Gene Overview
Target Gene: DOK7
NCBI Official Symbol: DOK7
Entrez ID: 285489
Ensembl ID: ENSG00000175920
Gene Full Name: docking protein 7
Strand: +
Gene Locus: 4p16.3
External Links:

DOK7 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate DOK7   
T(co)Fs that Repress DOK7
The Intensity of the Gene Regulated by T(co)Fs:
DOK7-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
DOK7 ZIC2 siRNA Pancreas PANC1 0.16776 -2.57553 - - DataSet_01_121
DOK7 TFAP2C shRNA Mammary_gland MCF7 0.31003 -1.68951 4.17039e-15 4.61448e-13 DataSet_01_150
DOK7 ELK1 siRNA Peripheral_blood CD4+ T cells 1.54986 0.63214 0.03179 0.11527 DataSet_01_162
DOK7 NFATC3 siRNA Peripheral_blood CD4+ T cells 1.74525 0.80343 0.00949 0.08912 DataSet_01_166
DOK7 HOXB7 siRNA Pancreas MIA PaCa-2 2.67934 1.42188 0.26868 0.7035 DataSet_01_169
DOK7 GATA2 siRNA Prostate LNCaP 2.17791 1.12294 1.53357e-05 0.00028 DataSet_01_193
DOK7 IRX1 shRNA Bone_marrow 143B 0.42384 -1.23841 0.10273 0.32748 DataSet_01_227
DOK7 SIX4 siRNA Ovary PEO1 1.604 0.68167 0.15121 0.38974 DataSet_01_269
DOK7 ESRRA shRNA Embryo_kidney 293T 0.55792 -0.84188 0.01757 0.61379 DataSet_01_280
DOK7 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 0.62251 -0.68382 0.03662 0.30112 DataSet_01_313
DOK7 ARNT siRNA Upper_aerodigestive_tract HSC3 0.51837 -0.94795 - - DataSet_01_315
DOK7 MYC siRNA Colon HCT116 1.88986 0.91828 1.94982e-09 5.85578e-08 DataSet_01_324
DOK7 CDX2 siRNA Colon COLO320 1.95659 0.96834 - - DataSet_01_357
DOK7 FIP1L1 shRNA Liver HepG2 2.14286 1.09954 0.38678 0.49457 DataSet_02_103
DOK7 HDGF shRNA Liver HepG2 1.68421 0.75207 0.80463 0.88774 DataSet_02_104
DOK7 SSB shRNA Liver HepG2 0.45455 -1.1375 0.88092 0.91027 DataSet_02_107
DOK7 HNRNPUL1 shRNA Liver HepG2 5.5 2.45943 0.00017 0.0175 DataSet_02_109
DOK7 BCLAF1 shRNA Liver HepG2 2.85714 1.51457 0.56204 0.66404 DataSet_02_112
DOK7 TARDBP shRNA Liver HepG2 0.15 -2.73697 0.00257 0.02084 DataSet_02_116
DOK7 CEBPZ shRNA Liver HepG2 0.57143 -0.80735 0.00581 1 DataSet_02_118
DOK7 PCBP2 shRNA Liver HepG2 8 3 0.46941 0.63085 DataSet_02_123
DOK7 PRPF4 shRNA Liver HepG2 0.63158 -0.66297 0.62389 0.72385 DataSet_02_128
DOK7 RBFOX2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.6 -0.73697 0.13929 0.50958 DataSet_02_139
DOK7 ZFX siRNA Prostate C4-2B 0.64478 -0.63313 0.26915 0.38187 DataSet_02_172
DOK7 MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 4 2 0.0633 1 DataSet_02_173
DOK7 LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 2.42857 1.28011 0.13547 1 DataSet_02_175
DOK7 CEBPZ siRNA Haematopoietic_and_lymphoid_tissue K562 47 5.55459 0.27015 1 DataSet_02_176
DOK7 ZNF180 siRNA Haematopoietic_and_lymphoid_tissue K562 4 2 0.05791 1 DataSet_02_177
DOK7 VEZF1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.66667 1.41504 0.68432 1 DataSet_02_179
DOK7 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.51742 1 DataSet_02_182
DOK7 MAFK siRNA Haematopoietic_and_lymphoid_tissue K562 9 3.16993 0.04898 1 DataSet_02_183
DOK7 CTCF siRNA Haematopoietic_and_lymphoid_tissue K562 1.6 0.67807 0.59765 1 DataSet_02_185
DOK7 BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 9 3.16993 0.1652 1 DataSet_02_188
DOK7 MAFG siRNA Haematopoietic_and_lymphoid_tissue K562 12 3.58496 0.0359 1 DataSet_02_189
DOK7 LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.14286 -2.80735 0.42437 1 DataSet_02_191
DOK7 MAX siRNA Haematopoietic_and_lymphoid_tissue K562 10 3.32193 0.17387 1 DataSet_02_192
DOK7 TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.28571 -1.80735 0.84057 1 DataSet_02_194
DOK7 LMNB1 siRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.09982 1 DataSet_02_195
DOK7 CDAN1 siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.19833 1 DataSet_02_197
DOK7 E2F4 siRNA Haematopoietic_and_lymphoid_tissue K562 1.57143 0.65208 0.22058 1 DataSet_02_200
DOK7 RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 7 2.80735 0.0391 1 DataSet_02_204
DOK7 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.525043 -0.929492 - - DataSet_03_096
DOK7 MEF2D shRNA Liver HuH7 21.071 4.39718 - - DataSet_03_162
DOK7 MITF siRNA Skin SK-MEL-5 0.610864 -0.711077 0.00222383835859091 0.00644639039008004 DataSet_03_168
DOK7 PBX1 siRNA Mammary_gland MCF7 0.648792 -0.624172 0.000336105282732946 0.0190342307579794 DataSet_03_209
DOK7 SOX2 siRNA Mammary_gland GSC-11 0.428124 -1.2239 0.0230856494633393 0.130123468319779 DataSet_03_245
DOK7 STAT3 CRISPR Embryo hESC 1.6695 0.739419 0.0990122454698248 0.185512527900407 DataSet_03_258
DOK7 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 23.4125 4.54921 0.977954584558739 0.986214080120253 DataSet_04_014
DOK7 YBX1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.647059 -0.628031 0.325697266603524 0.66985076641065 DataSet_04_022
DOK7 MECP2 CRISPR Liver HepG2 2.125 1.08746 0.0532170877824478 0.295655154617719 DataSet_04_031
DOK7 PAN2 CRISPR Liver HepG2 2 1 0.163433356016635 0.337835722294761 DataSet_04_033
DOK7 SMAD2 CRISPR Liver HepG2 0.25 -2 0.0628266490939002 0.612703117514337 DataSet_04_034
DOK7 SMAD4 CRISPR Liver HepG2 2 1 0.830796394297009 0.890093450835475 DataSet_04_035
DOK7 SMAD5 CRISPR Liver HepG2 7.33333 2.87447 0.184049931947647 0.581132301090642 DataSet_04_036
DOK7 WRN shRNA Liver HepG2 2.25 1.16992 0.104391872289975 0.318604007242526 DataSet_04_038
DOK7 ZNF574 CRISPR Liver HepG2 3 1.58496 0.477174392472546 0.609644229374673 DataSet_04_041
DOK7 DDX20 CRISPR Liver HepG2 2 1 0.0509428201189422 0.147519857907814 DataSet_04_043
DOK7 CHCHD3 CRISPR Liver HepG2 30.5 4.93074 0.0233571379408115 0.462359872902174 DataSet_04_067
DOK7 PAN2 CRISPR Liver HepG2 2 1 0.494700183039292 0.669239402164337 DataSet_04_066
DOK7 SEPT11 CRISPR Liver HepG2 5 2.32193 0.413276210973653 0.668240970163044 DataSet_04_068
DOK7 ABT1 shRNA Liver HepG2 3.77778 1.91754 0.334224642584713 0.465186822434784 DataSet_04_052
DOK7 CALR shRNA Liver HepG2 0.357143 -1.48543 0.476905185949747 0.618195694658981 DataSet_04_053
DOK7 RIOK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.6 1.37851 0.553111263589774 0.889614029176953 DataSet_04_076
DOK7 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 2 1 0.911976657786598 0.959244138482525 DataSet_04_049
DOK7 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.487179 -1.03747 0.0403395452929396 0.200694809592774 DataSet_02_38
DOK7 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.551282 -0.859137 0.0771761525065699 0.165034998602605 DataSet_02_14
DOK7 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.346154 -1.53051 0.0245595168880528 0.0802534461444406 DataSet_02_34
DOK7 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.397436 -1.33121 0.0263682183147935 0.0781369260018679 DataSet_02_35
DOK7 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.480769 -1.05658 0.172225970961172 0.467982979525033 DataSet_02_32
DOK7 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.423077 -1.24101 0.0224217846208635 0.0668955727813385 DataSet_02_47
DOK7 TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.192308 -2.37851 0.0102501921622545 0.052529663713119 DataSet_02_43
DOK7 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.371795 -1.42742 0.10880473567743 0.207370897982971 DataSet_02_33
DOK7 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.448718 -1.15612 0.0316268355221698 0.104533999905352 DataSet_02_53
DOK7 EZH2 knockdown Uterus Ishikawa (ISK) cell 1.89649 0.923333 - - DataSet_03_324
DOK7 SMARCA4 siRNA Colon HCT116 1.51486 0.599187 2.344513e-01 9.892536e-01 DataSet_03_301
DOK7 ELF3 CRISPR Bile_duct HBDEC2 0.212908 -2.2317 8.259041e-08 4.259940e-05 DataSet_03_304
DOK7 SNAI2 shRNA Pancreas KLM1 1.78427 0.835336 5.638608e-02 0.32175146 DataSet_03_307
DOK7 ACTR5 siRNA Muscle RD 1.72124 0.783451 - - DataSet_03_343
DOK7 PBX1 siRNA Mammary_gland MCF7 0.648792 -0.624172 3.914086e-04 1.994211e-02 DataSet_03_326
DOK7 EZH2 shRNA Mammary_gland LM2 0.203864 -2.29432 5.142339e-04 4.606852e-02 DataSet_03_350
DOK7 SKI CRISPR Blood HL60 9 3.16992 1.854966e-04 0.037511715 DataSet_03_351
DOK7 ESR1 siRNA Mammary_gland MCF7 0.516522 -0.953097 6.731946e-05 0.0082241015 DataSet_03_352
DOK7 ETV5 knockdown Colon HT29 2.93413 1.55293 1.162011e-02 0.124461589 DataSet_03_353
DOK7 PARP1 siRNA Prostate LNCaP 3.45046 1.78679 4.135518e-01 0.682233117 DataSet_03_354
DOK7 TET1 CRISPR Mammary_gland Hs578T 14.0801 3.81558 3.482302e-04 6.739096e-03 DataSet_03_355
DOK7 CREBBP CRISPR Brain U5-NPC 4.20482 2.07204 0.1341695742 0.7490853 DataSet_03_356
DOK7 PTPN14 CRISPR Brain U5-NPC 0.645669 -0.631133 9.639720e-01 0.98168954 DataSet_03_357
DOK7 NCOA2 siRNA Uterus endometrial stromal cells 0.610169 -0.712718 0.4655676846 1 DataSet_03_360
DOK7 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 0.425371 -1.2332 2.210195e-01 3.235782e-01 DataSet_03_362
DOK7 TP53 knockout Stomach SNU1 0.0948883 -3.39763 0.1887528222 0.9301241 DataSet_03_365
DOK7 DNMT3A knockout Embryo_kidney HEK293T 0.480914 -1.05615 - - DataSet_03_369
DOK7 ZFP36L1 siRNA Urinary_bladder J82 7.91111 2.98388 - - DataSet_03_371
DOK7 ZNF213 siRNA Mammary_gland MCF7 0.374521 -1.41688 4.781897e-01 7.135032e-01 DataSet_03_376
DOK7 EZH2 CRISPR Ovary SKOV3 5.7587 2.52574 4.466894e-05 0.0035299974 DataSet_03_378
DOK7 DDX5 shRNA Stomach HGC-27 0.321429 -1.63743 - - DataSet_03_379
DOK7 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 3.48145 1.79969 0.1392117987 0.8388073 DataSet_03_387
DOK7 NFKBIA shRNA Bone_marrow U2OS 0.102369 -3.28816 1.337188e-01 0.87005461 DataSet_03_389
DOK7 YY1 knockdown Liver HepG2 1.75 0.807355 4.196993e-01 5.965989e-01 DataSet_03_390
DOK7 ILF2 siRNA Stomach SGC-7901 1.5632 0.644504 0.3460192599 0.54723310 DataSet_03_393
DOK7 ASXL1 CRISPR Embryo iPSC 1.62677 0.702006 0.1623668878 0.8187866 DataSet_03_394
DOK7 RELA CRISPR Brain T30 0.00835973 -6.90233 0.3270441417 0.8400824 DataSet_03_399
DOK7 HMGA1 shRNA Bile_duct HUCCT1 9.44961 3.24026 2.507217e-04 0.019863701 DataSet_03_400
DOK7 CDK7 shRNA Bone_marrow D458 4.33333 2.11548 1.900633e-01 0.53698854 DataSet_03_404
DOK7 TFAP2A knockout Embryo H9 2.85 1.51096 5.853329e-04 0.02303534 DataSet_03_405
DOK7 SATB2 CRISPR Colon Colon organoid 1.61519 0.691704 2.169156e-01 0.95735254 DataSet_03_406
DOK7 STRAP knockout Nerve SK-N-AS 4.91777 2.29801 - - DataSet_03_409
DOK7 SIRT1 siRNA Pancreas PANC1 3.1 1.63227 1.310906e-01 0.264935029 DataSet_03_410
DOK7 E2F1 siRNA Prostate LNCaP 0.35 -1.51457 4.695234e-02 0.5197326406 DataSet_03_413
DOK7 ZKSCAN3 CRISPR Colon HCT116 0.338461 -1.56294 3.015251e-03 0.131771574 DataSet_03_415
DOK7 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 2.02941 1.02106 6.668483e-02 0.198321588 DataSet_03_418
DOK7 FOXK2 shRNA Ovary OVCAR-5 0.215385 -2.21501 3.678704e-02 0.15523001 DataSet_03_419
DOK7 BRD4 CRISPR Lymph CD8+ T cells 0.444444 -1.16992 - - DataSet_03_420
DOK7 FOXQ1 CRISPR Lymph Primary CD4+ T cells 1.75 0.807355 - - DataSet_03_422
DOK7 MAEL CRISPR Liver Alexander cells 0.428571 -1.22239 - - DataSet_03_423
DOK7 STAT5B CRISPR Embryo_kidney HEK293 0.4 -1.32193 4.743327e-02 0.542587590 DataSet_03_424
DOK7 LHX2 shRNA Bone_marrow ES-derived RPE cells 0.40172 -1.31574 6.073851e-02 1.000000e+00 DataSet_03_428
DOK7 STAT3 siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 3 1.58496 0.5819392905 1 DataSet_03_430
DOK7 USP7 shRNA Skin xenograft cells 0.596774 -0.744743 0.35895396 0.4901191 DataSet_03_431
DOK7 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 3 1.58496 - - DataSet_03_432
DOK7 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 3.14371 1.65247 1.838018e-03 0.161018501 DataSet_03_434
DOK7 POU2AF1 CRISPR Lymph SUDHL4 9.33733 3.22301 1.746484e-02 0.059129006 DataSet_03_435
DOK7 EP300 knockout Pancreas HPAF-II orthotopic cells 1.92896 0.947827 4.242345e-03 2.238375e-02 DataSet_03_436
DOK7 HMG20A siRNA Mammary_gland MDA-MB-231 0.444444 -1.16992 0.3292704581 0.5171592 DataSet_03_442
DOK7 PHF14 siRNA Mammary_gland MDA-MB-231 0.444444 -1.16992 0.3554602584 0.6499907 DataSet_03_443
DOK7 CAMTA1 knockout Embryo_kidney HEK293T 6.33333 2.66297 8.024104e-05 0.04476915 DataSet_03_448
DOK7 CBX2 siRNA Mammary_gland MDA-MB-231 0.442685 -1.17565 1.598693e-01 3.383289e-01 DataSet_03_450
DOK7 CBX2 siRNA Mammary_gland MCF7 0.333101 -1.58597 1.827562e-03 0.0086155838 DataSet_03_451
DOK7 ZFP36L1 CRISPR Lung NCI-H1876 1.72657 0.787909 1.516420e-01 0.992381486 DataSet_03_454
DOK7 SMARCA2 shRNA Lung HCC2302 20.3076 4.34395 1.557141e-08 6.523104e-08 DataSet_03_455
DOK7 PPARG siRNA Aortic_valve Valvular endothelial cell 0.615385 -0.70044 5.852726e-01 8.576435e-01 DataSet_03_456
DOK7 ARID1A shRNA Bile_duct MMNK1 0.112723 -3.14915 6.349222e-04 0.023783120 DataSet_03_458
DOK7 SOX9 knockout Liver HuH7 2.5 1.32193 4.626408e-01 5.818547e-01 DataSet_03_463
DOK7 PARP1 knockout Embryo_kidney HEK293a 0.265101 -1.91539 8.640969e-07 1.251926e-05 DataSet_03_464
DOK7 STAT3 shRNA Liver HepG2 0.588384 -0.76517 4.825333e-02 0.3495103560 DataSet_03_465
DOK7 SMARCA1 Cas13 Embryo_kidney HEK293T 0.625 -0.678072 - - DataSet_03_466
DOK7 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.65625 0.72792 - - DataSet_03_467
DOK7 SMARCA1 shRNA Embryo_kidney HEK293T 0.625 -0.678072 - - DataSet_03_468
DOK7 EZH2 siRNA Prostate LNCaP 0.237703 -2.07277 - - DataSet_03_472
DOK7 EZH2 siRNA Umbilical_vein HUVEC 2.16667 1.11548 2.169970e-02 0.187071047 DataSet_03_473
DOK7 EZH2 siRNA Prostate LNCaP 3 1.58496 3.592827e-01 1.0000000 DataSet_03_475
DOK7 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 0.4375 -1.19264 0.4032535 0.8030605 DataSet_04_072
Regulation Region
 
T(co)Fs that significantly regulate SMAD5 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of DOK7
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines