Gene Overview
| Target Gene: | Rgs4 |
| NCBI Official Symbol: | Rgs4 |
| Entrez ID: | 19736 |
| Ensembl ID: | ENSMUSG00000038530 |
| Gene Full Name: | regulator of G-protein signaling 4 |
| Strand: | - |
| Gene Locus: | 1 H2.3|1 76.84 cM |
| External Links: |
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Rgs4 Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate Rgs4
T(co)Fs
that Repress Rgs4
The Intensity of the Gene Regulated by T(co)Fs:
Rgs4-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| Rgs4 | Bcl11a | knockout | Bone_marrow | Bone marrow erythoid progenitors | 1.54421 | 0.626869 | 0.100122063637856 | 0.480901250544034 | DataSet_11_013 |
| Rgs4 | Bhlha9 | knockout | Limb | Whole limb bud | 18.9037 | 4.2406 | - | - | DataSet_11_016 |
| Rgs4 | Cbx2 | knockout | Gonads | Embryonic gonads | 1.60367 | 0.681379 | 3.26798997304447e-06 | 8.64558418761675e-05 | DataSet_11_018 |
| Rgs4 | Dmrt1 | knockout | Testis | Testes | 0.0913078 | -3.45312 | 0.288639932978338 | 0.857187470302841 | DataSet_11_024 |
| Rgs4 | E2f4 | knockout | Brain | Forebrain | 0.604532 | -0.72611 | - | - | DataSet_11_033 |
| Rgs4 | Gata2 | knockout | Kidney | renal collecting duct cells | 0.219175 | -2.18985 | - | - | DataSet_11_047 |
| Rgs4 | Hsf4 | knockout | Eye | Lens | 0.574476 | -0.799682 | 0.452839552025581 | 0.987999303842427 | DataSet_11_058 |
| Rgs4 | Junb | shRNA | Tibialis_anterior_muscle | Tibialis anterior muscle | 1.66655 | 0.736865 | 0.0440697118290014 | 0.211520467469688 | DataSet_11_065 |
| Rgs4 | Mafg | knockout | Embryo | Whole embryo | 0.507931 | -0.977297 | 0.308916054210044 | 1 | DataSet_11_073 |
| Rgs4 | Mef2b | shRNA | Muscle | C2C12 | 0.565738 | -0.821793 | 1.09619848707781e-06 | 0.000210177066359027 | DataSet_11_078 |
| Rgs4 | Mef2c | shRNA | Muscle | C2C12 | 0.594356 | -0.750602 | 7.19243617904833e-05 | 0.0031511657603455 | DataSet_11_079 |
| Rgs4 | Nelfb | knockout | Embryo | Embryonic fibroblasts | 2.08973 | 1.06332 | 7.89716664126153e-07 | 0.000161262194419145 | DataSet_11_086 |
| Rgs4 | Nhlh2 | knockout | Eye | Retina | 0.465147 | -1.10424 | 0.165308926452175 | 0.523726874680013 | DataSet_11_092 |
| Rgs4 | Npas4 | RNAi | Brain | Hippocampal Neurons | 0.484081 | -1.04668 | 2.59172774552516e-10 | 4.09161385009291e-08 | DataSet_11_093 |
| Rgs4 | Nrf1 | knockdown | Liver | Liver | 0.666536 | -0.585245 | 0.117544141970891 | 0.218654770980286 | DataSet_11_096 |
| Rgs4 | Otx2 | knockout | Eye | Retina | 0.65455 | -0.611425 | 0.55749053296171 | 0.999923528647439 | DataSet_11_097 |
| Rgs4 | Pitx2 | knockout | Eye | Cornea | 3.07688 | 1.62147 | 0.338649695849183 | 0.680110606452178 | DataSet_11_103 |
| Rgs4 | Prox1 | knockout | Liver | Liver | 11.726 | 3.55164 | - | - | DataSet_11_109 |
| Rgs4 | Rest | shRNA | Brain | NSP | 1.78306 | 0.834353 | 0.00081396198484716 | 0.999899167758865 | DataSet_11_111 |
| Rgs4 | Runx1 | knockout | Lymph | ProB cells | 2.22133 | 1.15143 | 0.0115174648707483 | 0.0918623985176315 | DataSet_11_116 |
| Rgs4 | Runx2 | knockout | Humeri | Embryonic humeri | 0.452448 | -1.14418 | 0.0822910312073167 | 0.423204141806716 | DataSet_11_120 |
| Rgs4 | Sall4 | shRNA | Embryo | ES cells | 2.02521 | 1.01807 | 0.134615763497345 | 0.998682831465415 | DataSet_11_123 |
| Rgs4 | Smad4 | siRNA | Brain | bEnd3 | 60.1854 | 5.91134 | - | - | DataSet_11_127 |
| Rgs4 | Smad4 | knockout | Aorta | Aortic arteries | 0.602268 | -0.731523 | 0.384845721518041 | 0.769283453161689 | DataSet_11_128 |
| Rgs4 | Snai1 | knockout | Embryo | Teratoma | 1.96825 | 0.976912 | - | - | DataSet_11_130 |
| Rgs4 | Stat3 | knockout | Lung | Lung typeII cells | 2.81201 | 1.4916 | 0.00252337606390961 | 0.480449251018387 | DataSet_11_151 |
| Rgs4 | Tbx1 | knockout | Ear | Otic vesicles | 2.20441 | 1.14039 | 0.0569212822925069 | 0.996209135879357 | DataSet_11_154 |
| Rgs4 | Thap1 | knockout | Brain | Cerebellum | 0.0465249 | -4.42585 | 1.42350514111612e-11 | 3.68484473671772e-08 | DataSet_11_164 |
| Rgs4 | Thap1 | knockout | Brain | Cortex | 0.0433872 | -4.52659 | 4.49466775343479e-12 | 7.4039436083853e-09 | DataSet_11_165 |
| Rgs4 | Vdr | knockout | Bone_marrow | Bone marrow-derived macrophages | 2.63611 | 1.39841 | 0.216747075644557 | 0.999827445128963 | DataSet_11_174 |
| Rgs4 | Wt1 | siRNA | Embryo_kidney | LB-22 | 0.545741 | -0.873711 | 0.141026026146569 | 0.362221645717921 | DataSet_11_179 |
| Rgs4 | Yy1 | knockout | Muscle | Skeletal muscle | 0.438731 | -1.18859 | 2.40931785286617e-07 | 4.67207144430588e-05 | DataSet_11_182 |
| Rgs4 | Pogz | knockdown | Liver | fetal liver | 0.45607 | -1.13267 | 1.487691e-02 | 0.3028267 | DataSet_11_188 |
| Rgs4 | Cpeb1 | siRNA | Neuron | Neuro-2a | 18.0392 | 4.17307 | - | - | DataSet_11_189 |
| Rgs4 | Siah2 | knockout | Heart | Primary isolated cells | 2.56127 | 1.35686 | 3.931032e-03 | 0.80704381 | DataSet_11_235 |
| Rgs4 | Dnmt1 | knockout | Embryo | Embryonic fibroblasts | 0.528223 | -0.920781 | 1.464521e-02 | 7.514381e-02 | DataSet_11_192 |
| Rgs4 | Dnmt1 | shRNA | Embryo | Embryonic fibroblasts | 3.24303 | 1.69734 | - | - | DataSet_11_196 |
| Rgs4 | Bptf | knockout | Embryo | Embryonic fibroblasts | 1.72697 | 0.78824 | 8.097296e-03 | 0.28767426 | DataSet_11_197 |
| Rgs4 | Ezh2 | knockdown | Brain | Brain | 2.91322 | 1.54262 | 3.147400e-04 | 0.0145236902 | DataSet_11_221 |
| Rgs4 | Smarca4 | shRNA | Embryo | ES cells | 0.121067 | -3.04612 | - | - | DataSet_11_224 |
| Rgs4 | Smarca4 | shRNA | Embryo | ES cells | 0.121067 | -3.04612 | - | - | DataSet_11_225 |
| Rgs4 | Bcl11b | knockdown | Embryo | Embryonic fibroblasts | 0.483414 | -1.04867 | - | - | DataSet_11_226 |
| Rgs4 | Rag1 | knockout | Bone | Mice fractured callus | 1.52717 | 0.610865 | 9.873646e-03 | 4.079578e-02 | DataSet_11_230 |
| Rgs4 | Dux | siRNA | Embryo | ES cells | 2.22222 | 1.152 | 4.813961e-01 | 0.8774371149 | DataSet_11_239 |
| Rgs4 | Ncl | siRNA | Embryo | ES cells | 1.77778 | 0.830075 | 2.054497e-01 | 0.5465025070 | DataSet_11_240 |
| Rgs4 | Dnmt3a | siRNA | Embryo | iPSC | 0.216148 | -2.20991 | - | - | DataSet_11_241 |
| Rgs4 | Twist1 | knockout | Bone_marrow | stromal cells | 5.36376e-20 | -64.0153 | - | - | DataSet_11_244 |
| Rgs4 | Fubp1 | shRNA | Brain | brain neural progenitors | 1.51218 | 0.596628 | 0.2032186852 | 1 | DataSet_11_246 |
| Rgs4 | Kmt2d | knockout | Skin | iBiP melanoma mouse model tumor cell | 1.70557 | 0.770257 | 5.869492e-02 | 1.636803e-01 | DataSet_11_250 |
| Rgs4 | Zbp1 | siRNA | Bone_marrow | bone marrow-derived mesenchymal stem_progenitor cells | 0.436312 | -1.19657 | 9.090203e-03 | 0.056497980 | DataSet_11_252 |
| Rgs4 | Brca1 | siRNA | Embryo | Embryonic fibroblasts | 1.54681 | 0.629296 | 0.0749930357 | 0.4310485 | DataSet_11_256 |
| Rgs4 | Bcl3 | knockout | Bone | Osteoblast | 0.593336 | -0.753079 | 7.401464e-02 | 7.235482e-01 | DataSet_11_263 |
| Rgs4 | Nr4a1 | knockout | Mammary_gland | PyVT mouse mammary tumor cells | 5.80539 | 2.53739 | 5.191080e-05 | 0.1435114 | DataSet_11_268 |
| Rgs4 | Myc | CRISPR | Skeletal_muscle | muscle stem cells | 0.627022 | -0.673412 | 6.061316e-01 | 0.90653677 | DataSet_11_272 |
| Rgs4 | Myod1 | CRISPR | Skeletal_muscle | myoblast | 0.102909 | -3.28056 | 5.881902e-07 | 1.878431e-05 | DataSet_11_275 |
| Rgs4 | Ezh2 | siRNA | Bone_marrow | Mesenchymal stem cells | 0.527303 | -0.923295 | 1.059586e-01 | 3.854445e-01 | DataSet_11_276 |
| Rgs4 | Dnmt1 | knockout | Cortex | mature Pvergic cortical interneurons | 2.06295 | 1.04471 | 7.020536e-03 | 0.5482339 | DataSet_11_283 |
| Rgs4 | Zmat3 | knockout | Embryo | Embryonic fibroblasts | 0.32313 | -1.62981 | 9.110516e-02 | 0.5395938 | DataSet_11_284 |
| Rgs4 | Setd2 | knockout | Kidney | primary renal tubular epithelial (RTE) cells | 3 | 1.58496 | - | - | DataSet_11_285 |
| Rgs4 | Usp7 | siRNA | Embryo | ES cells | 12.5 | 3.64386 | 2.915894e-01 | 0.6667924 | DataSet_11_287 |
| Rgs4 | Mkl1 | knockout | Bone_marrow | Bone marrow differentiated macrophages | 8 | 3 | 1.815910e-01 | 0.5976223158 | DataSet_11_294 |
| Rgs4 | Sirt3 | knockout | Pancreatic_islets | pancreatic beta cell | 1.80651 | 0.853203 | 1.639464e-02 | 2.707942e-01 | DataSet_11_297 |
| Rgs4 | Dnmt1 | knockout | Skin | Keratinocytes | 9.60097 | 3.26318 | 5.837068e-04 | 0.0227456819 | DataSet_11_303 |
| Rgs4 | Jmjd6 | knockout | Bone_marrow | Lin-Sca1+Kit+ (LSK) haematopoietic stem and progenitor cells | 2 | 1 | - | - | DataSet_11_306 |
| Rgs4 | Actl6a | knockout | Nerve | sciatic nerve | 1.56468 | 0.645872 | 2.645372e-02 | 0.224649138 | DataSet_11_314 |
| Rgs4 | Satb2 | knockout | Colon | Intestine epithelium | 1.72035 | 0.782705 | 6.730980e-01 | 0.8336635188 | DataSet_11_316 |
| Rgs4 | Arid1b | knockout | Bone_marrow | bone marrow leukemia cells | 3 | 1.58496 | 6.515509e-02 | 0.3451652618 | DataSet_11_317 |
| Rgs4 | Arid2 | knockout | Bone_marrow | bone marrow leukemia cells | 0.333333 | -1.58496 | 3.397807e-01 | 0.7527440 | DataSet_11_318 |
| Rgs4 | Kat7 | knockout | Thymic_lobes | Thymic epithelial cells | 0.570057 | -0.810821 | 1.577002e-01 | 3.617285e-01 | DataSet_11_320 |
| Rgs4 | Bud31 | knockout | Testis | Spermatogonial stem cells | 3.2987 | 1.7219 | 9.877469e-01 | 1.0000000 | DataSet_11_321 |
| Rgs4 | Tet1 | siRNA | Embryo | Embryonic fibroblasts | 0.282913 | -1.82157 | 5.378638e-01 | 0.9609895 | DataSet_11_327 |
| Rgs4 | Ezh2 | shRNA | Brain | SVZ derived neural stem cells | 1.60703 | 0.684393 | 1.192386e-01 | 3.852278e-01 | DataSet_11_332 |
| Rgs4 | Ezh2 | knockout | Eye | Retina | 0.0268918 | -5.21669 | 0.3162169099 | 1.0000000 | DataSet_11_334 |
| Rgs4 | Dnmt3a | knockout | Peritoneum | peritoneal macrophages | 1.89275 | 0.920484 | - | - | DataSet_11_336 |
| Rgs4 | Dnmt3a | siRNA | Heart | embryonic cardiomyocytes | 1.76292 | 0.817965 | 1.153825e-01 | 0.65158498 | DataSet_11_337 |
| Rgs4 | Dnmt3b | siRNA | Heart | embryonic cardiomyocytes | 2.46505 | 1.30161 | 1.480873e-02 | 0.38643495 | DataSet_11_338 |
| Rgs4 | Dnmt1 | siRNA | Heart | embryonic cardiomyocytes | 0.288754 | -1.79209 | 9.110198e-03 | 0.024348386 | DataSet_11_340 |
| Rgs4 | Ezh2 | knockout | Small_intestinal_crypts | small intestinal crypts | 4.62857 | 2.21057 | 0.0430416648 | 0.1712697 | DataSet_11_341 |
| Rgs4 | Hnrnpk | siRNA | Embryo | ES cells | 3.17236 | 1.66556 | 3.360281e-01 | 0.447286933 | DataSet_11_342 |
| Rgs4 | Dux | shRNA | Embryo | ES cells | 0.115385 | -3.11548 | 9.335885e-03 | 3.844386e-01 | DataSet_11_345 |
Regulation Region
Expression Atlas of Rgs4