Gene Overview
Target Gene: LRTM2
NCBI Official Symbol: LRTM2
Entrez ID: 654429
Ensembl ID: ENSG00000166159
Gene Full Name: leucine rich repeats and transmembrane domains 2
Strand: +
Gene Locus: 12p13.33
External Links:

LRTM2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate LRTM2   
T(co)Fs that Repress LRTM2
The Intensity of the Gene Regulated by T(co)Fs:
LRTM2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
LRTM2 ID1 siRNA Lung A549 2.93978 1.55571 0.12304 0.34561 DataSet_01_117
LRTM2 ID1 siRNA Lung H1650 0.66296 -0.59301 0.14269 0.49622 DataSet_01_118
LRTM2 HOXB7 siRNA Pancreas MIA PaCa-2 0.56874 -0.81417 0.05397 0.61361 DataSet_01_169
LRTM2 GATA2 siRNA Prostate LNCaP 1.5011 0.58602 0.09649 0.19118 DataSet_01_193
LRTM2 CREB1 shRNA Parotid_gland H3118 MEC 1.96403 0.97382 0.68359 0.87639 DataSet_01_194
LRTM2 TP63 siRNA Head_and_neck SCC-6 2.9465 1.559 - - DataSet_01_202
LRTM2 HIC1 shRNA Mammary_gland HBL100 0.66115 -0.59694 - - DataSet_01_205
LRTM2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 4.01695 2.0061 - - DataSet_01_208
LRTM2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 5.51365 2.46301 - - DataSet_01_209
LRTM2 REST siRNA Prostate LNCaP 37.5238 5.22973 0.00038 0.04595 DataSet_01_211
LRTM2 LIN28A siRNA Embryo H9 0.54736 -0.86943 0.03165 0.10241 DataSet_01_215
LRTM2 TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 1.69697 0.76296 0.00114 0.01544 DataSet_01_217
LRTM2 IRX1 shRNA Bone_marrow 143B 0.35984 -1.47455 0.0043 0.07178 DataSet_01_227
LRTM2 TWIST1 shRNA Stomach CAF32 1.67157 0.7412 0.15828 0.29954 DataSet_01_253
LRTM2 ESRRA shRNA Embryo_kidney 293T 2.1258 1.088 0.15553 0.74554 DataSet_01_280
LRTM2 TFAP4 siRNA Brain BE(2)-C 0.13817 -2.85547 0.26611 0.51625 DataSet_01_295
LRTM2 PTEN shRNA Lung HCC827 0.26509 -1.91543 0.00758 0.40161 DataSet_01_302
LRTM2 PTEN shRNA Mammary_gland SKBR3 2.54296 1.34651 0.24658 0.69983 DataSet_01_303
LRTM2 MYC siRNA Colon HCT116 1.51671 0.60095 0.01276 0.02548 DataSet_01_324
LRTM2 KLF4 siRNA Embryo HCE 0.60685 -0.72058 0.10625 0.57112 DataSet_01_341
LRTM2 GATA3 siRNA Oral_cavity OEC-M1 0.60899 -0.71551 0.14475 0.99787 DataSet_01_347
LRTM2 ELK1 siRNA Mammary_gland MDA-MB-231 0.48276 -1.05063 - - DataSet_01_354
LRTM2 SAFB2 shRNA Liver HepG2 3 1.58496 0.03817 0.08846 DataSet_02_102
LRTM2 FIP1L1 shRNA Liver HepG2 2.75 1.45943 0.15706 0.24754 DataSet_02_103
LRTM2 HDGF shRNA Liver HepG2 0.52632 -0.926 0.02751 0.13231 DataSet_02_104
LRTM2 TAF15 shRNA Liver HepG2 0.41379 -1.27302 0.02116 0.04809 DataSet_02_106
LRTM2 SSB shRNA Liver HepG2 0.21053 -2.24793 0.0536 0.09144 DataSet_02_107
LRTM2 ZNF622 shRNA Liver HepG2 4.5 2.16993 0.03672 0.07107 DataSet_02_108
LRTM2 HNRNPUL1 shRNA Liver HepG2 2 1 0.31579 0.41239 DataSet_02_109
LRTM2 GTF2F1 shRNA Liver HepG2 0.54545 -0.87447 0.73455 0.89845 DataSet_02_110
LRTM2 BCLAF1 shRNA Liver HepG2 5.75 2.52356 0.59142 0.68876 DataSet_02_112
LRTM2 PCBP1 shRNA Liver HepG2 0.62069 -0.68806 0.28089 0.35831 DataSet_02_115
LRTM2 TARDBP shRNA Liver HepG2 0.05556 -4.16993 0.09214 0.15947 DataSet_02_116
LRTM2 RBM25 shRNA Liver HepG2 0.27586 -1.85798 0.0069 0.03373 DataSet_02_119
LRTM2 PTBP1 shRNA Liver HepG2 0.34483 -1.53605 0.17341 0.21926 DataSet_02_120
LRTM2 RBM34 shRNA Liver HepG2 0.36364 -1.45943 0.01868 0.39846 DataSet_02_121
LRTM2 EWSR1 shRNA Liver HepG2 0.39474 -1.34104 0.16176 0.27838 DataSet_02_122
LRTM2 PCBP2 shRNA Liver HepG2 1.54545 0.62803 0.96895 0.99468 DataSet_02_123
LRTM2 FUS shRNA Liver HepG2 0.18182 -2.45943 0.08343 0.23031 DataSet_02_124
LRTM2 HNRNPLL shRNA Liver HepG2 0.22222 -2.16993 0.09811 0.15855 DataSet_02_125
LRTM2 SNRNP70 shRNA Liver HepG2 0.22222 -2.16993 0.09407 0.18214 DataSet_02_126
LRTM2 SRSF3 shRNA Liver HepG2 0.5 -1 0.37026 0.52694 DataSet_02_127
LRTM2 BCLAF1 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.06937 0.20884 DataSet_02_142
LRTM2 SAFB2 shRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.04822 0.46775 DataSet_02_150
LRTM2 ZFX siRNA Prostate C4-2B 5 2.32193 0.31444 0.43124 DataSet_02_172
LRTM2 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.27044 1 DataSet_02_182
LRTM2 CTCF siRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.14774 1 DataSet_02_185
LRTM2 BHLHE40 siRNA Haematopoietic_and_lymphoid_tissue K562 0.42857 -1.22239 0.14304 1 DataSet_02_186
LRTM2 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 2.66667 1.41504 0.46898 1 DataSet_02_190
LRTM2 ARID3A siRNA Haematopoietic_and_lymphoid_tissue K562 0.57143 -0.80735 0.28334 1 DataSet_02_193
LRTM2 MAZ siRNA Haematopoietic_and_lymphoid_tissue K562 0.57143 -0.80735 0.27837 1 DataSet_02_199
LRTM2 ZFX siRNA Mammary_gland MCF7 0.48148 -1.05445 0.0015 0.03894 DataSet_02_206
LRTM2 ATF4 siRNA Skin A375 0.648912 -0.623905 0.139253812778024 0.775512819201899 DataSet_03_018
LRTM2 BCL6 siRNA Lymph OCI-Ly7 DLBCL 1.65962 0.730854 0.106906596105343 0.764919186474744 DataSet_03_025
LRTM2 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.553967 -0.852127 - - DataSet_03_096
LRTM2 GATA2 siRNA Uterus Decidual stromal cells 0.426835 -1.22825 0.0830630141504797 0.711979515884985 DataSet_03_100
LRTM2 GATA6 siRNA Stomach YCC3 0.610634 -0.711619 0.213272071969489 0.811255978207627 DataSet_03_110
LRTM2 HNF4a siRNA Liver HepG2 2.52632 1.33703 0.22143292951978 0.814528637464046 DataSet_03_126
LRTM2 KLF5 siRNA Stomach YCC3 0.477772 -1.06561 0.0468953001103239 0.324172436700531 DataSet_03_151
LRTM2 MEF2D shRNA Liver HuH7 4.95306 2.30832 - - DataSet_03_162
LRTM2 MYC siRNA Colon HT29 0.362977 -1.46205 - - DataSet_03_177
LRTM2 MYCN siRNA Brain BE(2)C cells 0.597123 -0.7439 - - DataSet_03_188
LRTM2 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.301698 -1.72882 0.0388258765264439 0.0923724847484227 DataSet_03_211
LRTM2 PPARG siRNA Peripheral_blood GM-CSF Macrophage 1.54399 0.626667 0.0517629410389653 0.853728474855977 DataSet_03_214
LRTM2 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 2.5 1.32193 - - DataSet_03_246
LRTM2 SP1 siRNA Ovary OVSAYO 0.561659 -0.832233 0.197157139693986 0.520542293023601 DataSet_03_251
LRTM2 STAT6 siRNA Umbilical_vein HUVEC 4.375 2.12928 0.00238093038550852 0.397236882887962 DataSet_03_264
LRTM2 TFAP2C siRNA Mammary_gland MCF7 2.97535 1.57306 0.261230376995701 0.600843740185013 DataSet_03_274
LRTM2 ZNF746 siRNA Colon HCT116 0.502432 -0.993 - - DataSet_03_293
LRTM2 CIZ1 CRISPR Liver HepG2 2.14286 1.09954 0.0783016204109376 0.29610512599638 DataSet_04_026
LRTM2 CTCF CRISPR Liver HepG2 2.16667 1.11548 0.0215212015060099 0.826365031008184 DataSet_04_027
LRTM2 E4F1 CRISPR Liver HepG2 1.7 0.765535 0.0755022708468769 0.341859476388232 DataSet_04_028
LRTM2 ERN1 CRISPR Liver HepG2 1.72222 0.784271 0.00987417367478584 0.096636765061073 DataSet_04_029
LRTM2 FUBP1 shRNA Liver HepG2 1.77778 0.830075 0.0107308298254586 0.374476004820591 DataSet_04_030
LRTM2 SMAD2 CRISPR Liver HepG2 1.73913 0.798366 0.164525522058966 0.690113789319112 DataSet_04_034
LRTM2 SMAD5 CRISPR Liver HepG2 1.55556 0.63743 0.596869656435658 0.841501457380629 DataSet_04_036
LRTM2 ZNF574 CRISPR Liver HepG2 0.555556 -0.847997 0.289569906129277 0.431876337776761 DataSet_04_041
LRTM2 DDX20 CRISPR Liver HepG2 2.05556 1.03953 0.304268040787996 0.453987893562853 DataSet_04_043
LRTM2 APTX CRISPR Liver HepG2 2.16667 1.11548 0.470067566163866 0.923909681300969 DataSet_04_069
LRTM2 CHCHD3 CRISPR Liver HepG2 0.133333 -2.90689 0.319962083074393 0.653473541205788 DataSet_04_067
LRTM2 CNOT7 CRISPR Liver HepG2 0.478261 -1.06413 0.145931296661525 0.277740813141115 DataSet_04_045
LRTM2 RIOK2 CRISPR Liver HepG2 0.588235 -0.765535 0.636623010594031 1 DataSet_04_070
LRTM2 ABT1 shRNA Liver HepG2 20.5 4.35755 0.0370888611081051 0.0893087246371193 DataSet_04_052
LRTM2 CCAR1 shRNA Liver HepG2 2.5 1.32193 0.47854438530234 0.633366329929608 DataSet_04_054
LRTM2 CNOT7 shRNA Liver HepG2 0.444444 -1.16992 0.438890904662741 0.548141197131265 DataSet_04_051
LRTM2 DDX1 shRNA Liver HepG2 2 1 0.63544981534746 0.814433094634885 DataSet_04_057
LRTM2 UBE2L3 shRNA Liver HepG2 7.5 2.90689 0.177617631407274 0.306930946890743 DataSet_04_055
LRTM2 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.909890834149205 0.959244138482525 DataSet_04_049
LRTM2 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.716932528986779 0.873204327184704 DataSet_02_38
LRTM2 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 8 3 0.533503235873896 0.864263018694768 DataSet_02_45
LRTM2 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 5.75 2.52356 0.560443777513536 0.752704469827588 DataSet_02_32
LRTM2 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.225806 -2.14684 0.445476233739801 0.803208482719222 DataSet_02_49
LRTM2 ELF3 knockdown Bile_duct HBDEC2 0.612364 -0.707539 1.916927e-01 3.313336e-01 DataSet_03_305
LRTM2 INO80 siRNA Muscle RD 0.540322 -0.888108 - - DataSet_03_344
LRTM2 BRCA1 siRNA Mammary_gland MCF7 0.66387 -0.591028 9.316051e-01 0.9999931 DataSet_03_308
LRTM2 ESR1 siRNA Mammary_gland MCF7 0.370821 -1.43121 7.403976e-02 0.2334092137 DataSet_03_352
LRTM2 TET1 CRISPR Mammary_gland Hs578T 6.65059 2.73348 4.816634e-01 6.671280e-01 DataSet_03_355
LRTM2 CREBBP CRISPR Brain U5-NPC 0.333333 -1.58496 0.7867459462 0.8739497 DataSet_03_356
LRTM2 TP53 CRISPR Brain U5-NPC 0.5 -1 9.385907e-01 9.632447e-01 DataSet_03_358
LRTM2 TP53 knockout Stomach SNU1 0.145687 -2.77905 0.3705636909 0.9301241 DataSet_03_365
LRTM2 E2F1 siRNA Nasopharynx HK1 2.25 1.16992 2.113940e-01 8.374502e-01 DataSet_03_373
LRTM2 GLI1 siRNA Skeletal_muscle RMS13 0.489671 -1.03012 7.739171e-03 0.065349234 DataSet_03_375
LRTM2 ZNF213 siRNA Mammary_gland MCF7 0.00661841 -7.2393 2.018635e-01 6.592819e-01 DataSet_03_376
LRTM2 SMARCA2 shRNA Lung NCI-H1944 0.4 -1.32193 6.205181e-01 8.379515e-01 DataSet_03_377
LRTM2 DNMT1 siRNA Skin Human melanoma cells 5.04291 2.33426 1.272776e-04 6.356113e-04 DataSet_03_382
LRTM2 TCF19 CRISPR Oral_squamous CAL27 0.335703 -1.57474 7.037034e-01 0.8694390433 DataSet_03_383
LRTM2 YY1 shRNA Brain GSC1517 2 1 - - DataSet_03_384
LRTM2 NFKBIA shRNA Bone_marrow U2OS 0.0131853 -6.24493 7.414974e-01 0.88999509 DataSet_03_389
LRTM2 YY1 knockdown Liver HepG2 9.625 3.26679 1.828851e-08 4.967031e-07 DataSet_03_390
LRTM2 BMI1 shRNA Bile_duct QBC-939 0.328344 -1.60672 3.300691e-01 0.5496314050 DataSet_03_395
LRTM2 HMGA1 shRNA Bile_duct HUCCT1 2 1 4.579621e-01 0.664532869 DataSet_03_400
LRTM2 CDK7 shRNA Bone_marrow D458 0.272727 -1.87447 1.964115e-02 0.22009339 DataSet_03_404
LRTM2 TFAP2A knockout Embryo H9 0.5 -1 7.112712e-01 0.79089949 DataSet_03_405
LRTM2 CHD1 shRNA Prostate LNCaP 0.5 -1 1.752835e-01 7.166165e-01 DataSet_03_407
LRTM2 E2F2 siRNA Prostate LNCaP 2 1 4.311998e-01 6.097703e-01 DataSet_03_414
LRTM2 BRD4 CRISPR Lymph CD8+ T cells 0.25 -2 - - DataSet_03_420
LRTM2 PRDM1 CRISPR Lymph CD8+ T cells 0.5 -1 - - DataSet_03_421
LRTM2 FOXQ1 CRISPR Lymph Primary CD4+ T cells 2.66667 1.41504 - - DataSet_03_422
LRTM2 USP7 shRNA Skin xenograft cells 0.538462 -0.893085 0.15740658 0.4348960 DataSet_03_431
LRTM2 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 14.9776 3.90474 3.697607e-01 0.90558273 DataSet_03_439
LRTM2 CBX2 siRNA Mammary_gland MDA-MB-231 0.492727 -1.02114 7.964028e-01 8.973622e-01 DataSet_03_450
LRTM2 CBX2 siRNA Mammary_gland MCF7 0.143654 -2.79933 4.946029e-02 0.1075609642 DataSet_03_451
LRTM2 OGT siRNA Embryo BeWo cells 0.534884 -0.902703 5.462062e-02 0.55837810 DataSet_03_453
LRTM2 SOX9 knockout Liver HuH7 3.5 1.80735 4.126948e-01 5.378812e-01 DataSet_03_463
LRTM2 PARP1 knockout Embryo_kidney HEK293a 2.45902 1.29808 6.023412e-04 3.035214e-03 DataSet_03_464
LRTM2 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 9 3.16992 - - DataSet_03_467
LRTM2 SMARCA1 shRNA Embryo_kidney HEK293T 9.5 3.24793 - - DataSet_03_468
LRTM2 LIN28A siRNA Mammary_gland MCF7M 1.55872 0.640361 3.100124e-01 0.6888604 DataSet_03_469
LRTM2 LIN28A siRNA Mammary_gland MCF7M 1.55872 0.640361 3.100124e-01 0.6888604 DataSet_03_470
LRTM2 CREBBP CRISPR Lymph U2932 4.5 2.16992 4.884938e-02 1.0000000 DataSet_03_474
LRTM2 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.7396225 0.9527008 DataSet_04_072
Regulation Region
 
T(co)Fs that significantly regulate REST by the evidences of both expression and ChIP-seq/motif
Expression Atlas of LRTM2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines