Gene Overview
Target Gene: AKNAD1
NCBI Official Symbol: AKNAD1
Entrez ID: 254268
Ensembl ID: ENSG00000162641
Gene Full Name: AKNA domain containing 1
Strand: -
Gene Locus: 1p13.3
External Links:

AKNAD1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate AKNAD1   
T(co)Fs that Repress AKNAD1
The Intensity of the Gene Regulated by T(co)Fs:
AKNAD1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
AKNAD1 FOXM1 siRNA Central_nervous_system U87 19.7737 4.30551 - - DataSet_01_122
AKNAD1 JUN siRNA Peripheral_blood CD4+ T cells 0.5684 -0.81501 0.00475 0.04232 DataSet_01_164
AKNAD1 CREB1 shRNA Parotid_gland H3118 MEC 4.00937 2.00337 0.47088 0.7745 DataSet_01_194
AKNAD1 CREB1 shRNA Parotid_gland HSY 1.50085 0.58578 0.51783 0.98114 DataSet_01_195
AKNAD1 TP63 siRNA Immortalized_keratinocyte HaCaT 2.39333 1.25902 - - DataSet_01_200
AKNAD1 TP63 siRNA Head_and_neck SCC-012 1.64081 0.71441 - - DataSet_01_201
AKNAD1 HIC1 shRNA Mammary_gland HBL100 1.50166 0.58656 - - DataSet_01_205
AKNAD1 SNAI2 shRNA Skin Primary human keratinocytes 2.00469 1.00338 0.02342 0.0787 DataSet_01_225
AKNAD1 IRX1 shRNA Bone_marrow 143B 0.62244 -0.68398 0.10132 0.32525 DataSet_01_227
AKNAD1 YBX1 shRNA Mammary_gland MDA 1.75077 0.80799 0.02686 0.10382 DataSet_01_257
AKNAD1 FOXO3 siRNA Pancreas PANC1 0.48481 -1.0445 - - DataSet_01_267
AKNAD1 POSTN shRNA Brain GSC272 1.54598 0.62852 0.27274 0.63494 DataSet_01_293
AKNAD1 TFAP4 siRNA Brain BE(2)-C 0.19567 -2.35354 0.36049 0.51625 DataSet_01_295
AKNAD1 PTEN shRNA Skin A431 2.87916 1.52565 0.09541 0.25808 DataSet_01_301
AKNAD1 PTEN shRNA Mammary_gland SKBR3 3.15979 1.65983 0.00929 0.45224 DataSet_01_303
AKNAD1 ARNT siRNA Upper_aerodigestive_tract HSC3 2.22912 1.15647 - - DataSet_01_315
AKNAD1 MYC siRNA Colon HCT116 1.58047 0.66035 3.15909e-07 3.2467e-06 DataSet_01_324
AKNAD1 KLF4 siRNA Embryo HCE 0.50081 -0.99768 0.00032 0.06067 DataSet_01_339
AKNAD1 GATA3 siRNA Oral_cavity OEC-M1 1.57831 0.65838 0.13294 0.99787 DataSet_01_347
AKNAD1 ZNF622 shRNA Liver HepG2 0.5 -1 0.06387 0.10769 DataSet_02_108
AKNAD1 POLR2G shRNA Haematopoietic_and_lymphoid_tissue K562 0.0625 -4 0.01356 0.69659 DataSet_02_130
AKNAD1 SRSF7 shRNA Haematopoietic_and_lymphoid_tissue K562 0.2 -2.32193 0.6719 0.82353 DataSet_02_133
AKNAD1 PCBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.53333 -0.90689 0.72441 0.85766 DataSet_02_137
AKNAD1 RBM17 shRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.07568 0.33536 DataSet_02_138
AKNAD1 RBM34 shRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.98716 1 DataSet_02_141
AKNAD1 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.09091 -3.45943 0.00463 0.02696 DataSet_02_143
AKNAD1 DROSHA shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.91571 0.97626 DataSet_02_145
AKNAD1 NONO shRNA Haematopoietic_and_lymphoid_tissue K562 1.8 0.848 0.02521 0.2037 DataSet_02_149
AKNAD1 SAFB2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.5625 -0.83007 0.71514 0.92168 DataSet_02_150
AKNAD1 RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 0.36364 -1.45943 0.06449 0.26758 DataSet_02_151
AKNAD1 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.30259 0.60359 DataSet_02_152
AKNAD1 HNRNPUL1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.27273 -1.87447 0.04084 0.51515 DataSet_02_156
AKNAD1 GTF2F1 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.09341 0.92135 DataSet_02_157
AKNAD1 XRCC5 shRNA Haematopoietic_and_lymphoid_tissue K562 2.11765 1.08246 0.91614 0.99142 DataSet_02_159
AKNAD1 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 42 5.39232 0.00856 0.11927 DataSet_02_160
AKNAD1 SUB1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.11765 -3.08746 0.01935 0.66851 DataSet_02_161
AKNAD1 AGO1 shRNA Haematopoietic_and_lymphoid_tissue K562 4 2 0.03692 0.53443 DataSet_02_162
AKNAD1 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.5625 -0.83007 0.03011 0.27773 DataSet_02_163
AKNAD1 SSB shRNA Haematopoietic_and_lymphoid_tissue K562 3.66667 1.87447 0.03936 0.22715 DataSet_02_164
AKNAD1 U2AF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.125 -3 0.00537 0.05092 DataSet_02_170
AKNAD1 MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.65306 -0.61471 0.0799 1 DataSet_02_173
AKNAD1 LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 1.81818 0.8625 0.67673 1 DataSet_02_175
AKNAD1 ZNF180 siRNA Haematopoietic_and_lymphoid_tissue K562 0.4898 -1.02975 0.1135 1 DataSet_02_177
AKNAD1 ATF3 siRNA Haematopoietic_and_lymphoid_tissue K562 0.13636 -2.87447 0.03819 1 DataSet_02_180
AKNAD1 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 0.57143 -0.80735 0.35304 1 DataSet_02_182
AKNAD1 MAFK siRNA Haematopoietic_and_lymphoid_tissue K562 0.65909 -0.60145 0.30923 1 DataSet_02_183
AKNAD1 KAT2B siRNA Haematopoietic_and_lymphoid_tissue K562 0.40741 -1.29546 0.12523 1 DataSet_02_184
AKNAD1 BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.22727 -2.1375 0.06664 1 DataSet_02_188
AKNAD1 MAFG siRNA Haematopoietic_and_lymphoid_tissue K562 2.63636 1.39855 0.66516 1 DataSet_02_189
AKNAD1 MAX siRNA Haematopoietic_and_lymphoid_tissue K562 1.86364 0.89812 0.78719 1 DataSet_02_192
AKNAD1 TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.45455 -1.1375 0.20654 1 DataSet_02_194
AKNAD1 LMNB1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.09091 1.06413 0.86366 1 DataSet_02_195
AKNAD1 CHD2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.61364 -0.70454 0.69379 0.7729 DataSet_02_196
AKNAD1 E2F4 siRNA Haematopoietic_and_lymphoid_tissue K562 0.27273 -1.87447 0.09381 1 DataSet_02_200
AKNAD1 BRCA1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.22449 -2.15528 0.05267 1 DataSet_02_202
AKNAD1 ZFX siRNA Mammary_gland MCF7 4.46667 2.1592 0.07819 0.25571 DataSet_02_206
AKNAD1 ASCL1 siRNA Lung DMS79 10.1389 3.34183 0.00896921040665229 0.577978708511504 DataSet_03_016
AKNAD1 BCL6 siRNA Lymph Pfeiffer DLBCL 0.641025 -0.641547 0.29237560942019 0.739668074298015 DataSet_03_026
AKNAD1 GATA2 siRNA Uterus Decidual stromal cells 2.46617 1.30227 0.0238945488377339 0.519514513133663 DataSet_03_100
AKNAD1 GATA4 siRNA Stomach KatoIII 2.15036 1.10458 0.041554346631757 0.863208745436085 DataSet_03_106
AKNAD1 GATA4 siRNA Stomach YCC3 1.93097 0.949326 0.07352216153055 0.616918961213603 DataSet_03_107
AKNAD1 GATA6 siRNA Stomach AGS 1.7565 0.8127 0.231333188807782 0.724032338336199 DataSet_03_108
AKNAD1 KLF5 siRNA Stomach KatoIII 2.16436 1.11394 0.085253606291084 0.514983009329188 DataSet_03_150
AKNAD1 MEF2D shRNA Liver HuH7 1.59434 0.672963 - - DataSet_03_162
AKNAD1 MEF2D siRNA Liver HuH7 1.82369 0.866857 - - DataSet_03_163
AKNAD1 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.521352 -0.939671 0.11139173621088 0.210686700148945 DataSet_03_211
AKNAD1 RELB siRNA Immortalized_keratinocyte HaCaT 1.92509 0.944923 0.00012885350924894 0.0015385055648833 DataSet_03_227
AKNAD1 SOX11 siRNA Lung_fibroblast NHLF 2.01731 1.01244 0.00328226722199645 0.304507242190339 DataSet_03_237
AKNAD1 SOX11 siRNA Lung_fibroblast NHLF 2.18491 1.12758 0.0053965670569873 0.182424226026699 DataSet_03_238
AKNAD1 SOX2 siRNA Mammary_gland GSC-11 0.365634 -1.45153 0.00034585531751777 0.0117839070436438 DataSet_03_245
AKNAD1 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.168317 -2.57075 - - DataSet_03_246
AKNAD1 SSRP1 siRNA Brain BE(2)C cells 0.666441 -0.58545 0.0237728286110249 0.335918519871921 DataSet_03_255
AKNAD1 STAT3 CRISPR Embryo hESC 5.85454 2.54956 0.00686946974302536 0.0558857310358167 DataSet_03_258
AKNAD1 STAT6 siRNA Umbilical_vein HUVEC 0.602857 -0.730111 0.838379645046694 0.979175182430748 DataSet_03_264
AKNAD1 CIZ1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.592593 -0.754888 0.320729542562345 0.42193451091471 DataSet_04_004
AKNAD1 E4F1 CRISPR Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.463247462409503 0.784908271100831 DataSet_04_007
AKNAD1 ERN1 CRISPR Haematopoietic_and_lymphoid_tissue K562 8.33333 3.05889 0.0400099408964869 0.66157425514643 DataSet_04_009
AKNAD1 FUBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.26668762250394 0.390527107346166 DataSet_04_010
AKNAD1 MECP2 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.94737 0.961526 0.231778904635151 0.843217471663667 DataSet_04_013
AKNAD1 PAN2 CRISPR Haematopoietic_and_lymphoid_tissue K562 3.16667 1.66297 0.464733126392753 0.90935082757349 DataSet_04_016
AKNAD1 SMAD4 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.52632 0.610053 0.63328162840287 0.759448097813947 DataSet_04_019
AKNAD1 SMAD5 CRISPR Haematopoietic_and_lymphoid_tissue K562 12 3.58496 0.00170823110260678 0.392743003922383 DataSet_04_020
AKNAD1 YBX1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.583333 -0.777608 0.267354001339707 0.633423095474555 DataSet_04_022
AKNAD1 APTX CRISPR Liver HepG2 9.33333 3.22239 0.00179247393439127 0.291664407635924 DataSet_04_025
AKNAD1 SMAD2 CRISPR Liver HepG2 0.483871 -1.04731 0.001179315294677 0.317487513062549 DataSet_04_034
AKNAD1 APTX CRISPR Liver HepG2 0.2 -2.32193 0.683050414825257 0.975953837146029 DataSet_04_069
AKNAD1 PAN2 CRISPR Liver HepG2 0.142857 -2.80735 0.371523476219119 0.554416451024539 DataSet_04_066
AKNAD1 ACTN4 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.11111 1.078 0.587114610149714 0.766954927932629 DataSet_04_048
AKNAD1 DDX17 CRISPR Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.506822310625628 0.88405669458489 DataSet_04_047
AKNAD1 NPM1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.631579 -0.662965 0.636483959251806 0.794324132739838 DataSet_04_046
AKNAD1 SEPT11 CRISPR Haematopoietic_and_lymphoid_tissue K562 3.33333 1.73697 0.601014765737826 1 DataSet_04_077
AKNAD1 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.614077027995646 0.761264001758184 DataSet_04_049
AKNAD1 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.58318552837401 0.851086694849772 DataSet_02_75
AKNAD1 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 5.66667 2.5025 0.335377914751226 0.49885962230021 DataSet_04_060
AKNAD1 CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 0.466667 -1.09954 0.609943654361987 0.77729955088988 DataSet_04_061
AKNAD1 ELF3 CRISPR Bile_duct HBDEC2 1.58476 0.664261 1.173478e-04 1.348607e-03 DataSet_03_304
AKNAD1 ACTR5 siRNA Muscle RD 0.578052 -0.79073 - - DataSet_03_343
AKNAD1 ESR1 siRNA Mammary_gland MCF7 0.391051 -1.35457 5.980006e-04 0.0154393895 DataSet_03_352
AKNAD1 TET1 CRISPR Mammary_gland Hs578T 2.78511 1.47774 1.716378e-02 6.946301e-02 DataSet_03_355
AKNAD1 CREBBP CRISPR Brain U5-NPC 2.19718 1.13566 0.2168053847 0.7490853 DataSet_03_356
AKNAD1 TP53 CRISPR Brain U5-NPC 3.53521 1.8218 9.795454e-03 1.623145e-01 DataSet_03_358
AKNAD1 EP300 shRNA Mammary_gland MCF10AT 0.4 -1.32193 7.215665e-02 0.226303635 DataSet_03_364
AKNAD1 TP53 knockout Stomach SNU1 0.336073 -1.57315 0.4630939504 0.9375704 DataSet_03_365
AKNAD1 ZNF148 shRNA Mammary_gland MDA-MB-231 2.43426 1.28348 4.422711e-01 0.657843484 DataSet_03_366
AKNAD1 TPR shRNA Bone_marrow U2OS 1.66917 0.739129 2.924700e-02 2.537743e-01 DataSet_03_370
AKNAD1 E2F1 siRNA Nasopharynx HK1 1.65 0.722466 8.029914e-01 1.000000e+00 DataSet_03_373
AKNAD1 GLI1 siRNA Skeletal_muscle RMS13 2.70291 1.43451 6.265627e-03 0.057569743 DataSet_03_375
AKNAD1 ZBTB7A siRNA Stomach BGC823 0.541576 -0.884764 - - DataSet_03_380
AKNAD1 DNMT1 siRNA Skin Human melanoma cells 2.01786 1.01282 1.027724e-02 2.224116e-02 DataSet_03_382
AKNAD1 TCF19 CRISPR Oral_squamous CAL27 0.233289 -2.09981 9.188844e-02 0.3126738840 DataSet_03_383
AKNAD1 YY1 shRNA Brain GSC1517 2.06646 1.04716 - - DataSet_03_384
AKNAD1 TRIM8 siRNA Mammary_gland MCF7 13.5333 3.75845 3.307830e-03 0.0256578466 DataSet_03_388
AKNAD1 NFKBIA shRNA Bone_marrow U2OS 0.119573 -3.06404 7.091021e-01 0.88097923 DataSet_03_389
AKNAD1 ILF2 siRNA Stomach SGC-7901 0.642857 -0.63743 0.4457946010 0.65928663 DataSet_03_393
AKNAD1 IKZF2 CRISPR Lymph CAR T Cell 0.256941 -1.96049 5.960814e-01 0.889890512 DataSet_03_397
AKNAD1 EHF shRNA Stomach MKN7 0.0122244 -6.35409 - - DataSet_03_402
AKNAD1 SATB2 CRISPR Colon Colon organoid 0.25 -2 3.602472e-01 0.95735254 DataSet_03_406
AKNAD1 FOXK2 shRNA Ovary OVCAR-5 5 2.32193 2.527818e-02 0.12704666 DataSet_03_419
AKNAD1 FOXQ1 CRISPR Lymph Primary CD4+ T cells 5 2.32193 - - DataSet_03_422
AKNAD1 MAEL CRISPR Liver Alexander cells 0.375 -1.41504 - - DataSet_03_423
AKNAD1 USP7 shRNA Skin xenograft cells 0.502618 -0.992466 0.29451803 0.4408743 DataSet_03_431
AKNAD1 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.571429 -0.807355 - - DataSet_03_432
AKNAD1 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 2.70306 1.43459 4.131621e-01 0.627137707 DataSet_03_434
AKNAD1 POU2AF1 CRISPR Lymph SUDHL4 5.352 2.42008 6.758936e-02 0.157228519 DataSet_03_435
AKNAD1 CIC knockout Brain Immortalized Astrocyte Cells 1.61043 0.687446 1.186082e-01 5.612322e-01 DataSet_03_438
AKNAD1 SETDB1 shRNA Colon HCT116 0.248641 -2.00786 - - DataSet_03_440
AKNAD1 DAXX shRNA Mammary_gland MDA-MB-231 2.37584 1.24844 1.697947e-01 0.47902159 DataSet_03_441
AKNAD1 HMG20A siRNA Mammary_gland MDA-MB-231 0.625 -0.678072 0.1792234799 0.4402072 DataSet_03_442
AKNAD1 PHF14 siRNA Mammary_gland MDA-MB-231 0.21875 -2.19265 0.0065915785 0.2543655 DataSet_03_443
AKNAD1 PURA siRNA Cervix HeLa 2.22034 1.15078 5.499132e-02 0.218601409 DataSet_03_444
AKNAD1 CBX2 siRNA Mammary_gland MCF7 3.1066 1.63533 1.210384e-02 0.0352109963 DataSet_03_451
AKNAD1 ZFP36L1 CRISPR Lung NCI-H1876 0.2513 -1.99251 2.424080e-01 0.992381486 DataSet_03_454
AKNAD1 SREBF2 siRNA Umbilical_vein HUVEC 0.647409 -0.62725 6.068984e-01 8.898775e-01 DataSet_03_457
AKNAD1 ARID1A shRNA Bile_duct MMNK1 7.09816 2.82745 7.581115e-04 0.025655861 DataSet_03_458
AKNAD1 TXNIP shRNA Cord_Blood CD34+ cells 0.444444 -1.16992 - - DataSet_03_461
AKNAD1 PARP1 knockout Embryo_kidney HEK293a 7 2.80735 1.332311e-04 8.507939e-04 DataSet_03_464
AKNAD1 STAT3 shRNA Liver HepG2 5.5 2.45943 2.581580e-02 0.2545315635 DataSet_03_465
AKNAD1 LIN28A siRNA Mammary_gland MCF7M 0.262242 -1.93103 2.946423e-01 0.6743450 DataSet_03_469
AKNAD1 LIN28A siRNA Mammary_gland MCF7M 0.262242 -1.93103 2.946423e-01 0.6743450 DataSet_03_470
AKNAD1 WHSC1 siRNA Prostate PC3 0.461538 -1.11548 1.802323e-01 0.40962565 DataSet_03_471
AKNAD1 HMGB2 knockdown Umbilical_vein HUVEC 2.3 1.20163 2.648110e-02 0.11852933 DataSet_03_476
AKNAD1 CHCHD3 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.33333 1.22239 0.7355993 0.9961615 DataSet_04_071
Regulation Region
 
T(co)Fs that significantly regulate ERN1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of AKNAD1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines