Gene Overview
Target Gene: HRCT1
NCBI Official Symbol: HRCT1
Entrez ID: 646962
Ensembl ID: ENSG00000196196
Gene Full Name: histidine rich carboxyl terminus 1
Strand: +
Gene Locus: 9p13.3
External Links:

HRCT1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate HRCT1   
T(co)Fs that Repress HRCT1
The Intensity of the Gene Regulated by T(co)Fs:
HRCT1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
HRCT1 HNF1B shRNA Ovary RMG2 1.90527 0.93 0.01508 0.03573 DataSet_01_103
HRCT1 HOXA1 siRNA Lung_fibroblast IMR-90 0.50733 -0.97902 0.05037 0.2398 DataSet_01_110
HRCT1 ID1 siRNA Lung A549 2.35394 1.23507 0.02128 0.17741 DataSet_01_117
HRCT1 ZIC2 siRNA Pancreas PANC1 5.06322 2.34005 - - DataSet_01_121
HRCT1 FOXM1 siRNA Central_nervous_system U87 9.38986 3.2311 - - DataSet_01_122
HRCT1 ZNF431 siRNA Gastrointestinal_tissue GIST-T1 1.57586 0.65614 0.00159 0.01164 DataSet_01_128
HRCT1 SF1 siRNA Adrenal_gland H295R/TR 1.50655 0.59124 4.4245e-05 0.00148 DataSet_01_146
HRCT1 STAT1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 2.58333 1.36923 0.03776 0.23698 DataSet_01_154
HRCT1 GATA3 siRNA Peripheral_blood CD4+ T cells 0.6648 -0.58901 0.52992 0.79108 DataSet_01_163
HRCT1 NFKB1 siRNA Peripheral_blood CD4+ T cells 0.59885 -0.73973 0.34033 0.81139 DataSet_01_167
HRCT1 STAT3 siRNA Peripheral_blood CD4+ T cells 0.63585 -0.65324 0.4435 0.99183 DataSet_01_168
HRCT1 HOXB7 siRNA Pancreas MIA PaCa-2 0.53587 -0.90004 0.01198 0.57972 DataSet_01_169
HRCT1 HOXB7 siRNA Pancreas Capan-1 0.64123 -0.64108 0.04671 0.5441 DataSet_01_170
HRCT1 GATA2 siRNA Prostate LNCaP 2.33358 1.22254 0.02129 0.06183 DataSet_01_193
HRCT1 CREB1 shRNA Parotid_gland H3118 MEC 1.59416 0.6728 0.71606 0.89027 DataSet_01_194
HRCT1 TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.66721 0.73743 - - DataSet_01_197
HRCT1 TP63 siRNA Head_and_neck SCC-1 1.7997 0.84776 - - DataSet_01_199
HRCT1 TP63 siRNA Immortalized_keratinocyte HaCaT 0.58845 -0.76501 - - DataSet_01_200
HRCT1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 0.62057 -0.68834 - - DataSet_01_208
HRCT1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 6.40008 2.67809 - - DataSet_01_210
HRCT1 EGR3 shRNA Prostate M12 1.79161 0.84125 0.08762 0.29639 DataSet_01_212
HRCT1 KLF2 shRNA Bone_marrow RPMI8226 0.2895 -1.78837 0.1599 0.76358 DataSet_01_226
HRCT1 MYC siRNA White_adipose_tissue Adipose stem cells 1.65191 0.72414 0.11069 0.34636 DataSet_01_231
HRCT1 TWIST1 shRNA Stomach CAF14 0.6064 -0.72166 0.34902 0.99996 DataSet_01_252
HRCT1 FOXO3 siRNA Pancreas PANC1 0.38111 -1.39173 - - DataSet_01_267
HRCT1 STAT5 shRNA Prostate CWR22Pc 1.51994 0.60402 0.03774 0.12478 DataSet_01_279
HRCT1 POSTN shRNA Brain GSC272 0.32209 -1.63447 0.03458 0.529 DataSet_01_293
HRCT1 TFAP4 siRNA Brain BE(2)-C 0.12586 -2.99005 0.22572 0.51625 DataSet_01_295
HRCT1 ETV5 siRNA Soft_tissue hADSC 0.6434 -0.6362 0.0097 0.07607 DataSet_01_304
HRCT1 ARNT siRNA Upper_aerodigestive_tract HSC3 0.63841 -0.64744 - - DataSet_01_315
HRCT1 MYC siRNA Colon HCT116 1.75223 0.80919 0.00124 0.00364 DataSet_01_324
HRCT1 SAFB2 shRNA Liver HepG2 2.16176 1.11221 0.00371 0.02737 DataSet_02_102
HRCT1 TAF15 shRNA Liver HepG2 2.54 1.34483 0.09604 0.14803 DataSet_02_106
HRCT1 ZNF622 shRNA Liver HepG2 1.57895 0.65896 0.33305 0.41138 DataSet_02_108
HRCT1 BCLAF1 shRNA Liver HepG2 2.52727 1.33758 0.08054 0.16603 DataSet_02_112
HRCT1 SUB1 shRNA Liver HepG2 0.36842 -1.44057 0.46306 0.63317 DataSet_02_117
HRCT1 PTBP1 shRNA Liver HepG2 3.04 1.60407 0.00041 0.00601 DataSet_02_120
HRCT1 RBM34 shRNA Liver HepG2 1.78947 0.83954 0.09363 0.4494 DataSet_02_121
HRCT1 EWSR1 shRNA Liver HepG2 1.84615 0.88452 0.18648 0.30617 DataSet_02_122
HRCT1 PRPF4 shRNA Liver HepG2 0.55 -0.8625 0.22701 0.34889 DataSet_02_128
HRCT1 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.04571 0.14829 DataSet_02_147
HRCT1 RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 1.6 0.67807 0.19694 0.39967 DataSet_02_151
HRCT1 ZFX siRNA Prostate C4-2B 0.14667 -2.76939 0.27624 0.38956 DataSet_02_172
HRCT1 TBL1XR1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.55556 1.35364 0.1195 1 DataSet_02_178
HRCT1 VEZF1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.36111 -1.46949 0.78385 1 DataSet_02_179
HRCT1 ZMIZ1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.47826 -1.06413 0.17402 1 DataSet_02_181
HRCT1 CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.34375 -1.54057 0.64515 1 DataSet_02_187
HRCT1 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 0.3908 -1.35548 0.669 1 DataSet_02_190
HRCT1 UBTF siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.7535 1 DataSet_02_198
HRCT1 MAZ siRNA Haematopoietic_and_lymphoid_tissue K562 1.90625 0.93074 0.24274 1 DataSet_02_199
HRCT1 ZNF384 siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.18786 1 DataSet_02_203
HRCT1 BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.635636 -0.653728 0.41811568183043 0.884899832880958 DataSet_03_025
HRCT1 FOXF2 siRNA Mammary_gland MCF10A 1.69922 0.764871 - - DataSet_03_086
HRCT1 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 2.44128 1.28764 - - DataSet_03_096
HRCT1 GATA2 siRNA Uterus Decidual stromal cells 1.96347 0.973408 0.211447518647796 0.819182319100469 DataSet_03_100
HRCT1 GATA2 siRNA Lymph Lymphatic endothelial cells 2.77973 1.47494 0.00100780096271067 0.00390402507422515 DataSet_03_101
HRCT1 GATA4 siRNA Stomach AGS 0.573862 -0.801224 0.422496364591149 0.910001867437968 DataSet_03_105
HRCT1 GATA6 siRNA Stomach KatoIII 1.56699 0.647992 0.119867374836213 0.642645251074052 DataSet_03_109
HRCT1 MEF2D shRNA Liver HuH7 0.386166 -1.37271 - - DataSet_03_162
HRCT1 MEF2D siRNA Liver HuH7 0.563758 -0.826852 - - DataSet_03_163
HRCT1 PHB shRNA Embryo Embryonic stem cells (ESCs) 2.11187 1.07852 0.0696908489538283 0.146473514292256 DataSet_03_211
HRCT1 RELB siRNA Immortalized_keratinocyte HaCaT 1.5126 0.597027 0.00173313814715772 0.0130796174848313 DataSet_03_227
HRCT1 SOX2 siRNA Mammary_gland GSC-11 0.546322 -0.872177 0.175689480277337 0.419236490598517 DataSet_03_245
HRCT1 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.10101 -3.30743 - - DataSet_03_246
HRCT1 SP1 siRNA Cervix HeLa 0.638904 -0.646329 4.09511624984151e-05 0.00105815560677776 DataSet_03_249
HRCT1 SP1 siRNA Ovary OVSAYO 5.6527 2.49894 0.0726097724882328 0.32934807878625 DataSet_03_251
HRCT1 STAT3 CRISPR Embryo hESC 0.513294 -0.962143 0.797689612048834 0.834837863009253 DataSet_03_258
HRCT1 ZNF165 siRNA Mammary_gland SUM159 0.615723 -0.699647 0.516468743405553 0.999998167536832 DataSet_03_288
HRCT1 ZNF746 siRNA Colon HCT116 0.575146 -0.798 - - DataSet_03_293
HRCT1 CTCF CRISPR Liver HepG2 2.47619 1.30812 0.0198793342274287 0.826365031008184 DataSet_04_027
HRCT1 NFX1 CRISPR Liver HepG2 0.626866 -0.673772 0.025487909232763 0.0643671537653258 DataSet_04_032
HRCT1 PAN2 CRISPR Liver HepG2 1.53704 0.620152 0.124604452763418 0.287674304272545 DataSet_04_033
HRCT1 SMAD2 CRISPR Liver HepG2 0.564706 -0.824428 0.120425453299605 0.661976857135891 DataSet_04_034
HRCT1 ZNF574 CRISPR Liver HepG2 0.574074 -0.800691 0.028028241266589 0.106848814826493 DataSet_04_041
HRCT1 DDX20 CRISPR Liver HepG2 2.07843 1.0555 0.0648882956418673 0.170031718546859 DataSet_04_043
HRCT1 APTX CRISPR Liver HepG2 2.47619 1.30812 0.0534724871834385 0.748396033496868 DataSet_04_069
HRCT1 CHCHD3 CRISPR Liver HepG2 0.472222 -1.08246 0.100605597344418 0.489086928296688 DataSet_04_067
HRCT1 ABT1 shRNA Liver HepG2 0.104478 -3.25873 0.00800477747855802 0.0300630913670257 DataSet_04_052
HRCT1 CCAR1 shRNA Liver HepG2 3.74419 1.90465 0.0225223573073526 0.0777974345677119 DataSet_04_054
HRCT1 PRPF6 shRNA Liver HepG2 2.15789 1.10962 0.558491858680496 0.752924269288033 DataSet_04_056
HRCT1 YBX3 shRNA Liver HepG2 0.25 -2 0.0353038678535636 0.138121627067473 DataSet_02_98
HRCT1 RIOK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.227273 -2.1375 0.420111851828336 0.838706352315303 DataSet_04_076
HRCT1 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.44186 -1.17834 0.340828200406892 0.600163021936628 DataSet_02_38
HRCT1 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.209302 -2.25634 0.146657696991537 0.284295402577796 DataSet_02_34
HRCT1 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.6 -0.736966 0.811538540949827 0.954884013412453 DataSet_02_75
HRCT1 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.95349 1.56242 0.106438469827564 0.591056747702649 DataSet_02_45
HRCT1 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.302326 -1.72583 0.168835311050955 0.466149450429617 DataSet_02_32
HRCT1 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.186047 -2.42626 0.118533956307779 0.229414304108837 DataSet_02_47
HRCT1 TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.255814 -1.96683 0.170355824959357 0.329757744549297 DataSet_02_43
HRCT1 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.372093 -1.42626 0.191146324304373 0.345632749727845 DataSet_02_53
HRCT1 EZH2 knockdown Uterus Ishikawa (ISK) cell 1.60585 0.683333 - - DataSet_03_324
HRCT1 SMARCA4 siRNA Colon HCT116 0.476926 -1.06816 1.087093e-02 0.1381439 DataSet_03_302
HRCT1 SNAI2 shRNA Pancreas pancreatic cancer stem cells 0.656117 -0.607974 2.011931e-01 0.6510154 DataSet_03_306
HRCT1 AEBP1 siRNA Central_nervous_system U87MG 0.610479 -0.711987 3.965328e-02 0.9964883 DataSet_03_338
HRCT1 BRCA1 siRNA Mammary_gland MCF7 0.556166 -0.846412 9.473473e-02 0.9999931 DataSet_03_308
HRCT1 EZH2 shRNA Mammary_gland LM2 1.7126 0.776192 5.749969e-01 8.704736e-01 DataSet_03_350
HRCT1 ESR1 siRNA Mammary_gland MCF7 1.64727 0.720079 3.518297e-02 0.1486469429 DataSet_03_352
HRCT1 PARP1 siRNA Prostate LNCaP 0.634575 -0.656138 4.281905e-01 0.692047400 DataSet_03_354
HRCT1 PTPN14 CRISPR Brain U5-NPC 2.29787 1.2003 3.132909e-02 0.26086414 DataSet_03_357
HRCT1 TP53 CRISPR Brain U5-NPC 0.425703 -1.23208 1.284975e-01 2.637828e-01 DataSet_03_358
HRCT1 TP53 knockout Stomach SNU1 2.4215 1.2759 0.4226710970 0.9354741 DataSet_03_365
HRCT1 USP22 shRNA Liver PLC_PRF_5 cells 4 2 1.973918e-03 0.07176012 DataSet_03_368
HRCT1 TPR shRNA Bone_marrow U2OS 2.46727 1.30291 7.950671e-09 1.194403e-05 DataSet_03_370
HRCT1 GLI1 siRNA Skeletal_muscle RMS13 0.44023 -1.18367 2.530791e-02 0.129392757 DataSet_03_375
HRCT1 SMARCA2 shRNA Lung NCI-H1944 0.58693 -0.76874 1.240656e-02 2.398145e-01 DataSet_03_377
HRCT1 EZH2 CRISPR Ovary SKOV3 3.77161 1.91518 1.602819e-02 0.1003059362 DataSet_03_378
HRCT1 DDX5 shRNA Stomach HGC-27 0.407407 -1.29546 - - DataSet_03_379
HRCT1 ZBTB7A siRNA Stomach BGC823 1.61269 0.689472 - - DataSet_03_380
HRCT1 NFKB2 siRNA Bone_marrow U2OS 0.372727 -1.42381 2.013843e-03 0.07524581 DataSet_03_381
HRCT1 TCF19 CRISPR Oral_squamous CAL27 0.499231 -1.00222 4.320771e-01 0.7049313714 DataSet_03_383
HRCT1 YY1 shRNA Brain GSC1517 4 2 - - DataSet_03_384
HRCT1 YY1 shRNA Brain GSC23 3.66667 1.87447 - - DataSet_03_385
HRCT1 YY1 shRNA Brain GSC3028 2 1 - - DataSet_03_386
HRCT1 TRIM8 siRNA Mammary_gland MCF7 2 1 6.651309e-01 0.8015595295 DataSet_03_388
HRCT1 NFKBIA shRNA Bone_marrow U2OS 0.325984 -1.61713 1.356105e-01 0.87005461 DataSet_03_389
HRCT1 KDM5A CRISPR Lung GLC16 2.18024 1.12449 6.261664e-01 0.763345107 DataSet_03_392
HRCT1 ILF2 siRNA Stomach SGC-7901 1.75 0.807355 0.0123619935 0.05372910 DataSet_03_393
HRCT1 RELA CRISPR Brain T30 1.61207 0.688918 0.4434150364 0.8400824 DataSet_03_399
HRCT1 HMGA1 shRNA Bile_duct HUCCT1 2.15772 1.10951 1.930085e-03 0.052079589 DataSet_03_400
HRCT1 EHF shRNA Stomach MKN7 0.123615 -3.01607 - - DataSet_03_402
HRCT1 TFAP2A knockout Embryo H9 2 1 6.758596e-01 0.76331870 DataSet_03_405
HRCT1 SATB2 CRISPR Colon Colon organoid 0.513265 -0.962223 3.856733e-01 0.95735254 DataSet_03_406
HRCT1 CHD1 shRNA Prostate LNCaP 0.618182 -0.693897 5.688052e-01 9.223102e-01 DataSet_03_407
HRCT1 E2F2 siRNA Prostate LNCaP 0.4 -1.32193 1.949631e-01 4.399543e-01 DataSet_03_414
HRCT1 FOXQ1 CRISPR Lymph Primary CD4+ T cells 0.5 -1 - - DataSet_03_422
HRCT1 MAEL CRISPR Liver Alexander cells 2.28571 1.19265 - - DataSet_03_423
HRCT1 USP7 shRNA Skin xenograft cells 0.457926 -1.12681 0.33437580 0.4751451 DataSet_03_431
HRCT1 EP300 knockout Pancreas HPAF-II orthotopic cells 2.01936 1.01389 2.398079e-06 1.545350e-04 DataSet_03_436
HRCT1 SUFU shRNA Mammary_gland HCC1954 cells 4.16667 2.05889 0.0537131715 0.5453361 DataSet_03_437
HRCT1 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 5.83333 2.54432 2.179079e-01 0.90558273 DataSet_03_439
HRCT1 DAXX shRNA Mammary_gland MDA-MB-231 0.352076 -1.50604 6.348918e-02 0.27938677 DataSet_03_441
HRCT1 HMG20A siRNA Mammary_gland MDA-MB-231 0.375 -1.41504 0.0265330182 0.2073166 DataSet_03_442
HRCT1 PHF14 siRNA Mammary_gland MDA-MB-231 0.555556 -0.847997 0.0969204673 0.5143929 DataSet_03_443
HRCT1 CAMTA1 knockout Embryo_kidney HEK293T 2.5 1.32193 3.800421e-01 0.50814887 DataSet_03_448
HRCT1 RELB CRISPR Colon SW480 1.88816 0.916979 2.543752e-02 1.290773e-01 DataSet_03_449
HRCT1 CBX2 siRNA Mammary_gland MDA-MB-231 0.404659 -1.30522 7.968318e-02 2.089012e-01 DataSet_03_450
HRCT1 CBX2 siRNA Mammary_gland MCF7 3.0523 1.6099 3.835610e-02 0.0880031077 DataSet_03_451
HRCT1 OGT siRNA Embryo BeWo cells 0.6 -0.736966 4.066336e-01 0.74549979 DataSet_03_453
HRCT1 ZFP36L1 CRISPR Lung NCI-H1876 0.480386 -1.05773 6.231689e-01 0.992381486 DataSet_03_454
HRCT1 PPARG siRNA Aortic_valve Valvular endothelial cell 0.613582 -0.704671 2.598553e-05 3.061541e-03 DataSet_03_456
HRCT1 ARID1A shRNA Bile_duct MMNK1 1.94403 0.959053 2.304280e-03 0.044666842 DataSet_03_458
HRCT1 SOX9 knockout Liver HuH7 0.181818 -2.45943 4.542713e-02 1.316927e-01 DataSet_03_463
Regulation Region
 
T(co)Fs that significantly regulate BCL11A by the evidences of both expression and ChIP-seq/motif
Expression Atlas of HRCT1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines