Gene Overview
Target Gene: Lox
NCBI Official Symbol: Lox
Entrez ID: 16948
Ensembl ID: ENSMUSG00000024529
Gene Full Name: lysyl oxidase
Strand: -
Gene Locus: 18 D1|18 28.22 cM
External Links:

Lox Significantly Regulated by These T(co)Fs

T(co)Fs that Activate Lox   
T(co)Fs that Repress Lox
The Intensity of the Gene Regulated by T(co)Fs:
Lox-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
Lox Ahr knockout Lung Lung 1.60967 0.686767 0.331912835763196 0.999996968611848 DataSet_11_003
Lox Arid1a knockout Liver Liver 1.8851 0.91464 0.331660340347377 0.999999999999956 DataSet_11_004
Lox Bcl6 knockout Bone_marrow Bone marrow-derived macrophages 0.238269 -2.06934 0.00142822766677248 0.191115290558245 DataSet_11_014
Lox Cebpb knockout Mammary_gland Mammary epithlial cells (MECs) 0.461424 -1.11583 0.270591149107697 0.999788745984441 DataSet_11_020
Lox Cebpb shRNA Mammary_gland 4T1 mammary tumor cells 0.112543 -3.15145 0.360637396697619 0.999984070881864 DataSet_11_022
Lox E2f4 knockout Brain Forebrain 1.72901 0.789943 - - DataSet_11_033
Lox Elf5 knockout Mammary_gland Mammary gland 1.85343 0.890195 0.0576448446546974 0.325602321073823 DataSet_11_035
Lox Foxp1 knockout Eye Lens 0.589844 -0.761595 - - DataSet_11_044
Lox Gata2 knockout Kidney renal collecting duct cells 0.510038 -0.971322 - - DataSet_11_047
Lox Gata3 siRNA Peripheral_blood CD4+ T helper (Th) cells 3.54591 1.82615 0.0129587813971635 0.987135756219234 DataSet_11_048
Lox Hsf4 knockout Eye Lens 0.281121 -1.83074 0.115234935085683 0.987999303842427 DataSet_11_058
Lox Klf17 shRNA Mammary_gland 168FARN 0.321415 -1.63749 0.000570389310773263 0.00921672974573672 DataSet_11_066
Lox Lhx8 knockout Gonads Oocytes 0.578713 -0.78908 0.468849464140737 0.998630964563827 DataSet_11_069
Lox Lhx8 knockout Ovary Ovary 1.81134 0.857059 0.00393957876384919 0.0315377596077173 DataSet_11_070
Lox Lmx1b knockout Kidney Kidney 2.09778 1.06886 0.00193902195920955 0.084577999981933 DataSet_11_072
Lox Mafg knockout Embryo Whole embryo 0.486849 -1.03845 0.21314704295958 1 DataSet_11_073
Lox Meis1 knockout Hematopoietic KSL hematopoietic cells 0.62776 -0.671714 0.2030191226322 0.995635220774426 DataSet_11_081
Lox Mkx knockout Tooth PDL 1.85783 0.893618 0.212603782870335 0.999970897748702 DataSet_11_083
Lox Myb shRNA Lung Tracheal epithelial cell 1.68305 0.751075 0.0800037244659405 0.39206778386079 DataSet_11_085
Lox Neurod1 knockout Eye Retina 1.81244 0.85793 0.00356541078309555 0.0311508815135222 DataSet_11_088
Lox Nr2f2 knockout Ovary E14.5 Ovary 3.28659 1.71659 0.304456076352298 0.857914046488004 DataSet_11_094
Lox Nr2f2 knockout Ovary E16.5 Ovary 1.62833 0.703396 0.492392806441605 0.792359314020121 DataSet_11_095
Lox Nrf1 knockdown Liver Liver 7.08645 2.82506 0.00022982007964176 0.0197210817355474 DataSet_11_096
Lox Otx2 knockout Eye Retina 0.527291 -0.923329 0.582272120897912 0.999923528647439 DataSet_11_097
Lox Otx2 knockout Brain Ganglionic eminences and septum 0.518161 -0.948528 0.35463322093471 0.777823969298727 DataSet_11_098
Lox Pitx2 knockout Eye Cornea 40.2612 5.33132 0.001375523237932 0.0607517808891136 DataSet_11_103
Lox Plagl2 knockout Intestine Small intestine 1.58345 0.66307 0.130234482353639 0.41663745382469 DataSet_11_104
Lox Pparg siRNA Adipose_tissue Preadipocytes 3.67214 1.87662 0.0723959588882961 0.611181626276371 DataSet_11_105
Lox Prox1 knockout Liver Liver 2.10977 1.07709 - - DataSet_11_109
Lox Rest knockout Brain Brain 4.18702 2.06592 0.104710644068023 1 DataSet_11_113
Lox Runx1 knockout Mammary_gland Luminal epithelial cells 0.574447 -0.799755 0.0620849218948261 0.999784944667092 DataSet_11_117
Lox Sall1 knockout Kidney Kidney 1.53683 0.619954 0.0367514072027068 0.466676805062465 DataSet_11_121
Lox Smad4 siRNA Brain bEnd3 2126.34 11.0541 - - DataSet_11_127
Lox Snai1 knockout Embryo Teratoma 0.578309 -0.790088 - - DataSet_11_130
Lox Sohlh1 knockout Ovary Ovary 1.69349 0.76 0.000218942753576938 0.00310136913310232 DataSet_11_134
Lox Sohlh2 knockout Ovary Ovary 1.66825 0.738333 2.52218198050191e-05 0.000452850229610287 DataSet_11_135
Lox Stat3 knockout Lung Lung typeII cells 0.660304 -0.598798 0.423226661724911 0.850919056095606 DataSet_11_151
Lox Stat6 knockout Bone_marrow Bone marrow-derived macrophages 2.08141 1.05756 0.553889541736912 0.735152864879474 DataSet_11_153
Lox Vdr knockout Bone_marrow Bone marrow-derived macrophages 0.45419 -1.13863 0.0864632366953058 0.999827445128963 DataSet_11_174
Lox Wt1 siRNA Embryo_kidney LB-22 0.507493 -0.978539 5.51039110124109e-06 0.00115137399978927 DataSet_11_179
Lox Yy1 knockout Muscle Skeletal muscle 2.23488 1.1602 0.000202065021535484 0.00171007365303374 DataSet_11_182
Lox Yy1 knockout White_adipose_tissue Visceral white adipose tissue 0.454482 -1.13771 0.0300357943230067 0.132726470301559 DataSet_11_185
Lox Zbed6 siRNA Muscle C2C12 1.97262 0.980116 0.000109330741263835 0.00227709543873643 DataSet_11_186
Lox Pogz knockdown Liver fetal liver 0.308101 -1.69852 5.618177e-02 0.3587523 DataSet_11_188
Lox Cpeb1 siRNA Neuron Neuro-2a 5.92081 2.56579 - - DataSet_11_189
Lox Mapk9 knockout Hip Mouse Hip Cartilage 0.533648 -0.90604 1.452994e-03 5.959311e-03 DataSet_11_236
Lox Hipk2 knockout Heart cardiac tissue 0.472885 -1.08044 1.382326e-04 3.169128e-02 DataSet_11_238
Lox Kdm5b knockout Heart left ventricles 0.437045 -1.19414 0.5060861222 0.9999827 DataSet_11_210
Lox Dnmt1 knockout Embryo Embryonic fibroblasts 0.148888 -2.74769 9.954293e-05 3.137671e-03 DataSet_11_192
Lox Bcl3 siRNA Bone_marrow bone marrow derived macrophage (BMDM) 0.62401 -0.680359 - - DataSet_11_193
Lox Ezh2 knockdown Brain Brain 0.448188 -1.15782 5.078880e-04 0.0190157463 DataSet_11_221
Lox Brca1 knockout Brain mouse P7 cortex 2.50839 1.32676 1.870917e-04 1.217473e-02 DataSet_11_203
Lox Bptf shRNA Mammary_gland 4T1 cells 0.595979 -0.746666 9.716382e-04 0.081268814 DataSet_11_223
Lox Rag1 knockout Bone Mice fractured callus 4.81571 2.26775 1.030981e-05 2.639912e-04 DataSet_11_230
Lox Dux siRNA Embryo ES cells 1.77419 0.827163 6.859379e-02 0.8147855797 DataSet_11_239
Lox Ncl siRNA Embryo ES cells 1.74194 0.800691 1.715933e-01 0.5291541051 DataSet_11_240
Lox Dnmt3a siRNA Embryo iPSC 18.3726 4.19949 - - DataSet_11_241
Lox Dnmt3b siRNA Embryo iPSC 0.542513 -0.882271 - - DataSet_11_242
Lox Lin28a knockout Heart Heart 0.162033 -2.62564 0.4447632929 0.8777652 DataSet_11_243
Lox Twist1 knockout Bone_marrow stromal cells 0.0139736 -6.16115 - - DataSet_11_244
Lox Fubp1 shRNA Brain brain neural progenitors 2.25821 1.17518 0.8493896994 1 DataSet_11_246
Lox Kmt2d knockout Skin iBiP melanoma mouse model tumor cell 4.1306 2.04635 1.274933e-04 1.992742e-03 DataSet_11_250
Lox Mecp2 knockout Adipose_tissue brown adipose tissue 1.66212 0.733027 2.050763e-03 0.105277425 DataSet_11_253
Lox Brca1 siRNA Embryo Embryonic fibroblasts 2.14372 1.10012 0.0854647781 0.4427337 DataSet_11_256
Lox Eed knockout Brain Forebrain 1.74396 0.802368 1.218964e-02 2.929451e-01 DataSet_11_258
Lox Eed knockout Brain hindbrain 1.96672 0.975791 2.358165e-02 5.680413e-01 DataSet_11_259
Lox Eed knockout Brain midbrain 1.5071 0.591774 1.067792e-01 9.564060e-01 DataSet_11_260
Lox Eed knockout Spinal_cord spinal cord 0.592679 -0.754676 4.718155e-01 9.999790e-01 DataSet_11_261
Lox Fubp1 shRNA Bone_marrow BM cells 59 5.88264 5.299951e-02 0.486725791 DataSet_11_262
Lox Nsd2 knockout Bone_marrow Bone marrow immature B cells 7.42707 2.89279 2.967621e-01 0.56244364 DataSet_11_267
Lox Nr4a1 knockout Mammary_gland PyVT mouse mammary tumor cells 1.7879 0.838268 1.466490e-01 0.7273107 DataSet_11_268
Lox Dux knockout Embryo Embryo 3.92508 1.97272 2.026924e-01 3.781312e-01 DataSet_11_269
Lox Kat6b shRNA Bone_marrow LT-HSCs 8 3 5.589504e-01 0.7467559 DataSet_11_271
Lox Dux knockout Embryo Embryo 3.92508 1.97272 2.026987e-01 3.781406e-01 DataSet_11_273
Lox Myod1 CRISPR Skeletal_muscle myoblast 0.635355 -0.654366 4.319358e-05 4.087599e-04 DataSet_11_275
Lox Usp7 knockout Embryo ES cells 0.6 -0.736966 4.128891e-01 0.6831203 DataSet_11_279
Lox Pcgf6 knockout Brain Brain 1.61973 0.695756 1.801201e-01 0.988876895 DataSet_11_280
Lox Pdx1 CRISPR Liver Liver 0.284211 -1.81497 1.760482e-02 0.320198855 DataSet_11_286
Lox Kmt2d CRISPR Liver MA1L 1.68215 0.750304 2.183120e-06 4.707602e-04 DataSet_11_290
Lox Kmt2d CRISPR Liver MA1L 1.71962 0.78209 4.188945e-06 7.232671e-04 DataSet_11_291
Lox Mkl1 knockout Bone_marrow Bone marrow differentiated macrophages 0.539587 -0.890071 6.858261e-01 0.8631304772 DataSet_11_294
Lox Sirt3 knockout Pancreatic_islets pancreatic beta cell 1.57653 0.656753 2.813201e-01 7.144686e-01 DataSet_11_297
Lox Phf8 knockout prostate Prostate 5.27052 2.39794 0.0312653879 0.2202517 DataSet_11_298
Lox Arid2 knockout Muscle LSK 4.5 2.16992 1.558163e-02 3.860418e-01 DataSet_11_301
Lox Dnmt1 knockout Skin Keratinocytes 3.12765 1.64508 1.179554e-01 0.4582292651 DataSet_11_303
Lox Jmjd6 knockout Bone_marrow Lin-Sca1+Kit+ (LSK) haematopoietic stem and progenitor cells 0.181818 -2.45943 - - DataSet_11_306
Lox Suz12 knockout Lung Alveolar macrophage 18.8965 4.24005 1.804427e-02 0.2143982513 DataSet_11_311
Lox Suz12 knockout Lung Alveolar macrophage 2.32558 1.21759 7.241074e-02 1.411805e-01 DataSet_11_312
Lox Irf7 knockout Bone_marrow c-kit+ leukemic cells 0.551724 -0.857981 - - DataSet_11_313
Lox Arid2 knockout Bone_marrow bone marrow leukemia cells 0.247312 -2.0156 1.335666e-03 0.2471872 DataSet_11_318
Lox Kat7 knockout Thymic_lobes Thymic epithelial cells 2.24453 1.16641 9.309688e-02 2.681813e-01 DataSet_11_320
Lox Setdb1 shRNA Neuron NE-4C 0.13101 -2.93225 - - DataSet_11_323
Lox Ezh2 shRNA Brain SVZ derived neural stem cells 0.14302 -2.80571 1.932122e-03 3.633189e-02 DataSet_11_332
Lox Ezh2 knockout Eye Retina 0.487179 -1.03747 2.171988e-02 2.067263e-01 DataSet_11_333
Lox Dnmt1 siRNA Heart embryonic cardiomyocytes 0.522713 -0.935909 3.276771e-03 0.012200753 DataSet_11_340
Lox Ezh2 knockout Small_intestinal_crypts small intestinal crypts 0.431372 -1.21299 0.1168198544 0.1901505 DataSet_11_341
Lox Dux shRNA Embryo ES cells 5.5 2.45943 1.930988e-01 6.644478e-01 DataSet_11_345
Regulation Region
 
T(co)Fs that significantly regulate Cebpb by the evidences of both expression and ChIP-seq/motif
Expression Atlas of Lox
T(co)F Expression in Mouse Cell (Fantom5) T(co)F Expression in Mouse Tissue (Fantom5)