Gene Overview
| Target Gene: | Nfe2 |
| NCBI Official Symbol: | Nfe2 |
| Entrez ID: | 18022 |
| Ensembl ID: | ENSMUSG00000058794 |
| Gene Full Name: | nuclear factor, erythroid derived 2 |
| Strand: | - |
| Gene Locus: | 15 F3|15 58.62 cM |
| External Links: |
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Nfe2 Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate Nfe2
T(co)Fs
that Repress Nfe2
The Intensity of the Gene Regulated by T(co)Fs:
Nfe2-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| Nfe2 | Arid1a | knockout | Liver | Liver | 2.27706 | 1.18717 | 0.387477766992158 | 0.999999999999956 | DataSet_11_004 |
| Nfe2 | Cbfb | knockdown | Peripheral_blood | Peripheral CD4+CD25hi cells | 1.53333 | 0.616667 | 0.0410226606775531 | 0.75150687640695 | DataSet_11_017 |
| Nfe2 | Cebpb | knockout | Mammary_gland | Mammary epithlial cells (MECs) | 2.53151 | 1.34 | 0.100470918183434 | 0.999788745984441 | DataSet_11_020 |
| Nfe2 | Dmrt1 | knockout | Testis | Juvenile testes | 1.74001 | 0.799096 | 0.0141979639532121 | 0.405517655473241 | DataSet_11_025 |
| Nfe2 | Dmrt1 | knockout | Testis | Juvenile testes | 1.633 | 0.707524 | 0.0305747428241988 | 0.653934846995712 | DataSet_11_027 |
| Nfe2 | Dmrt1 | knockout | Testis | Juvenile testes | 1.86597 | 0.899925 | 0.00578975739864157 | 0.498483480867158 | DataSet_11_028 |
| Nfe2 | E2f4 | knockout | Brain | Forebrain | 0.350302 | -1.51333 | - | - | DataSet_11_033 |
| Nfe2 | Esrrb | shRNA | Embryo | ES cells | 0.63873 | -0.646721 | - | - | DataSet_11_039 |
| Nfe2 | Foxa2 | knockout | Lung | Whole lung | 1.86134 | 0.896339 | 0.00255222073393868 | 0.118792052153797 | DataSet_11_041 |
| Nfe2 | Foxp1 | knockout | Eye | Lens | 0.087886 | -3.50822 | - | - | DataSet_11_044 |
| Nfe2 | Gata3 | siRNA | Peripheral_blood | CD4+ T helper (Th) cells | 4.21248 | 2.07467 | 0.26041288305134 | 0.987135756219234 | DataSet_11_048 |
| Nfe2 | Gata4 | knockout | Intestine | Jejunum | 0.63076 | -0.664838 | 0.192851876828984 | 0.684662941028434 | DataSet_11_049 |
| Nfe2 | Gfi1 | knockout | Cord_Blood | T-cells | 4.37069 | 2.12786 | 0.00872409464694882 | 0.21282988913561 | DataSet_11_053 |
| Nfe2 | Hsf4 | knockout | Eye | Lens | 0.500157 | -0.999546 | 0.140902864119888 | 0.987999303842427 | DataSet_11_058 |
| Nfe2 | Irf6 | knockout | Skin | Skin | 0.185885 | -2.42752 | 0.000446347890524445 | 0.0308996774328233 | DataSet_11_062 |
| Nfe2 | Jarid2 | knockout | Pancreas | Embryonic pancreas | 1.50943 | 0.594008 | 0.290066377376849 | 0.846495221756725 | DataSet_11_064 |
| Nfe2 | Lhx8 | knockout | Ovary | Ovary | 2.88009 | 1.52611 | 0.15923233659612 | 0.303467600233403 | DataSet_11_070 |
| Nfe2 | Mbd1 | siRNA | Adipose_tissue | 3T3-L1 cells | 1.57143 | 0.652077 | - | - | DataSet_11_074 |
| Nfe2 | Mbd2 | knockout | Lymph | GFP+ BM leukemia cells | 49.1009 | 5.61768 | 1.83176276296802e-10 | 2.28803288180389e-07 | DataSet_11_076 |
| Nfe2 | Nfix | shRNA | Muscle | LSK | 0.596527 | -0.74534 | 3.53120220786384e-05 | 0.00832692413875044 | DataSet_11_091 |
| Nfe2 | Nhlh2 | knockout | Eye | Retina | 1.89247 | 0.920273 | 0.762666904041535 | 0.827285706231654 | DataSet_11_092 |
| Nfe2 | Nrf1 | knockdown | Liver | Liver | 1.72751 | 0.788693 | 0.158932626377332 | 0.274943043634689 | DataSet_11_096 |
| Nfe2 | Pax5 | knockout | Bone_marrow | B220+ cells | 4.85534 | 2.27957 | 0.0169442324278353 | 0.170767893481891 | DataSet_11_100 |
| Nfe2 | Rest | knockout | Brain | Brain | 1.53391 | 0.617218 | 0.700543612247061 | 1 | DataSet_11_113 |
| Nfe2 | Runx1 | knockout | Embryo | Embryo | 0.371935 | -1.42688 | 0.0223937687928839 | 0.999961610631375 | DataSet_11_114 |
| Nfe2 | Runx1 | knockout | Lymph | ProB cells | 4.33411 | 2.11574 | 0.000706971899332019 | 0.0160640988915743 | DataSet_11_116 |
| Nfe2 | Sall4 | shRNA | Embryo | ES cells | 0.4125 | -1.27753 | 0.202053790724547 | 0.999840995136314 | DataSet_11_123 |
| Nfe2 | Smad4 | siRNA | Brain | bEnd3 | 7.02696 | 2.8129 | - | - | DataSet_11_127 |
| Nfe2 | Smad4 | knockout | Aorta | Aortic arteries | 2.7913 | 1.48093 | 0.105051914962182 | 0.476362432931921 | DataSet_11_128 |
| Nfe2 | Snai1 | knockout | Embryo | Embryoid body | 0.0430534 | -4.53773 | - | - | DataSet_11_129 |
| Nfe2 | Snai1 | knockout | Embryo | Embryonic stem cells (ESCs) | 0.642684 | -0.637818 | 0.127904691106378 | 0.999994003527217 | DataSet_11_132 |
| Nfe2 | Sohlh1 | knockout | Ovary | Ovary | 2.59053 | 1.37325 | 0.00303197650546369 | 0.022200324311703 | DataSet_11_134 |
| Nfe2 | Sox11 | knockout | Eye | Retina | 0.565217 | -0.823122 | - | - | DataSet_11_137 |
| Nfe2 | Stat3 | knockout | Lung | Lung typeII cells | 0.625039 | -0.677983 | 0.243027398938658 | 0.793201814237797 | DataSet_11_151 |
| Nfe2 | Stat6 | knockout | Bone_marrow | Bone marrow-derived macrophages | 9.9007 | 3.30753 | 0.00244414376367555 | 0.0174403374567644 | DataSet_11_153 |
| Nfe2 | Thap11 | knockout | Heart | Heart | 1.64458 | 0.717716 | 0.581995360667045 | 0.999994817864919 | DataSet_11_167 |
| Nfe2 | Pogz | knockdown | Liver | fetal liver | 0.617774 | -0.694849 | 1.353880e-02 | 0.3010359 | DataSet_11_188 |
| Nfe2 | Mapk9 | knockout | Hip | Mouse Hip Cartilage | 1.86158 | 0.896527 | 6.881314e-04 | 3.327599e-03 | DataSet_11_236 |
| Nfe2 | Mapk9 | knockout | Knee | Mouse total knee | 0.373383 | -1.42127 | 3.869176e-02 | 0.198372147 | DataSet_11_237 |
| Nfe2 | Hipk2 | knockout | Heart | cardiac tissue | 0.44188 | -1.17827 | 2.748971e-02 | 2.178891e-01 | DataSet_11_238 |
| Nfe2 | Kdm5b | knockout | Heart | left ventricles | 0.558413 | -0.840596 | 0.3963948703 | 0.9999827 | DataSet_11_210 |
| Nfe2 | Dnmt1 | knockout | Embryo | Embryonic fibroblasts | 1.54145 | 0.624289 | 7.625758e-02 | 2.056653e-01 | DataSet_11_192 |
| Nfe2 | Ncoa3 | shRNA | Embryo | ES cells | 0.618564 | -0.693006 | 1.976872e-08 | 7.914923e-07 | DataSet_11_194 |
| Nfe2 | Ncoa3 | shRNA | Embryo | ES cells | 0.618564 | -0.693006 | 1.976872e-08 | 7.914923e-07 | DataSet_11_195 |
| Nfe2 | Dnmt1 | shRNA | Embryo | Embryonic fibroblasts | 2.22348 | 1.15282 | - | - | DataSet_11_196 |
| Nfe2 | Ezh2 | knockout | Bone_marrow | CD45.2+LSK cells | 0.00000531415 | -17.5217 | - | - | DataSet_11_220 |
| Nfe2 | Smarca4 | shRNA | Embryo | ES cells | 0.654161 | -0.612283 | - | - | DataSet_11_224 |
| Nfe2 | Smarca4 | shRNA | Embryo | ES cells | 0.654161 | -0.612283 | - | - | DataSet_11_225 |
| Nfe2 | Rag1 | knockout | Bone | Mice fractured callus | 0.227027 | -2.13906 | 1.683448e-06 | 7.177431e-05 | DataSet_11_230 |
| Nfe2 | Dnmt3b | siRNA | Embryo | iPSC | 0.588836 | -0.764061 | - | - | DataSet_11_242 |
| Nfe2 | Twist1 | knockout | Bone_marrow | stromal cells | 4.89198 | 2.29042 | - | - | DataSet_11_244 |
| Nfe2 | Kat6a | knockout | Embryo | Embryonic fibroblasts | 1.52381 | 0.607683 | 7.148165e-01 | 0.9063102346 | DataSet_11_245 |
| Nfe2 | Ezh2 | knockout | Calvaria | calvaria | 0.653333 | -0.614109 | 1.875596e-01 | 0.54183850 | DataSet_11_247 |
| Nfe2 | Dnmt1 | siRNA | Embryo | Embryo | 0.304348 | -1.71621 | - | - | DataSet_11_248 |
| Nfe2 | Kmt2d | knockout | Skin | iBiP melanoma mouse model tumor cell | 0.358491 | -1.47999 | 1.260230e-02 | 5.548981e-02 | DataSet_11_250 |
| Nfe2 | Kdm2a | CRISPR | Embryo | ES cells | 0.487805 | -1.03562 | 0.4187087136 | 1.0000000 | DataSet_11_251 |
| Nfe2 | Zbp1 | siRNA | Bone_marrow | bone marrow-derived mesenchymal stem_progenitor cells | 2.67568 | 1.41991 | 2.233791e-02 | 0.091877261 | DataSet_11_252 |
| Nfe2 | Sirt6 | knockout | Liver | Liver | 0.440678 | -1.1822 | 5.298176e-02 | 6.440764e-01 | DataSet_11_265 |
| Nfe2 | Dux | knockout | Embryo | Embryo | 0.161937 | -2.62649 | 1.851403e-01 | 3.558652e-01 | DataSet_11_269 |
| Nfe2 | Myc | CRISPR | Skeletal_muscle | muscle stem cells | 2.39067 | 1.25741 | 6.763066e-01 | 0.93605697 | DataSet_11_272 |
| Nfe2 | Dux | knockout | Embryo | Embryo | 0.161937 | -2.62649 | 1.851402e-01 | 3.558637e-01 | DataSet_11_273 |
| Nfe2 | Lin28b | knockout | Bone_marrow | Bone marrow immature B cells | 1.78723 | 0.837729 | 7.125013e-01 | 0.9858719 | DataSet_11_274 |
| Nfe2 | Myod1 | CRISPR | Skeletal_muscle | myoblast | 0.302409 | -1.72543 | 1.107385e-02 | 3.566936e-02 | DataSet_11_275 |
| Nfe2 | Ezh2 | siRNA | Bone_marrow | Mesenchymal stem cells | 0.168675 | -2.56768 | 1.441829e-04 | 8.513062e-03 | DataSet_11_276 |
| Nfe2 | Dnmt1 | knockout | Cortex | mature Pvergic cortical interneurons | 2.57143 | 1.36257 | 2.702739e-02 | 0.6936949 | DataSet_11_283 |
| Nfe2 | Zmat3 | knockout | Embryo | Embryonic fibroblasts | 1.66001 | 0.731194 | 1.372203e-01 | 0.5395938 | DataSet_11_284 |
| Nfe2 | Setd2 | knockout | Kidney | primary renal tubular epithelial (RTE) cells | 0.571429 | -0.807355 | - | - | DataSet_11_285 |
| Nfe2 | Fli1 | CRISPR | Lymph | CD8 T cells | 0.504075 | -0.988289 | 1.664127e-01 | 0.9999740103 | DataSet_11_288 |
| Nfe2 | Kmt2d | CRISPR | Liver | MA1L | 2.827 | 1.49927 | 1.675274e-01 | 4.092007e-01 | DataSet_11_290 |
| Nfe2 | Kmt2d | CRISPR | Liver | MA1L | 2.88572 | 1.52893 | 1.642363e-01 | 3.965420e-01 | DataSet_11_291 |
| Nfe2 | Setd1a | shRNA | Eye | Retina | 1.71456 | 0.777835 | 4.697438e-01 | 0.6853417602 | DataSet_11_293 |
| Nfe2 | Ssrp1 | CRISPR | Embryo | ES cells | 1.71429 | 0.777608 | 2.000044e-01 | 0.51630530 | DataSet_11_296 |
| Nfe2 | Sirt3 | knockout | Pancreatic_islets | pancreatic beta cell | 2.35714 | 1.23704 | 1.922413e-02 | 2.994873e-01 | DataSet_11_297 |
| Nfe2 | Phf8 | knockout | prostate | Prostate | 3.5 | 1.80736 | 0.5539030249 | 0.6941589 | DataSet_11_298 |
| Nfe2 | Brpf1 | shRNA | Nerve | Neural progenitor cells | 0.544718 | -0.876417 | 8.282698e-01 | 0.9999903 | DataSet_11_299 |
| Nfe2 | Hmg20a | siRNA | Hypothalamus | Primary hypothalamic astrocytes | 2.42857 | 1.28011 | 0.0221117064 | 0.2554116 | DataSet_11_300 |
| Nfe2 | Myc | CRISPR | Skeletal_muscle | quiescent muscle stem cell | 1.61993 | 0.695928 | 5.625280e-01 | 0.88447564 | DataSet_11_310 |
| Nfe2 | Suz12 | knockout | Lung | Alveolar macrophage | 1.61361 | 0.690293 | 1.425938e-01 | 2.184271e-01 | DataSet_11_312 |
| Nfe2 | Actl6a | knockout | Nerve | sciatic nerve | 1.80851 | 0.854802 | 3.619703e-02 | 0.263861243 | DataSet_11_314 |
| Nfe2 | Ahr | knockout | Liver | Liver | 0.454545 | -1.1375 | 4.253421e-03 | 0.2260448984 | DataSet_11_315 |
| Nfe2 | Gata2 | knockout | Brain | Pituitary gland | 15 | 3.90689 | 0.402670440 | 1.0000000 | DataSet_11_322 |
| Nfe2 | Padi2 | knockout | Testis | Testis | 0.660714 | -0.597902 | 9.449790e-02 | 0.9481885 | DataSet_11_324 |
| Nfe2 | Prmt1 | siRNA | Adipose_tissue | 3T3-L1 cells | 1.92857 | 0.947533 | 3.309053e-02 | 0.9832045 | DataSet_11_325 |
| Nfe2 | Snai1 | knockdown | Heart | Heart | 0.546032 | -0.872944 | 3.661867e-01 | 0.56276955 | DataSet_11_326 |
| Nfe2 | Tet1 | siRNA | Embryo | Embryonic fibroblasts | 2 | 1 | 5.868657e-01 | 0.9609895 | DataSet_11_327 |
| Nfe2 | Dnmt3l | knockout | Testis | Spermatogonial progenitor cells | 8.16931 | 3.03022 | - | - | DataSet_11_328 |
| Nfe2 | Dnmt1 | knockout | Brain | Cortex | 2.36264 | 1.2404 | 4.515573e-01 | 0.8200661245 | DataSet_11_329 |
| Nfe2 | Dnmt3a | knockout | Brain | Cortex | 0.244104 | -2.03443 | 7.848610e-02 | 0.6964864 | DataSet_11_330 |
| Nfe2 | Kdm5b | siRNA | Embryo | ES cells | 7.23205 | 2.8544 | 0.0248473136 | 0.8933528 | DataSet_11_331 |
| Nfe2 | Ezh2 | shRNA | Brain | SVZ derived neural stem cells | 0.328889 | -1.60433 | 5.898172e-03 | 7.038522e-02 | DataSet_11_332 |
| Nfe2 | Ezh2 | knockout | Eye | Retina | 0.0425159 | -4.55585 | 0.5786703262 | 1.0000000 | DataSet_11_334 |
| Nfe2 | Atrx | knockout | Embryo | ES cells | 0.375 | -1.41504 | - | - | DataSet_11_335 |
| Nfe2 | Dnmt3a | knockout | Peritoneum | peritoneal macrophages | 0.186691 | -2.42127 | - | - | DataSet_11_336 |
| Nfe2 | Dnmt1 | siRNA | Heart | embryonic cardiomyocytes | 0.432432 | -1.20945 | 3.232531e-02 | 0.071451338 | DataSet_11_340 |
| Nfe2 | Ezh2 | knockout | Small_intestinal_crypts | small intestinal crypts | 5 | 2.32193 | 0.1313034927 | 0.2043963 | DataSet_11_341 |
| Nfe2 | Hnrnpk | siRNA | Embryo | ES cells | 2.92193 | 1.54692 | 7.556347e-04 | 0.006143897 | DataSet_11_342 |
| Nfe2 | Pcbp1 | shRNA | Thymus | Th1 | 2 | 1 | 8.778262e-01 | 0.96819087 | DataSet_11_343 |
| Nfe2 | Dnmt1 | knockout | Kidney | kidney Cap Mesenchyme | 0.657678 | -0.604547 | 7.179392e-02 | 2.816384e-01 | DataSet_11_344 |
| Nfe2 | Dux | shRNA | Embryo | ES cells | 1.57107 | 0.651744 | 6.102776e-02 | 5.224914e-01 | DataSet_11_345 |
| Nfe2 | Gata4 | CRISPR | Heart | primary cardiac fibroblasts | 0.333333 | -1.58496 | 3.184647e-01 | 0.84419466 | DataSet_11_347 |
Regulation Region
Expression Atlas of Nfe2