Gene Overview
Target Gene: C6orf141
NCBI Official Symbol: C6orf141
Entrez ID: 135398
Ensembl ID: ENSG00000197261
Gene Full Name: chromosome 6 open reading frame 141
Strand: +
Gene Locus: 6p12.3
External Links:

C6orf141 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate C6orf141   
T(co)Fs that Repress C6orf141
The Intensity of the Gene Regulated by T(co)Fs:
C6orf141-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
C6orf141 FOXO1 shRNA Bone EWS-FLI1 2.30807 1.20669 0.12002 0.62813 DataSet_01_106
C6orf141 ESR1 siRNA Mammary_gland MCF7 0.51442 -0.95897 9.21691e-08 0.00015 DataSet_01_111
C6orf141 HSF1 siRNA Upper_aerodigestive_tract HSC3 0.57191 -0.80615 0.00019 0.03593 DataSet_01_112
C6orf141 ID1 siRNA Lung H1650 0.64196 -0.63945 0.04409 0.36902 DataSet_01_118
C6orf141 FOXM1 siRNA Central_nervous_system U87 2.69204 1.4287 - - DataSet_01_122
C6orf141 TCF4 siRNA Autonomic_ganglia SH-SY5Y 3.96341 1.98674 0.14855 0.32456 DataSet_01_185
C6orf141 GATA2 siRNA Prostate LNCaP 0.41643 -1.26384 0.04931 0.11732 DataSet_01_193
C6orf141 CREB1 shRNA Parotid_gland H3118 MEC 2.09825 1.06919 0.9587 0.98641 DataSet_01_194
C6orf141 XBP1 shRNA Mammary_gland T47D 4.09772 2.03482 3.46654e-06 0.00025 DataSet_01_203
C6orf141 HIC1 shRNA Mammary_gland HBL100 0.29548 -1.75888 - - DataSet_01_205
C6orf141 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 0.44325 -1.1738 - - DataSet_01_208
C6orf141 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.14176 -2.81843 - - DataSet_01_210
C6orf141 BCLAF1 shRNA Colon RKO 1.52719 0.61088 - - DataSet_01_214
C6orf141 SNAI2 shRNA Skin Primary human keratinocytes 1.82607 0.86874 0.00313 0.02494 DataSet_01_225
C6orf141 KLF2 shRNA Bone_marrow RPMI8226 0.44087 -1.18159 0.07056 0.6653 DataSet_01_226
C6orf141 IRX1 shRNA Bone_marrow 143B 0.56307 -0.82862 0.14259 0.38569 DataSet_01_227
C6orf141 FOXP1 siRNA Prostate LNCaP 1.68094 0.74927 0.00546 0.21892 DataSet_01_234
C6orf141 ARNT shRNA Embryo hESC HSF1 0.49437 -1.01634 0.46079 0.99999 DataSet_01_240
C6orf141 TWIST1 shRNA Stomach CAF14 1.81899 0.86314 0.02207 0.99996 DataSet_01_252
C6orf141 TWIST1 shRNA Stomach CAF32 2.02339 1.01678 0.08658 0.19937 DataSet_01_253
C6orf141 TWIST1 shRNA Stomach CAF 1.91847 0.93996 0.0096 0.52717 DataSet_01_254
C6orf141 AR shRNA Prostate CWR22Pc 0.60001 -0.73694 0.36592 0.59628 DataSet_01_278
C6orf141 ESRRA shRNA Embryo_kidney 293T 1.57916 0.65915 0.36217 0.83136 DataSet_01_280
C6orf141 MSX1 siRNA Tooth Dental Pulp Cells 1.59945 0.67757 0.06383 0.13221 DataSet_01_281
C6orf141 ZIC5 siRNA Skin A375 3.59263 1.84504 - - DataSet_01_284
C6orf141 POSTN shRNA Brain GSC272 0.45276 -1.14317 0.13303 0.56088 DataSet_01_293
C6orf141 TFAP4 siRNA Brain BE(2)-C 0.22206 -2.17097 0.33885 0.51625 DataSet_01_295
C6orf141 PTEN shRNA Mammary_gland SKBR3 3.45062 1.78685 0.10821 0.6188 DataSet_01_303
C6orf141 ELK3 shRNA Mammary_gland MDA-MB-231 0.44889 -1.15556 6.95258e-06 1e-04 DataSet_01_318
C6orf141 MYC siRNA Colon HCT116 1.56962 0.65041 0.0037 0.00894 DataSet_01_324
C6orf141 TP63 shRNA Immortalized_keratinocyte HaCaT 1.60965 0.68675 1.94285e-07 1.10551e-05 DataSet_01_325
C6orf141 TP63 shRNA Immortalized_keratinocyte HaCaT 1.60965 0.68675 1.94285e-07 1.10551e-05 DataSet_01_328
C6orf141 HIF1A siRNA Oral_cavity OEC-M1 0.51005 -0.9713 0.13837 0.85151 DataSet_01_348
C6orf141 RBFOX2 shRNA Liver HepG2 0.47619 -1.07039 0.33855 0.72019 DataSet_02_101
C6orf141 SAFB2 shRNA Liver HepG2 2.15517 1.1078 0.01748 0.05444 DataSet_02_102
C6orf141 FIP1L1 shRNA Liver HepG2 8.41176 3.07241 0.03108 0.08026 DataSet_02_103
C6orf141 HDGF shRNA Liver HepG2 0.5 -1 0.77348 0.86677 DataSet_02_104
C6orf141 RBM39 shRNA Liver HepG2 2.2381 1.16227 0.22747 0.48136 DataSet_02_111
C6orf141 U2AF2 shRNA Liver HepG2 0.21429 -2.22239 0.41946 0.56331 DataSet_02_113
C6orf141 XRCC5 shRNA Liver HepG2 0.31429 -1.66985 0.27483 0.47686 DataSet_02_114
C6orf141 PCBP1 shRNA Liver HepG2 3 1.58496 0.03478 0.0721 DataSet_02_115
C6orf141 TARDBP shRNA Liver HepG2 0.20755 -2.26849 0.20676 0.29659 DataSet_02_116
C6orf141 SUB1 shRNA Liver HepG2 0.42857 -1.22239 0.72611 0.83561 DataSet_02_117
C6orf141 RBM25 shRNA Liver HepG2 2.25 1.16993 0.05614 0.11492 DataSet_02_119
C6orf141 PTBP1 shRNA Liver HepG2 74.75 6.224 0.00852 0.02055 DataSet_02_120
C6orf141 RBM34 shRNA Liver HepG2 0.08571 -3.54432 0.02228 0.39846 DataSet_02_121
C6orf141 EWSR1 shRNA Liver HepG2 0.38462 -1.37851 0.39985 0.52625 DataSet_02_122
C6orf141 PCBP2 shRNA Liver HepG2 1.62857 0.70361 0.12447 0.27107 DataSet_02_123
C6orf141 FUS shRNA Liver HepG2 2.8 1.48543 0.04621 0.16796 DataSet_02_124
C6orf141 HNRNPLL shRNA Liver HepG2 0.15094 -2.72792 0.51546 0.59372 DataSet_02_125
C6orf141 ZFX siRNA Prostate C4-2B 5.25 2.39232 0.40336 0.52084 DataSet_02_172
C6orf141 BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.625 -0.67807 0.33031 1 DataSet_02_188
C6orf141 LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.125 -3 0.04759 1 DataSet_02_191
C6orf141 LMNB1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.125 -3 0.03627 1 DataSet_02_195
C6orf141 AR siRNA Prostate abl cells 3.51449 1.81332 0.0470265359428948 0.999852161656754 DataSet_03_004
C6orf141 AR siRNA Prostate LNCaP 1.625 0.70044 0.287048196839634 1 DataSet_03_005
C6orf141 ASCL1 siRNA Lung DMS79 0.663043 -0.592825 0.126103094584661 0.792964388652408 DataSet_03_016
C6orf141 BCL6 siRNA Mammary_gland MCF7 0.626527 -0.674551 0.195893113741062 0.989541443114508 DataSet_03_024
C6orf141 CEBPA siRNA Mammary_gland MCF7 1.79646 0.845159 0.117193610714932 0.999962793175751 DataSet_03_047
C6orf141 CENPF siRNA Mammary_gland MCF7 1.84864 0.886468 0.103314056068219 0.999662524742916 DataSet_03_052
C6orf141 CREBBP siRNA Mammary_gland MCF7 0.611373 -0.709875 0.176362371529767 0.966455540764243 DataSet_03_055
C6orf141 E2F1 siRNA Mammary_gland MCF7 1.52131 0.605319 0.239943775856055 0.999927373439084 DataSet_03_061
C6orf141 E2F5 siRNA Mammary_gland MCF7 1.79829 0.846627 0.11667035949515 0.999540347732068 DataSet_03_062
C6orf141 ESR1 siRNA Mammary_gland MCF7 0.584391 -0.774993 0.0589607986014454 0.999753934970283 DataSet_03_068
C6orf141 FOXJ2 siRNA Mammary_gland MCF7 0.559252 -0.838429 0.11962093695329 0.999965704179325 DataSet_03_088
C6orf141 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.28903 -1.79071 - - DataSet_03_096
C6orf141 FOXP1 siRNA Mammary_gland MCF7 0.573818 -0.801336 0.133897902920388 0.999975993110711 DataSet_03_099
C6orf141 GATA2 siRNA Uterus Decidual stromal cells 0.64341 -0.636189 0.720396569129052 0.972965534057115 DataSet_03_100
C6orf141 GATA6 siRNA Stomach AGS 0.603793 -0.727875 0.00903922507522901 0.287317876422877 DataSet_03_108
C6orf141 HDAC3 siRNA Mammary_gland MCF7 0.640372 -0.643018 0.214969593070676 0.99997791025972 DataSet_03_114
C6orf141 HDAC5 siRNA Mammary_gland MCF7 1.71948 0.78197 0.141988681677813 0.999966625300244 DataSet_03_115
C6orf141 HIF1A siRNA Mammary_gland MCF7 0.435004 -1.2009 0.0396981027518023 0.999966843283762 DataSet_03_119
C6orf141 HMGA1 siRNA Mammary_gland MDA-MB-231 1.61917 0.695254 7.42820759405698e-06 0.000122760787277422 DataSet_03_124
C6orf141 HOXB7 siRNA Mammary_gland MCF7 0.561446 -0.832781 0.121695515297791 0.999977683706165 DataSet_03_127
C6orf141 ID1 siRNA Mammary_gland MCF7 0.577786 -0.791393 0.137995133496391 0.999926480273844 DataSet_03_133
C6orf141 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.90061 0.926461 0.052491393416004 0.837939897203358 DataSet_03_134
C6orf141 Klf4 siRNA Skin Primary neonatal keratinocytes 2.43816 1.28579 7.47551556013091e-05 0.00185644827356233 DataSet_03_147
C6orf141 MAX siRNA Mammary_gland MCF7 0.590077 -0.761026 0.151261758257377 0.999907009675999 DataSet_03_158
C6orf141 MCM2 siRNA Mammary_gland MCF7 0.477689 -1.06586 0.0597190352802139 0.999925560383539 DataSet_03_161
C6orf141 MEF2D shRNA Liver HuH7 1.58143 0.661231 - - DataSet_03_162
C6orf141 MYBL2 siRNA Mammary_gland MCF7 0.587427 -0.767519 0.148327061958987 0.999907476570542 DataSet_03_176
C6orf141 MYC siRNA Mammary_gland MCF7 0.597015 -0.74416 0.159142459229895 0.999887767096734 DataSet_03_182
C6orf141 PAX3 siRNA Mammary_gland MCF7 0.583549 -0.777074 0.10989703480712 0.919978041032696 DataSet_03_206
C6orf141 PHB shRNA Embryo Embryonic stem cells (ESCs) 1.89768 0.92424 0.00109155961024337 0.00600246911117831 DataSet_03_211
C6orf141 RB1 siRNA Mammary_gland MCF7 1.6101 0.687147 0.188712198918043 0.999890290262508 DataSet_03_219
C6orf141 SOX11 siRNA Lung_fibroblast NHLF 0.578592 -0.789382 0.0891385362518879 0.468267963359167 DataSet_03_237
C6orf141 SOX11 siRNA Lung_fibroblast NHLF 0.498632 -1.00395 0.0102876974823339 0.201591575045647 DataSet_03_238
C6orf141 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 1.75 0.807355 - - DataSet_03_246
C6orf141 SP1 siRNA Ovary OVSAYO 0.546595 -0.871455 0.0276861981422016 0.20814858070555 DataSet_03_251
C6orf141 STAT3 CRISPR Embryo hESC 0.0610529 -4.0338 0.00967126020818878 0.0635423118601446 DataSet_03_258
C6orf141 STAT6 siRNA Umbilical_vein HUVEC 0.476043 -1.07083 0.163813372435083 0.835278631521068 DataSet_03_264
C6orf141 TCEA1 siRNA Mammary_gland MCF7 1.58173 0.661503 0.203593240666134 0.999762252994287 DataSet_03_266
C6orf141 TFAP2C siRNA Mammary_gland MCF7 1.54347 0.626176 0.0650382415260689 0.402930093390995 DataSet_03_274
C6orf141 ZNF750 siRNA Skin Primary neonatal keratinocytes 1.63306 0.707574 0.00379812221618241 0.0511494630543719 DataSet_03_294
C6orf141 CIZ1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.434783 -1.20163 0.986362964474482 0.991663258652372 DataSet_04_004
C6orf141 E4F1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.615385 -0.70044 0.081665457740454 0.527721400919947 DataSet_04_007
C6orf141 ERN1 CRISPR Liver HepG2 0.625 -0.678072 0.216920692919703 0.417656473662155 DataSet_04_029
C6orf141 PAN2 CRISPR Liver HepG2 1.88889 0.917538 0.257731509513323 0.435372745317843 DataSet_04_033
C6orf141 SMAD4 CRISPR Liver HepG2 2.66667 1.41504 0.0930511883460862 0.226080503027195 DataSet_04_035
C6orf141 SMAD5 CRISPR Liver HepG2 2.22222 1.152 0.039125905007425 0.409118259548603 DataSet_04_036
C6orf141 DDX20 CRISPR Liver HepG2 0.375 -1.41504 0.146693923750203 0.285598609624859 DataSet_04_043
C6orf141 CNOT7 CRISPR Liver HepG2 0.291667 -1.77761 0.236886549494614 0.393723793759292 DataSet_04_045
C6orf141 PAN2 CRISPR Liver HepG2 2.66667 1.41504 0.0536065641086217 0.152440145327804 DataSet_04_066
C6orf141 RIOK2 CRISPR Liver HepG2 0.387097 -1.36923 0.324606336022442 1 DataSet_04_070
C6orf141 SEPT11 CRISPR Liver HepG2 10.25 3.35755 0.0330011713036496 0.176355341350995 DataSet_04_068
C6orf141 ABT1 shRNA Liver HepG2 0.517857 -0.949374 0.290650768113421 0.41902000738038 DataSet_04_052
C6orf141 CCAR1 shRNA Liver HepG2 4 2 0.00411078926277838 0.0301340691223827 DataSet_04_054
C6orf141 CNOT7 shRNA Liver HepG2 31.15 4.96116 1.84508546994643e-05 0.00162589398721925 DataSet_04_051
C6orf141 NPM1 shRNA Liver HepG2 1.92857 0.947533 0.256408565738314 0.669559030332775 DataSet_04_058
C6orf141 PRPF6 shRNA Liver HepG2 0.285714 -1.80735 0.142393163109943 0.326204295107491 DataSet_04_056
C6orf141 UBE2L3 shRNA Liver HepG2 1.58621 0.665581 0.50650131208433 0.65994817619731 DataSet_04_055
C6orf141 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 5.66667 2.5025 0.23760264358773 0.392649786626258 DataSet_04_049
C6orf141 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 9.5 3.24793 0.226390468260549 0.698962786640698 DataSet_02_45
C6orf141 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2 1 0.7709083733733 0.879697444183763 DataSet_02_35
C6orf141 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 4.875 2.2854 0.391844181108032 0.631263548213136 DataSet_02_32
C6orf141 TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 7 2.80735 0.341144925994479 0.530966348503139 DataSet_02_43
C6orf141 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.581376677001611 0.729684196628447 DataSet_02_33
C6orf141 SMARCA4 siRNA Colon HCT116 1.968 0.976732 5.662054e-02 7.932358e-01 DataSet_03_301
C6orf141 INO80 siRNA Muscle RD 1.64637 0.719287 - - DataSet_03_344
C6orf141 EZH2 shRNA Mammary_gland MCF7 1.53772 0.62079 2.305158e-03 4.991514e-02 DataSet_03_331
C6orf141 EZH2 knockdown Colon HCT116 3.74493 1.90494 0.093826258 0.8488990 DataSet_03_334
C6orf141 TET1 CRISPR Mammary_gland MDA-MB-231 11.0787 3.46971 1.299827e-06 1.394217e-04 DataSet_03_347
C6orf141 ESR1 siRNA Mammary_gland MCF7 0.525043 -0.929493 1.716422e-04 0.0106488504 DataSet_03_352
C6orf141 ETV5 knockdown Colon HT29 2.59349 1.37489 2.406442e-04 0.030742017 DataSet_03_353
C6orf141 TET1 CRISPR Mammary_gland Hs578T 0.117151 -3.09355 1.546688e-01 3.189028e-01 DataSet_03_355
C6orf141 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 0.194875 -2.35938 3.466120e-02 6.700008e-02 DataSet_03_362
C6orf141 TP53 knockout Stomach SNU1 0.637894 -0.64861 0.5273671437 0.9487047 DataSet_03_365
C6orf141 ABL1 shRNA Liver HuH7 0.60205 -0.732044 3.287555e-03 0.0137398576 DataSet_03_367
C6orf141 USP22 shRNA Liver PLC_PRF_5 cells 0.222222 -2.16992 6.991889e-02 0.25164065 DataSet_03_368
C6orf141 DNMT3A knockout Embryo_kidney HEK293T 149.796 7.22686 - - DataSet_03_369
C6orf141 SMARCA2 shRNA Lung NCI-H1944 0.52 -0.943416 2.548124e-02 3.074144e-01 DataSet_03_377
C6orf141 NFKB2 siRNA Bone_marrow U2OS 5 2.32193 2.458815e-01 0.57739488 DataSet_03_381
C6orf141 DNMT1 siRNA Skin Human melanoma cells 0.472887 -1.08043 7.526652e-05 4.315326e-04 DataSet_03_382
C6orf141 YY1 shRNA Brain GSC23 1.8 0.847997 - - DataSet_03_385
C6orf141 YY1 shRNA Brain GSC3028 2 1 - - DataSet_03_386
C6orf141 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 3.56301 1.8331 0.4009856896 0.8583205 DataSet_03_387
C6orf141 TRIM8 siRNA Mammary_gland MCF7 1.56746 0.648429 1.109295e-02 0.0558406116 DataSet_03_388
C6orf141 NFKBIA shRNA Bone_marrow U2OS 0.00187617 -9.05799 5.062854e-01 0.87005461 DataSet_03_389
C6orf141 ILF2 siRNA Stomach SGC-7901 0.6 -0.736966 0.6363679069 0.71334537 DataSet_03_393
C6orf141 CDK7 shRNA Bone_marrow D458 0.558824 -0.839535 1.831745e-01 0.52642486 DataSet_03_404
C6orf141 TFAP2A knockout Embryo H9 0.0892857 -3.48543 4.706534e-03 0.04787291 DataSet_03_405
C6orf141 STRAP knockout Nerve SK-N-AS 0.422301 -1.24366 - - DataSet_03_409
C6orf141 SIRT1 siRNA Pancreas PANC1 0.5 -1 6.459874e-01 0.764487326 DataSet_03_410
C6orf141 E2F6 shRNA Liver HuH7 0.495432 -1.01324 - - DataSet_03_412
C6orf141 E2F2 siRNA Prostate LNCaP 0.333333 -1.58496 2.320941e-01 4.911073e-01 DataSet_03_414
C6orf141 FOXK2 shRNA Ovary OVCAR-5 2.37585 1.24844 5.463640e-02 0.19176957 DataSet_03_419
C6orf141 PRDM1 CRISPR Lymph CD8+ T cells 4 2 - - DataSet_03_421
C6orf141 MAEL CRISPR Liver Alexander cells 0.113636 -3.1375 - - DataSet_03_423
C6orf141 LHX2 shRNA Bone_marrow ES-derived RPE cells 1.69463 0.760971 3.049837e-01 1.000000e+00 DataSet_03_428
C6orf141 USP7 shRNA Skin xenograft cells 0.470588 -1.08746 0.42771671 0.5487581 DataSet_03_431
C6orf141 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.275862 -1.85798 - - DataSet_03_432
C6orf141 SUFU shRNA Mammary_gland HCC1954 cells 0.520231 -0.942775 0.4292055787 0.7352052 DataSet_03_437
C6orf141 DAXX shRNA Mammary_gland MDA-MB-231 0.662125 -0.594824 1.243533e-01 0.40725815 DataSet_03_441
C6orf141 HMG20A siRNA Mammary_gland MDA-MB-231 0.665803 -0.586832 0.0458904158 0.2420476 DataSet_03_442
C6orf141 CBX2 siRNA Mammary_gland MCF7 1.93071 0.949132 3.565758e-02 0.0830780501 DataSet_03_451
C6orf141 SREBF2 siRNA Umbilical_vein HUVEC 0.636197 -0.652454 4.454320e-01 8.202050e-01 DataSet_03_457
C6orf141 ARID1A shRNA Bile_duct MMNK1 0.363219 -1.46109 5.944783e-01 0.768363014 DataSet_03_458
C6orf141 SOX9 knockout Liver HuH7 2.54839 1.34958 6.036983e-05 1.618728e-03 DataSet_03_463
C6orf141 PARP1 knockout Embryo_kidney HEK293a 2.35427 1.23528 3.546320e-07 5.962276e-06 DataSet_03_464
C6orf141 SMARCA1 Cas13 Embryo_kidney HEK293T 0.0714286 -3.80735 - - DataSet_03_466
C6orf141 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.82143 0.86507 - - DataSet_03_467
C6orf141 SMARCA1 shRNA Embryo_kidney HEK293T 0.142857 -2.80735 - - DataSet_03_468
C6orf141 EZH2 siRNA Umbilical_vein HUVEC 2.66667 1.41504 1.292043e-01 0.373379173 DataSet_03_473
C6orf141 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 0.621622 -0.685891 0.7039781 0.9433803 DataSet_04_072
Regulation Region
 
T(co)Fs that significantly regulate MCM2 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of C6orf141
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines