Gene Overview
Target Gene: AGT
NCBI Official Symbol: AGT
Entrez ID: 183
Ensembl ID: ENSG00000135744
Gene Full Name: angiotensinogen
Strand: -
Gene Locus: 1q42.2
External Links:

AGT Significantly Regulated by These T(co)Fs

T(co)Fs that Activate AGT   
T(co)Fs that Repress AGT
The Intensity of the Gene Regulated by T(co)Fs:
AGT-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
AGT HOXA1 siRNA Lung_fibroblast IMR-90 2.75625 1.4627 0.00324 0.05964 DataSet_01_110
AGT ID1 siRNA Lung A549 1.51752 0.60172 0.29528 0.52848 DataSet_01_117
AGT ZIC2 siRNA Pancreas PANC1 0.29973 -1.73828 - - DataSet_01_121
AGT IKZF1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.6776 0.7464 0.49691 0.99993 DataSet_01_138
AGT POLR3A siRNA Mammary_gland MCF7 2.26891 1.182 - - DataSet_01_139
AGT ETV1 shRNA Prostate LNCaP 1.95438 0.96671 2.38812e-11 6.31941e-09 DataSet_01_161
AGT CREB1 shRNA Parotid_gland H3118 MEC 1.73489 0.79484 0.07841 0.38635 DataSet_01_194
AGT TP63 siRNA Head_and_neck SCC-1 0.46009 -1.12003 - - DataSet_01_198
AGT TP63 siRNA Head_and_neck SCC-6 1.73177 0.79225 - - DataSet_01_202
AGT LIN28A siRNA Embryo H9 4.28369 2.09885 3.6912e-05 0.00176 DataSet_01_215
AGT ERG siRNA Prostate VCaP 1.98354 0.98808 0.01699 0.12518 DataSet_01_216
AGT MYC siRNA White_adipose_tissue Adipose stem cells 0.54652 -0.87164 0.21477 0.49706 DataSet_01_231
AGT FOXP1 siRNA Prostate LNCaP 0.50279 -0.99196 0.00555 0.22003 DataSet_01_234
AGT TWIST1 shRNA Stomach CAF14 1.58984 0.66888 0.24209 0.99996 DataSet_01_252
AGT TWIST1 shRNA Stomach CAF32 0.61869 -0.69271 0.00741 0.04394 DataSet_01_253
AGT MYT1L shRNA Fetal_spinal_cord SPC04 0.40958 -1.28778 0.00047 0.06175 DataSet_01_264
AGT MEF2A shRNA Fetal_spinal_cord SPC04 2.94133 1.55647 0.03587 0.89906 DataSet_01_265
AGT MSX1 siRNA Tooth Dental Pulp Cells 3.24636 1.69882 5.87207e-05 0.00073 DataSet_01_281
AGT SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.78602 0.83675 0.03148 0.78856 DataSet_01_290
AGT TFAP4 siRNA Brain BE(2)-C 0.19965 -2.32449 0.29737 0.51625 DataSet_01_295
AGT SOX17 siRNA Umbilical_vein HUVEC 3.12608 1.64436 0.24132 0.99998 DataSet_01_300
AGT NR2E1 shRNA Neuroepithelium PBT003 0.09218 -3.43935 0.00404 0.42474 DataSet_01_306
AGT MYC siRNA Colon HCT116 1.68756 0.75494 0.0059 0.01327 DataSet_01_324
AGT SOX2 shRNA Neuroepithelium HF2303 0.35075 -1.5115 0.01173 1 DataSet_01_349
AGT ELK1 siRNA Mammary_gland MDA-MB-231 0.63806 -0.64823 - - DataSet_01_354
AGT NFYA siRNA Mammary_gland MDA-MB-231 0.54 -0.88898 - - DataSet_01_355
AGT ETV4 shRNA Prostate PC3 1.91132 0.93457 - - DataSet_01_356
AGT PAX3 shRNA Soft_tissue Rh30 2.56372 1.35824 - - DataSet_01_359
AGT FIP1L1 shRNA Liver HepG2 0.44487 -1.16855 0.00229 0.02045 DataSet_02_103
AGT TAF15 shRNA Liver HepG2 0.51086 -0.96899 0.0012 0.01182 DataSet_02_106
AGT BCLAF1 shRNA Liver HepG2 2.52024 1.33356 0.00155 0.02576 DataSet_02_112
AGT XRCC5 shRNA Liver HepG2 0.58075 -0.78401 0.02016 0.1603 DataSet_02_114
AGT TARDBP shRNA Liver HepG2 2.0741 1.05249 0.01276 0.04268 DataSet_02_116
AGT HNRNPLL shRNA Liver HepG2 1.78755 0.83798 0.02325 0.05643 DataSet_02_125
AGT SNRNP70 shRNA Liver HepG2 1.77359 0.82667 0.0417 0.10902 DataSet_02_126
AGT PRPF4 shRNA Liver HepG2 1.65266 0.72479 0.00307 0.03421 DataSet_02_128
AGT RBM17 shRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.84883 0.93677 DataSet_02_138
AGT RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 25 4.64386 0.01817 0.05146 DataSet_02_143
AGT HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.07655 0.22679 DataSet_02_160
AGT ZFX siRNA Prostate C4-2B 2.03448 1.02466 0.0797 0.14911 DataSet_02_172
AGT AR siRNA Prostate LNCaP 1.65972 0.730942 0.503899653644967 1 DataSet_03_005
AGT ARID1A siRNA Mammary_gland MDA-MB-157 0.61033 -0.712338 - - DataSet_03_014
AGT ATF4 siRNA Skin A375 0.659685 -0.600151 0.216497369669951 0.775512819201899 DataSet_03_018
AGT GATA6 siRNA Stomach YCC3 1.82218 0.865662 0.0111815518778368 0.419647323942036 DataSet_03_110
AGT MTA2 siRNA Stomach SGC-7901 0.593082 -0.753697 - - DataSet_03_169
AGT MYB siRNA Cord_Blood CD34+ progenitor cells 0.376489 -1.40932 - - DataSet_03_170
AGT PHB shRNA Embryo Embryonic stem cells (ESCs) 0.392717 -1.34844 6.56436349576268e-05 0.000986781190480212 DataSet_03_211
AGT SOX11 siRNA Lung_fibroblast NHLF 2.03363 1.02406 0.0732486143231985 0.384091066807901 DataSet_03_238
AGT SOX2 CRISPR Seminoma-like TCam-2 3.02914 1.59891 0.275517238096668 0.999580851453413 DataSet_03_244
AGT SOX2 siRNA Mammary_gland GSC-11 1.75336 0.810121 0.000172879952333473 0.00826282133288283 DataSet_03_245
AGT SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.37931 -1.39855 - - DataSet_03_246
AGT SP1 siRNA Ovary OVSAYO 9.53255 3.25286 6.20737116630071e-05 0.056096333732979 DataSet_03_251
AGT STAT3 CRISPR Embryo hESC 0.0381339 -4.71278 0.00256661717036801 0.0363635961460709 DataSet_03_258
AGT TP53 knockout Haematopoietic_and_lymphoid_tissue MOLP8 0.505902 -0.983071 0.00251620884131348 0.352594717534504 DataSet_03_280
AGT APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 1.55556 0.63743 0.63599919210128 0.891903626520938 DataSet_04_001
AGT CTCF CRISPR Haematopoietic_and_lymphoid_tissue K562 0.638889 -0.646363 0.335815516741324 0.641669597416697 DataSet_04_005
AGT ERN1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.0833333 -3.58496 0.00701631324696594 0.495181622793445 DataSet_04_009
AGT SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.307692 -1.70044 0.372524105474956 0.520573192852608 DataSet_04_018
AGT SMAD4 CRISPR Haematopoietic_and_lymphoid_tissue K562 8.33333 3.05889 0.00242708337626832 0.0979887211869635 DataSet_04_019
AGT SMAD5 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.111111 -3.16992 0.00453067406008154 0.394951331771279 DataSet_04_020
AGT ANXA2 CRISPR Liver HepG2 8 3 0.020036821343425 0.588482325535747 DataSet_04_024
AGT CNOT7 shRNA Liver HepG2 0.389785 -1.35925 6.14093594169133e-05 0.00238885972522865 DataSet_04_051
AGT YBX3 shRNA Liver HepG2 1.67635 0.745326 0.000390206684724353 0.0326236437319542 DataSet_02_98
AGT ACTN4 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.905132296351811 0.960554945712433 DataSet_04_048
AGT KDM5A shRNA Brain NCH644 1.65893 0.73025 1.433275e-01 0.614305085 DataSet_03_316
AGT YBX1 siRNA Prostate LNCaP 1.99432 0.995895 2.783762e-06 6.544535e-04 DataSet_03_322
AGT SMARCA4 siRNA Colon HCT116 0.633101 -0.659493 1.920131e-02 0.1560735 DataSet_03_302
AGT ELF3 CRISPR Bile_duct HBDEC2 1.53308 0.616432 1.282076e-03 7.348822e-03 DataSet_03_304
AGT SNAI2 shRNA Pancreas pancreatic cancer stem cells 1.6545 0.726395 3.860597e-02 0.6330193 DataSet_03_306
AGT PRMT1 shRNA Lung A549 1.61279 0.689557 - - DataSet_03_342
AGT ACTR5 siRNA Muscle RD 2.6026 1.37995 - - DataSet_03_343
AGT INO80 siRNA Muscle RD 2.24832 1.16885 - - DataSet_03_344
AGT ESR1 siRNA Mammary_gland MCF7 1.7155 0.778631 1.927360e-01 0.4283279248 DataSet_03_352
AGT ETV5 knockdown Colon HT29 0.281083 -1.83093 2.571994e-04 0.031201549 DataSet_03_353
AGT PARP1 siRNA Prostate LNCaP 5.69053 2.50856 8.891770e-02 0.341887322 DataSet_03_354
AGT TET1 CRISPR Mammary_gland Hs578T 0.500047 -0.999864 1.664802e-03 1.578944e-02 DataSet_03_355
AGT CREBBP CRISPR Brain U5-NPC 0.384086 -1.3805 0.0556421643 0.7490853 DataSet_03_356
AGT PTPN14 CRISPR Brain U5-NPC 0.0402098 -4.63631 1.396173e-03 0.16084932 DataSet_03_357
AGT TP53 CRISPR Brain U5-NPC 3.46758 1.79393 8.016079e-01 8.485523e-01 DataSet_03_358
AGT NCOA3 siRNA Mammary_gland MDA-MB-231 1.65886 0.730196 8.062742e-01 0.9847841 DataSet_03_361
AGT ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 2.19358 1.13329 4.190859e-01 5.274763e-01 DataSet_03_362
AGT TPR shRNA Bone_marrow U2OS 0.577626 -0.791792 4.268143e-03 8.815613e-02 DataSet_03_370
AGT BHLHE40 shRNA Cervix HeLaS3 2.52381 1.3356 4.486572e-01 0.89058166 DataSet_03_372
AGT GLI1 siRNA Skeletal_muscle RMS13 3.52598 1.81802 5.322796e-05 0.005519110 DataSet_03_375
AGT DDX5 shRNA Stomach HGC-27 6 2.58496 - - DataSet_03_379
AGT NFKB2 siRNA Bone_marrow U2OS 0.555556 -0.847997 4.888026e-02 0.28742827 DataSet_03_381
AGT DNMT1 siRNA Skin Human melanoma cells 1.60494 0.682515 3.018448e-04 1.225412e-03 DataSet_03_382
AGT KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 1.57006 0.650824 0.0045255339 0.8388073 DataSet_03_387
AGT ILF2 siRNA Stomach SGC-7901 2.75 1.45943 0.0448812189 0.14628707 DataSet_03_393
AGT SUMO1 CRISPR Bone_marrow U2OS 3.27273 1.71049 3.435386e-06 4.035215e-04 DataSet_03_401
AGT CDK7 shRNA Bone_marrow D458 3 1.58496 3.863852e-01 0.66962085 DataSet_03_404
AGT MAP3K7 shRNA Prostate LNCaP 0.573413 -0.802354 7.545886e-04 1.696270e-02 DataSet_03_408
AGT STRAP knockout Nerve SK-N-AS 0.302714 -1.72397 - - DataSet_03_409
AGT SIRT1 siRNA Pancreas PANC1 2.15385 1.10691 1.598540e-01 0.304899568 DataSet_03_410
AGT USP22 shRNA Liver HuH7 0.294915 -1.76163 - - DataSet_03_411
AGT E2F6 shRNA Liver HuH7 0.479264 -1.06111 - - DataSet_03_412
AGT ZKSCAN3 CRISPR Colon HCT116 1.88889 0.917538 6.501525e-01 0.856659793 DataSet_03_415
AGT FOXK2 shRNA Ovary OVCAR-5 0.441177 -1.18057 1.046855e-01 0.28643106 DataSet_03_419
AGT MAEL CRISPR Liver Alexander cells 2.29189 1.19654 - - DataSet_03_423
AGT LHX2 shRNA Bone_marrow ES-derived RPE cells 0.410714 -1.28379 6.396290e-02 1.000000e+00 DataSet_03_428
AGT USP7 shRNA Skin xenograft cells 0.459863 -1.12072 0.26508683 0.4348960 DataSet_03_431
AGT PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.105263 -3.24793 - - DataSet_03_432
AGT POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 10 3.32193 1.046626e-02 0.312288825 DataSet_03_434
AGT EP300 knockout Pancreas HPAF-II orthotopic cells 3.06641 1.61655 3.048467e-03 1.755372e-02 DataSet_03_436
AGT CIC knockout Brain Immortalized Astrocyte Cells 0.193878 -2.36678 2.898399e-02 3.110081e-01 DataSet_03_438
AGT FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 6.06856 2.60136 2.983630e-04 0.15801904 DataSet_03_439
AGT SETDB1 shRNA Colon HCT116 2.73505 1.45157 - - DataSet_03_440
AGT HMG20A siRNA Mammary_gland MDA-MB-231 2.0566 1.04026 0.0033856552 0.1396478 DataSet_03_442
AGT PHF14 siRNA Mammary_gland MDA-MB-231 0.584906 -0.773724 0.0109165518 0.2772439 DataSet_03_443
AGT FOSL1 siRNA Prostate MSKPCa3 1.57692 0.657112 0.0231628822 0.3753898 DataSet_03_445
AGT RELB CRISPR Colon SW480 4 2 3.218630e-02 1.494327e-01 DataSet_03_449
AGT CBX2 siRNA Mammary_gland MCF7 0.0515042 -4.27917 4.734324e-02 0.1038221620 DataSet_03_451
AGT ZFP36L1 CRISPR Lung NCI-H1876 0.556656 -0.845142 7.135778e-01 0.992381486 DataSet_03_454
AGT HAND1 siRNA Placenta HPMVEC 2.25 1.16992 7.204401e-01 0.9463341 DataSet_03_459
AGT IRF2 shRNA Cord_Blood CD34+ cells 2.66667 1.41504 - - DataSet_03_460
AGT SOX9 knockout Liver HuH7 1.90454 0.929443 4.272756e-04 5.253767e-03 DataSet_03_463
AGT PARP1 knockout Embryo_kidney HEK293a 0.59751 -0.742964 1.225591e-01 2.346775e-01 DataSet_03_464
AGT SMARCA1 shRNA Embryo_kidney HEK293T 2.71429 1.44057 - - DataSet_03_468
AGT WHSC1 siRNA Prostate PC3 0.6 -0.736966 5.203710e-01 0.70487955 DataSet_03_471
AGT APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 1.55556 0.63743 0.7050048 0.944054 DataSet_04_072
Regulation Region
 
T(co)Fs that significantly regulate ERN1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of AGT
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines