Gene Overview
Target Gene: MCOLN3
NCBI Official Symbol: MCOLN3
Entrez ID: 55283
Ensembl ID: ENSG00000055732
Gene Full Name: mucolipin 3
Strand: -
Gene Locus: 1p22.3
External Links:

MCOLN3 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate MCOLN3   
T(co)Fs that Repress MCOLN3
The Intensity of the Gene Regulated by T(co)Fs:
MCOLN3-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
MCOLN3 SPDEF shRNA Mammary_gland MCF7 0.29247 -1.77364 0.68966 0.99999 DataSet_01_107
MCOLN3 TCF3 shRNA Mammary_gland MDA-MB468 2.10823 1.07603 6.04999e-06 0.00035 DataSet_01_116
MCOLN3 ID1 siRNA Lung A549 3.63278 1.86107 0.00179 0.09817 DataSet_01_117
MCOLN3 FOXM1 siRNA Central_nervous_system U87 0.1239 -3.01275 - - DataSet_01_122
MCOLN3 ZNF91 siRNA Gastrointestinal_tissue GIST-T1 0.64974 -0.62206 0.00079 0.0156 DataSet_01_123
MCOLN3 ZNF85 siRNA Gastrointestinal_tissue GIST-T1 0.47477 -1.07469 1.16241e-05 0.00127 DataSet_01_126
MCOLN3 ZNF431 siRNA Gastrointestinal_tissue GIST-T1 0.53563 -0.90069 4.91762e-05 0.00128 DataSet_01_128
MCOLN3 ELK1 siRNA Peripheral_blood CD4+ T cells 1.97085 0.97882 0.01219 0.05888 DataSet_01_162
MCOLN3 GATA3 siRNA Peripheral_blood CD4+ T cells 1.51401 0.59838 0.04019 0.32638 DataSet_01_163
MCOLN3 HSF1 shRNA Liver KYN2 1.66516 0.73566 - - DataSet_01_178
MCOLN3 GABPA shRNA Prostate C4-2B 1968.59 10.943 0.238 0.43934 DataSet_01_190
MCOLN3 GABPA shRNA Prostate LNCaP 1446.98 10.4988 0.46106 0.7048 DataSet_01_191
MCOLN3 CREB1 shRNA Parotid_gland H3118 MEC 2.42726 1.27933 0.00251 0.1173 DataSet_01_194
MCOLN3 CREB1 shRNA Parotid_gland HSY 1.88602 0.91535 0.11574 0.75188 DataSet_01_195
MCOLN3 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.46875 -1.09311 - - DataSet_01_196
MCOLN3 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.65393 -0.6128 - - DataSet_01_197
MCOLN3 MITF shRNA Skin COLO829 0.40498 -1.30406 5.94584e-06 0.00111 DataSet_01_207
MCOLN3 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.63404 -0.65735 - - DataSet_01_209
MCOLN3 REST siRNA Prostate LNCaP 1.51611 0.60037 0.00926 0.16922 DataSet_01_211
MCOLN3 EGR3 shRNA Prostate M12 0.42029 -1.25054 0.00712 0.101 DataSet_01_212
MCOLN3 ATM shRNA Mammary_gland MCF10A 2.16818 1.11649 1.22935e-08 7.88678e-07 DataSet_01_219
MCOLN3 HIF1A shRNA Liver HuH7 1.53934 0.62231 - - DataSet_01_224
MCOLN3 IRX1 shRNA Bone_marrow 143B 2.44812 1.29167 0.00281 0.05867 DataSet_01_227
MCOLN3 MYC siRNA White_adipose_tissue Adipose stem cells 1.73551 0.79536 0.01476 0.09972 DataSet_01_231
MCOLN3 TWIST1 shRNA Stomach CAF14 1.67607 0.74508 0.18394 0.99996 DataSet_01_252
MCOLN3 YBX1 shRNA Mammary_gland MDA 0.56848 -0.81482 2.38578e-09 2.46959e-07 DataSet_01_255
MCOLN3 YBX1 shRNA Mammary_gland MDA 0.62643 -0.67478 0.00012 0.0021 DataSet_01_257
MCOLN3 SOX4 shRNA Mammary_gland MDA-MB-231 1.9559 0.96783 0.00043 0.02154 DataSet_01_260
MCOLN3 ZIC5 siRNA Skin SK-MEL-28 1.79792 0.84633 - - DataSet_01_285
MCOLN3 NFYA shRNA Colon HCT1163 0.43806 -1.19082 0.00136 0.02533 DataSet_01_287
MCOLN3 TFAP4 siRNA Brain BE(2)-C 0.27318 -1.87205 0.43738 0.51625 DataSet_01_295
MCOLN3 SOX17 siRNA Umbilical_vein HUVEC 3.82775 1.9365 0.11037 0.99998 DataSet_01_300
MCOLN3 PTEN shRNA Skin A431 2.09708 1.06838 0.00364 0.07331 DataSet_01_301
MCOLN3 PTEN shRNA Mammary_gland SKBR3 1.7389 0.79817 0.2332 0.69614 DataSet_01_303
MCOLN3 ETV5 siRNA Soft_tissue hADSC 1.54528 0.62787 0.00107 0.02064 DataSet_01_304
MCOLN3 REST siRNA Skin NHEK 1.71158 0.77533 0.00013 0.01181 DataSet_01_337
MCOLN3 KLF7 siRNA Embryo HCE 0.58791 -0.76633 0.20192 0.64233 DataSet_01_340
MCOLN3 GATA3 siRNA Oral_cavity OEC-M1 0.59467 -0.74985 0.13894 0.99787 DataSet_01_347
MCOLN3 SSB shRNA Liver HepG2 2.33333 1.22239 0.93156 0.95184 DataSet_02_107
MCOLN3 BCLAF1 shRNA Liver HepG2 0.07692 -3.70044 0.00188 0.02682 DataSet_02_112
MCOLN3 TARDBP shRNA Liver HepG2 0.14286 -2.80735 0.46422 0.55872 DataSet_02_116
MCOLN3 HNRNPLL shRNA Liver HepG2 0.14286 -2.80735 0.45635 0.5423 DataSet_02_125
MCOLN3 SRSF3 shRNA Liver HepG2 2 1 0.30509 0.46278 DataSet_02_127
MCOLN3 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 1 1 DataSet_02_131
MCOLN3 SRSF7 shRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 1 1 DataSet_02_133
MCOLN3 PCBP2 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.04574 0.15664 DataSet_02_135
MCOLN3 CCAR2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.66667 1.41504 0.19014 0.61321 DataSet_02_146
MCOLN3 RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 5 2.32193 0.05164 0.25594 DataSet_02_151
MCOLN3 SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 0.42857 -1.22239 0.06976 0.401 DataSet_02_154
MCOLN3 FUS shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.89603 0.95108 DataSet_02_155
MCOLN3 GTF2F1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.28571 -1.80735 0.03848 0.84451 DataSet_02_157
MCOLN3 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 3.66667 1.87447 0.49272 0.65543 DataSet_02_160
MCOLN3 SUB1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.57143 -0.80735 0.1127 0.73994 DataSet_02_161
MCOLN3 SSB shRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.04746 0.23342 DataSet_02_164
MCOLN3 U2AF1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.33333 1.22239 0.51734 0.66749 DataSet_02_165
MCOLN3 RBM22 shRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.00381 0.05934 DataSet_02_168
MCOLN3 U2AF2 shRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.10509 0.21363 DataSet_02_170
MCOLN3 MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.43478 -1.20163 0.16931 1 DataSet_02_173
MCOLN3 CEBPZ siRNA Haematopoietic_and_lymphoid_tissue K562 1.94444 0.95936 0.87731 1 DataSet_02_176
MCOLN3 TBL1XR1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.51351 -0.96153 0.47672 1 DataSet_02_178
MCOLN3 ATF3 siRNA Haematopoietic_and_lymphoid_tissue K562 0.54545 -0.87447 0.74491 1 DataSet_02_180
MCOLN3 KAT2B siRNA Haematopoietic_and_lymphoid_tissue K562 0.52941 -0.91754 0.51373 1 DataSet_02_184
MCOLN3 CTCF siRNA Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.28147 1 DataSet_02_185
MCOLN3 CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.9645 1 DataSet_02_187
MCOLN3 BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.66667 0.73697 0.63472 1 DataSet_02_188
MCOLN3 ARID3A siRNA Haematopoietic_and_lymphoid_tissue K562 3.5 1.80735 0.70453 1 DataSet_02_193
MCOLN3 LMNB1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.05556 1.03953 0.91381 1 DataSet_02_195
MCOLN3 CDAN1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.83333 1.5025 0.23732 1 DataSet_02_197
MCOLN3 MAZ siRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.62127 1 DataSet_02_199
MCOLN3 E2F4 siRNA Haematopoietic_and_lymphoid_tissue K562 0.64 -0.64386 0.57431 1 DataSet_02_200
MCOLN3 TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.28571 -1.80735 0.20994 1 DataSet_02_201
MCOLN3 ZNF384 siRNA Haematopoietic_and_lymphoid_tissue K562 0.40541 -1.30256 0.92019 1 DataSet_02_203
MCOLN3 ZFX siRNA Mammary_gland MCF7 0.63118 -0.66388 0.00592 0.06836 DataSet_02_206
MCOLN3 BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.654567 -0.611388 0.0778768915474428 0.750786024942965 DataSet_03_025
MCOLN3 GATA4 siRNA Stomach KatoIII 0.547344 -0.869481 0.0707187891318001 0.881216717151197 DataSet_03_106
MCOLN3 GATA6 siRNA Stomach AGS 1.88664 0.91582 0.0691591263259543 0.530161957073537 DataSet_03_108
MCOLN3 KLF5 siRNA Stomach AGS 1.80617 0.852935 0.169128309939903 0.648960120936423 DataSet_03_149
MCOLN3 MEF2D shRNA Liver HuH7 1.90029 0.926223 - - DataSet_03_162
MCOLN3 MITF siRNA Skin MZ7 0.461343 -1.11609 1.1667896080912e-09 4.24324933575642e-08 DataSet_03_165
MCOLN3 MYC siRNA Colon HT29 0.465102 -1.10438 - - DataSet_03_177
MCOLN3 NR4A3 siRNA Pancreas 1.1B4 2.20944 1.14368 4.67757329701292e-07 1.89120707183126e-05 DataSet_03_203
MCOLN3 PHB shRNA Embryo Embryonic stem cells (ESCs) 2.4299 1.2809 7.45740096374009e-06 0.000318574770350918 DataSet_03_211
MCOLN3 RELB siRNA Immortalized_keratinocyte HaCaT 1.65527 0.727066 0.00149702744342762 0.0116195925521495 DataSet_03_227
MCOLN3 SOX2 siRNA Embryo 2102Ep 3.47069 1.79522 1.1496427320871e-08 5.04996838598486e-06 DataSet_03_242
MCOLN3 SP1 siRNA Ovary OVSAYO 1.77913 0.831173 0.0495239672630038 0.273177754842127 DataSet_03_251
MCOLN3 STAT1 knockout Liver Huh-7.5 1.51897 0.603093 0.00103268270958177 0.0338625289945493 DataSet_03_257
MCOLN3 STAT3 CRISPR Embryo hESC 0.582808 -0.778908 0.719100444437691 0.76716743015534 DataSet_03_258
MCOLN3 TFE3 siRNA Kidney UOK257-2 0.612523 -0.707164 - - DataSet_03_275
MCOLN3 TWIST1 siRNA Bone_marrow MSCs 2.37778 1.24961 - - DataSet_03_283
MCOLN3 YBX1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.526316 -0.925999 0.184686035095034 0.58496328879269 DataSet_04_022
MCOLN3 SMAD2 CRISPR Liver HepG2 1.66667 0.736966 0.118795351927992 0.66041260025524 DataSet_04_034
MCOLN3 CHCHD3 CRISPR Liver HepG2 4 2 0.478648532850504 0.7619281376529 DataSet_04_067
MCOLN3 CNOT7 CRISPR Liver HepG2 0.333333 -1.58496 0.520154381152209 0.680508582002569 DataSet_04_045
MCOLN3 SEPT11 CRISPR Liver HepG2 0.333333 -1.58496 0.62980974436334 0.824216614053955 DataSet_04_068
MCOLN3 UBE2L3 shRNA Liver HepG2 0.25 -2 0.786620397246829 0.881696737189737 DataSet_04_055
MCOLN3 DDX17 CRISPR Haematopoietic_and_lymphoid_tissue K562 2 1 0.906826311370114 0.98976397934186 DataSet_04_047
MCOLN3 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.77778 1.47393 0.376025488071448 0.628665455497639 DataSet_02_38
MCOLN3 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 7.55556 2.91754 0.223194398342121 0.697712433509231 DataSet_02_45
MCOLN3 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.11111 1.63743 0.213040902308232 0.368681991503325 DataSet_02_35
MCOLN3 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 6.55556 2.71272 0.0295871098309653 0.343718476218146 DataSet_02_32
MCOLN3 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2 1 0.487982470402648 0.644316198469991 DataSet_02_47
MCOLN3 TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.555556 -0.847997 0.784533502301764 0.893433937759132 DataSet_02_43
MCOLN3 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.77778 1.91754 0.14054521752833 0.279280331749543 DataSet_02_53
MCOLN3 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 4 2 0.600113351417141 0.739160615236626 DataSet_04_060
MCOLN3 CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.809439261611894 0.913361165890038 DataSet_04_061
MCOLN3 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 1.6 0.678072 0.857431311252994 0.917734057252644 DataSet_04_059
MCOLN3 EZH2 shRNA Colon SW480 3.82969 1.93723 - - DataSet_03_298
MCOLN3 ARID3B CRISPR Colon HCT15 0.57517 -0.79794 - - DataSet_03_335
MCOLN3 SKI CRISPR Blood HL60 17 4.08746 9.687325e-03 0.184965054 DataSet_03_351
MCOLN3 ESR1 siRNA Mammary_gland MCF7 2.21461 1.14705 1.989290e-04 0.0111385193 DataSet_03_352
MCOLN3 ETV5 knockdown Colon HT29 0.342593 -1.54543 2.458133e-04 0.030978016 DataSet_03_353
MCOLN3 TET1 CRISPR Mammary_gland Hs578T 1.90949 0.933189 1.741694e-02 7.016885e-02 DataSet_03_355
MCOLN3 MYC siRNA Peripheral_blood T lymphocyte 3.45192 1.7874 7.691475e-02 0.267576289 DataSet_03_363
MCOLN3 TP53 knockout Stomach SNU1 1.72378 0.785575 0.2991593296 0.9301241 DataSet_03_365
MCOLN3 DNMT3A knockout Embryo_kidney HEK293T 2.79603 1.48338 - - DataSet_03_369
MCOLN3 ZFP36L1 siRNA Urinary_bladder J82 2.64038 1.40074 - - DataSet_03_371
MCOLN3 DDX5 shRNA Stomach HGC-27 1.67725 0.746097 - - DataSet_03_379
MCOLN3 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 2.49018 1.31625 0.1092628288 0.8388073 DataSet_03_387
MCOLN3 NFKBIA shRNA Bone_marrow U2OS 0.0027023 -8.5316 3.308152e-01 0.87005461 DataSet_03_389
MCOLN3 PRDM15 CRISPR Kidney Immortalized human podocytes 0.0997777 -3.32514 3.214587e-05 9.426055e-04 DataSet_03_391
MCOLN3 ASXL1 CRISPR Embryo iPSC 0.634131 -0.657147 0.6695346474 0.9196471 DataSet_03_394
MCOLN3 BMI1 shRNA Bile_duct QBC-939 1.99238 0.994494 3.199708e-02 0.0963189578 DataSet_03_395
MCOLN3 TLE4 CRISPR Lymph CAR T Cell 0.54023 -0.888353 4.470980e-03 0.10381879 DataSet_03_398
MCOLN3 RELA CRISPR Brain T30 1.70796 0.772273 0.4011830940 0.8400824 DataSet_03_399
MCOLN3 HMGA1 shRNA Bile_duct HUCCT1 1.88889 0.917538 9.866921e-01 1.000000000 DataSet_03_400
MCOLN3 SATB2 CRISPR Colon Colon organoid 2.19118 1.13171 9.941536e-02 0.95735254 DataSet_03_406
MCOLN3 CHD1 shRNA Prostate LNCaP 0.5 -1 5.174496e-02 4.792531e-01 DataSet_03_407
MCOLN3 MAP3K7 shRNA Prostate LNCaP 0.384615 -1.37851 1.502812e-02 1.030121e-01 DataSet_03_408
MCOLN3 STRAP knockout Nerve SK-N-AS 6.71788 2.74801 - - DataSet_03_409
MCOLN3 SIRT1 siRNA Pancreas PANC1 2.40553 1.26636 5.137251e-03 0.035644422 DataSet_03_410
MCOLN3 ZKSCAN3 CRISPR Colon HCT116 0.597841 -0.742166 5.608139e-03 0.176581427 DataSet_03_415
MCOLN3 FOXK2 shRNA Ovary OVCAR-5 1.57857 0.65862 1.834845e-01 0.41800359 DataSet_03_419
MCOLN3 BRD4 CRISPR Lymph CD8+ T cells 1.93985 0.955945 - - DataSet_03_420
MCOLN3 PRDM1 CRISPR Lymph CD8+ T cells 1.58647 0.665817 - - DataSet_03_421
MCOLN3 FOXQ1 CRISPR Lymph Primary CD4+ T cells 0.552727 -0.85536 - - DataSet_03_422
MCOLN3 MAEL CRISPR Liver Alexander cells 0.591429 -0.757724 - - DataSet_03_423
MCOLN3 FOXP3 CRISPR Peripheral_blood Naive Treg 0.500433 -0.998752 1.343471e-01 0.479076619 DataSet_03_427
MCOLN3 LHX2 shRNA Bone_marrow ES-derived RPE cells 0.655405 -0.609541 3.508025e-01 1.000000e+00 DataSet_03_428
MCOLN3 IKZF2 shRNA Lymph Hut78 1.69777 0.763644 3.526155e-02 0.43111519 DataSet_03_429
MCOLN3 USP7 shRNA Skin xenograft cells 0.442416 -1.17652 0.26471956 0.4348960 DataSet_03_431
MCOLN3 NFE2L1 knockout Lung A549 0.592768 -0.75446 1.113183e-01 7.563853e-01 DataSet_03_433
MCOLN3 EP300 knockout Pancreas HPAF-II orthotopic cells 3.27273 1.71049 2.950684e-01 5.053505e-01 DataSet_03_436
MCOLN3 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 0.38975 -1.35938 3.056726e-01 0.90558273 DataSet_03_439
MCOLN3 SETDB1 shRNA Colon HCT116 0.510752 -0.969305 - - DataSet_03_440
MCOLN3 DAXX shRNA Mammary_gland MDA-MB-231 0.047338 -4.40086 6.666458e-02 0.28745727 DataSet_03_441
MCOLN3 CAMTA1 knockout Embryo_kidney HEK293T 2.80645 1.48875 1.960641e-02 0.13105762 DataSet_03_448
MCOLN3 CBX2 siRNA Mammary_gland MCF7 2.46289 1.30035 1.124499e-05 0.0005253143 DataSet_03_451
MCOLN3 SMARCA2 shRNA Lung HCC2302 2.44065 1.28726 1.339192e-11 1.499370e-10 DataSet_03_455
MCOLN3 SOX9 knockout Liver HuH7 0.461126 -1.11677 5.075043e-03 2.657407e-02 DataSet_03_463
MCOLN3 STAT3 shRNA Liver HepG2 0.133333 -2.90689 3.308333e-03 0.0741454288 DataSet_03_465
MCOLN3 SMARCA1 Cas13 Embryo_kidney HEK293T 0.286116 -1.80533 - - DataSet_03_466
MCOLN3 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 2.89681 1.53447 - - DataSet_03_467
MCOLN3 SMARCA1 shRNA Embryo_kidney HEK293T 0.450281 -1.1511 - - DataSet_03_468
MCOLN3 WHSC1 siRNA Prostate PC3 0.642695 -0.637794 2.301215e-02 0.14704911 DataSet_03_471
MCOLN3 CHCHD3 CRISPR Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.8474363 1 DataSet_04_071
MCOLN3 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.81533 0.9729878 DataSet_04_072
MCOLN3 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 8 3 0.4495239 0.610937394 DataSet_04_074
Regulation Region
 
T(co)Fs that significantly regulate BCL11A by the evidences of both expression and ChIP-seq/motif
Expression Atlas of MCOLN3
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines