Gene Overview
Target Gene: LSAMP
NCBI Official Symbol: LSAMP
Entrez ID: 4045
Ensembl ID: ENSG00000185565
Gene Full Name: limbic system associated membrane protein
Strand: -
Gene Locus: 3q13.31
External Links:

LSAMP Significantly Regulated by These T(co)Fs

T(co)Fs that Activate LSAMP   
T(co)Fs that Repress LSAMP
The Intensity of the Gene Regulated by T(co)Fs:
LSAMP-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
LSAMP HOXA1 siRNA Lung_fibroblast IMR-90 2.0653 1.04635 0.00283 0.05527 DataSet_01_110
LSAMP FOXM1 siRNA Central_nervous_system U87 2.6648 1.41403 - - DataSet_01_122
LSAMP ZNF100 siRNA Gastrointestinal_tissue GIST-T1 1.6017 0.6796 0.00117 0.02474 DataSet_01_124
LSAMP IKZF1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 2.19651 1.13521 0.04212 0.99993 DataSet_01_138
LSAMP POLR3A siRNA Mammary_gland MCF7 1.74159 0.8004 - - DataSet_01_139
LSAMP NR3C1 siRNA Uterus Endometrial stromal cells 0.61557 -0.7 0.00787 0.99972 DataSet_01_141
LSAMP TFAP2C shRNA Mammary_gland MCF7 2.67682 1.42052 9.70176e-09 1.15768e-07 DataSet_01_150
LSAMP STAT1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.59002 0.66904 0.00496 0.0948 DataSet_01_154
LSAMP MYCN siRNA Autonomic_ganglia SKNBE2 1.50803 0.59267 0.04154 0.25206 DataSet_01_160
LSAMP GATA3 siRNA Peripheral_blood CD4+ T cells 1.66363 0.73434 0.09885 0.42749 DataSet_01_163
LSAMP HOXB7 siRNA Pancreas Capan-1 0.53769 -0.89516 0.05429 0.55358 DataSet_01_170
LSAMP FOSL1 siRNA Mammary_gland BT549 0.54457 -0.87682 1.86864e-05 0.00214 DataSet_01_171
LSAMP JUN siRNA Mammary_gland BT549 0.60284 -0.73014 0.00306 0.11251 DataSet_01_172
LSAMP TP53 siRNA Lung SAECs 3.10227 1.63333 0.08699 0.47202 DataSet_01_175
LSAMP TP63 siRNA Immortalized_keratinocyte HaCaT RG 2.13492 1.09418 - - DataSet_01_196
LSAMP TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.6994 0.76502 - - DataSet_01_197
LSAMP TP63 siRNA Head_and_neck SCC-6 1.64346 0.71674 - - DataSet_01_202
LSAMP HIC1 shRNA Mammary_gland HBL100 0.28038 -1.83455 - - DataSet_01_205
LSAMP MITF shRNA Skin COLO829 1.71561 0.77872 0.20218 0.41111 DataSet_01_207
LSAMP REST siRNA Prostate LNCaP 1.66082 0.7319 0.00462 0.14544 DataSet_01_211
LSAMP LIN28A siRNA Embryo H9 2.75853 1.4639 0.00028 0.00572 DataSet_01_215
LSAMP ESR2 siRNA Mammary_gland BT549 1.94082 0.95667 3.49288e-07 3.59777e-05 DataSet_01_229
LSAMP ARNT shRNA Embryo hESC HSF1 0.62025 -0.68908 0.27025 0.99999 DataSet_01_240
LSAMP MSX1 siRNA Tooth Dental Pulp Cells 0.27223 -1.87712 4.417e-07 5.24808e-05 DataSet_01_281
LSAMP JUN siRNA Mammary_gland BT549 0.6624 -0.59423 1.89771e-07 1.70995e-05 DataSet_01_291
LSAMP POSTN shRNA Brain GSC272 1.8413 0.88072 0.14776 0.57007 DataSet_01_293
LSAMP TFAP4 siRNA Brain BE(2)-C 0.11892 -3.07195 0.22575 0.51625 DataSet_01_295
LSAMP PTEN shRNA Skin A431 0.34402 -1.53944 0.07874 0.23346 DataSet_01_301
LSAMP PTEN shRNA Lung HCC827 0.62662 -0.67435 0.14883 0.63936 DataSet_01_302
LSAMP ARNT siRNA Upper_aerodigestive_tract HSC3 11676.8 13.5114 - - DataSet_01_315
LSAMP ZNF25 siRNA Bone_marrow hMSC-TERT4 1.61663 0.69299 0.00099 0.12636 DataSet_01_319
LSAMP RBFOX2 shRNA Liver HepG2 8 3 0.02652 0.65168 DataSet_02_101
LSAMP SAFB2 shRNA Liver HepG2 10.5 3.39232 0.29053 0.3915 DataSet_02_102
LSAMP HNRNPUL1 shRNA Liver HepG2 0.5 -1 1 1 DataSet_02_109
LSAMP GTF2F1 shRNA Liver HepG2 9 3.16993 0.18751 0.51482 DataSet_02_110
LSAMP RBM39 shRNA Liver HepG2 3 1.58496 0.07112 0.28462 DataSet_02_111
LSAMP BCLAF1 shRNA Liver HepG2 0.06667 -3.90689 0.13002 0.23058 DataSet_02_112
LSAMP XRCC5 shRNA Liver HepG2 19 4.24793 0.25388 0.45512 DataSet_02_114
LSAMP RBM34 shRNA Liver HepG2 9 3.16993 0.01747 0.39846 DataSet_02_121
LSAMP PCBP2 shRNA Liver HepG2 4 2 0.03363 0.13175 DataSet_02_123
LSAMP FUS shRNA Liver HepG2 35 5.12928 0.02586 0.12883 DataSet_02_124
LSAMP SRSF3 shRNA Liver HepG2 18 4.16993 0.00129 0.0663 DataSet_02_127
LSAMP PRPF4 shRNA Liver HepG2 0.53846 -0.89308 0.79225 0.85674 DataSet_02_128
LSAMP AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 1 1 DataSet_02_132
LSAMP SRSF7 shRNA Haematopoietic_and_lymphoid_tissue K562 14 3.80735 0.01668 0.23714 DataSet_02_133
LSAMP PCBP2 shRNA Haematopoietic_and_lymphoid_tissue K562 20 4.32193 0.0685 0.19116 DataSet_02_135
LSAMP PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 1 1 DataSet_02_144
LSAMP ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.875 1.52356 0.05866 0.32773 DataSet_02_152
LSAMP SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 0.02564 -5.2854 0.01044 0.37537 DataSet_02_154
LSAMP XRCC5 shRNA Haematopoietic_and_lymphoid_tissue K562 0.02564 -5.2854 0.00871 0.59238 DataSet_02_159
LSAMP AGO1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.04348 -4.52356 0.01221 0.53443 DataSet_02_162
LSAMP ZNF180 siRNA Haematopoietic_and_lymphoid_tissue K562 6 2.58496 0.03359 1 DataSet_02_177
LSAMP RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 1.77778 0.83007 0.17644 1 DataSet_02_190
LSAMP ARID1A siRNA Mammary_gland MDA-MB-157 0.391343 -1.3535 - - DataSet_03_014
LSAMP CEBPB siRNA Embryo hESC 0.229955 -2.12057 0.277148890362821 0.654728480628766 DataSet_03_049
LSAMP FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.181705 -2.46033 - - DataSet_03_096
LSAMP GATA2 siRNA Uterus Decidual stromal cells 0.270241 -1.88768 0.375285253620616 0.896415157927495 DataSet_03_100
LSAMP GATA6 siRNA Stomach KatoIII 1.5819 0.661656 0.00742520366284823 0.357961590691862 DataSet_03_109
LSAMP GATA6 siRNA Stomach YCC3 1.66983 0.739697 0.271596014679314 0.833986803717292 DataSet_03_110
LSAMP MEF2D shRNA Liver HuH7 1.8689 0.902191 - - DataSet_03_162
LSAMP MITF siRNA Skin MZ7 1.81149 0.857177 0.0175272904820322 0.0788194187924336 DataSet_03_165
LSAMP MITF siRNA Skin Ma-Mel-15 2.10746 1.07551 0.00899105379054088 0.196001580809109 DataSet_03_166
LSAMP MITF siRNA Skin Ma-Mel-15 1.79743 0.845931 0.0165061282600455 0.182160854224607 DataSet_03_167
LSAMP MYB siRNA Cord_Blood CD34+ progenitor cells 15.4574 3.95023 - - DataSet_03_170
LSAMP MYC siRNA Central_nervous_system DAOY M2.1 1.86624 0.900136 1.49920486815963e-07 2.08333792997445e-06 DataSet_03_178
LSAMP MYCN siRNA Autonomic_ganglia SKNBE2 1.50803 0.592668 0.0404453871418876 0.25928486627426 DataSet_03_185
LSAMP MYCN siRNA Brain BE(2)C cells 1.57735 0.6575 - - DataSet_03_187
LSAMP MYCN siRNA Brain BE(2)C cells 1.68319 0.7512 - - DataSet_03_188
LSAMP SOX11 siRNA Lung_fibroblast NHLF 1.65873 0.730081 0.192217446394654 0.583415477499823 DataSet_03_237
LSAMP SOX11 siRNA Lung_fibroblast NHLF 2.00008 1.00006 0.0990538340853783 0.437324187453928 DataSet_03_238
LSAMP STAT3 CRISPR Embryo hESC 0.604955 -0.725101 0.0506994418906518 0.125545322582725 DataSet_03_258
LSAMP TET1 siRNA Embryo NCCIT 1.5384 0.621435 0.000856889366514642 0.00970065288202335 DataSet_03_269
LSAMP CTCF CRISPR Haematopoietic_and_lymphoid_tissue K562 0.428571 -1.22239 0.505378912580829 0.756279757888027 DataSet_04_005
LSAMP YBX1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.176471 -2.5025 0.396555910131823 0.708121686223769 DataSet_04_022
LSAMP NFX1 CRISPR Liver HepG2 21 4.39232 0.00140760640703437 0.0152110304033303 DataSet_04_032
LSAMP APTX CRISPR Liver HepG2 0.333333 -1.58496 0.827328516453556 0.99600891928032 DataSet_04_069
LSAMP CHCHD3 CRISPR Liver HepG2 5.5 2.45943 0.531191867604828 0.798974994218975 DataSet_04_067
LSAMP CCAR1 shRNA Liver HepG2 1.86667 0.900464 0.405106635195359 0.562908710322408 DataSet_04_054
LSAMP DDX1 shRNA Liver HepG2 0.5 -1 0.928723887981523 0.975812401808597 DataSet_04_057
LSAMP SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 4 2 0.75322833148921 0.867309401785622 DataSet_04_049
LSAMP CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2 1 0.926401189199421 0.973965380711594 DataSet_02_38
LSAMP DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2 1 0.919915392624596 0.960584600082578 DataSet_02_14
LSAMP HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.294118 -1.76553 0.522557506067377 0.82146561108426 DataSet_02_75
LSAMP HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 5 2.32193 0.852172504976276 0.974925505904985 DataSet_02_45
LSAMP LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 15 3.90689 0.376523148595699 0.560012087688842 DataSet_02_35
LSAMP NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 13.5 3.75489 0.466836448228511 0.686912826526849 DataSet_02_32
LSAMP SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.0666667 -3.90689 0.518900767295638 0.84820725174659 DataSet_02_49
LSAMP TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2 1 0.915526612530346 0.957784588237768 DataSet_02_53
LSAMP PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 0.307692 -1.70044 0.453536588787103 0.781882934567706 DataSet_04_065
LSAMP UBE2L3 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.734993830793335 0.890488509743155 DataSet_04_062
LSAMP CNOT3 shRNA Lung A549 0.511457 -0.967316 3.390417e-02 0.8830540 DataSet_03_340
LSAMP SNAI2 shRNA Pancreas pancreatic cancer stem cells 0.591624 -0.757246 1.630819e-01 0.6510154 DataSet_03_306
LSAMP ACTR5 siRNA Muscle RD 0.619591 -0.690612 - - DataSet_03_343
LSAMP TET1 CRISPR Mammary_gland MDA-MB-231 3.16553 1.66245 5.607319e-01 7.317670e-01 DataSet_03_347
LSAMP EZH2 shRNA Mammary_gland LM2 0.336305 -1.57216 5.554209e-01 8.619423e-01 DataSet_03_350
LSAMP SKI CRISPR Blood HL60 2 1 4.509686e-01 0.700104641 DataSet_03_351
LSAMP ESR1 siRNA Mammary_gland MCF7 4.26554 2.09273 5.722769e-02 0.2043085799 DataSet_03_352
LSAMP ETV5 knockdown Colon HT29 0.4 -1.32193 3.908815e-01 0.593447858 DataSet_03_353
LSAMP PTPN14 CRISPR Brain U5-NPC 0.394584 -1.3416 6.314399e-02 0.28637604 DataSet_03_357
LSAMP TP53 CRISPR Brain U5-NPC 2.17328 1.11987 7.009480e-02 2.051046e-01 DataSet_03_358
LSAMP RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 8.77779 3.13386 8.005225e-01 9.159370e-01 DataSet_03_359
LSAMP NCOA3 siRNA Mammary_gland MDA-MB-231 0.552954 -0.854768 9.608351e-01 1.0000000 DataSet_03_361
LSAMP ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 3.37328 1.75415 1.153823e-02 2.595285e-02 DataSet_03_362
LSAMP EP300 shRNA Mammary_gland MCF10AT 0.25 -2 1.164910e-01 0.309872467 DataSet_03_364
LSAMP E2F1 siRNA Nasopharynx HK1 1.625 0.70044 7.522250e-01 1.000000e+00 DataSet_03_373
LSAMP GLI1 siRNA Skeletal_muscle RMS13 1.57466 0.655041 3.773267e-01 0.566761229 DataSet_03_375
LSAMP SMARCA2 shRNA Lung NCI-H1944 0.571429 -0.807355 1.019246e-01 4.941607e-01 DataSet_03_377
LSAMP EZH2 CRISPR Ovary SKOV3 27 4.75489 1.114597e-03 0.0223600417 DataSet_03_378
LSAMP ZBTB7A siRNA Stomach BGC823 0.464208 -1.10716 - - DataSet_03_380
LSAMP TCF19 CRISPR Oral_squamous CAL27 5.63206 2.49366 6.620229e-01 0.8506596862 DataSet_03_383
LSAMP YY1 shRNA Brain GSC1517 0.629139 -0.668548 - - DataSet_03_384
LSAMP TRIM8 siRNA Mammary_gland MCF7 0.363162 -1.46132 1.232665e-04 0.0045047582 DataSet_03_388
LSAMP NFKBIA shRNA Bone_marrow U2OS 0.140897 -2.82729 5.847266e-01 0.87005461 DataSet_03_389
LSAMP YY1 knockdown Liver HepG2 12.25 3.61471 1.501896e-03 7.194030e-03 DataSet_03_390
LSAMP PRDM15 CRISPR Kidney Immortalized human podocytes 118.687 6.89102 2.883887e-02 9.301835e-02 DataSet_03_391
LSAMP KDM5A CRISPR Lung GLC16 0.616896 -0.696901 7.155015e-03 0.036190628 DataSet_03_392
LSAMP ILF2 siRNA Stomach SGC-7901 8 3 0.1451458049 0.31662166 DataSet_03_393
LSAMP ASXL1 CRISPR Embryo iPSC 3.41437 1.77162 0.0786424536 0.8048302 DataSet_03_394
LSAMP IKZF2 CRISPR Lymph CAR T Cell 4.05579 2.01998 2.375736e-01 0.728024116 DataSet_03_397
LSAMP HMGA1 shRNA Bile_duct HUCCT1 3.75 1.90689 5.345080e-02 0.276671174 DataSet_03_400
LSAMP SUMO1 CRISPR Bone_marrow U2OS 0.548 -0.867752 2.072668e-03 2.151157e-02 DataSet_03_401
LSAMP JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.55262 0.634706 4.928883e-02 0.3239928 DataSet_03_403
LSAMP CDK7 shRNA Bone_marrow D458 0.571429 -0.807355 4.800125e-01 0.71519084 DataSet_03_404
LSAMP TFAP2A knockout Embryo H9 1.89836 0.924754 1.137103e-02 0.06966423 DataSet_03_405
LSAMP CHD1 shRNA Prostate LNCaP 0.277778 -1.848 1.000300e-01 6.104301e-01 DataSet_03_407
LSAMP MAP3K7 shRNA Prostate LNCaP 0.555556 -0.847997 5.182270e-01 7.155825e-01 DataSet_03_408
LSAMP STRAP knockout Nerve SK-N-AS 0.598377 -0.740874 - - DataSet_03_409
LSAMP FOXK2 shRNA Ovary OVCAR-5 5.69231 2.50901 5.053364e-02 0.18431587 DataSet_03_419
LSAMP MAEL CRISPR Liver Alexander cells 0.25 -2 - - DataSet_03_423
LSAMP FOXP3 CRISPR Peripheral_blood Naive Treg 2 1 6.606483e-01 0.835281136 DataSet_03_427
LSAMP USP7 shRNA Skin xenograft cells 0.429676 -1.21868 0.26315186 0.4348960 DataSet_03_431
LSAMP POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.0428669 -4.54399 4.429952e-03 0.230185354 DataSet_03_434
LSAMP CIC knockout Brain Immortalized Astrocyte Cells 1.99094 0.993448 5.415086e-02 3.984720e-01 DataSet_03_438
LSAMP FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 0.394818 -1.34074 1.040384e-02 0.51553437 DataSet_03_439
LSAMP SETDB1 shRNA Colon HCT116 7.45922 2.89903 - - DataSet_03_440
LSAMP HMG20A siRNA Mammary_gland MDA-MB-231 3 1.58496 0.1307764072 0.3756411 DataSet_03_442
LSAMP FOSL1 siRNA Prostate MSKPCa3 7 2.80735 0.0270941500 0.3919961 DataSet_03_445
LSAMP CAMTA1 knockout Embryo_kidney HEK293T 2.33333 1.22239 1.550494e-01 0.34179148 DataSet_03_448
LSAMP RELB CRISPR Colon SW480 0.3125 -1.67807 3.401403e-01 5.110708e-01 DataSet_03_449
LSAMP CBX2 siRNA Mammary_gland MDA-MB-231 1.61665 0.693004 5.546006e-01 7.536136e-01 DataSet_03_450
LSAMP CBX2 siRNA Mammary_gland MCF7 2.21944 1.1502 8.650943e-01 0.9199286571 DataSet_03_451
LSAMP ZFP36L1 CRISPR Lung NCI-H1876 0.530514 -0.914536 7.757363e-01 0.992664775 DataSet_03_454
LSAMP SREBF2 siRNA Umbilical_vein HUVEC 0.641383 -0.640741 3.328284e-01 7.541525e-01 DataSet_03_457
LSAMP ARID1A shRNA Bile_duct MMNK1 0.118183 -3.0809 2.511253e-02 0.164987760 DataSet_03_458
LSAMP HAND1 siRNA Placenta HPMVEC 1.875 0.906891 4.973552e-01 0.9463341 DataSet_03_459
LSAMP PARP1 knockout Embryo_kidney HEK293a 16.6035 4.05341 7.359329e-16 4.679715e-13 DataSet_03_464
LSAMP SMARCA1 Cas13 Embryo_kidney HEK293T 0.567568 -0.817136 - - DataSet_03_466
LSAMP LIN28A siRNA Mammary_gland MCF7M 2.10217 1.07188 9.494457e-01 1.0000000 DataSet_03_469
LSAMP LIN28A siRNA Mammary_gland MCF7M 2.10217 1.07188 9.494457e-01 1.0000000 DataSet_03_470
LSAMP EZH2 siRNA Umbilical_vein HUVEC 1.8 0.847997 1.252541e-01 0.366939879 DataSet_03_473
Regulation Region
 
T(co)Fs that significantly regulate FUS by the evidences of both expression and ChIP-seq/motif
Expression Atlas of LSAMP
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines