Gene Overview
Target Gene: AMBP
NCBI Official Symbol: AMBP
Entrez ID: 259
Ensembl ID: ENSG00000106927
Gene Full Name: alpha-1-microglobulin/bikunin precursor
Strand: -
Gene Locus: 9q32
External Links:

AMBP Significantly Regulated by These T(co)Fs

T(co)Fs that Activate AMBP   
T(co)Fs that Repress AMBP
The Intensity of the Gene Regulated by T(co)Fs:
AMBP-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
AMBP ID1 siRNA Lung A549 2.468 1.30334 0.00827 0.13579 DataSet_01_117
AMBP ZIC2 siRNA Pancreas PANC1 1.56738 0.64835 - - DataSet_01_121
AMBP FOXM1 siRNA Central_nervous_system U87 3.82368 1.93496 - - DataSet_01_122
AMBP EGR4 siRNA Lung SBC-5 1.82145 0.86509 0.15668 0.54346 DataSet_01_132
AMBP IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 4.08545 2.03049 0.00521 0.2025 DataSet_01_137
AMBP IKZF1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 4.03099 2.01113 0.00041 0.19071 DataSet_01_138
AMBP HOXB7 siRNA Pancreas MIA PaCa-2 1.77947 0.83145 0.28423 0.71474 DataSet_01_169
AMBP HSF1 shRNA Liver KYN2 2.01574 1.01131 - - DataSet_01_178
AMBP TP63 siRNA Immortalized_keratinocyte HaCaT 0.59189 -0.75659 - - DataSet_01_200
AMBP FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 2.25857 1.17541 - - DataSet_01_210
AMBP REST siRNA Prostate LNCaP 1.83265 0.87393 0.05475 0.2776 DataSet_01_211
AMBP FOXM1 siRNA Mammary_gland MCF7 1.70712 0.77156 0.54976 0.92965 DataSet_01_223
AMBP KLF2 shRNA Bone_marrow RPMI8226 1.96102 0.97161 0.16946 0.7675 DataSet_01_226
AMBP IRX1 shRNA Bone_marrow 143B 0.66443 -0.58982 0.17902 0.43275 DataSet_01_227
AMBP TWIST1 shRNA Stomach CAF14 1.67559 0.74467 0.07049 0.99996 DataSet_01_252
AMBP TWIST1 shRNA Stomach CAF32 2.12696 1.08879 0.08078 0.18984 DataSet_01_253
AMBP TWIST1 shRNA Stomach CAF 1.88784 0.91673 0.01068 0.52717 DataSet_01_254
AMBP STAT5 shRNA Prostate CWR22Pc 1.56893 0.64978 0.30445 0.48576 DataSet_01_279
AMBP MSX1 siRNA Tooth Dental Pulp Cells 0.34019 -1.5556 0.00804 0.0248 DataSet_01_281
AMBP POSTN shRNA Brain GSC272 3.58241 1.84093 0.13622 0.56204 DataSet_01_293
AMBP TFAP4 siRNA Brain BE(2)-C 0.16556 -2.59457 0.30711 0.51625 DataSet_01_295
AMBP PTEN shRNA Skin A431 1.79747 0.84596 0.06783 0.21405 DataSet_01_301
AMBP PTEN shRNA Lung HCC827 0.17975 -2.47596 0.0084 0.41262 DataSet_01_302
AMBP OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 0.4272 -1.22703 0.01075 0.24213 DataSet_01_313
AMBP ARNT siRNA Upper_aerodigestive_tract HSC3 0.25765 -1.95654 - - DataSet_01_315
AMBP NFE2L2 siRNA Lung A549 0.61765 -0.69513 4.85773e-05 0.00116 DataSet_01_335
AMBP HIF1A siRNA Oral_cavity OEC-M1 0.60317 -0.72935 0.20305 0.85151 DataSet_01_348
AMBP SOX17 siRNA Umbilical_vein HUVEC 2.02768 1.01983 - - DataSet_01_360
AMBP FIP1L1 shRNA Liver HepG2 0.40482 -1.30464 0.00093 0.01432 DataSet_02_103
AMBP SSB shRNA Liver HepG2 1.63744 0.71144 0.00287 0.01247 DataSet_02_107
AMBP BCLAF1 shRNA Liver HepG2 3.17737 1.66783 0.00021 0.02312 DataSet_02_112
AMBP TARDBP shRNA Liver HepG2 2.70637 1.43636 0.00287 0.0216 DataSet_02_116
AMBP HNRNPLL shRNA Liver HepG2 3.22672 1.69007 0.00115 0.01333 DataSet_02_125
AMBP SNRNP70 shRNA Liver HepG2 2.62643 1.3931 0.00234 0.03283 DataSet_02_126
AMBP PRPF4 shRNA Liver HepG2 1.74387 0.8023 0.01099 0.05613 DataSet_02_128
AMBP NONO shRNA Haematopoietic_and_lymphoid_tissue K562 0.63636 -0.65208 0.1326 0.32561 DataSet_02_149
AMBP MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.23529 -2.08746 0.05905 1 DataSet_02_173
AMBP ZNF180 siRNA Haematopoietic_and_lymphoid_tissue K562 0.23529 -2.08746 0.05299 1 DataSet_02_177
AMBP STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 1.69231 0.75899 0.94161 1 DataSet_02_182
AMBP KAT2B siRNA Haematopoietic_and_lymphoid_tissue K562 0.47059 -1.08746 0.15884 1 DataSet_02_184
AMBP CTCF siRNA Haematopoietic_and_lymphoid_tissue K562 2.625 1.39232 0.93763 1 DataSet_02_185
AMBP RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.1358 1 DataSet_02_190
AMBP TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.04762 -4.39232 0.01664 1 DataSet_02_194
AMBP TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.38095 -1.39232 0.16982 1 DataSet_02_201
AMBP BRCA1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.11765 -3.08746 0.03405 1 DataSet_02_202
AMBP AR siRNA Prostate abl cells 1.75646 0.812669 0.299533881198185 0.999852161656754 DataSet_03_004
AMBP AR siRNA Prostate LNCaP 0.657426 -0.6051 0.420240596898176 1 DataSet_03_005
AMBP ARID1A siRNA Mammary_gland MDA-MB-157 0.165805 -2.59244 - - DataSet_03_014
AMBP BCL6 siRNA Lymph Pfeiffer DLBCL 1.68364 0.75158 0.18960033635273 0.666200759973772 DataSet_03_026
AMBP GATA2 siRNA Uterus Decidual stromal cells 0.625131 -0.67777 0.0856248748381804 0.715035882900968 DataSet_03_100
AMBP GATA4 siRNA Stomach AGS 1.69773 0.763606 0.116209075823192 0.769574170321472 DataSet_03_105
AMBP GATA4 siRNA Stomach KatoIII 1.74204 0.800774 0.00602870080749001 0.688409653659493 DataSet_03_106
AMBP GATA6 siRNA Stomach AGS 1.52498 0.608789 0.179440062231883 0.67831557084479 DataSet_03_108
AMBP IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.70289 0.767984 0.225205772750029 0.999948959532916 DataSet_03_134
AMBP KLF5 siRNA Stomach AGS 1.51812 0.602289 0.510947663437094 0.844659781887668 DataSet_03_149
AMBP KLF5 siRNA Stomach KatoIII 1.8525 0.889477 0.0118974599712979 0.27062972235132 DataSet_03_150
AMBP MITF siRNA Skin SK-MEL-5 0.618827 -0.692393 0.00276895621119138 0.00764081048104875 DataSet_03_168
AMBP MYB siRNA Cord_Blood CD34+ progenitor cells 2.01903 1.01366 - - DataSet_03_170
AMBP MYC siRNA Colon HT29 3.20418 1.67996 - - DataSet_03_177
AMBP MYCN siRNA Brain BE(2)C cells 0.641757 -0.6399 - - DataSet_03_188
AMBP NR2F2 siRNA Uterus Primary eutopic stromal cells 0.53742 -0.895879 0.143183536348316 0.99947668859931 DataSet_03_202
AMBP SOX11 siRNA Lung_fibroblast NHLF 4.45596 2.15574 0.00253577412704842 0.304507242190339 DataSet_03_237
AMBP SOX11 siRNA Lung_fibroblast NHLF 2.23172 1.15816 0.183298733641141 0.551882434469478 DataSet_03_238
AMBP SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 3.81818 1.93289 - - DataSet_03_246
AMBP SP1 siRNA Ovary OVSAYO 0.378934 -1.39998 0.00326827186946242 0.0904369303693968 DataSet_03_251
AMBP STAT3 CRISPR Embryo hESC 0.0406426 -4.62086 0.00267266315287653 0.0371060480901755 DataSet_03_258
AMBP STAT6 siRNA Umbilical_vein HUVEC 1.60851 0.685726 0.249132480641174 0.863601751404594 DataSet_03_264
AMBP TP63 siRNA Foreskin Neonatal foreskin keratinocytes 0.623918 -0.680572 0.036076318827386 0.729684006943091 DataSet_03_282
AMBP ZNF746 siRNA Colon HCT116 1.75321 0.81 - - DataSet_03_293
AMBP APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 1.76471 0.819428 0.354925276903618 0.770838185773786 DataSet_04_001
AMBP CTCF CRISPR Haematopoietic_and_lymphoid_tissue K562 0.59375 -0.752073 0.439026886217655 0.712680796630498 DataSet_04_005
AMBP ERN1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.09375 -3.41504 0.0156759365502171 0.586248468655899 DataSet_04_009
AMBP SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.541667 -0.884523 0.441695841538045 0.582983099882515 DataSet_04_018
AMBP NFX1 CRISPR Liver HepG2 1.94634 0.960767 0.000976689925857752 0.0135767274914811 DataSet_04_032
AMBP SMAD4 CRISPR Liver HepG2 0.638071 -0.648211 0.00118753075564482 0.0603611303910653 DataSet_04_035
AMBP ZC3H8 shRNA Liver HepG2 1.58056 0.660433 0.00783202872477724 0.0960488882356633 DataSet_04_040
AMBP ACTN4 CRISPR Liver HepG2 1.77638 0.828937 0.0111280119064578 0.0597268214165304 DataSet_04_042
AMBP PAN2 CRISPR Liver HepG2 0.638071 -0.648211 0.000131831080443467 0.0164855320006658 DataSet_04_066
AMBP ABT1 shRNA Liver HepG2 1.9724 0.979949 0.000238061200320279 0.00383731321029677 DataSet_04_052
AMBP CALR shRNA Liver HepG2 1.70159 0.766881 0.000228266723860462 0.00498013645532069 DataSet_04_053
AMBP CNOT7 shRNA Liver HepG2 0.631402 -0.66337 0.00208260483841434 0.0103377234464549 DataSet_04_051
AMBP YBX3 shRNA Liver HepG2 1.65055 0.722944 0.000348698799062067 0.0324624896745711 DataSet_02_98
AMBP SEPT11 CRISPR Haematopoietic_and_lymphoid_tissue K562 4.66667 2.22239 0.486940664254509 1 DataSet_04_077
AMBP CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.23077 1.15754 0.323717998167465 0.584115533515972 DataSet_02_38
AMBP HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 5.4 2.43296 0.183565255739229 0.581080186660935 DataSet_02_75
AMBP NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.11538 1.08092 0.627549096705498 0.79595190632339 DataSet_02_32
AMBP SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.615385 -0.70044 0.748650927326336 0.8545768918044 DataSet_02_47
AMBP TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.61538 0.691878 0.554967231873318 0.707775386018355 DataSet_02_53
AMBP HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 1.53846 0.621488 0.771759119141046 0.860543239191116 DataSet_04_059
AMBP CNOT3 shRNA Lung A549 0.624371 -0.679525 4.578219e-01 0.9194590 DataSet_03_340
AMBP SMARCA4 siRNA Colon HCT116 0.561585 -0.832423 1.549320e-01 9.892536e-01 DataSet_03_301
AMBP HDAC5 siRNA Liver human hepatocytes 0.600131 -0.73665 4.150390e-05 1.086679e-03 DataSet_03_346
AMBP SNAI2 shRNA Pancreas KLM1 0.490375 -1.02804 1.798602e-01 0.53526507 DataSet_03_307
AMBP PRMT1 shRNA Lung A549 1.56091 0.642386 - - DataSet_03_342
AMBP EZH2 knockdown Colon HCT116 1.73728 0.796829 0.453798188 0.9767661 DataSet_03_334
AMBP ESR1 siRNA Mammary_gland MCF7 0.602645 -0.73062 5.919377e-03 0.0502009327 DataSet_03_352
AMBP ETV5 knockdown Colon HT29 1.775 0.827819 4.281889e-02 0.242171164 DataSet_03_353
AMBP PARP1 siRNA Prostate LNCaP 1.68595 0.753564 4.234391e-01 0.689085869 DataSet_03_354
AMBP TET1 CRISPR Mammary_gland Hs578T 0.119452 -3.0655 2.490332e-01 4.397449e-01 DataSet_03_355
AMBP PTPN14 CRISPR Brain U5-NPC 0.5 -1 6.086390e-01 0.74542334 DataSet_03_357
AMBP TP53 CRISPR Brain U5-NPC 5 2.32193 1.391582e-01 2.739765e-01 DataSet_03_358
AMBP EP300 shRNA Mammary_gland MCF10AT 2 1 3.173779e-01 0.462324270 DataSet_03_364
AMBP TPR shRNA Bone_marrow U2OS 0.328646 -1.6054 1.013968e-02 1.425374e-01 DataSet_03_370
AMBP ZFP36L1 siRNA Urinary_bladder J82 13 3.70044 - - DataSet_03_371
AMBP BHLHE40 shRNA Cervix HeLaS3 0.027027 -5.20945 2.482144e-02 0.84447131 DataSet_03_372
AMBP E2F1 siRNA Nasopharynx HK1 1.77778 0.830075 4.028044e-01 1.000000e+00 DataSet_03_373
AMBP ZNF213 siRNA Mammary_gland MCF7 0.342737 -1.54483 1.941754e-01 6.592819e-01 DataSet_03_376
AMBP EZH2 CRISPR Ovary SKOV3 0.488636 -1.03317 3.578839e-02 0.1597916671 DataSet_03_378
AMBP ZBTB7A siRNA Stomach BGC823 1.62473 0.700198 - - DataSet_03_380
AMBP NFKB2 siRNA Bone_marrow U2OS 2 1 4.137906e-01 0.65348875 DataSet_03_381
AMBP DNMT1 siRNA Skin Human melanoma cells 3.32922 1.73518 2.582240e-04 1.090195e-03 DataSet_03_382
AMBP TCF19 CRISPR Oral_squamous CAL27 0.331906 -1.59115 3.217295e-01 0.6290121149 DataSet_03_383
AMBP YY1 shRNA Brain GSC3028 0.25 -2 - - DataSet_03_386
AMBP TRIM8 siRNA Mammary_gland MCF7 1.61039 0.68741 3.049374e-01 0.5234897623 DataSet_03_388
AMBP NFKBIA shRNA Bone_marrow U2OS 0.0288462 -5.11548 9.041198e-01 0.95909139 DataSet_03_389
AMBP ILF2 siRNA Stomach SGC-7901 7.875 2.97728 0.0742773418 0.20828335 DataSet_03_393
AMBP ASXL1 CRISPR Embryo iPSC 1.61628 0.692679 0.5736160378 0.8914526 DataSet_03_394
AMBP JAZF1 siRNA Cervix HeLa Kyoto 3.06188 1.61442 1.211467e-01 0.734844390 DataSet_03_396
AMBP HMGA1 shRNA Bile_duct HUCCT1 1.59727 0.675608 3.737692e-02 0.232325622 DataSet_03_400
AMBP JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.83333 0.874469 1.643891e-01 0.3720591 DataSet_03_403
AMBP CDK7 shRNA Bone_marrow D458 1.85714 0.893085 2.717342e-01 0.59093326 DataSet_03_404
AMBP USP22 shRNA Liver HuH7 0.399038 -1.3254 - - DataSet_03_411
AMBP USP7 shRNA Skin xenograft cells 0.433628 -1.20547 0.26439112 0.4348960 DataSet_03_431
AMBP NFE2L1 knockout Lung A549 0.457362 -1.12859 1.297359e-02 2.864112e-01 DataSet_03_433
AMBP FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 5.97803 2.57967 3.183735e-01 0.90558273 DataSet_03_439
AMBP SETDB1 shRNA Colon HCT116 0.414401 -1.2709 - - DataSet_03_440
AMBP HMG20A siRNA Mammary_gland MDA-MB-231 2 1 0.7194612309 0.8389054 DataSet_03_442
AMBP FOSL1 siRNA Prostate MSKPCa3 1.66667 0.736966 0.1988093064 0.5297688 DataSet_03_445
AMBP CAMTA1 knockout Embryo_kidney HEK293T 3 1.58496 6.743111e-01 0.77724377 DataSet_03_448
AMBP CBX2 siRNA Mammary_gland MCF7 0.0252318 -5.30862 1.043196e-05 0.0005077108 DataSet_03_451
AMBP ZFP36L1 CRISPR Lung NCI-H1876 0.52135 -0.939675 5.611601e-01 0.992381486 DataSet_03_454
AMBP SREBF2 siRNA Umbilical_vein HUVEC 101.035 6.65871 4.428916e-01 8.187989e-01 DataSet_03_457
AMBP SOX9 knockout Liver HuH7 1.91103 0.934351 2.539967e-04 3.830933e-03 DataSet_03_463
AMBP STAT3 shRNA Liver HepG2 2.06667 1.04731 3.017258e-02 0.2762051868 DataSet_03_465
AMBP LIN28A siRNA Mammary_gland MCF7M 0.357755 -1.48296 2.403517e-01 0.6189657 DataSet_03_469
AMBP LIN28A siRNA Mammary_gland MCF7M 0.357755 -1.48296 2.403517e-01 0.6189657 DataSet_03_470
AMBP WHSC1 siRNA Prostate PC3 0.480769 -1.05658 2.742692e-01 0.51195644 DataSet_03_471
AMBP EZH2 siRNA Prostate LNCaP 6.75 2.75489 2.173766e-01 1.0000000 DataSet_03_475
AMBP CHCHD3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.7112016 0.9936976 DataSet_04_071
AMBP APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 1.76471 0.819428 0.405174 0.8038104 DataSet_04_072
AMBP CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.6928014 0.816936438 DataSet_04_074
Regulation Region
 
T(co)Fs that significantly regulate ERN1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of AMBP
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines