Gene Overview
| Target Gene: | Lum |
| NCBI Official Symbol: | Lum |
| Entrez ID: | 17022 |
| Ensembl ID: | ENSMUSG00000036446 |
| Gene Full Name: | lumican |
| Strand: | + |
| Gene Locus: | 10 C3|10 50.32 cM |
| External Links: |
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Lum Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate Lum
T(co)Fs
that Repress Lum
The Intensity of the Gene Regulated by T(co)Fs:
Lum-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| Lum | Ahr | knockout | Lung | Lung | 0.643883 | -0.63513 | 0.431760041050608 | 0.999996968611848 | DataSet_11_003 |
| Lum | Bcl11a | knockout | Bone_marrow | Bone marrow erythoid progenitors | 1.66292 | 0.73372 | 0.0279491519969254 | 0.326940446935269 | DataSet_11_013 |
| Lum | Bcl6 | knockout | Bone_marrow | Bone marrow-derived macrophages | 1.97727 | 0.983512 | 0.411601448080289 | 0.726299128434517 | DataSet_11_014 |
| Lum | Cbx2 | knockout | Gonads | Embryonic gonads | 1.92381 | 0.943965 | 2.01658353715773e-05 | 0.000380719214680228 | DataSet_11_018 |
| Lum | Cebpb | knockout | Mammary_gland | Mammary epithlial cells (MECs) | 0.562529 | -0.83 | 0.677569519667726 | 0.999788745984441 | DataSet_11_020 |
| Lum | E2f4 | knockout | Brain | Forebrain | 4.09449 | 2.03368 | - | - | DataSet_11_033 |
| Lum | Elf5 | knockout | Mammary_gland | Mammary gland | 2.24439 | 1.16632 | 0.109261186558787 | 0.392583341512753 | DataSet_11_035 |
| Lum | Foxp1 | knockout | Eye | Lens | 11.3721 | 3.50743 | - | - | DataSet_11_044 |
| Lum | Gata3 | siRNA | Peripheral_blood | CD4+ T helper (Th) cells | 2.17733 | 1.12256 | 0.17016402137086 | 0.987135756219234 | DataSet_11_048 |
| Lum | Gfi1 | knockout | Cord_Blood | T-cells | 12.2934 | 3.61982 | 0.232999902264963 | 0.632431505074402 | DataSet_11_053 |
| Lum | Hsf4 | knockout | Eye | Lens | 0.189257 | -2.40158 | 0.014078290167608 | 0.987999303842427 | DataSet_11_058 |
| Lum | Lhx8 | knockout | Ovary | Ovary | 1.81341 | 0.858703 | 0.00614854765425227 | 0.0400650414379033 | DataSet_11_070 |
| Lum | Lmx1b | knockout | Limb | Proximal limb | 0.353007 | -1.50223 | 9.11020233821704e-05 | 0.0524874185269333 | DataSet_11_071 |
| Lum | Mafg | knockout | Embryo | Whole embryo | 0.527156 | -0.923697 | 0.184160076693147 | 1 | DataSet_11_073 |
| Lum | Mbd1 | siRNA | Adipose_tissue | 3T3-L1 cells | 0.517942 | -0.949137 | - | - | DataSet_11_074 |
| Lum | Meis1 | knockout | Hematopoietic | KSL hematopoietic cells | 0.452121 | -1.14522 | 0.330535460063791 | 0.995635220774426 | DataSet_11_081 |
| Lum | Neurod1 | knockout | Eye | Retina | 2.32016 | 1.21422 | 0.0232585886388445 | 0.101219557168609 | DataSet_11_088 |
| Lum | Nhlh2 | knockout | Eye | Retina | 0.605603 | -0.723555 | 0.245597530652275 | 0.523726874680013 | DataSet_11_092 |
| Lum | Nr2f2 | knockout | Ovary | E14.5 Ovary | 1.6734 | 0.742782 | 0.0677310398914018 | 0.834975080343504 | DataSet_11_094 |
| Lum | Nrf1 | knockdown | Liver | Liver | 5.72421 | 2.51708 | 0.000631179792324479 | 0.0226437736282449 | DataSet_11_096 |
| Lum | Otx2 | knockout | Brain | Ganglionic eminences and septum | 0.595587 | -0.747617 | 0.733778800110865 | 0.931886192678222 | DataSet_11_098 |
| Lum | Pitx2 | knockout | Eye | Cornea | 4.4459 | 2.15248 | 0.00227504664137556 | 0.0784741259081758 | DataSet_11_103 |
| Lum | Plagl2 | knockout | Intestine | Small intestine | 1.58008 | 0.659998 | 0.107984747230657 | 0.382296973850562 | DataSet_11_104 |
| Lum | Pparg | siRNA | Adipose_tissue | Preadipocytes | 1.96072 | 0.971385 | 0.634536764949679 | 0.999962577291099 | DataSet_11_105 |
| Lum | Prox1 | knockout | Liver | Liver | 2.82878 | 1.50018 | - | - | DataSet_11_109 |
| Lum | Rest | knockout | Brain | Brain | 12.379 | 3.62983 | 0.155596061226515 | 1 | DataSet_11_113 |
| Lum | Runx1 | knockout | Embryo | Embryo | 1.76686 | 0.821187 | 0.789962174924874 | 0.999961610631375 | DataSet_11_114 |
| Lum | Runx1 | knockout | Bone_marrow | KSL cells | 0.515708 | -0.955373 | 0.0543985347006698 | 0.7748688703859 | DataSet_11_115 |
| Lum | Sall1 | knockout | Kidney | Kidney | 1.60615 | 0.683605 | 0.07700025767217 | 0.468306917933347 | DataSet_11_121 |
| Lum | Sall1 | knockout | Kidney | Kidney | 1.97771 | 0.983828 | 0.0762061283515029 | 0.836944381037537 | DataSet_11_122 |
| Lum | Sall4 | shRNA | Embryo | ES cells | 2.32623 | 1.21799 | 0.49043548471842 | 0.999840995136314 | DataSet_11_123 |
| Lum | Snai1 | knockout | Embryo | Embryoid body | 0.0121474 | -6.3632 | - | - | DataSet_11_129 |
| Lum | Snai1 | knockout | Embryo | Teratoma | 0.438588 | -1.18906 | - | - | DataSet_11_130 |
| Lum | Snai1 | knockout | Embryo | Embryonic stem cells (ESCs) | 0.634574 | -0.656139 | 0.0232372621440635 | 0.177912164684393 | DataSet_11_131 |
| Lum | Sox11 | knockout | Eye | Retina | 10.25 | 3.35755 | - | - | DataSet_11_137 |
| Lum | Sox2 | shRNA | Embryo | ES cells | 1.63421 | 0.708592 | - | - | DataSet_11_140 |
| Lum | Srf | knockout | Aorta | Aorta | 2.49666 | 1.32 | 0.0141612895064846 | 0.993526315825099 | DataSet_11_148 |
| Lum | Stat3 | knockout | Lung | Lung typeII cells | 0.507329 | -0.979008 | 0.42448828524564 | 0.851375681540361 | DataSet_11_151 |
| Lum | Stat4 | knockout | Lymph | Lamina propria lymphocytes | 0.655093 | -0.610228 | 0.2128164758996 | 0.924261066168849 | DataSet_11_152 |
| Lum | Tsc22d4 | shRNA | Liver | Liver | 0.656665 | -0.606771 | 0.00641217756056585 | 0.0278501002710507 | DataSet_11_169 |
| Lum | Wt1 | siRNA | Embryo_kidney | LB-22 | 0.654456 | -0.611632 | 0.118204685731901 | 0.326847538563573 | DataSet_11_179 |
| Lum | Xbp1 | siRNA | Liver | Liver | 1.91667 | 0.9386 | 0.00359599757473361 | 0.0638455459219789 | DataSet_11_181 |
| Lum | Cpeb1 | siRNA | Neuron | Neuro-2a | 0.516785 | -0.952364 | - | - | DataSet_11_189 |
| Lum | Mapk9 | knockout | Hip | Mouse Hip Cartilage | 0.471128 | -1.08581 | 7.546452e-05 | 5.956599e-04 | DataSet_11_236 |
| Lum | Kdm5b | knockout | Heart | left ventricles | 0.530351 | -0.91498 | 0.1701312388 | 0.9999827 | DataSet_11_210 |
| Lum | Dnmt1 | knockout | Embryo | Embryonic fibroblasts | 0.105294 | -3.2475 | 2.865642e-04 | 6.362908e-03 | DataSet_11_192 |
| Lum | Dnmt1 | shRNA | Embryo | Embryonic fibroblasts | 2.22022 | 1.1507 | - | - | DataSet_11_196 |
| Lum | Ezh2 | knockdown | Brain | Brain | 0.324986 | -1.62155 | 7.524149e-04 | 0.0234464624 | DataSet_11_221 |
| Lum | Brca1 | knockout | Brain | mouse P7 brain | 2.59885 | 1.37787 | 5.464215e-04 | 0.12174746 | DataSet_11_201 |
| Lum | Dnmt1 | knockout | Liver | Liver | 4.19258 | 2.06784 | 8.482856e-05 | 7.962947e-03 | DataSet_11_232 |
| Lum | Dnmt3a | siRNA | Peritoneum | peritoneal macrophages | 0.415945 | -1.26554 | - | - | DataSet_11_222 |
| Lum | Bptf | shRNA | Mammary_gland | 4T1 cells | 0.378929 | -1.4 | 6.522981e-03 | 0.185833747 | DataSet_11_223 |
| Lum | Bcl11b | knockdown | Embryo | Embryonic fibroblasts | 0.433358 | -1.20637 | - | - | DataSet_11_226 |
| Lum | Sfpq | knockdown | Embryo | P19 cells | 1.59338 | 0.672093 | 7.066292e-05 | 0.005613532 | DataSet_11_228 |
| Lum | Sfpq | knockdown | Embryo | P19 cells | 1.59338 | 0.672093 | 7.066292e-05 | 0.005613532 | DataSet_11_229 |
| Lum | Rag1 | knockout | Bone | Mice fractured callus | 2.78228 | 1.47627 | 7.909508e-03 | 3.510171e-02 | DataSet_11_230 |
| Lum | Dux | siRNA | Embryo | ES cells | 2.5 | 1.32193 | 2.216756e-01 | 0.8774371149 | DataSet_11_239 |
| Lum | Dnmt3a | siRNA | Embryo | iPSC | 0.485727 | -1.04178 | - | - | DataSet_11_241 |
| Lum | Dnmt3b | siRNA | Embryo | iPSC | 0.168711 | -2.56737 | - | - | DataSet_11_242 |
| Lum | Twist1 | knockout | Bone_marrow | stromal cells | 0.00436407 | -7.84011 | - | - | DataSet_11_244 |
| Lum | Kat6a | knockout | Embryo | Embryonic fibroblasts | 0.0277574 | -5.17099 | 1.849586e-05 | 0.0041045761 | DataSet_11_245 |
| Lum | Kmt2d | knockout | Skin | iBiP melanoma mouse model tumor cell | 0.474178 | -1.0765 | 7.400312e-03 | 3.783044e-02 | DataSet_11_250 |
| Lum | Zbp1 | siRNA | Bone_marrow | bone marrow-derived mesenchymal stem_progenitor cells | 0.0370709 | -4.75357 | 4.367122e-03 | 0.039645699 | DataSet_11_252 |
| Lum | Eed | knockout | Brain | hindbrain | 2.6221 | 1.39072 | 9.040348e-03 | 3.784835e-01 | DataSet_11_259 |
| Lum | Eed | knockout | Spinal_cord | spinal cord | 0.655717 | -0.608856 | 7.312676e-01 | 9.999790e-01 | DataSet_11_261 |
| Lum | Fubp1 | shRNA | Bone_marrow | BM cells | 24 | 4.58496 | 2.138181e-01 | 0.823679313 | DataSet_11_262 |
| Lum | Bcl3 | knockout | Bone | Osteoblast | 1.54652 | 0.629023 | 9.744205e-02 | 7.519931e-01 | DataSet_11_263 |
| Lum | Arhgap35 | knockout | Ventral_spinal_cord | Ventral spinal cord | 5 | 2.32193 | 2.544634e-01 | 1.000000000 | DataSet_11_264 |
| Lum | Myod1 | CRISPR | Skeletal_muscle | myoblast | 0.171937 | -2.54005 | 2.871071e-05 | 2.981489e-04 | DataSet_11_275 |
| Lum | Ezh2 | siRNA | Bone_marrow | Mesenchymal stem cells | 0.210526 | -2.24793 | 2.692218e-04 | 1.237719e-02 | DataSet_11_276 |
| Lum | Gsk3b | CRISPR | Neuron | mPFC D2 neurons | 3.30252 | 1.72357 | 4.205215e-01 | 0.85874453 | DataSet_11_277 |
| Lum | Pcgf6 | knockout | Testis | Testis | 0.625453 | -0.677026 | 2.231658e-01 | 0.8964874 | DataSet_11_282 |
| Lum | Dnmt1 | knockout | Cortex | mature Pvergic cortical interneurons | 0.4 | -1.32193 | 6.182863e-02 | 0.6936949 | DataSet_11_283 |
| Lum | Setd2 | knockout | Kidney | primary renal tubular epithelial (RTE) cells | 5 | 2.32193 | - | - | DataSet_11_285 |
| Lum | Pdx1 | CRISPR | Liver | Liver | 0.443472 | -1.17308 | 5.754250e-02 | 0.372082196 | DataSet_11_286 |
| Lum | Kmt2d | CRISPR | Liver | MA1L | 0.648893 | -0.623947 | 4.249263e-04 | 8.522413e-03 | DataSet_11_290 |
| Lum | Kmt2d | CRISPR | Liver | MA1L | 0.663042 | -0.592828 | 3.691771e-04 | 8.277789e-03 | DataSet_11_291 |
| Lum | Irf8 | knockout | Brain | mice brain | 0.655122 | -0.610165 | 1.673130e-01 | 7.167173e-01 | DataSet_11_292 |
| Lum | Phf8 | knockout | prostate | Prostate | 0.594034 | -0.751382 | 0.5825499125 | 0.7087521 | DataSet_11_298 |
| Lum | Brpf1 | shRNA | Nerve | Neural progenitor cells | 0.310443 | -1.6876 | 6.629018e-01 | 0.9999903 | DataSet_11_299 |
| Lum | Dnmt1 | knockout | Skin | Keratinocytes | 1.65071 | 0.72309 | 6.879053e-01 | 0.8702234578 | DataSet_11_303 |
| Lum | Jmjd6 | knockout | Bone_marrow | Lin-Sca1+Kit+ (LSK) haematopoietic stem and progenitor cells | 2 | 1 | - | - | DataSet_11_306 |
| Lum | Cited2 | knockout | Haematopoietic_and_lymphoid_tissue | Hematopoietic stem cell (HSC) | 2.33333 | 1.22239 | - | - | DataSet_11_308 |
| Lum | Myc | CRISPR | Skeletal_muscle | quiescent muscle stem cell | 8.66069 | 3.11448 | 4.745785e-01 | 0.83323068 | DataSet_11_310 |
| Lum | Irf7 | knockout | Bone_marrow | c-kit+ leukemic cells | 0.571429 | -0.807355 | - | - | DataSet_11_313 |
| Lum | Arid1b | knockout | Bone_marrow | bone marrow leukemia cells | 0.625 | -0.678072 | 2.075806e-01 | 0.5979963050 | DataSet_11_317 |
| Lum | Kat7 | knockout | Thymic_lobes | Thymic epithelial cells | 0.405634 | -1.30175 | 8.182829e-01 | 8.928709e-01 | DataSet_11_319 |
| Lum | Bud31 | knockout | Testis | Spermatogonial stem cells | 0.454591 | -1.13736 | 1.314427e-01 | 0.8600602 | DataSet_11_321 |
| Lum | Tet1 | siRNA | Embryo | Embryonic fibroblasts | 7.76238 | 2.9565 | 1.081187e-02 | 0.7965268 | DataSet_11_327 |
| Lum | Ezh2 | shRNA | Brain | SVZ derived neural stem cells | 2.36686 | 1.24297 | 4.794151e-01 | 7.602579e-01 | DataSet_11_332 |
| Lum | Ezh2 | knockout | Eye | Retina | 6.82767 | 2.77139 | 0.8232359385 | 1.0000000 | DataSet_11_334 |
| Lum | Dnmt1 | siRNA | Heart | embryonic cardiomyocytes | 0.337079 | -1.56884 | 2.352406e-03 | 0.010517275 | DataSet_11_340 |
| Lum | Hnrnpk | siRNA | Embryo | ES cells | 5.46695 | 2.45074 | 1.260795e-01 | 0.197583848 | DataSet_11_342 |
| Lum | Dnmt1 | knockout | Kidney | kidney Cap Mesenchyme | 3.30571 | 1.72496 | 1.147853e-02 | 1.163736e-01 | DataSet_11_344 |
| Lum | Setdb1 | shRNA | Embryo | ES cells | 5.08858 | 2.34727 | 1.901562e-02 | 7.343094e-01 | DataSet_11_346 |
Regulation Region
Expression Atlas of Lum