Gene Overview
Target Gene: EVPL
NCBI Official Symbol: EVPL
Entrez ID: 2125
Ensembl ID: ENSG00000167880
Gene Full Name: envoplakin
Strand: -
Gene Locus: 17q25.1
External Links:

EVPL Significantly Regulated by These T(co)Fs

T(co)Fs that Activate EVPL   
T(co)Fs that Repress EVPL
The Intensity of the Gene Regulated by T(co)Fs:
EVPL-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
EVPL HOXA1 siRNA Lung_fibroblast IMR-90 1.66405 0.7347 0.08888 0.32244 DataSet_01_110
EVPL BRD4 shRNA Embryo_kidney HEK293 1.78881 0.839 - - DataSet_01_119
EVPL TFAP2C shRNA Mammary_gland MCF7 0.40764 -1.29462 3.36832e-11 1.02492e-09 DataSet_01_150
EVPL ELK1 siRNA Peripheral_blood CD4+ T cells 1206.36 10.2364 0.00666 0.03925 DataSet_01_162
EVPL GATA3 siRNA Peripheral_blood CD4+ T cells 1.56505 0.64621 0.00944 0.1848 DataSet_01_163
EVPL JUN siRNA Peripheral_blood CD4+ T cells 1.73513 0.79504 0.00084 0.01372 DataSet_01_164
EVPL NFATC3 siRNA Peripheral_blood CD4+ T cells 1.82117 0.86487 0.00101 0.02339 DataSet_01_166
EVPL HOXB7 siRNA Pancreas Capan-1 0.66523 -0.58808 0.01125 0.43018 DataSet_01_170
EVPL FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 3.22059 1.68732 - - DataSet_01_208
EVPL LIN28A siRNA Embryo H9 2.81152 1.49135 0.00016 0.0041 DataSet_01_215
EVPL TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 1.88189 0.91218 0.19757 0.37827 DataSet_01_217
EVPL ATM shRNA Mammary_gland MCF10A 0.4048 -1.30473 7.88911e-10 9.39931e-08 DataSet_01_219
EVPL KLF9 siRNA Liver HepG2 1.63233 0.70693 4.86383e-07 1.39855e-05 DataSet_01_222
EVPL HIF1A shRNA Liver HuH7 0.54516 -0.87525 - - DataSet_01_224
EVPL SNAI2 shRNA Skin Primary human keratinocytes 3.05311 1.61028 0.00112 0.01542 DataSet_01_225
EVPL IRX1 shRNA Bone_marrow 143B 0.60844 -0.71682 0.14965 0.39395 DataSet_01_227
EVPL TWIST1 shRNA Stomach CAF32 2.00772 1.00555 0.00959 0.05087 DataSet_01_253
EVPL SIX4 siRNA Ovary PEO1 1.63898 0.7128 0.0031 0.0314 DataSet_01_269
EVPL TFAP4 siRNA Brain BE(2)-C 0.1079 -3.21217 0.23297 0.51625 DataSet_01_295
EVPL ELK3 shRNA Mammary_gland MDA-MB-231 0.59535 -0.7482 9.38974e-05 0.00057 DataSet_01_318
EVPL HOXC6 siRNA Prostate LNCaP 2.93367 1.55271 0.03582 0.99927 DataSet_01_333
EVPL GATA3 siRNA Oral_cavity OEC-M1 0.64581 -0.63082 0.07628 0.99787 DataSet_01_347
EVPL GTF2B siRNA Cervix HeLa 0.63241 -0.66106 - - DataSet_01_362
EVPL SAFB2 shRNA Liver HepG2 2.4844 1.3129 0.00879 0.03856 DataSet_02_102
EVPL U2AF2 shRNA Liver HepG2 1.63214 0.70677 0.60547 0.72268 DataSet_02_105
EVPL HNRNPUL1 shRNA Liver HepG2 2.69458 1.43006 0.00501 0.03022 DataSet_02_109
EVPL BCLAF1 shRNA Liver HepG2 2.27508 1.18591 0.00667 0.04081 DataSet_02_112
EVPL SUB1 shRNA Liver HepG2 0.64643 -0.62944 0.10017 0.26955 DataSet_02_117
EVPL PTBP1 shRNA Liver HepG2 1.94505 0.95981 0.00102 0.00701 DataSet_02_120
EVPL RBM34 shRNA Liver HepG2 0.61786 -0.69465 0.07043 0.43538 DataSet_02_121
EVPL EWSR1 shRNA Liver HepG2 0.62439 -0.67949 0.02262 0.0868 DataSet_02_122
EVPL FUS shRNA Liver HepG2 1.65357 0.72559 0.05007 0.17506 DataSet_02_124
EVPL SNRNP70 shRNA Liver HepG2 0.56801 -0.81602 0.00615 0.04328 DataSet_02_126
EVPL SRSF3 shRNA Liver HepG2 0.53645 -0.89848 0.0091 0.08098 DataSet_02_127
EVPL TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 0.06667 -3.90689 0.00764 0.25699 DataSet_02_129
EVPL POLR2G shRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.11293 0.72262 DataSet_02_130
EVPL PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.26667 -1.90689 0.59044 0.68393 DataSet_02_131
EVPL SRSF9 shRNA Haematopoietic_and_lymphoid_tissue K562 0.13333 -2.90689 0.72812 0.81681 DataSet_02_134
EVPL RBM34 shRNA Haematopoietic_and_lymphoid_tissue K562 0.06667 -3.90689 0.47355 0.66673 DataSet_02_141
EVPL RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 1 1 DataSet_02_143
EVPL DROSHA shRNA Haematopoietic_and_lymphoid_tissue K562 4 2 0.26266 0.59461 DataSet_02_145
EVPL NONO shRNA Haematopoietic_and_lymphoid_tissue K562 5.33333 2.41504 0.41796 0.60646 DataSet_02_149
EVPL RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 4.5 2.16993 0.25834 0.4578 DataSet_02_151
EVPL ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 6 2.58496 0.10151 0.38683 DataSet_02_152
EVPL YBX3 shRNA Haematopoietic_and_lymphoid_tissue K562 22 4.45943 0.00839 0.41577 DataSet_02_153
EVPL SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 1 1 DataSet_02_154
EVPL PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 7 2.80735 0.01422 0.08998 DataSet_02_158
EVPL XRCC5 shRNA Haematopoietic_and_lymphoid_tissue K562 3.5 1.80735 0.00146 0.51074 DataSet_02_159
EVPL SUB1 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.28292 0.838 DataSet_02_161
EVPL RBM22 shRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.70179 0.78866 DataSet_02_168
EVPL MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 6.66667 2.73697 0.59988 1 DataSet_02_173
EVPL NFE2L2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.14286 -2.80735 0.10278 1 DataSet_02_174
EVPL LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 10.4286 3.38247 0.26484 1 DataSet_02_175
EVPL CEBPZ siRNA Haematopoietic_and_lymphoid_tissue K562 0.2 -2.32193 0.07692 1 DataSet_02_176
EVPL ATF3 siRNA Haematopoietic_and_lymphoid_tissue K562 0.14286 -2.80735 0.12711 1 DataSet_02_180
EVPL ZMIZ1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.01236 1 DataSet_02_181
EVPL STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 2.16667 1.11548 0.07026 1 DataSet_02_182
EVPL MAFK siRNA Haematopoietic_and_lymphoid_tissue K562 0.6 -0.73697 0.17872 1 DataSet_02_183
EVPL KAT2B siRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.12176 1 DataSet_02_184
EVPL BHLHE40 siRNA Haematopoietic_and_lymphoid_tissue K562 0.14286 -2.80735 0.12213 1 DataSet_02_186
EVPL BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.6 -0.73697 0.186 1 DataSet_02_188
EVPL MAX siRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.55949 1 DataSet_02_192
EVPL ARID3A siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.17459 1 DataSet_02_193
EVPL TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.28571 -1.80735 0.20557 1 DataSet_02_194
EVPL CDAN1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.6 -0.73697 0.1844 1 DataSet_02_197
EVPL UBTF siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 1 1 DataSet_02_198
EVPL MAZ siRNA Haematopoietic_and_lymphoid_tissue K562 0.44444 -1.16993 0.46348 1 DataSet_02_199
EVPL E2F4 siRNA Haematopoietic_and_lymphoid_tissue K562 0.14286 -2.80735 0.03283 1 DataSet_02_200
EVPL TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.28571 -1.80735 0.24049 1 DataSet_02_201
EVPL ZNF384 siRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.12324 1 DataSet_02_203
EVPL RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.66667 0.73697 0.55643 1 DataSet_02_204
EVPL ASCL1 siRNA Lung DMS79 2.36957 1.24462 0.783594783455852 0.962151000125514 DataSet_03_016
EVPL ATF4 siRNA Skin A375 0.570443 -0.809844 0.0840906967848314 0.775512819201899 DataSet_03_018
EVPL BCL6 siRNA Lymph Pfeiffer DLBCL 0.412131 -1.27883 0.246840046166434 0.711803143115384 DataSet_03_026
EVPL CEBPB siRNA Embryo hESC 2.04376 1.03123 0.109634059111734 0.480223100601992 DataSet_03_049
EVPL FOXA1 siRNA Mammary_gland MCF7 2.13378 1.09341 8.21065124618884e-08 1.23316162049903e-05 DataSet_03_080
EVPL GATA2 siRNA Uterus Decidual stromal cells 0.544939 -0.875834 0.576183592939327 0.950420923032117 DataSet_03_100
EVPL GATA4 siRNA Stomach AGS 0.59915 -0.73901 0.120647753745472 0.773015523839028 DataSet_03_105
EVPL GATA4 siRNA Stomach KatoIII 1.86685 0.900609 0.122068956538051 0.897846043350432 DataSet_03_106
EVPL GATA6 siRNA Stomach AGS 0.490015 -1.0291 0.0114622291848948 0.312469074374033 DataSet_03_108
EVPL GATA6 siRNA Stomach KatoIII 1.96808 0.976788 0.139093356563233 0.66242943399534 DataSet_03_109
EVPL GRHL3 siRNA Skin Primary neonatal keratinocytes 0.620617 -0.688225 0.00357634167462331 0.173720753983663 DataSet_03_113
EVPL KDM3A siRNA Mammary_gland MCF7 2.32146 1.21503 2.50126160230795e-05 0.00185013379872694 DataSet_03_146
EVPL KLF5 siRNA Stomach KatoIII 1.72506 0.786647 0.169474749326104 0.619287456403341 DataSet_03_150
EVPL KLF5 siRNA Stomach YCC3 0.524754 -0.930287 0.0588394609272275 0.354822758668647 DataSet_03_151
EVPL MYB siRNA Cord_Blood CD34+ progenitor cells 2.75163 1.46028 - - DataSet_03_170
EVPL NR2F2 siRNA Uterus Primary eutopic stromal cells 0.591586 -0.75734 0.157565657580465 0.99947668859931 DataSet_03_202
EVPL PRRX1 CRISPR Neuroblastoma 691-MES 0.553945 -0.852184 0.173783393881157 0.89189998148014 DataSet_03_217
EVPL RELB siRNA Immortalized_keratinocyte HaCaT 1.72773 0.788881 0.000227878740733144 0.00246050436511117 DataSet_03_227
EVPL STAT3 CRISPR Embryo hESC 0.544404 -0.87725 0.31336210900854 0.388581161681113 DataSet_03_258
EVPL DDX59 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.222222 -2.16992 0.0654683950484924 0.524294685794557 DataSet_04_006
EVPL E4F1 CRISPR Haematopoietic_and_lymphoid_tissue K562 2 1 0.275374570819935 0.673778456094445 DataSet_04_007
EVPL ERN1 CRISPR Haematopoietic_and_lymphoid_tissue K562 8.5 3.08746 0.107293072654955 0.728174578387128 DataSet_04_009
EVPL NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 92.9011 6.53762 0.658811208886154 0.764650918542855 DataSet_04_014
EVPL ZNF574 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.266767173947115 0.425450741768904 DataSet_04_023
EVPL APTX CRISPR Liver HepG2 3.5 1.80736 0.0368147151097437 0.453731461594758 DataSet_04_025
EVPL E4F1 CRISPR Liver HepG2 1.56848 0.649363 0.0426273405410531 0.294388593075213 DataSet_04_028
EVPL NFX1 CRISPR Liver HepG2 0.461224 -1.11646 0.00725215038889895 0.0303511561907606 DataSet_04_032
EVPL ACTN4 CRISPR Liver HepG2 0.369437 -1.4366 0.00144799357706603 0.0314387418505503 DataSet_04_042
EVPL DNMT3B CRISPR Liver HepG2 1.76227 0.817438 0.00507078938802968 0.0892507984669408 DataSet_04_044
EVPL RIOK2 CRISPR Liver HepG2 1.53684 0.619969 0.417755150005319 1 DataSet_04_070
EVPL CALR shRNA Liver HepG2 0.661337 -0.596542 0.00407317059416393 0.0213683251690886 DataSet_04_053
EVPL CNOT7 shRNA Liver HepG2 2.41542 1.27228 0.000729591451198914 0.00579469582147318 DataSet_04_051
EVPL UBE2L3 shRNA Liver HepG2 2.37413 1.2474 0.00106270362223458 0.011759481826852 DataSet_04_055
EVPL DDX17 CRISPR Haematopoietic_and_lymphoid_tissue K562 8 3 0.514168673114835 0.888796751887105 DataSet_04_047
EVPL RIOK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 4 2 0.775048776309849 0.967550733638122 DataSet_04_076
EVPL SEPT11 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.845012650222536 1 DataSet_04_077
EVPL SMG7 CRISPR Haematopoietic_and_lymphoid_tissue K562 4.66667 2.22239 0.463999193202031 0.771965126719142 DataSet_04_075
EVPL DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.285714 -1.80735 0.0670564737630437 0.148561749712113 DataSet_02_14
EVPL ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.648352 -0.625152 0.418271944960742 0.596079604821404 DataSet_02_34
EVPL HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.293878 -1.76671 0.00215208448836191 0.393478982766751 DataSet_02_75
EVPL HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 4.3956 2.13606 0.00447582600952326 0.369098762874113 DataSet_02_45
EVPL NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.74725 1.45799 0.377693968111685 0.619848370194229 DataSet_02_32
EVPL SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.0989011 -3.33787 0.02411774588836 0.0705590902825935 DataSet_02_47
EVPL SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 6.3 2.65535 0.0509757740040314 0.425660351885773 DataSet_02_49
EVPL TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.131868 -2.92283 0.0250522076492963 0.088736703146132 DataSet_02_43
EVPL TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.406593 -1.29834 0.126294114255157 0.232787312329794 DataSet_02_33
EVPL TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.274725 -1.86394 0.061182084993132 0.160173650674218 DataSet_02_53
EVPL CCAR1 shRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.895489069731582 0.952303727489409 DataSet_04_064
EVPL CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 5 2.32193 0.752558905799367 0.877410668278531 DataSet_04_061
EVPL HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.945843686235354 0.96968361281047 DataSet_04_059
EVPL TET1 siRNA Lung A549 0.596463 -0.745496 - - DataSet_03_318
EVPL TET1 siRNA Lung A549 0.596463 -0.745496 - - DataSet_03_320
EVPL ELF3 CRISPR Bile_duct HBDEC2 0.549194 -0.864613 3.229602e-06 2.084834e-04 DataSet_03_304
EVPL SKI CRISPR Blood HL60 0.5 -1 4.022023e-01 0.667077595 DataSet_03_351
EVPL TET1 CRISPR Mammary_gland Hs578T 0.180314 -2.47142 6.164775e-01 7.735662e-01 DataSet_03_355
EVPL USP22 shRNA Liver PLC_PRF_5 cells 2.16667 1.11548 2.277273e-01 0.44968796 DataSet_03_368
EVPL TPR shRNA Bone_marrow U2OS 1.93238 0.950376 3.832882e-02 2.895413e-01 DataSet_03_370
EVPL ZFP36L1 siRNA Urinary_bladder J82 2.58847 1.3721 - - DataSet_03_371
EVPL GLI1 siRNA Skeletal_muscle RMS13 0.628622 -0.669735 3.455736e-02 0.155977766 DataSet_03_375
EVPL ZNF213 siRNA Mammary_gland MCF7 3.69837 1.88689 3.951433e-01 6.676444e-01 DataSet_03_376
EVPL EZH2 CRISPR Ovary SKOV3 6.83333 2.77259 2.583233e-01 0.4939811976 DataSet_03_378
EVPL DNMT1 siRNA Skin Human melanoma cells 4.36883 2.12725 1.039843e-02 2.248015e-02 DataSet_03_382
EVPL YY1 shRNA Brain GSC1517 0.581395 -0.782409 - - DataSet_03_384
EVPL KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 0.363816 -1.45872 0.7898723820 0.9630615 DataSet_03_387
EVPL NFKBIA shRNA Bone_marrow U2OS 0.00477137 -7.71138 6.386841e-01 0.87005461 DataSet_03_389
EVPL ILF2 siRNA Stomach SGC-7901 2.00637 1.00459 0.2012754263 0.39054725 DataSet_03_393
EVPL ASXL1 CRISPR Embryo iPSC 2.0272 1.01949 0.3403860991 0.8349853 DataSet_03_394
EVPL BMI1 shRNA Bile_duct QBC-939 1.63198 0.706624 4.868884e-01 0.6789399394 DataSet_03_395
EVPL IKZF2 CRISPR Lymph CAR T Cell 0.431389 -1.21294 2.675343e-01 0.753482753 DataSet_03_397
EVPL EHF shRNA Stomach MKN7 0.537138 -0.896636 - - DataSet_03_402
EVPL CDK7 shRNA Bone_marrow D458 0.125 -3 2.151885e-01 0.57077118 DataSet_03_404
EVPL STRAP knockout Nerve SK-N-AS 0.624805 -0.678523 - - DataSet_03_409
EVPL E2F6 shRNA Liver HuH7 1.6296 0.704517 - - DataSet_03_412
EVPL ZKSCAN3 CRISPR Colon HCT116 0.625422 -0.677099 1.094068e-02 0.242148677 DataSet_03_415
EVPL NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 2.05556 1.03953 4.278000e-01 0.637428878 DataSet_03_418
EVPL FOXK2 shRNA Ovary OVCAR-5 1.64989 0.722373 5.529822e-02 0.19324885 DataSet_03_419
EVPL PRDM1 CRISPR Lymph CD8+ T cells 2 1 - - DataSet_03_421
EVPL MAEL CRISPR Liver Alexander cells 0.583893 -0.776225 - - DataSet_03_423
EVPL USP7 shRNA Skin xenograft cells 0.532467 -0.909235 0.26638259 0.4348960 DataSet_03_431
EVPL PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.0843949 -3.5667 - - DataSet_03_432
EVPL POU2AF1 CRISPR Lymph SUDHL4 0.580618 -0.784339 4.292143e-01 0.520653124 DataSet_03_435
EVPL EP300 knockout Pancreas HPAF-II orthotopic cells 1.50462 0.589398 1.879528e-05 5.580007e-04 DataSet_03_436
EVPL SUFU shRNA Mammary_gland HCC1954 cells 0.628113 -0.670904 0.1142107627 0.6455297 DataSet_03_437
EVPL SETDB1 shRNA Colon HCT116 0.336038 -1.5733 - - DataSet_03_440
EVPL CBX2 siRNA Mammary_gland MCF7 1.72804 0.789135 1.401510e-03 0.0070596888 DataSet_03_451
EVPL OGT siRNA Embryo BeWo cells 0.647707 -0.626586 6.436966e-03 0.32330279 DataSet_03_453
EVPL SMARCA2 shRNA Lung HCC2302 3.65599 1.87026 5.539606e-09 2.647882e-08 DataSet_03_455
EVPL ARID1A shRNA Bile_duct MMNK1 0.53478 -0.902982 2.884724e-01 0.545953811 DataSet_03_458
EVPL SOX9 knockout Liver HuH7 5.07407 2.34314 9.706795e-05 2.057930e-03 DataSet_03_463
EVPL PARP1 knockout Embryo_kidney HEK293a 5.31035 2.40881 1.299765e-07 2.595448e-06 DataSet_03_464
EVPL SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 88 6.45943 - - DataSet_03_467
EVPL SMARCA1 shRNA Embryo_kidney HEK293T 4 2 - - DataSet_03_468
EVPL CHCHD3 CRISPR Haematopoietic_and_lymphoid_tissue K562 2 1 0.9204263 1 DataSet_04_071
Regulation Region
 
T(co)Fs that significantly regulate ERN1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of EVPL
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines