Gene Overview
Target Gene: CYP39A1
NCBI Official Symbol: CYP39A1
Entrez ID: 51302
Ensembl ID: ENSG00000146233
Gene Full Name: cytochrome P450 family 39 subfamily A member 1
Strand: -
Gene Locus: 6p12.3
External Links:

CYP39A1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate CYP39A1   
T(co)Fs that Repress CYP39A1
The Intensity of the Gene Regulated by T(co)Fs:
CYP39A1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
CYP39A1 SPDEF shRNA Mammary_gland MCF7 1.92093 0.9418 0.58913 0.99999 DataSet_01_107
CYP39A1 ESRRA shRNA Colon HCT116 1.57989 0.65983 0.00071 0.84512 DataSet_01_115
CYP39A1 FOXM1 siRNA Central_nervous_system U87 0.28634 -1.80421 - - DataSet_01_122
CYP39A1 ZNF254 siRNA Gastrointestinal_tissue GIST-T1 1.76596 0.82045 7.31623e-05 0.00274 DataSet_01_127
CYP39A1 IKZF1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 10.093 3.33528 5e-04 0.22192 DataSet_01_138
CYP39A1 HSF1 shRNA Skin A375 0.26797 -1.89984 0.00139 0.01594 DataSet_01_155
CYP39A1 STAT3 siRNA Peripheral_blood CD4+ T cells 0.65759 -0.60473 0.51097 0.99183 DataSet_01_168
CYP39A1 HOXB7 siRNA Pancreas MIA PaCa-2 1.89258 0.92035 0.13394 0.6479 DataSet_01_169
CYP39A1 GABPA shRNA Prostate C4-2B 1780.6 10.7982 0.23631 0.43934 DataSet_01_190
CYP39A1 GABPA shRNA Prostate LNCaP 1339.32 10.3873 0.46142 0.7048 DataSet_01_191
CYP39A1 GATA2 siRNA Prostate LNCaP 0.19269 -2.37564 1.7483e-06 7.20086e-05 DataSet_01_193
CYP39A1 CREB1 shRNA Parotid_gland H3118 MEC 3.07484 1.62051 0.1049 0.43077 DataSet_01_194
CYP39A1 TP63 siRNA Head_and_neck SCC-1 0.22727 -2.1375 - - DataSet_01_198
CYP39A1 TP63 siRNA Head_and_neck SCC-1 0.37364 -1.42028 - - DataSet_01_199
CYP39A1 FOXA1 siRNA Prostate LNCaP 1.85225 0.88928 0.01536 0.20153 DataSet_01_233
CYP39A1 ARNT shRNA Embryo hESC HSF1 0.66495 -0.58868 0.06411 0.99999 DataSet_01_240
CYP39A1 TWIST1 shRNA Stomach CAF32 5.44823 2.44579 0.00019 0.01362 DataSet_01_253
CYP39A1 TWIST1 shRNA Stomach CAF 2.11158 1.07833 0.085 0.57538 DataSet_01_254
CYP39A1 FOXO3 siRNA Pancreas PANC1 0.53121 -0.91264 - - DataSet_01_267
CYP39A1 MSX1 siRNA Tooth Dental Pulp Cells 4.07773 2.02777 0.00094 0.00483 DataSet_01_281
CYP39A1 SNAI2 siRNA Mammary_gland MCFDCIS 1.85809 0.89382 0.0651 0.58596 DataSet_01_292
CYP39A1 TFAP4 siRNA Brain BE(2)-C 0.26377 -1.92266 0.4135 0.51625 DataSet_01_295
CYP39A1 PTEN shRNA Skin A431 1.87592 0.9076 0.01224 0.10224 DataSet_01_301
CYP39A1 PTEN shRNA Lung HCC827 1.80127 0.84902 0.16696 0.65244 DataSet_01_302
CYP39A1 PTEN shRNA Mammary_gland SKBR3 1.91143 0.93465 0.22824 0.69391 DataSet_01_303
CYP39A1 ARNT siRNA Upper_aerodigestive_tract HSC3 0.36992 -1.43471 - - DataSet_01_315
CYP39A1 ELK3 shRNA Mammary_gland MDA-MB-231 1.87587 0.90756 0.00129 0.0042 DataSet_01_318
CYP39A1 MYC siRNA Colon HCT116 2.2067 1.14189 0.00619 0.01383 DataSet_01_324
CYP39A1 CDX2 siRNA Colon COLO320 0.57943 -0.7873 - - DataSet_01_357
CYP39A1 GTF2B siRNA Cervix HeLa 0.333 -1.58639 - - DataSet_01_362
CYP39A1 RBFOX2 shRNA Liver HepG2 0.51724 -0.95109 0.01559 0.65168 DataSet_02_101
CYP39A1 FIP1L1 shRNA Liver HepG2 0.60256 -0.73081 0.35298 0.46033 DataSet_02_103
CYP39A1 HDGF shRNA Liver HepG2 0.62963 -0.66742 0.08213 0.22558 DataSet_02_104
CYP39A1 U2AF2 shRNA Liver HepG2 0.58904 -0.76356 0.00369 0.05368 DataSet_02_105
CYP39A1 TAF15 shRNA Liver HepG2 0.03846 -4.70044 0.63368 0.69698 DataSet_02_106
CYP39A1 SSB shRNA Liver HepG2 0.03061 -5.02975 0.01347 0.03289 DataSet_02_107
CYP39A1 ZNF622 shRNA Liver HepG2 1.64286 0.71621 0.87018 0.9034 DataSet_02_108
CYP39A1 HNRNPUL1 shRNA Liver HepG2 0.27513 -1.8618 0.00174 0.02256 DataSet_02_109
CYP39A1 GTF2F1 shRNA Liver HepG2 2.0411 1.02934 0.01651 0.23312 DataSet_02_110
CYP39A1 RBM39 shRNA Liver HepG2 0.58621 -0.77052 0.0707 0.28462 DataSet_02_111
CYP39A1 BCLAF1 shRNA Liver HepG2 0.5 -1 0.17129 0.27972 DataSet_02_112
CYP39A1 U2AF2 shRNA Liver HepG2 0.37931 -1.39855 0.06641 0.16836 DataSet_02_113
CYP39A1 PCBP1 shRNA Liver HepG2 0.23077 -2.11548 0.8922 0.92084 DataSet_02_115
CYP39A1 CEBPZ shRNA Liver HepG2 0.20513 -2.2854 0.97324 1 DataSet_02_118
CYP39A1 RBM25 shRNA Liver HepG2 0.19231 -2.37851 0.82506 0.87202 DataSet_02_119
CYP39A1 PTBP1 shRNA Liver HepG2 4.69231 2.2303 0.16618 0.21176 DataSet_02_120
CYP39A1 RBM34 shRNA Liver HepG2 0.41096 -1.28293 0.09096 0.44741 DataSet_02_121
CYP39A1 EWSR1 shRNA Liver HepG2 0.38889 -1.36257 0.04405 0.12275 DataSet_02_122
CYP39A1 FUS shRNA Liver HepG2 1.9863 0.99008 0.01887 0.11372 DataSet_02_124
CYP39A1 HNRNPLL shRNA Liver HepG2 0.05217 -4.26053 0.00095 0.01259 DataSet_02_125
CYP39A1 SNRNP70 shRNA Liver HepG2 0.17391 -2.52356 0.00591 0.04292 DataSet_02_126
CYP39A1 SRSF3 shRNA Liver HepG2 2.2 1.1375 0.02103 0.10634 DataSet_02_127
CYP39A1 PRPF4 shRNA Liver HepG2 0.18333 -2.44746 0.00496 0.04022 DataSet_02_128
CYP39A1 HNRNPUL1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.22222 -2.16993 0.03132 0.51515 DataSet_02_156
CYP39A1 AR siRNA Prostate abl cells 1.69833 0.76412 0.0846667102875691 0.999852161656754 DataSet_03_004
CYP39A1 BCL6 siRNA Lymph Pfeiffer DLBCL 0.66384 -0.591092 0.0371558517609862 0.460566668508389 DataSet_03_026
CYP39A1 CEBPB siRNA Embryo hESC 0.509226 -0.973622 0.507821999215609 0.802798631579061 DataSet_03_049
CYP39A1 GATA2 siRNA Uterus Decidual stromal cells 0.49815 -1.00535 0.0115962830859161 0.434993940341226 DataSet_03_100
CYP39A1 GATA4 siRNA Stomach AGS 3.12867 1.64555 0.0512122601992153 0.660167579048509 DataSet_03_105
CYP39A1 GATA6 siRNA Stomach AGS 1.78319 0.834463 0.267791865181926 0.749397680532564 DataSet_03_108
CYP39A1 Klf4 siRNA Skin Primary neonatal keratinocytes 2.38797 1.25578 0.0021272218242591 0.0150815658447644 DataSet_03_147
CYP39A1 KLF5 siRNA Stomach AGS 2.40476 1.26589 0.0881421893134675 0.56335115327082 DataSet_03_149
CYP39A1 KLF5 siRNA Stomach KatoIII 0.631024 -0.664234 0.092703828077631 0.528008747572935 DataSet_03_150
CYP39A1 KLF5 siRNA Stomach YCC3 0.594193 -0.750996 0.0012918803188198 0.0613501497895675 DataSet_03_151
CYP39A1 MEF2D shRNA Liver HuH7 2.4896 1.31591 - - DataSet_03_162
CYP39A1 MYC siRNA Colon HT29 2.13239 1.09247 - - DataSet_03_177
CYP39A1 MYC siRNA Central_nervous_system DAOY M2.1 1.71815 0.780858 2.67058671586522e-07 3.08106315034956e-06 DataSet_03_178
CYP39A1 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.358025 -1.48187 - - DataSet_03_246
CYP39A1 SRF siRNA Prostate LNCaP 0.634349 -0.656652 0.000716426854241249 0.00782290592762544 DataSet_03_254
CYP39A1 STAT3 CRISPR Embryo hESC 0.224552 -2.15488 0.000418170788080101 0.0161292328437846 DataSet_03_258
CYP39A1 STAT6 siRNA Umbilical_vein HUVEC 0.633588 -0.658384 0.390677700244658 0.892570927157164 DataSet_03_264
CYP39A1 TFAP2C siRNA Mammary_gland MCF7 0.520863 -0.941023 0.0267698916870151 0.332207452425394 DataSet_03_274
CYP39A1 ZNF750 siRNA Skin Primary neonatal keratinocytes 1.63087 0.705643 0.0343823704877947 0.156978754567403 DataSet_03_294
CYP39A1 E4F1 CRISPR Liver HepG2 0.0833333 -3.58496 0.117595864226171 0.399190109304468 DataSet_04_028
CYP39A1 ERN1 CRISPR Liver HepG2 0.166667 -2.58496 0.0572672519226824 0.204098069039519 DataSet_04_029
CYP39A1 FUBP1 shRNA Liver HepG2 0.5625 -0.830075 0.513495160353446 0.777460906082612 DataSet_04_030
CYP39A1 MECP2 CRISPR Liver HepG2 0.5 -1 0.432881818211467 0.678223571914349 DataSet_04_031
CYP39A1 NFX1 CRISPR Liver HepG2 0.131944 -2.922 0.013051683303254 0.0425029039792094 DataSet_04_032
CYP39A1 PAN2 CRISPR Liver HepG2 3.57143 1.8365 0.0275707248720641 0.146468945045782 DataSet_04_033
CYP39A1 SMAD4 CRISPR Liver HepG2 5.14286 2.36257 0.00042694247769014 0.0527443981287996 DataSet_04_035
CYP39A1 SRPK2 CRISPR Liver HepG2 0.291667 -1.77761 0.152502920039896 0.346006785940334 DataSet_04_037
CYP39A1 WRN shRNA Liver HepG2 0.395833 -1.33703 0.278484737470866 0.513919933232975 DataSet_04_038
CYP39A1 ZC3H8 shRNA Liver HepG2 0.527778 -0.921997 0.304845314513983 0.49737293080188 DataSet_04_040
CYP39A1 ZNF574 CRISPR Liver HepG2 2 1 0.0785905717574889 0.184036481554391 DataSet_04_041
CYP39A1 DDX20 CRISPR Liver HepG2 0.458333 -1.12553 0.363783820916947 0.510469851991584 DataSet_04_043
CYP39A1 CNOT7 CRISPR Liver HepG2 0.492308 -1.02237 0.020493123502801 0.0737452426116747 DataSet_04_045
CYP39A1 PAN2 CRISPR Liver HepG2 5.14286 2.36257 0.000614801800210313 0.0224228182685936 DataSet_04_066
CYP39A1 SEPT11 CRISPR Liver HepG2 1.57895 0.658963 0.549446503383129 0.77118539749928 DataSet_04_068
CYP39A1 ABT1 shRNA Liver HepG2 3.09722 1.63097 0.00582852605244986 0.0243690250873312 DataSet_04_052
CYP39A1 CALR shRNA Liver HepG2 2.28125 1.18982 0.00439869027556698 0.0223092384244492 DataSet_04_053
CYP39A1 CCAR1 shRNA Liver HepG2 0.5 -1 0.0353711220725216 0.103097756830279 DataSet_04_054
CYP39A1 CNOT7 shRNA Liver HepG2 12.6557 3.66172 7.63684997479033e-05 0.00249973432118664 DataSet_04_051
CYP39A1 NPM1 shRNA Liver HepG2 1.53448 0.617752 0.218562441938232 0.630270954522971 DataSet_04_058
CYP39A1 PRPF6 shRNA Liver HepG2 0.575342 -0.797507 0.187560453900438 0.38553787908286 DataSet_04_056
CYP39A1 UBE2L3 shRNA Liver HepG2 0.302013 -1.72732 0.0342754380700576 0.0922316110882882 DataSet_04_055
CYP39A1 YBX3 shRNA Liver HepG2 0.324607 -1.62323 0.00116267564832863 0.041507569511709 DataSet_02_98
CYP39A1 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.61823953800732 0.901411897829307 DataSet_02_45
CYP39A1 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.93333 0.95109 0.337235957005967 0.518923198855272 DataSet_02_35
CYP39A1 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.0666667 -3.90689 0.282244616761348 0.451050215582114 DataSet_02_53
CYP39A1 HDAC4 siRNA Liver human hepatocytes 0.656701 -0.606691 2.438056e-04 9.615888e-03 DataSet_03_345
CYP39A1 SNAI2 shRNA Pancreas pancreatic cancer stem cells 0.64421 -0.634396 2.092498e-01 0.6510154 DataSet_03_306
CYP39A1 SNAI2 shRNA Pancreas KLM1 0.634141 -0.657125 3.410482e-01 0.66661906 DataSet_03_307
CYP39A1 EZH2 knockdown Colon HCT116 5.77125 2.52888 0.092729986 0.8488990 DataSet_03_334
CYP39A1 TET1 CRISPR Mammary_gland MDA-MB-231 0.62786 -0.671484 2.152255e-01 4.291724e-01 DataSet_03_347
CYP39A1 PARP1 siRNA Prostate LNCaP 1.98896 0.992016 4.282385e-02 0.248087137 DataSet_03_354
CYP39A1 TET1 CRISPR Mammary_gland Hs578T 7.74107 2.95253 1.198200e-04 4.194555e-03 DataSet_03_355
CYP39A1 MYC siRNA Peripheral_blood T lymphocyte 1.76721 0.82147 2.995379e-05 0.005371332 DataSet_03_363
CYP39A1 TP53 knockout Stomach SNU1 2.15041 1.10461 0.2200198709 0.9301241 DataSet_03_365
CYP39A1 ZNF148 shRNA Mammary_gland MDA-MB-231 1.80928 0.855417 7.226998e-03 0.061925694 DataSet_03_366
CYP39A1 ZFP36L1 siRNA Urinary_bladder J82 2 1 - - DataSet_03_371
CYP39A1 E2F1 siRNA Nasopharynx HK1 0.396209 -1.33567 1.036833e-01 5.542060e-01 DataSet_03_373
CYP39A1 ZNF213 siRNA Mammary_gland MCF7 2.05769 1.04103 4.737260e-01 7.112191e-01 DataSet_03_376
CYP39A1 EZH2 CRISPR Ovary SKOV3 1.67416 0.743435 5.389094e-02 0.2029914853 DataSet_03_378
CYP39A1 NFKB2 siRNA Bone_marrow U2OS 0.568627 -0.814444 8.984433e-02 0.34907226 DataSet_03_381
CYP39A1 TCF19 CRISPR Oral_squamous CAL27 0.585755 -0.771631 2.814594e-02 0.1478630005 DataSet_03_383
CYP39A1 NFKBIA shRNA Bone_marrow U2OS 0.559189 -0.838592 5.877249e-01 0.87005461 DataSet_03_389
CYP39A1 ILF2 siRNA Stomach SGC-7901 2.25 1.16992 0.0728100506 0.20545516 DataSet_03_393
CYP39A1 ASXL1 CRISPR Embryo iPSC 3.78079 1.91869 0.0935999074 0.8068108 DataSet_03_394
CYP39A1 BMI1 shRNA Bile_duct QBC-939 3.09023 1.62771 8.053303e-05 0.0017716557 DataSet_03_395
CYP39A1 JAZF1 siRNA Cervix HeLa Kyoto 2.03114 1.02229 7.350032e-01 0.958709924 DataSet_03_396
CYP39A1 RELA CRISPR Brain T30 0.603454 -0.728685 0.6773697142 0.9095383 DataSet_03_399
CYP39A1 EHF shRNA Stomach MKN7 0.0794094 -3.65455 - - DataSet_03_402
CYP39A1 USP22 shRNA Liver HuH7 1.52382 0.607692 - - DataSet_03_411
CYP39A1 E2F6 shRNA Liver HuH7 0.44322 -1.1739 - - DataSet_03_412
CYP39A1 E2F2 siRNA Prostate LNCaP 0.558296 -0.840898 2.164655e-02 1.095893e-01 DataSet_03_414
CYP39A1 ZKSCAN3 CRISPR Colon HCT116 0.578269 -0.790188 3.952076e-02 0.390076496 DataSet_03_415
CYP39A1 FOXK2 shRNA Ovary OVCAR-5 0.333333 -1.58496 1.818267e-02 0.11319160 DataSet_03_419
CYP39A1 MAEL CRISPR Liver Alexander cells 0.158559 -2.65691 - - DataSet_03_423
CYP39A1 USP7 shRNA Skin xenograft cells 0.352709 -1.50345 0.26850499 0.4348960 DataSet_03_431
CYP39A1 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 2 1 - - DataSet_03_432
CYP39A1 EP300 knockout Pancreas HPAF-II orthotopic cells 0.632594 -0.660649 1.629220e-02 6.060478e-02 DataSet_03_436
CYP39A1 CIC knockout Brain Immortalized Astrocyte Cells 2.3528 1.23438 4.134783e-01 8.105979e-01 DataSet_03_438
CYP39A1 SETDB1 shRNA Colon HCT116 2.48641 1.31406 - - DataSet_03_440
CYP39A1 PURA siRNA Cervix HeLa 3.92308 1.97199 1.354164e-03 0.049398523 DataSet_03_444
CYP39A1 RELB CRISPR Colon SW480 1.78862 0.838845 2.935611e-03 3.984302e-02 DataSet_03_449
CYP39A1 CBX2 siRNA Mammary_gland MCF7 6.47808 2.69557 1.011559e-01 0.1914453408 DataSet_03_451
CYP39A1 OGT siRNA Embryo BeWo cells 4.25 2.08746 2.616959e-02 0.48469658 DataSet_03_453
CYP39A1 SMARCA2 shRNA Lung HCC2302 0.250978 -1.99436 1.631286e-09 9.120341e-09 DataSet_03_455
CYP39A1 ARID1A shRNA Bile_duct MMNK1 0.162077 -2.62525 2.202425e-01 0.543824160 DataSet_03_458
CYP39A1 SOX9 knockout Liver HuH7 0.534943 -0.902543 3.694270e-04 4.797537e-03 DataSet_03_463
CYP39A1 PARP1 knockout Embryo_kidney HEK293a 1.55669 0.63848 1.135432e-02 3.522844e-02 DataSet_03_464
CYP39A1 STAT3 shRNA Liver HepG2 1.58163 0.661415 1.148120e-01 0.4609577900 DataSet_03_465
CYP39A1 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.71383 0.777221 - - DataSet_03_467
CYP39A1 SMARCA1 shRNA Embryo_kidney HEK293T 1.64309 0.716409 - - DataSet_03_468
CYP39A1 WHSC1 siRNA Prostate PC3 0.181818 -2.45943 4.434886e-03 0.08619100 DataSet_03_471
CYP39A1 EZH2 siRNA Umbilical_vein HUVEC 0.571429 -0.807355 1.003076e-01 0.326612740 DataSet_03_473
CYP39A1 EZH2 siRNA Prostate LNCaP 0.664062 -0.590609 4.299650e-01 1.0000000 DataSet_03_475
Regulation Region
 
T(co)Fs that significantly regulate TAF15 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of CYP39A1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines