Gene Overview
Target Gene: MCF2L2
NCBI Official Symbol: MCF2L2
Entrez ID: 23101
Ensembl ID: ENSG00000053524
Gene Full Name: MCF.2 cell line derived transforming sequence-like 2
Strand: -
Gene Locus: 3q27.1
External Links:

MCF2L2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate MCF2L2   
T(co)Fs that Repress MCF2L2
The Intensity of the Gene Regulated by T(co)Fs:
MCF2L2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
MCF2L2 ID1 siRNA Lung A549 2.46305 1.30045 0.01854 0.16913 DataSet_01_117
MCF2L2 ZIC2 siRNA Pancreas PANC1 1.57234 0.65291 - - DataSet_01_121
MCF2L2 FOXM1 siRNA Central_nervous_system U87 4.60922 2.20452 - - DataSet_01_122
MCF2L2 ZNF85 siRNA Gastrointestinal_tissue GIST-T1 0.63031 -0.66587 0.00022 0.00478 DataSet_01_126
MCF2L2 POLR3A siRNA Mammary_gland MCF7 17.1429 4.09954 - - DataSet_01_139
MCF2L2 MAF siRNA Peripheral_blood CD4+ T cells 1.85349 0.89025 0.00084 0.02191 DataSet_01_165
MCF2L2 TP53 siRNA Lung SAECs 3.38636 1.75974 0.07679 0.45658 DataSet_01_175
MCF2L2 GABPA shRNA Prostate C4-2B 1712.16 10.7416 0.2362 0.43934 DataSet_01_190
MCF2L2 GABPA shRNA Prostate LNCaP 883.799 9.78757 0.46353 0.7048 DataSet_01_191
MCF2L2 GATA2 siRNA Prostate LNCaP 0.57934 -0.78751 0.1271 0.23249 DataSet_01_193
MCF2L2 CREB1 shRNA Parotid_gland H3118 MEC 2.09589 1.06756 0.88853 0.95959 DataSet_01_194
MCF2L2 CREB1 shRNA Parotid_gland HSY 1.98131 0.98646 0.21336 0.88168 DataSet_01_195
MCF2L2 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.23529 -2.08746 - - DataSet_01_196
MCF2L2 TP63 siRNA Head_and_neck SCC-1 15.5882 3.96239 - - DataSet_01_198
MCF2L2 TP63 siRNA Immortalized_keratinocyte HaCaT 2.51333 1.3296 - - DataSet_01_200
MCF2L2 TP63 siRNA Head_and_neck SCC-6 0.31863 -1.65006 - - DataSet_01_202
MCF2L2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 1.6904 0.75736 - - DataSet_01_210
MCF2L2 SNAI2 shRNA Skin Primary human keratinocytes 4.2263 2.0794 0.23915 0.37894 DataSet_01_225
MCF2L2 IRX1 shRNA Bone_marrow 143B 1.79503 0.84401 0.00884 0.09939 DataSet_01_227
MCF2L2 STAT5 shRNA Haematopoietic_and_lymphoid_tissue K562 2.20458 1.1405 4.01763e-05 0.00094 DataSet_01_239
MCF2L2 SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 0.16974 -2.55864 0.03385 0.79194 DataSet_01_290
MCF2L2 POSTN shRNA Brain GSC272 0.36112 -1.46947 0.12235 0.55804 DataSet_01_293
MCF2L2 TFAP4 siRNA Brain BE(2)-C 0.23134 -2.11191 0.34577 0.51625 DataSet_01_295
MCF2L2 PTEN shRNA Skin A431 3.21896 1.68659 0.18236 0.37307 DataSet_01_301
MCF2L2 PTEN shRNA Lung HCC827 0.23282 -2.10269 0.01596 0.4772 DataSet_01_302
MCF2L2 PTEN shRNA Mammary_gland SKBR3 0.5479 -0.86801 0.22982 0.69516 DataSet_01_303
MCF2L2 FOXO1 shRNA Haematopoietic_and_lymphoid_tissue 018Z 0.57664 -0.79426 0.05306 0.93203 DataSet_01_322
MCF2L2 HOXC6 siRNA Prostate LNCaP 0.10429 -3.26127 0.0056 0.96954 DataSet_01_333
MCF2L2 GATA3 siRNA Oral_cavity OEC-M1 2.12851 1.08984 0.01706 0.68576 DataSet_01_347
MCF2L2 HIF1A siRNA Oral_cavity OEC-M1 1.5661 0.64718 0.11546 0.85151 DataSet_01_348
MCF2L2 RBM17 shRNA Liver HepG2 4 2 0.05129 0.30005 DataSet_02_100
MCF2L2 RBFOX2 shRNA Liver HepG2 5 2.32193 0.4247 0.76484 DataSet_02_101
MCF2L2 FIP1L1 shRNA Liver HepG2 10 3.32193 0.00388 0.02603 DataSet_02_103
MCF2L2 TAF15 shRNA Liver HepG2 4.44444 2.152 0.84326 0.88402 DataSet_02_106
MCF2L2 HNRNPUL1 shRNA Liver HepG2 2.125 1.08746 0.36342 0.46091 DataSet_02_109
MCF2L2 GTF2F1 shRNA Liver HepG2 0.3125 -1.67807 0.01696 0.23312 DataSet_02_110
MCF2L2 BCLAF1 shRNA Liver HepG2 0.07692 -3.70044 0.01115 0.05167 DataSet_02_112
MCF2L2 PCBP1 shRNA Liver HepG2 0.22222 -2.16993 0.02418 0.0568 DataSet_02_115
MCF2L2 PTBP1 shRNA Liver HepG2 0.11111 -3.16993 0.01385 0.02866 DataSet_02_120
MCF2L2 RBM34 shRNA Liver HepG2 0.125 -3 0.03562 0.40242 DataSet_02_121
MCF2L2 SNRNP70 shRNA Liver HepG2 3.5 1.80735 0.03576 0.09898 DataSet_02_126
MCF2L2 SRSF3 shRNA Liver HepG2 21.5 4.42626 0.01115 0.08591 DataSet_02_127
MCF2L2 PRPF4 shRNA Liver HepG2 0.45455 -1.1375 0.05617 0.13656 DataSet_02_128
MCF2L2 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.42878 -1.22169 0.00501 0.03546 DataSet_02_131
MCF2L2 AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.33647 -1.57145 0.02921 0.14451 DataSet_02_132
MCF2L2 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.40521 -1.30325 0.00202 0.02173 DataSet_02_143
MCF2L2 SAFB2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.64667 -0.62891 0.10282 0.54039 DataSet_02_150
MCF2L2 EWSR1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.47444 -1.0757 0.02165 0.22555 DataSet_02_167
MCF2L2 ZFX siRNA Prostate C4-2B 1.61194 0.6888 0.22703 0.33518 DataSet_02_172
MCF2L2 ATF3 siRNA Haematopoietic_and_lymphoid_tissue K562 0.61102 -0.71071 0.24883 1 DataSet_02_180
MCF2L2 ZMIZ1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.73697 0.79657 0.28947 1 DataSet_02_181
MCF2L2 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 1.70222 0.76742 0.76215 1 DataSet_02_190
MCF2L2 AR siRNA Prostate LNCaP 2.16667 1.11548 0.142448786108709 1 DataSet_03_005
MCF2L2 BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.576636 -0.794268 0.262751413821156 0.839958940994557 DataSet_03_025
MCF2L2 BCL6 siRNA Lymph Pfeiffer DLBCL 0.417217 -1.26113 0.0105634348582148 0.331043678516123 DataSet_03_026
MCF2L2 GATA4 siRNA Stomach AGS 2.35013 1.23274 0.39171185569229 0.898636693256255 DataSet_03_105
MCF2L2 GATA4 siRNA Stomach KatoIII 0.194719 -2.36054 0.0291834116458471 0.823675022430061 DataSet_03_106
MCF2L2 GATA6 siRNA Stomach AGS 1.50822 0.592848 0.656759427060319 0.920253422660644 DataSet_03_108
MCF2L2 GATA6 siRNA Stomach KatoIII 0.138648 -2.8505 0.00267046926594176 0.241962393112841 DataSet_03_109
MCF2L2 GATA6 siRNA Stomach YCC3 0.36244 -1.46419 0.374697553231592 0.868744701844767 DataSet_03_110
MCF2L2 HNF4a siRNA Liver HepG2 0.647059 -0.628031 0.28445222645438 0.84556108161803 DataSet_03_126
MCF2L2 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.73322 0.793456 0.31219776533559 0.999948959532916 DataSet_03_134
MCF2L2 MEF2D shRNA Liver HuH7 1.58924 0.668339 - - DataSet_03_162
MCF2L2 MYB siRNA Cord_Blood CD34+ progenitor cells 0.122605 -3.02791 - - DataSet_03_170
MCF2L2 MYC siRNA Colon HT29 0.129382 -2.95029 - - DataSet_03_177
MCF2L2 NR2F2 siRNA Uterus Primary eutopic stromal cells 0.35722 -1.48512 0.159452551565675 0.99947668859931 DataSet_03_202
MCF2L2 PPARG siRNA Peripheral_blood GM-CSF Macrophage 0.51883 -0.946667 0.0777260206149801 0.888195818476953 DataSet_03_214
MCF2L2 PRRX1 CRISPR Neuroblastoma 691-MES 0.601178 -0.734137 0.171081446696061 0.89189998148014 DataSet_03_217
MCF2L2 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.263158 -1.926 - - DataSet_03_246
MCF2L2 STAT6 siRNA Umbilical_vein HUVEC 0.342342 -1.54649 0.16769634346034 0.836958415665057 DataSet_03_264
MCF2L2 TFAP2C siRNA Mammary_gland MCF7 1.50224 0.58712 0.56378811062608 0.800684124843112 DataSet_03_274
MCF2L2 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 0.628499 -0.670018 0.0373291634540988 0.110946378838515 DataSet_04_002
MCF2L2 FUBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.95258 0.96538 0.02210251261765 0.0884798824661244 DataSet_04_010
MCF2L2 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 32.2527 5.01135 0.00362061793495409 0.0265090820769047 DataSet_04_014
MCF2L2 ZNF574 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.392947 -1.34759 0.00415681367435224 0.113567209536072 DataSet_04_023
MCF2L2 APTX CRISPR Liver HepG2 0.5 -1 0.908935442775218 0.996016383997267 DataSet_04_069
MCF2L2 CNOT7 CRISPR Liver HepG2 0.6 -0.736966 0.779272531455801 0.871866924320915 DataSet_04_045
MCF2L2 PAN2 CRISPR Liver HepG2 3 1.58496 0.766650791222066 0.873568327742526 DataSet_04_066
MCF2L2 ABT1 shRNA Liver HepG2 1.61538 0.691878 0.723640752549935 0.819710812277556 DataSet_04_052
MCF2L2 PRPF6 shRNA Liver HepG2 0.125 -3 0.305238402955071 0.522207473868859 DataSet_04_056
MCF2L2 UBE2L3 shRNA Liver HepG2 2 1 0.928620617409338 0.963489806410696 DataSet_04_055
MCF2L2 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.72792 0.789032 0.0696607832832401 0.152751558314297 DataSet_02_14
MCF2L2 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.90459 0.929483 0.0395773235343459 0.111355836156757 DataSet_02_34
MCF2L2 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.62862 -0.66974 0.0404585999747584 0.405123309920551 DataSet_02_75
MCF2L2 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.39576 1.26048 0.0266105752738282 0.480607566711255 DataSet_02_45
MCF2L2 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.60954 0.686649 0.0810404621890526 0.404197314477055 DataSet_02_32
MCF2L2 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.09691 1.06826 0.00541130187514681 0.0389964449216454 DataSet_04_060
MCF2L2 CCAR1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.65227 0.724452 0.0167889989474326 0.084089362431762 DataSet_04_064
MCF2L2 BRCA1 siRNA Mammary_gland MCF7 1.5559 0.637751 3.942693e-01 0.9999931 DataSet_03_308
MCF2L2 ZFX siRNA Prostate C4-2B 2.81955 1.49547 1.673896e-04 8.858989e-04 DataSet_03_348
MCF2L2 ZFX siRNA Mammary_gland MCF7 1.75027 0.80758 7.899908e-03 5.198726e-02 DataSet_03_349
MCF2L2 EZH2 shRNA Mammary_gland LM2 1.54284 0.625591 2.645488e-01 6.643949e-01 DataSet_03_350
MCF2L2 CREBBP CRISPR Brain U5-NPC 4.54545 2.18442 0.0356831990 0.7490853 DataSet_03_356
MCF2L2 TP53 CRISPR Brain U5-NPC 3.81818 1.93289 1.074812e-02 1.623145e-01 DataSet_03_358
MCF2L2 EP300 shRNA Mammary_gland MCF10AT 0.539007 -0.891624 9.888615e-03 0.073969650 DataSet_03_364
MCF2L2 TP53 knockout Stomach SNU1 0.52684 -0.924564 0.2979692234 0.9301241 DataSet_03_365
MCF2L2 USP22 shRNA Liver PLC_PRF_5 cells 0.141176 -2.82443 2.307738e-03 0.07383509 DataSet_03_368
MCF2L2 ZFP36L1 siRNA Urinary_bladder J82 2.44828 1.29177 - - DataSet_03_371
MCF2L2 E2F1 siRNA Nasopharynx HK1 0.488189 -1.03449 3.585621e-02 2.815643e-01 DataSet_03_373
MCF2L2 GLI1 siRNA Skeletal_muscle RMS13 2.07115 1.05043 2.475676e-01 0.480543030 DataSet_03_375
MCF2L2 ZNF213 siRNA Mammary_gland MCF7 0.532936 -0.907965 7.213943e-01 8.815597e-01 DataSet_03_376
MCF2L2 EZH2 CRISPR Ovary SKOV3 0.257812 -1.95561 5.434544e-02 0.2040188780 DataSet_03_378
MCF2L2 TCF19 CRISPR Oral_squamous CAL27 0.450482 -1.15046 1.824205e-02 0.1110581164 DataSet_03_383
MCF2L2 YY1 shRNA Brain GSC1517 1.54664 0.629139 - - DataSet_03_384
MCF2L2 YY1 shRNA Brain GSC23 0.633851 -0.657784 - - DataSet_03_385
MCF2L2 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 0.600305 -0.736232 0.5162403000 0.8939260 DataSet_03_387
MCF2L2 NFKBIA shRNA Bone_marrow U2OS 0.0579198 -4.1098 5.771511e-01 0.87005461 DataSet_03_389
MCF2L2 PRDM15 CRISPR Kidney Immortalized human podocytes 0.620534 -0.688417 2.733844e-02 8.933158e-02 DataSet_03_391
MCF2L2 KDM5A CRISPR Lung GLC16 0.637722 -0.649001 8.539036e-03 0.039332859 DataSet_03_392
MCF2L2 ILF2 siRNA Stomach SGC-7901 1.73333 0.793549 0.0299177575 0.10842829 DataSet_03_393
MCF2L2 ASXL1 CRISPR Embryo iPSC 0.561996 -0.831367 0.6174109739 0.9044929 DataSet_03_394
MCF2L2 JAZF1 siRNA Cervix HeLa Kyoto 0.629931 -0.666734 1.712065e-01 0.766122791 DataSet_03_396
MCF2L2 RELA CRISPR Brain T30 0.618929 -0.692154 0.6263183004 0.8891161 DataSet_03_399
MCF2L2 HMGA1 shRNA Bile_duct HUCCT1 1.52347 0.607357 3.959784e-02 0.238607137 DataSet_03_400
MCF2L2 SUMO1 CRISPR Bone_marrow U2OS 1.83582 0.876425 7.441962e-04 1.169225e-02 DataSet_03_401
MCF2L2 EHF shRNA Stomach MKN7 3.70148 1.8881 - - DataSet_03_402
MCF2L2 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.66667 0.736966 5.711773e-01 0.6863958 DataSet_03_403
MCF2L2 CDK7 shRNA Bone_marrow D458 0.0740741 -3.75489 2.252821e-02 0.23122961 DataSet_03_404
MCF2L2 E2F1 siRNA Prostate LNCaP 0.632035 -0.661924 5.274430e-02 0.5393518624 DataSet_03_413
MCF2L2 ZKSCAN3 CRISPR Colon HCT116 0.552598 -0.855697 3.092535e-03 0.133091970 DataSet_03_415
MCF2L2 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 2.51852 1.33257 1.083038e-03 0.012769784 DataSet_03_418
MCF2L2 FOXK2 shRNA Ovary OVCAR-5 0.413386 -1.27444 9.267258e-02 0.26271368 DataSet_03_419
MCF2L2 MAEL CRISPR Liver Alexander cells 0.0625 -4 - - DataSet_03_423
MCF2L2 IKZF2 shRNA Lymph Hut78 1.73776 0.797231 1.909811e-01 0.69455278 DataSet_03_429
MCF2L2 STAT3 siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 1.6875 0.754888 0.3521007799 1 DataSet_03_430
MCF2L2 USP7 shRNA Skin xenograft cells 0.398791 -1.32629 0.25963736 0.4348960 DataSet_03_431
MCF2L2 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.425806 -1.23173 - - DataSet_03_432
MCF2L2 NFE2L1 knockout Lung A549 2.80395 1.48746 4.041942e-01 9.984904e-01 DataSet_03_433
MCF2L2 CIC knockout Brain Immortalized Astrocyte Cells 2.41772 1.27365 1.227761e-01 5.689575e-01 DataSet_03_438
MCF2L2 RELB CRISPR Colon SW480 1.74803 0.805731 7.058352e-02 2.404444e-01 DataSet_03_449
MCF2L2 CBX2 siRNA Mammary_gland MCF7 0.647888 -0.626185 2.482317e-01 0.3955897390 DataSet_03_451
MCF2L2 SREBF2 siRNA Umbilical_vein HUVEC 0.42801 -1.22428 1.475859e-01 5.770757e-01 DataSet_03_457
MCF2L2 ARID1A shRNA Bile_duct MMNK1 1.62139 0.697231 1.497344e-01 0.429332446 DataSet_03_458
MCF2L2 TXNIP shRNA Cord_Blood CD34+ cells 20 4.32193 - - DataSet_03_461
MCF2L2 TXNIP shRNA Cord_blood ST3 1.58333 0.662965 5.432097e-01 0.7077963307 DataSet_03_462
MCF2L2 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 2.92 1.54597 - - DataSet_03_467
MCF2L2 EZH2 siRNA Prostate LNCaP 2.10842 1.07616 - - DataSet_03_472
MCF2L2 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 0.628499 -0.670018 0.01513033 0.055619136 DataSet_04_074
Regulation Region
 
T(co)Fs that significantly regulate HOXC6 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of MCF2L2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines