67322 0.84921 DataSet_01_163
AGR3 JUN siRNA Peripheral_blood CD4+ T cells 0.48228 -1.05205 0.5793 0.77517 DataSet_01_164
AGR3 MAF siRNA Peripheral_blood CD4+ T cells 0.48679 -1.03863 0.59292 0.83468 DataSet_01_165
AGR3 NFKB1 siRNA Peripheral_blood CD4+ T cells 0.56267 -0.82964 0.78804 0.91245 DataSet_01_167
AGR3 STAT3 siRNA Peripheral_blood CD4+ T cells 0.50259 -0.99256 0.64137 0.99183 DataSet_01_168
AGR3 TP53 siRNA Lung SAECs 1.72973 0.79055 0.96657 0.99049 DataSet_01_175
AGR3 NR5A2 siRNA Mammary_gland MCF7 0.57425 -0.80024 0.00064 0.01407 DataSet_01_182
AGR3 GABPA shRNA Prostate C4-2B 1442.69 10.4945 0.23964 0.43934 DataSet_01_190
AGR3 GABPA shRNA Prostate LNCaP 1092.2 10.093 0.46327 0.7048 DataSet_01_191
AGR3 CREB1 shRNA Parotid_gland H3118 MEC 3.70796 1.89063 0.41956 0.74414 DataSet_01_194
AGR3 TP63 siRNA Immortalized_keratinocyte HaCaT RG 2.3882 1.25592 - - DataSet_01_197
AGR3 TP63 siRNA Immortalized_keratinocyte HaCaT 0.16036 -2.64061 - - DataSet_01_200
AGR3 TP63 siRNA Head_and_neck SCC-6 2.59302 1.37464 - - DataSet_01_202
AGR3 XBP1 shRNA Mammary_gland T47D 2.21592 1.1479 6.80964e-06 0.00034 DataSet_01_203
AGR3 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 2.15562 1.1081 - - DataSet_01_208
AGR3 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 2.89731 1.53471 - - DataSet_01_210
AGR3 ERG siRNA Prostate VCaP 0.60979 -0.71361 0.01487 0.11526 DataSet_01_216
AGR3 SNAI2 shRNA Skin Primary human keratinocytes 0.18688 -2.41983 0.02265 0.07704 DataSet_01_225
AGR3 KLF2 shRNA Bone_marrow RPMI8226 0.62403 -0.68031 0.13244 0.74047 DataSet_01_226
AGR3 IRX1 shRNA Bone_marrow 143B 0.1395 -2.84171 0.36633 0.61684 DataSet_01_227
AGR3 AR shRNA Prostate CWR22Pc 0.6248 -0.67853 0.27279 0.50244 DataSet_01_278
AGR3 STAT5 shRNA Prostate CWR22Pc 1.53381 0.61712 0.03687 0.12297 DataSet_01_279
AGR3 SNAI2 siRNA Mammary_gland MCFDCIS 0.4651 -1.10437 0.22875 0.74674 DataSet_01_292
AGR3 POSTN shRNA Brain GSC272 13.4783 3.75256 0.01271 0.48243 DataSet_01_293
AGR3 TFAP4 siRNA Brain BE(2)-C 0.26871 -1.89589 0.41057 0.51625 DataSet_01_295
AGR3 PTEN shRNA Skin A431 1.9604 0.97115 0.24874 0.44729 DataSet_01_301
AGR3 PTEN shRNA Mammary_gland SKBR3 4.65036 2.21734 0.10661 0.61614 DataSet_01_303
AGR3 MYC siRNA Colon HCT116 1.94233 0.95779 0.09338 0.13783 DataSet_01_324
AGR3 HIF1A siRNA Oral_cavity OEC-M1 1.87568 0.90741 0.21741 0.85151 DataSet_01_348
AGR3 SOX2 shRNA Neuroepithelium HF2303 0.52118 -0.94015 0.05448 1 DataSet_01_349
AGR3 ABL1 siRNA Mammary_gland MCF7 0.414594 -1.27023 0.437629717694558 0.976385569407162 DataSet_03_001
AGR3 AKT1 siRNA Mammary_gland MCF7 0.488461 -1.03368 0.524225470743669 0.942543420455519 DataSet_03_002
AGR3 AR siRNA Prostate VCaP 0.652439 -0.616085 0.003117971923085 0.0330118237664697 DataSet_03_007
AGR3 ARID2 CRISPR Liver JHH4 0.648954 -0.623812 0.420670428783949 1 DataSet_03_015
AGR3 ASCL1 siRNA Lung DMS79 0.333333 -1.58496 0.14670202639975 0.810683683797745 DataSet_03_016
AGR3 ATR siRNA Mammary_gland MCF7 0.383864 -1.38133 0.400658002014194 0.999819450785634 DataSet_03_020
AGR3 BCL6 siRNA Mammary_gland MCF7 0.223399 -2.1623 0.205280662437872 0.989541443114508 DataSet_03_024
AGR3 BCL6 siRNA Lymph Pfeiffer DLBCL 0.593605 -0.752426 0.322632417392712 0.757910413208268 DataSet_03_026
AGR3 BRCA1 siRNA Mammary_gland MCF7 0.212217 -2.23639 0.192031550880702 0.999850583334387 DataSet_03_028
AGR3 BRCA2 siRNA Mammary_gland MCF7 0.488077 -1.03482 0.523785460431133 0.999441861952364 DataSet_03_029
AGR3 CCNA2 siRNA Mammary_gland MCF7 0.497833 -1.00627 0.53494070597168 0.926030654671715 DataSet_03_034
AGR3 CDK2 siRNA Mammary_gland MCF7 0.470006 -1.08925 0.502935733877282 0.99987175116756 DataSet_03_044
AGR3 CEBPA siRNA Mammary_gland MCF7 6.35392 2.66765 0.129379448161411 0.999962793175751 DataSet_03_047
AGR3 CEBPB siRNA Mammary_gland MCF7 0.499295 -1.00204 0.536605724509856 0.993756826434039 DataSet_03_048
AGR3 CEBPD siRNA Mammary_gland MCF7 0.471045 -1.08606 0.504140303219358 0.999848455332859 DataSet_03_050
AGR3 CENPF siRNA Mammary_gland MCF7 5.10215 2.35111 0.173051368160535 0.999662524742916 DataSet_03_052
AGR3 CHEK1 siRNA Mammary_gland MCF7 0.349861 -1.51515 0.359294274296571 0.999587656258211 DataSet_03_053
AGR3 CREBBP siRNA Mammary_gland MCF7 0.335627 -1.57507 0.341883327085859 0.968255936317567 DataSet_03_055
AGR3 CTNNB1 siRNA Mammary_gland MCF7 6.09594 2.60785 0.136731271419775 0.999436862066063 DataSet_03_058
AGR3 E2F1 siRNA Mammary_gland MCF7 5.87025 2.55342 0.143769433122178 0.999927373439084 DataSet_03_061
AGR3 E2F5 siRNA Mammary_gland MCF7 5.97769 2.57959 0.140343626715685 0.999540347732068 DataSet_03_062
AGR3 ERBB2 siRNA Mammary_gland MCF7 0.515356 -0.95636 0.554792687910802 0.998282799776643 DataSet_03_066
AGR3 ERF siRNA Mammary_gland MCF7 0.475455 -1.07262 0.509247509258013 0.999855523449227 DataSet_03_067
AGR3 ESR1 siRNA Mammary_gland MCF7 0.236896 -2.07768 0.112202446256601 0.999753934970283 DataSet_03_068
AGR3 ESRRA siRNA Mammary_gland MCF7 0.192047 -2.38047 0.168480008899275 0.999964003642835 DataSet_03_072
AGR3 FOS siRNA Mammary_gland MCF7 0.41628 -1.26437 0.439643734791773 0.999966427400474 DataSet_03_079
AGR3 FOXA1 siRNA Mammary_gland MCF7 0.510057 -0.971271 6.34113114995004e-06 0.000284236697824763 DataSet_03_080
AGR3 FOXA1 siRNA Mammary_gland MCF7 0.664448 -0.589772 1.04745679758402e-08 3.84231522838358e-07 DataSet_03_081
AGR3 FOXA1 siRNA Mammary_gland MCF7 0.664448 -0.589772 1.04745679758402e-08 3.84231522838358e-07 DataSet_03_082
AGR3 FOXC1 siRNA Mammary_gland MCF7 0.534861 -0.902764 0.576604887936104 0.999669928105298 DataSet_03_084
AGR3 FOXJ2 siRNA Mammary_gland MCF7 0.493146 -1.01991 0.529590616418618 0.999965704179325 DataSet_03_088
AGR3 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 11.8462 3.56636 - - DataSet_03_096
AGR3 FOXP1 siRNA Mammary_gland MCF7 0.430119 -1.21719 0.45611878647241 0.999975993110711 DataSet_03_099
AGR3 GATA2 siRNA Uterus Decidual stromal cells 1.93225 0.950282 0.333612273090642 0.881044130717347 DataSet_03_100
AGR3 GATA3 siRNA Mammary_gland MCF7 0.497976 -1.00585 0.535103366164903 0.999831535534034 DataSet_03_102
AGR3 GATA4 siRNA Stomach AGS 2.45604 1.29633 0.293808128590465 0.863862954196157 DataSet_03_105
AGR3 GATA6 siRNA Stomach AGS 2.60055 1.37882 0.181054056588518 0.679071658376477 DataSet_03_108
AGR3 HDAC3 siRNA Mammary_gland MCF7 0.585234 -0.772914 0.631472737737885 0.99997791025972 DataSet_03_114
AGR3 HDAC5 siRNA Mammary_gland MCF7 5.81057 2.53868 0.145734202793385 0.999966625300244 DataSet_03_115
AGR3 HIF1A siRNA Mammary_gland MCF7 0.304632 -1.71486 0.303884943297666 0.999966843283762 DataSet_03_119
AGR3 HNF4a siRNA Liver HepG2 2.46316 1.30051 0.344138167403551 0.866584186479088 DataSet_03_126
AGR3 HOXB7 siRNA Mammary_gland MCF7 0.161281 -2.63235 0.133671291016888 0.999977683706165 DataSet_03_127
AGR3 HSF2 siRNA Mammary_gland MCF7 7.34273 2.87632 0.106601400547364 0.990969613280381 DataSet_03_130
AGR3 ID1 siRNA Mammary_gland MCF7 0.448069 -1.15821 0.477316077233528 0.999926480273844 DataSet_03_133
AGR3 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 0.652655 -0.615607 0.4504849399596 0.999948959532916 DataSet_03_134
AGR3 JUN siRNA Mammary_gland MCF7 0.432561 -1.20902 0.465811377188251 0.999857657786768 DataSet_03_142
AGR3 JUND siRNA Mammary_gland MCF7 0.438305 -1.18999 0.459015070240901 0.999848956486105 DataSet_03_145
AGR3 KLF5 siRNA Stomach AGS 1.96392 0.973737 0.282387480438651 0.736270982532718 DataSet_03_149
AGR3 KLF5 siRNA Stomach YCC3 0.568753 -0.814126 0.00994829349477721 0.163648118141855 DataSet_03_151
AGR3 MAPK1 siRNA Mammary_gland MCF7 0.545823 -0.873495 0.66721208631669 0.999829384224364 DataSet_03_156
AGR3 MAPK14 siRNA Mammary_gland MCF7 0.619178 -0.691574 0.58872673929936 0.999824418484635 DataSet_03_157
AGR3 MAX siRNA Mammary_gland MCF7 0.456286 -1.13199 0.486951510433881 0.999907009675999 DataSet_03_158
AGR3 MCM2 siRNA Mammary_gland MCF7 0.475058 -1.07383 0.508787386421848 0.999925560383539 DataSet_03_161
AGR3 MEF2D shRNA Liver HuH7 1.60957 0.686673 - - DataSet_03_162
AGR3 MEF2D siRNA Liver HuH7 0.276574 -1.85426 - - DataSet_03_163
AGR3 MYB siRNA Prostate VCaP 0.409755 -1.28717 1.94588076574493e-05 0.00579431308649417 DataSet_03_174
AGR3 MYBL2 siRNA Mammary_gland MCF7 0.452386 -1.14437 0.482383926274 0.999907476570542 DataSet_03_176
AGR3 MYC siRNA Mammary_gland MCF7 0.471629 -1.08428 0.504817696836114 0.999887767096734 DataSet_03_182
AGR3 NCOR2 siRNA Mammary_gland MCF7 0.566644 -0.819485 0.611474650312523 0.999834929103349 DataSet_03_193
AGR3 NMI siRNA Mammary_gland MCF7 0.28174 -1.82756 0.275847046877205 0.803982481999547 DataSet_03_199
AGR3 NR2F2 siRNA Uterus Primary eutopic stromal cells 1.93059 0.949044 0.978142861701817 0.99947668859931 DataSet_03_202
AGR3 PAX3 siRNA Mammary_gland MCF7 0.215926 -2.21139 0.102345118688963 0.919978041032696 DataSet_03_206
AGR3 PBX1 siRNA Mammary_gland MCF7 1.69036 0.757329 1.2368505767502e-06 0.000911048908151788 DataSet_03_209
AGR3 PCNA siRNA Mammary_gland MCF7 6.69874 2.74389 0.120556158988654 0.999448838103647 DataSet_03_210
AGR3 PHB shRNA Embryo Embryonic stem cells (ESCs) 2.77857 1.47434 0.461349886637384 0.603292951023282 DataSet_03_211
AGR3 PRRX1 CRISPR Neuroblastoma 691-MES 0.469753 -1.09003 0.120453814901964 0.89189998148014 DataSet_03_217
AGR3 RB1 siRNA Mammary_gland MCF7 5.05241 2.33697 0.175292635761984 0.999890290262508 DataSet_03_219
AGR3 RBL2 siRNA Mammary_gland MCF7 0.390552 -1.35641 0.408742120428079 0.999927471951507 DataSet_03_220
AGR3 RELA siRNA Mammary_gland MCF7 0.478072 -1.0647 0.512271129348705 0.999993711976373 DataSet_03_224
AGR3 SMAD7 siRNA Mammary_gland MCF7 0.368079 -1.44191 0.381505538428591 0.99858912864726 DataSet_03_234
AGR3 SOX11 siRNA Lung_fibroblast NHLF 0.661713 -0.595723 0.356236901288324 0.700204360608286 DataSet_03_238
AGR3 SP1 siRNA Ovary OVSAYO 0.127754 -2.96855 0.147027495744355 0.453199003192642 DataSet_03_251
AGR3 SP100 siRNA Mammary_gland MCF7 0.224902 -2.15263 0.207070188878138 0.999952086018951 DataSet_03_252
AGR3 STAT1 siRNA Mammary_gland MCF7 0.310213 -1.68867 0.310728371987364 0.999890411872485 DataSet_03_256
AGR3 STAT3 CRISPR Embryo hESC 0.0274267 -5.18827 0.00131513840257039 0.0272471626757297 DataSet_03_258
AGR3 STAT5B siRNA Mammary_gland MCF7 5.56517 2.47643 0.154315756955031 0.999932708473107 DataSet_03_263
AGR3 TCEA1 siRNA Mammary_gland MCF7 4.72795 2.24121 0.191195984613865 0.999762252994287 DataSet_03_266
AGR3 TP53 siRNA Mammary_gland MCF7 3.94839 1.98126 0.241174511274508 0.999938217444253 DataSet_03_277
AGR3 WT1 siRNA Mammary_gland MCF7 0.422709 -1.24226 0.447311772194102 0.999957852801679 DataSet_03_285
AGR3 EZH2 knockdown Uterus Ishikawa (ISK) cell 0.429283 -1.22 - - DataSet_03_324
AGR3 INO80 siRNA Muscle RD 0.536615 -0.89804 - - DataSet_03_344
AGR3 PBX1 siRNA Mammary_gland MCF7 1.69036 0.757329 1.554867e-06 1.036600e-03 DataSet_03_326
AGR3 EZH2 shRNA Mammary_gland MCF7 1.63402 0.708425 2.227602e-04 9.551371e-03 DataSet_03_331
AGR3 ESR1 siRNA Mammary_gland MCF7 0.148622 -2.75028 1.964726e-05 0.0057786800 DataSet_03_352
AGR3 ETV5 knockdown Colon HT29 4.21687 2.07617 4.310425e-02 0.243292021 DataSet_03_353
AGR3 TRIM8 siRNA Mammary_gland MCF7 0.117021 -3.09516 2.502956e-01 0.4716501418 DataSet_03_388
AGR3 KDM5A CRISPR Lung GLC16 1.62461 0.700094 8.614612e-02 0.179853978 DataSet_03_392
AGR3 CHD1 shRNA Prostate LNCaP 0.0689655 -3.85798 1.773942e-01 7.209399e-01 DataSet_03_407
AGR3 MAP3K7 shRNA Prostate LNCaP 0.0689655 -3.85798 2.215814e-01 4.578078e-01 DataSet_03_408
AGR3 E2F1 siRNA Prostate LNCaP 2 1 5.300378e-01 0.8184360010 DataSet_03_413
AGR3 E2F2 siRNA Prostate LNCaP 6 2.58496 1.276338e-01 3.539459e-01 DataSet_03_414
AGR3 ZFP36L1 CRISPR Lung NCI-H1876 3.51683 1.81428 2.225828e-01 0.992381486 DataSet_03_454
AGR3 HAND1 siRNA Placenta HPMVEC 2.25 1.16992 5.134861e-01 0.9463341 DataSet_03_459
Regulation Region
 
T(co)Fs that significantly regulate SP100 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of AGR3
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines