Gene Overview
Target Gene: KCNH6
NCBI Official Symbol: KCNH6
Entrez ID: 81033
Ensembl ID: ENSG00000173826
Gene Full Name: potassium voltage-gated channel subfamily H member 6
Strand: +
Gene Locus: 17q23.3
External Links:

KCNH6 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate KCNH6   
T(co)Fs that Repress KCNH6
The Intensity of the Gene Regulated by T(co)Fs:
KCNH6-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
KCNH6 HOXA1 siRNA Lung_fibroblast IMR-90 8.82119 3.14097 0.00013 0.01279 DataSet_01_110
KCNH6 ID1 siRNA Lung H1650 1.53604 0.61922 0.15585 0.51066 DataSet_01_118
KCNH6 FOXM1 siRNA Central_nervous_system U87 0.34177 -1.54889 - - DataSet_01_122
KCNH6 ID1 shRNA Neuroepithelium GSC8 0.53036 -0.91496 8.36681e-10 3.4887e-09 DataSet_01_134
KCNH6 REST siRNA Adrenal_gland H295R/TR 1.58541 0.66486 5.70327e-05 0.0139 DataSet_01_145
KCNH6 HSF1 shRNA Skin A375 1.60485 0.68244 0.06163 0.22126 DataSet_01_155
KCNH6 JUN siRNA Peripheral_blood CD4+ T cells 0.6408 -0.64205 0.27625 0.54165 DataSet_01_164
KCNH6 NFKB1 siRNA Peripheral_blood CD4+ T cells 1.84133 0.88075 0.05095 0.59432 DataSet_01_167
KCNH6 HOXB7 siRNA Pancreas MIA PaCa-2 1.52437 0.60821 0.26648 0.70153 DataSet_01_169
KCNH6 TP53 siRNA Lung SAECs 3.97134 1.98962 0.00883 0.25051 DataSet_01_175
KCNH6 HSF1 shRNA Liver KYN2 1.77058 0.82422 - - DataSet_01_178
KCNH6 GABPA shRNA Prostate C4-2B 874.411 9.77217 0.23863 0.43934 DataSet_01_190
KCNH6 GABPA shRNA Prostate LNCaP 419.117 8.71121 0.45988 0.7048 DataSet_01_191
KCNH6 GATA2 siRNA Prostate LNCaP 6.7255 2.74964 9.89038e-06 0.00021 DataSet_01_193
KCNH6 CREB1 shRNA Parotid_gland H3118 MEC 3.96244 1.98639 0.20456 0.56858 DataSet_01_194
KCNH6 TP63 siRNA Head_and_neck SCC-012 2.54377 1.34697 - - DataSet_01_201
KCNH6 TP63 siRNA Head_and_neck SCC-6 2.45433 1.29533 - - DataSet_01_202
KCNH6 ATF2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.35452 -1.49608 0.3601 0.98802 DataSet_01_206
KCNH6 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 2.98347 1.57699 - - DataSet_01_208
KCNH6 REST siRNA Prostate LNCaP 53.0967 5.73055 0.00029 0.04199 DataSet_01_211
KCNH6 LIN28A siRNA Embryo H9 0.47555 -1.07233 0.00203 0.01874 DataSet_01_215
KCNH6 IRF4 shRNA Lymph BL2 0.59928 -0.7387 - - DataSet_01_262
KCNH6 FOXO1 siRNA Umbilical_vein HUVEC 0.59744 -0.74314 0.00561 0.0483 DataSet_01_270
KCNH6 MSX1 siRNA Tooth Dental Pulp Cells 0.39766 -1.3304 0.08921 0.17346 DataSet_01_281
KCNH6 POSTN shRNA Brain GSC272 2.71414 1.44049 0.06591 0.53976 DataSet_01_293
KCNH6 TFAP4 siRNA Brain BE(2)-C 0.17423 -2.52091 0.29738 0.51625 DataSet_01_295
KCNH6 MYCN siRNA Brain BE(2)-C 1.62833 0.70339 0.87292 1 DataSet_01_296
KCNH6 SOX7 siRNA Umbilical_vein HUVEC 0.41087 -1.28326 0.00669 0.89788 DataSet_01_299
KCNH6 SOX17 siRNA Umbilical_vein HUVEC 0.45341 -1.14111 0.0256 0.99998 DataSet_01_300
KCNH6 ARNT siRNA Upper_aerodigestive_tract HSC3 1.73626 0.79598 - - DataSet_01_315
KCNH6 CDX2 siRNA Colon COLO320 2.32095 1.21472 - - DataSet_01_357
KCNH6 SAFB2 shRNA Liver HepG2 2.55556 1.35364 0.03397 0.0822 DataSet_02_102
KCNH6 FIP1L1 shRNA Liver HepG2 0.33333 -1.58496 0.46505 0.56702 DataSet_02_103
KCNH6 HDGF shRNA Liver HepG2 2.5 1.32193 0.08695 0.23344 DataSet_02_104
KCNH6 SSB shRNA Liver HepG2 1.66667 0.73697 0.49263 0.56138 DataSet_02_107
KCNH6 HNRNPUL1 shRNA Liver HepG2 3.66667 1.87447 0.01786 0.05521 DataSet_02_109
KCNH6 PCBP1 shRNA Liver HepG2 0.10345 -3.27302 0.00785 0.02893 DataSet_02_115
KCNH6 TARDBP shRNA Liver HepG2 0.5 -1 0.07479 0.1367 DataSet_02_116
KCNH6 SUB1 shRNA Liver HepG2 0.16667 -2.58496 0.00423 0.12645 DataSet_02_117
KCNH6 CEBPZ shRNA Liver HepG2 2 1 0.82777 1 DataSet_02_118
KCNH6 RBM25 shRNA Liver HepG2 0.41379 -1.27302 0.05816 0.11786 DataSet_02_119
KCNH6 PTBP1 shRNA Liver HepG2 0.03448 -4.85798 0.01498 0.03036 DataSet_02_120
KCNH6 HNRNPLL shRNA Liver HepG2 0.5 -1 0.07063 0.12402 DataSet_02_125
KCNH6 PRPF4 shRNA Liver HepG2 2.14286 1.09954 0.02983 0.09423 DataSet_02_128
KCNH6 XRCC5 shRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.08535 0.65208 DataSet_02_159
KCNH6 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.08472 0.27842 DataSet_02_171
KCNH6 MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.18151 1 DataSet_02_173
KCNH6 MAFK siRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.09267 1 DataSet_02_183
KCNH6 AR siRNA Prostate abl cells 3.44271 1.78354 0.0300293349204783 0.999852161656754 DataSet_03_004
KCNH6 AR siRNA Prostate LNCaP 0.663569 -0.591682 0.347820030820645 1 DataSet_03_005
KCNH6 ARID1A siRNA Mammary_gland MDA-MB-157 0.583588 -0.776977 - - DataSet_03_014
KCNH6 ATF4 siRNA Skin A375 0.63133 -0.663535 0.155289901566546 0.775512819201899 DataSet_03_018
KCNH6 BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.272737 -1.87442 7.64981032008196e-05 0.141642738119488 DataSet_03_025
KCNH6 GATA4 siRNA Stomach YCC3 1.6961 0.762222 0.176345021739777 0.713359804762575 DataSet_03_107
KCNH6 GATA6 siRNA Stomach YCC3 1.61769 0.693937 0.135195060019869 0.754574804685218 DataSet_03_110
KCNH6 HNF4a siRNA Liver HepG2 0.596698 -0.744927 0.223069850563665 0.816311318364832 DataSet_03_126
KCNH6 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 0.471004 -1.08619 0.0380086232076586 0.771416876084002 DataSet_03_134
KCNH6 MEF2D shRNA Liver HuH7 0.589458 -0.76254 - - DataSet_03_162
KCNH6 MEF2D siRNA Liver HuH7 1.62578 0.701134 - - DataSet_03_163
KCNH6 MITF siRNA Skin SK-MEL-5 0.605136 -0.724668 0.00163375657087668 0.00502124376681803 DataSet_03_168
KCNH6 MYB siRNA Cord_Blood CD34+ progenitor cells 0.615964 -0.699083 - - DataSet_03_170
KCNH6 MYC siRNA Colon HT29 0.638648 -0.646906 - - DataSet_03_177
KCNH6 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.586898 -0.768819 0.0184750471625293 0.051338812723325 DataSet_03_211
KCNH6 SOX2 siRNA Lung LK2 2.02213 1.01588 - - DataSet_03_241
KCNH6 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 1.75 0.807355 - - DataSet_03_246
KCNH6 TFAP2C siRNA Mammary_gland MCF7 3.438 1.78157 0.00401836268196176 0.224272278035778 DataSet_03_274
KCNH6 ZNF746 siRNA Colon HCT116 2.30218 1.203 - - DataSet_03_293
KCNH6 CIZ1 CRISPR Liver HepG2 1.875 0.906891 0.00494225809787018 0.172884254387876 DataSet_04_026
KCNH6 E4F1 CRISPR Liver HepG2 0.461538 -1.11548 0.10186967293429 0.378909970700666 DataSet_04_028
KCNH6 ERN1 CRISPR Liver HepG2 2.05556 1.03953 0.0255227237620613 0.139923046600299 DataSet_04_029
KCNH6 MECP2 CRISPR Liver HepG2 1.83333 0.874469 0.0405403775901804 0.272553694228538 DataSet_04_031
KCNH6 NFX1 CRISPR Liver HepG2 0.5625 -0.830075 0.157305667566405 0.237887669552951 DataSet_04_032
KCNH6 WRN shRNA Liver HepG2 2.22222 1.152 0.0435377828083825 0.230684183046447 DataSet_04_038
KCNH6 YBX1 CRISPR Liver HepG2 3 1.58496 0.145083911702128 0.972884761036538 DataSet_04_039
KCNH6 CHCHD3 CRISPR Liver HepG2 0.227273 -2.1375 0.241078118628093 0.595742324674931 DataSet_04_067
KCNH6 DNMT3B CRISPR Liver HepG2 0.615385 -0.70044 0.581799313571314 0.801047182022706 DataSet_04_044
KCNH6 PAN2 CRISPR Liver HepG2 0.2 -2.32193 0.537946226853737 0.706983820702152 DataSet_04_066
KCNH6 SEPT11 CRISPR Liver HepG2 2.14286 1.09954 0.366300142234916 0.624752936354353 DataSet_04_068
KCNH6 CALR shRNA Liver HepG2 0.333333 -1.58496 0.845757463754948 0.914661901021958 DataSet_04_053
KCNH6 CCAR1 shRNA Liver HepG2 2.83333 1.5025 0.392297963876578 0.550529244125708 DataSet_04_054
KCNH6 CNOT7 shRNA Liver HepG2 0.438596 -1.18903 0.113730038377421 0.18444534936853 DataSet_04_051
KCNH6 PRPF6 shRNA Liver HepG2 2.5 1.32193 0.484679595154054 0.695011314784902 DataSet_04_056
KCNH6 UBE2L3 shRNA Liver HepG2 1.8 0.847997 0.741876637362663 0.848100157193072 DataSet_04_055
KCNH6 SEPT11 CRISPR Haematopoietic_and_lymphoid_tissue K562 2 1 0.920488752644846 1 DataSet_04_077
KCNH6 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 14 3.80735 0.303762690366752 0.565941315879848 DataSet_02_38
KCNH6 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2 1 0.921487806554394 0.960584600082578 DataSet_02_14
KCNH6 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 7 2.80735 0.634476236324436 0.780909387455737 DataSet_02_34
KCNH6 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 54 5.75489 0.0794855879692876 0.55508167510044 DataSet_02_45
KCNH6 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 22 4.45943 0.194365643066971 0.343679926108228 DataSet_02_35
KCNH6 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 65 6.02237 0.0753862802515142 0.401193784258846 DataSet_02_32
KCNH6 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2 1 0.917590898575421 0.958356513436659 DataSet_02_47
KCNH6 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 9.5 3.24793 0.474426396215819 0.822873772792637 DataSet_02_49
KCNH6 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 18 4.16993 0.155705802626087 0.30026248049925 DataSet_02_53
KCNH6 SMARCA4 siRNA Colon HCT116 1.77493 0.827762 2.314191e-01 9.892536e-01 DataSet_03_301
KCNH6 ACTR5 siRNA Muscle RD 0.551275 -0.859157 - - DataSet_03_343
KCNH6 INO80 siRNA Muscle RD 0.387148 -1.36904 - - DataSet_03_344
KCNH6 EZH2 knockdown Colon HCT116 2.03836 1.02741 0.029121037 0.8488990 DataSet_03_334
KCNH6 SKI CRISPR Blood HL60 2 1 2.435363e-01 0.615851377 DataSet_03_351
KCNH6 ESR1 siRNA Mammary_gland MCF7 2.29618 1.19923 2.852190e-03 0.0325819685 DataSet_03_352
KCNH6 PARP1 siRNA Prostate LNCaP 0.292885 -1.77159 6.427419e-02 0.293660489 DataSet_03_354
KCNH6 CREBBP CRISPR Brain U5-NPC 3 1.58496 0.1012259700 0.7490853 DataSet_03_356
KCNH6 PTPN14 CRISPR Brain U5-NPC 0.5 -1 9.235481e-02 0.31899967 DataSet_03_357
KCNH6 TP53 CRISPR Brain U5-NPC 1.83333 0.874469 2.390336e-01 3.720864e-01 DataSet_03_358
KCNH6 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 4.71535 2.23736 2.098417e-01 4.433892e-01 DataSet_03_359
KCNH6 TP53 knockout Stomach SNU1 1.83528 0.876001 0.4665380573 0.9392557 DataSet_03_365
KCNH6 USP22 shRNA Liver PLC_PRF_5 cells 0.12 -3.05889 6.658068e-03 0.10332434 DataSet_03_368
KCNH6 DNMT3A knockout Embryo_kidney HEK293T 0.00748909 -7.06099 - - DataSet_03_369
KCNH6 GLI1 siRNA Skeletal_muscle RMS13 2.06551 1.0465 6.720421e-02 0.218162002 DataSet_03_375
KCNH6 NFKB2 siRNA Bone_marrow U2OS 0.5 -1 7.185697e-01 0.86784391 DataSet_03_381
KCNH6 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 3.67221 1.87665 0.4871085772 0.8850353 DataSet_03_387
KCNH6 NFKBIA shRNA Bone_marrow U2OS 0.0216682 -5.52828 6.371182e-01 0.87005461 DataSet_03_389
KCNH6 YY1 knockdown Liver HepG2 2.625 1.39232 1.461659e-01 3.021343e-01 DataSet_03_390
KCNH6 JAZF1 siRNA Cervix HeLa Kyoto 0.589252 -0.763043 5.815403e-01 0.906221222 DataSet_03_396
KCNH6 IKZF2 CRISPR Lymph CAR T Cell 0.527988 -0.921422 4.374599e-01 0.797215632 DataSet_03_397
KCNH6 EHF shRNA Stomach MKN7 0.0392628 -4.67069 - - DataSet_03_402
KCNH6 CDK7 shRNA Bone_marrow D458 0.424901 -1.2348 4.425784e-02 0.30154055 DataSet_03_404
KCNH6 SATB2 CRISPR Colon Colon organoid 2.53333 1.34104 1.901696e-02 0.95735254 DataSet_03_406
KCNH6 STRAP knockout Nerve SK-N-AS 2.99727 1.58365 - - DataSet_03_409
KCNH6 ZKSCAN3 CRISPR Colon HCT116 0.354839 -1.49477 7.042344e-02 0.439319430 DataSet_03_415
KCNH6 FOXK2 shRNA Ovary OVCAR-5 0.210526 -2.24793 9.256687e-02 0.26261731 DataSet_03_419
KCNH6 MAEL CRISPR Liver Alexander cells 0.0967742 -3.36923 - - DataSet_03_423
KCNH6 STAT3 siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 5.75 2.52356 0.2309549519 1 DataSet_03_430
KCNH6 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 4.001 2.00036 1.898302e-01 0.548485481 DataSet_03_434
KCNH6 EP300 knockout Pancreas HPAF-II orthotopic cells 0.5625 -0.830075 8.691101e-01 9.250529e-01 DataSet_03_436
KCNH6 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 3 1.58496 6.415297e-03 0.42002870 DataSet_03_439
KCNH6 SETDB1 shRNA Colon HCT116 0.621602 -0.685937 - - DataSet_03_440
KCNH6 CAMTA1 knockout Embryo_kidney HEK293T 6 2.58496 1.912453e-01 0.38937054 DataSet_03_448
KCNH6 RELB CRISPR Colon SW480 3.42857 1.77761 9.446225e-03 7.632990e-02 DataSet_03_449
KCNH6 CBX2 siRNA Mammary_gland MDA-MB-231 1.57447 0.654862 8.510861e-01 9.240417e-01 DataSet_03_450
KCNH6 CBX2 siRNA Mammary_gland MCF7 0.442171 -1.17733 2.654444e-01 0.4169303037 DataSet_03_451
KCNH6 ZFP36L1 CRISPR Lung NCI-H1876 0.233047 -2.10131 3.538687e-01 0.992381486 DataSet_03_454
KCNH6 SREBF2 siRNA Umbilical_vein HUVEC 0.451189 -1.1482 1.103239e-01 5.087863e-01 DataSet_03_457
KCNH6 HAND1 siRNA Placenta HPMVEC 3 1.58496 2.122994e-01 0.9463341 DataSet_03_459
KCNH6 PARP1 knockout Embryo_kidney HEK293a 0.255814 -1.96683 3.401999e-01 4.948818e-01 DataSet_03_464
KCNH6 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 0.25 -2 - - DataSet_03_467
KCNH6 SMARCA1 shRNA Embryo_kidney HEK293T 0.25 -2 - - DataSet_03_468
KCNH6 EZH2 siRNA Umbilical_vein HUVEC 0.4 -1.32193 8.723084e-02 0.306005163 DataSet_03_473
Regulation Region
 
T(co)Fs that significantly regulate REST by the evidences of both expression and ChIP-seq/motif
Expression Atlas of KCNH6
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines