Gene Overview
Target Gene: NPHP1
NCBI Official Symbol: NPHP1
Entrez ID: 4867
Ensembl ID: ENSG00000144061
Gene Full Name: nephrocystin 1
Strand: -
Gene Locus: 2q13
External Links:

NPHP1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate NPHP1   
T(co)Fs that Repress NPHP1
The Intensity of the Gene Regulated by T(co)Fs:
NPHP1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
NPHP1 HOXA1 siRNA Lung_fibroblast IMR-90 1.60782 0.68511 0.03016 0.18518 DataSet_01_110
NPHP1 TCF3 shRNA Mammary_gland MDA-MB468 0.645 -0.63264 5.03155e-06 3e-04 DataSet_01_116
NPHP1 ZIC2 siRNA Pancreas PANC1 3.65946 1.87163 - - DataSet_01_121
NPHP1 POLR3A siRNA Mammary_gland MCF7 0.64529 -0.63199 - - DataSet_01_139
NPHP1 ELK1 siRNA Peripheral_blood CD4+ T cells 2.80276 1.48685 0.01337 0.06268 DataSet_01_162
NPHP1 JUN siRNA Peripheral_blood CD4+ T cells 1.59236 0.67117 0.14105 0.35596 DataSet_01_164
NPHP1 NFATC3 siRNA Peripheral_blood CD4+ T cells 2.35452 1.23543 0.02682 0.16459 DataSet_01_166
NPHP1 STAT3 siRNA Peripheral_blood CD4+ T cells 0.47342 -1.0788 0.28116 0.99183 DataSet_01_168
NPHP1 GABPA shRNA Prostate C4-2B 1758.24 10.7799 0.23755 0.43934 DataSet_01_190
NPHP1 GABPA shRNA Prostate LNCaP 1256.88 10.2956 0.46315 0.7048 DataSet_01_191
NPHP1 GATA2 siRNA Prostate LNCaP 1.59073 0.66969 0.01473 0.04663 DataSet_01_193
NPHP1 CREB1 shRNA Parotid_gland H3118 MEC 0.65958 -0.60038 0.18181 0.54295 DataSet_01_194
NPHP1 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.50929 -0.97345 - - DataSet_01_196
NPHP1 TP63 siRNA Head_and_neck SCC-1 0.51252 -0.96433 - - DataSet_01_199
NPHP1 XBP1 shRNA Mammary_gland T47D 0.4903 -1.02827 8.32296e-06 0.00035 DataSet_01_203
NPHP1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 1.51262 0.59705 - - DataSet_01_210
NPHP1 SNAI2 shRNA Skin Primary human keratinocytes 0.55946 -0.83789 0.00123 0.01601 DataSet_01_225
NPHP1 KLF2 shRNA Bone_marrow RPMI8226 1.95549 0.96753 0.10331 0.71091 DataSet_01_226
NPHP1 FOXO3 siRNA Pancreas PANC1 0.34098 -1.55223 - - DataSet_01_267
NPHP1 STAT5 shRNA Prostate CWR22Pc 0.52529 -0.92882 0.00714 0.04342 DataSet_01_279
NPHP1 ZIC5 siRNA Skin A375 0.66576 -0.58694 - - DataSet_01_284
NPHP1 SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 2.51727 1.33186 0.01928 0.77909 DataSet_01_290
NPHP1 POSTN shRNA Brain GSC272 0.53179 -0.91107 0.23776 0.61625 DataSet_01_293
NPHP1 TFAP4 siRNA Brain BE(2)-C 0.3513 -1.50922 0.44801 0.51638 DataSet_01_295
NPHP1 ELK3 shRNA Mammary_gland MDA-MB-231 2.24043 1.16378 0.00024 0.00113 DataSet_01_318
NPHP1 MYC siRNA Colon HCT116 0.60624 -0.72203 5.18623e-06 3.40542e-05 DataSet_01_324
NPHP1 GATA3 siRNA Oral_cavity OEC-M1 1.97037 0.97847 0.14362 0.99787 DataSet_01_347
NPHP1 PAX3 shRNA Soft_tissue Rh30 1.70438 0.76925 - - DataSet_01_359
NPHP1 SOX17 siRNA Umbilical_vein HUVEC 0.49469 -1.0154 - - DataSet_01_360
NPHP1 FIP1L1 shRNA Liver HepG2 2.42471 1.27781 0.00677 0.03377 DataSet_02_103
NPHP1 U2AF2 shRNA Liver HepG2 0.52126 -0.93993 0.00456 0.05599 DataSet_02_105
NPHP1 TAF15 shRNA Liver HepG2 1.57018 0.65093 0.08317 0.13213 DataSet_02_106
NPHP1 SSB shRNA Liver HepG2 0.43257 -1.20898 0.00014 0.00391 DataSet_02_107
NPHP1 ZNF622 shRNA Liver HepG2 0.54483 -0.87613 0.21311 0.2844 DataSet_02_108
NPHP1 BCLAF1 shRNA Liver HepG2 0.61391 -0.70389 0.0115 0.05252 DataSet_02_112
NPHP1 U2AF2 shRNA Liver HepG2 0.20935 -2.25601 0.06843 0.17166 DataSet_02_113
NPHP1 PCBP1 shRNA Liver HepG2 1.52924 0.61281 0.04825 0.09061 DataSet_02_115
NPHP1 TARDBP shRNA Liver HepG2 0.26949 -1.89171 0.00134 0.01764 DataSet_02_116
NPHP1 HNRNPLL shRNA Liver HepG2 0.17372 -2.52517 0.00038 0.01127 DataSet_02_125
NPHP1 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 0.6 -0.73697 0.12144 0.40183 DataSet_02_129
NPHP1 AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.76471 0.81943 0.63658 0.75824 DataSet_02_132
NPHP1 SRSF9 shRNA Haematopoietic_and_lymphoid_tissue K562 0.3 -1.73697 0.04149 0.14442 DataSet_02_134
NPHP1 RBM34 shRNA Haematopoietic_and_lymphoid_tissue K562 4.8 2.26303 0.36369 0.57732 DataSet_02_141
NPHP1 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.29412 -1.76553 0.04457 0.23818 DataSet_02_144
NPHP1 CCAR2 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.79378 0.94239 DataSet_02_146
NPHP1 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.2 -2.32193 0.47318 0.61456 DataSet_02_147
NPHP1 ILF3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.26667 -1.90689 0.05225 0.31777 DataSet_02_148
NPHP1 NONO shRNA Haematopoietic_and_lymphoid_tissue K562 0.04762 -4.39232 0.0117 0.19424 DataSet_02_149
NPHP1 YBX3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.26667 -1.90689 0.03066 0.44818 DataSet_02_153
NPHP1 SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 1 1 DataSet_02_154
NPHP1 GTF2F1 shRNA Haematopoietic_and_lymphoid_tissue K562 3.66667 1.87447 0.96945 1 DataSet_02_157
NPHP1 XRCC5 shRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.04588 0.62786 DataSet_02_159
NPHP1 SUB1 shRNA Haematopoietic_and_lymphoid_tissue K562 10.3333 3.36923 0.05276 0.70349 DataSet_02_161
NPHP1 AGO1 shRNA Haematopoietic_and_lymphoid_tissue K562 3.5 1.80735 0.02538 0.53443 DataSet_02_162
NPHP1 U2AF1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.7 0.76553 0.66934 0.78962 DataSet_02_165
NPHP1 RBM22 shRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.05462 0.14508 DataSet_02_168
NPHP1 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 37 5.20945 0.00242 0.04354 DataSet_02_169
NPHP1 U2AF2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.8 1.48543 0.20514 0.33354 DataSet_02_170
NPHP1 LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 5 2.32193 0.082 1 DataSet_02_175
NPHP1 CEBPZ siRNA Haematopoietic_and_lymphoid_tissue K562 15 3.90689 0.61752 1 DataSet_02_176
NPHP1 ZNF180 siRNA Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.12911 1 DataSet_02_177
NPHP1 ZMIZ1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.16667 -2.58496 0.15067 1 DataSet_02_181
NPHP1 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.27044 1 DataSet_02_182
NPHP1 CTCF siRNA Haematopoietic_and_lymphoid_tissue K562 0.55556 -0.848 0.43584 1 DataSet_02_185
NPHP1 BHLHE40 siRNA Haematopoietic_and_lymphoid_tissue K562 0.47619 -1.07039 0.05869 1 DataSet_02_186
NPHP1 BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 6 2.58496 0.04887 1 DataSet_02_188
NPHP1 MAFG siRNA Haematopoietic_and_lymphoid_tissue K562 13 3.70044 0.21569 1 DataSet_02_189
NPHP1 LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.26485 1 DataSet_02_191
NPHP1 MAX siRNA Haematopoietic_and_lymphoid_tissue K562 3.5 1.80735 0.45499 1 DataSet_02_192
NPHP1 ARID3A siRNA Haematopoietic_and_lymphoid_tissue K562 0.28571 -1.80735 0.07998 1 DataSet_02_193
NPHP1 TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 15.5 3.9542 0.389 1 DataSet_02_194
NPHP1 CHD2 siRNA Haematopoietic_and_lymphoid_tissue K562 5.5 2.45943 0.00122 0.12618 DataSet_02_196
NPHP1 CDAN1 siRNA Haematopoietic_and_lymphoid_tissue K562 6 2.58496 0.04068 1 DataSet_02_197
NPHP1 UBTF siRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.58031 1 DataSet_02_198
NPHP1 TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.26667 -1.90689 0.09635 1 DataSet_02_201
NPHP1 BRCA1 siRNA Haematopoietic_and_lymphoid_tissue K562 12 3.58496 0.09013 1 DataSet_02_202
NPHP1 RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.17391 -2.52356 0.73314 1 DataSet_02_204
NPHP1 E2F6 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.17717 1 DataSet_02_205
NPHP1 AR siRNA Prostate LNCaP 0.661434 -0.596331 0.355269034670521 1 DataSet_03_005
NPHP1 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 4.638 2.2135 - - DataSet_03_096
NPHP1 GATA6 siRNA Stomach YCC3 1.51017 0.594708 0.144599568531183 0.761059349898558 DataSet_03_110
NPHP1 HIF3A siRNA Liver Hep3B 0.617709 -0.695 0.309422543750194 1 DataSet_03_120
NPHP1 HIF3A siRNA Liver Hep3B 0.617709 -0.695 0.309422543750194 1 DataSet_03_121
NPHP1 KLF5 siRNA Stomach KatoIII 0.506461 -0.981476 0.149606294036041 0.596277104029289 DataSet_03_150
NPHP1 MYB siRNA Cord_Blood CD34+ progenitor cells 0.244765 -2.03053 - - DataSet_03_170
NPHP1 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.581618 -0.781855 0.0146547117520453 0.0427193308646462 DataSet_03_211
NPHP1 SOX11 siRNA Lung_fibroblast NHLF 1.76035 0.815862 0.117281322993881 0.514592478043163 DataSet_03_237
NPHP1 SOX11 siRNA Lung_fibroblast NHLF 2.30838 1.20688 0.0302634406806234 0.269693815603863 DataSet_03_238
NPHP1 SP1 siRNA Ovary OVSAYO 0.646635 -0.628977 0.101128981400151 0.385635122128086 DataSet_03_251
NPHP1 STAT3 CRISPR Embryo hESC 2.50199 1.32307 0.0251492934895262 0.0911981547876567 DataSet_03_258
NPHP1 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 136.962 7.09763 0.054105676761795 0.1440935917853 DataSet_04_014
NPHP1 SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.588235 -0.765535 0.909737747119775 0.942341308922786 DataSet_04_018
NPHP1 ANXA2 CRISPR Liver HepG2 2.5 1.32193 0.000294714762040831 0.252504623891802 DataSet_04_024
NPHP1 NFX1 CRISPR Liver HepG2 0.42547 -1.23287 0.0245487267085825 0.0628896406295812 DataSet_04_032
NPHP1 ZC3H8 shRNA Liver HepG2 0.516643 -0.952762 0.00718203018946455 0.0940129719426895 DataSet_04_040
NPHP1 ACTN4 CRISPR Liver HepG2 2.02581 1.0185 0.0153295897484306 0.0694756930331399 DataSet_04_042
NPHP1 CHCHD3 CRISPR Liver HepG2 0.598901 -0.73961 0.0442399680366991 0.462359872902174 DataSet_04_067
NPHP1 RIOK2 CRISPR Liver HepG2 1.61146 0.688373 0.055353345028231 0.944114636228534 DataSet_04_070
NPHP1 CALR shRNA Liver HepG2 0.559406 -0.838033 0.00630338794132837 0.0276487270377238 DataSet_04_053
NPHP1 CCAR1 shRNA Liver HepG2 1.50912 0.593711 0.00312139020039622 0.0263914173191917 DataSet_04_054
NPHP1 CNOT7 shRNA Liver HepG2 3.54406 1.8254 0.000170292609546435 0.00320836806862655 DataSet_04_051
NPHP1 UBE2L3 shRNA Liver HepG2 0.39359 -1.34524 0.00187296556171697 0.0154902289960225 DataSet_04_055
NPHP1 YBX3 shRNA Liver HepG2 0.564019 -0.826183 0.0561096204006691 0.177972974188201 DataSet_02_98
NPHP1 ACTN4 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.181818 -2.45943 0.366058918168957 0.577108141897441 DataSet_04_048
NPHP1 DDX17 CRISPR Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.68508665269571 0.947200401449688 DataSet_04_047
NPHP1 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 5 2.32193 0.212173211807761 0.475150352476328 DataSet_02_38
NPHP1 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.230769 -2.11548 0.382379122377555 0.546267563319235 DataSet_02_14
NPHP1 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.0769231 -3.70044 0.381276216680169 0.560167028222086 DataSet_02_34
NPHP1 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 4.53846 2.1822 0.271608890758819 0.728576391750762 DataSet_02_45
NPHP1 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.38462 1.25376 0.338891989749796 0.520630776025398 DataSet_02_35
NPHP1 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 4.15385 2.05445 0.164211821038729 0.463981609884261 DataSet_02_32
NPHP1 TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 4.30769 2.10692 0.0878478412433201 0.205635880136174 DataSet_02_43
NPHP1 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.230769 -2.11548 0.394910880804969 0.555190301408604 DataSet_02_33
NPHP1 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.69231 1.42884 0.0936184584369755 0.211854662095546 DataSet_02_53
NPHP1 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.357143 -1.48543 0.573043432172289 0.718073913770655 DataSet_04_060
NPHP1 CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 5 2.32193 0.478619180655053 0.672613408012759 DataSet_04_061
NPHP1 DDX1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.66667 0.736966 0.637111853942719 0.90284635326174 DataSet_04_063
NPHP1 PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 3.33333 1.73697 0.656180449027297 0.895795649908308 DataSet_04_065
NPHP1 UBE2L3 shRNA Haematopoietic_and_lymphoid_tissue K562 2.66667 1.41504 0.610558884068826 0.816981947114318 DataSet_04_062
NPHP1 SMARCA4 siRNA Colon HCT116 0.641498 -0.640484 1.234648e-02 0.1422748 DataSet_03_302
NPHP1 SNAI2 shRNA Pancreas pancreatic cancer stem cells 0.648143 -0.625617 2.122010e-01 0.6510154 DataSet_03_306
NPHP1 TET1 CRISPR Mammary_gland MDA-MB-231 0.541667 -0.884522 1.220968e-03 1.492906e-02 DataSet_03_347
NPHP1 SKI CRISPR Blood HL60 0.539267 -0.890928 1.278964e-02 0.211155768 DataSet_03_351
NPHP1 ESR1 siRNA Mammary_gland MCF7 1.65949 0.730741 8.736282e-04 0.0178123755 DataSet_03_352
NPHP1 ETV5 knockdown Colon HT29 0.614872 -0.701641 1.542903e-02 0.143811360 DataSet_03_353
NPHP1 TET1 CRISPR Mammary_gland Hs578T 0.638964 -0.646195 6.031569e-02 1.656295e-01 DataSet_03_355
NPHP1 PTPN14 CRISPR Brain U5-NPC 0.5839 -0.776206 4.579341e-02 0.26997021 DataSet_03_357
NPHP1 TP53 CRISPR Brain U5-NPC 1.75775 0.813731 8.831366e-02 2.253640e-01 DataSet_03_358
NPHP1 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 0.528551 -0.919885 7.830918e-02 2.845989e-01 DataSet_03_359
NPHP1 EP300 shRNA Mammary_gland MCF10AT 2.09524 1.06711 6.944514e-03 0.059759149 DataSet_03_364
NPHP1 DNMT3A knockout Embryo_kidney HEK293T 3.68904 1.88325 - - DataSet_03_369
NPHP1 ZFP36L1 siRNA Urinary_bladder J82 2.41667 1.27302 - - DataSet_03_371
NPHP1 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 5.42808 2.44044 0.4180956479 0.8638808 DataSet_03_387
NPHP1 NFKBIA shRNA Bone_marrow U2OS 0.433014 -1.20751 7.709501e-01 0.90300187 DataSet_03_389
NPHP1 JAZF1 siRNA Cervix HeLa Kyoto 0.590328 -0.76041 1.287128e-01 0.746342017 DataSet_03_396
NPHP1 IKZF2 CRISPR Lymph CAR T Cell 1.70861 0.772821 2.325940e-01 0.722792919 DataSet_03_397
NPHP1 TLE4 CRISPR Lymph CAR T Cell 1.93148 0.949703 1.024876e-01 0.36211058 DataSet_03_398
NPHP1 HMGA1 shRNA Bile_duct HUCCT1 1.59048 0.669459 3.461003e-02 0.221559847 DataSet_03_400
NPHP1 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.52613 0.60988 3.407826e-02 0.3239928 DataSet_03_403
NPHP1 CDK7 shRNA Bone_marrow D458 0.63125 -0.663717 2.274678e-01 0.58092604 DataSet_03_404
NPHP1 TFAP2A knockout Embryo H9 1.69588 0.762031 4.802803e-03 0.04840786 DataSet_03_405
NPHP1 STRAP knockout Nerve SK-N-AS 1.68915 0.756294 - - DataSet_03_409
NPHP1 FOXK2 shRNA Ovary OVCAR-5 0.423868 -1.23831 3.525668e-02 0.15298980 DataSet_03_419
NPHP1 PRDM1 CRISPR Lymph CD8+ T cells 1.89286 0.920566 - - DataSet_03_421
NPHP1 FOXQ1 CRISPR Lymph Primary CD4+ T cells 1.50388 0.588686 - - DataSet_03_422
NPHP1 IKZF2 shRNA Lymph Hut78 1.61677 0.693114 2.641343e-01 0.73609286 DataSet_03_429
NPHP1 USP7 shRNA Skin xenograft cells 0.454234 -1.13849 0.25914378 0.4348960 DataSet_03_431
NPHP1 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.589286 -0.762961 - - DataSet_03_432
NPHP1 SUFU shRNA Mammary_gland HCC1954 cells 1.67969 0.748193 0.1736698518 0.6455297 DataSet_03_437
NPHP1 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 0.594378 -0.750549 7.386435e-01 0.99496042 DataSet_03_439
NPHP1 DAXX shRNA Mammary_gland MDA-MB-231 1.64773 0.720484 2.033493e-01 0.52701752 DataSet_03_441
NPHP1 RELB CRISPR Colon SW480 1.71591 0.778973 2.195484e-03 3.374711e-02 DataSet_03_449
NPHP1 CBX2 siRNA Mammary_gland MCF7 4.71551 2.23741 3.321282e-06 0.0003154395 DataSet_03_451
NPHP1 IRF2 shRNA Cord_Blood CD34+ cells 2.68182 1.42321 - - DataSet_03_460
NPHP1 STAT3 shRNA Liver HepG2 2.16129 1.11189 3.842294e-03 0.0826351896 DataSet_03_465
NPHP1 SMARCA1 Cas13 Embryo_kidney HEK293T 0.465544 -1.10301 - - DataSet_03_466
NPHP1 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 2.05207 1.03708 - - DataSet_03_467
NPHP1 WHSC1 siRNA Prostate PC3 0.447368 -1.16047 1.668208e-03 0.07741793 DataSet_03_471
NPHP1 CHCHD3 CRISPR Haematopoietic_and_lymphoid_tissue K562 3.5 1.80736 0.6697643 0.9839673 DataSet_04_071
NPHP1 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.7399587 0.851910702 DataSet_04_074
Regulation Region
 
T(co)Fs that significantly regulate NONO by the evidences of both expression and ChIP-seq/motif
Expression Atlas of NPHP1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines