Gene Overview
Target Gene: S100A1
NCBI Official Symbol: S100A1
Entrez ID: 6271
Ensembl ID: ENSG00000160678
Gene Full Name: S100 calcium binding protein A1
Strand: +
Gene Locus: 1q21.3
External Links:

S100A1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate S100A1   
T(co)Fs that Repress S100A1
The Intensity of the Gene Regulated by T(co)Fs:
S100A1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
S100A1 HNF1B shRNA Ovary RMG2 0.46974 -1.09006 0.00097 0.0041 DataSet_01_103
S100A1 ID1 siRNA Lung A549 4.63392 2.21223 0.00394 0.11092 DataSet_01_117
S100A1 ZIC2 siRNA Pancreas PANC1 2.39653 1.26095 - - DataSet_01_121
S100A1 TFAP2C shRNA Mammary_gland MCF7 2.94873 1.56009 1.99602e-11 6.5542e-10 DataSet_01_150
S100A1 TP53 siRNA Lung SAECs 2.59091 1.37346 0.11096 0.50914 DataSet_01_175
S100A1 GATA2 siRNA Prostate LNCaP 1.96366 0.97354 0.01328 0.04292 DataSet_01_193
S100A1 CREB1 shRNA Parotid_gland H3118 MEC 2.36536 1.24206 0.08599 0.39687 DataSet_01_194
S100A1 TP63 siRNA Immortalized_keratinocyte HaCaT 0.62673 -0.67409 - - DataSet_01_200
S100A1 TP63 siRNA Head_and_neck SCC-6 3.12278 1.64283 - - DataSet_01_202
S100A1 HIC1 shRNA Mammary_gland HBL100 0.21938 -2.18847 - - DataSet_01_205
S100A1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 0.3036 -1.71978 - - DataSet_01_208
S100A1 KLF2 shRNA Bone_marrow RPMI8226 1.94139 0.95709 0.28863 0.82787 DataSet_01_226
S100A1 FOXO3 siRNA Pancreas PANC1 1.74967 0.80708 - - DataSet_01_267
S100A1 TFAP4 siRNA Brain BE(2)-C 0.1964 -2.34816 0.37439 0.51625 DataSet_01_295
S100A1 PTEN shRNA Lung HCC827 3.57208 1.83676 0.00643 0.39947 DataSet_01_302
S100A1 ETV5 siRNA Soft_tissue hADSC 0.36693 -1.44644 0.01041 0.07903 DataSet_01_304
S100A1 SOX9 siRNA Prostate VCaP 0.43007 -1.21736 0.08718 0.9316 DataSet_01_308
S100A1 SOX9 siRNA Prostate VCaP 0.43007 -1.21736 0.08718 0.9316 DataSet_01_309
S100A1 MYC siRNA Colon HCT116 2.54948 1.3502 0.00205 0.00549 DataSet_01_324
S100A1 CDX2 siRNA Colon COLO320 25.1189 4.6507 - - DataSet_01_357
S100A1 PAX3 shRNA Soft_tissue Rh30 2.72052 1.44388 - - DataSet_01_359
S100A1 GTF2B siRNA Cervix HeLa 0.22233 -2.16922 - - DataSet_01_362
S100A1 RBM17 shRNA Liver HepG2 0.39158 -1.35263 0.01752 0.26816 DataSet_02_100
S100A1 SAFB2 shRNA Liver HepG2 1.75128 0.80841 0.00413 0.02855 DataSet_02_102
S100A1 FIP1L1 shRNA Liver HepG2 0.53615 -0.89929 0.00139 0.01648 DataSet_02_103
S100A1 SSB shRNA Liver HepG2 0.47204 -1.08303 8e-04 0.00689 DataSet_02_107
S100A1 GTF2F1 shRNA Liver HepG2 0.58008 -0.78567 0.02313 0.25527 DataSet_02_110
S100A1 RBM39 shRNA Liver HepG2 0.58228 -0.7802 0.08587 0.30812 DataSet_02_111
S100A1 BCLAF1 shRNA Liver HepG2 2.29223 1.19675 0.00093 0.02512 DataSet_02_112
S100A1 U2AF2 shRNA Liver HepG2 0.55466 -0.85032 0.18244 0.31738 DataSet_02_113
S100A1 EWSR1 shRNA Liver HepG2 0.59804 -0.74167 0.00128 0.04273 DataSet_02_122
S100A1 PCBP2 shRNA Liver HepG2 0.51648 -0.95322 0.01349 0.08581 DataSet_02_123
S100A1 SNRNP70 shRNA Liver HepG2 0.35519 -1.49335 0.00052 0.03074 DataSet_02_126
S100A1 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.32675 -1.61376 0.00134 0.02779 DataSet_02_131
S100A1 AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.55943 -0.83796 0.04008 0.16211 DataSet_02_132
S100A1 SRSF9 shRNA Haematopoietic_and_lymphoid_tissue K562 1.57563 0.65593 0.01255 0.10104 DataSet_02_134
S100A1 HNRNPK shRNA Haematopoietic_and_lymphoid_tissue K562 0.59633 -0.74582 0.01578 0.16384 DataSet_02_136
S100A1 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 2.47838 1.30939 0.00141 0.02038 DataSet_02_143
S100A1 ILF3 shRNA Haematopoietic_and_lymphoid_tissue K562 1.69451 0.76087 0.01931 0.26121 DataSet_02_148
S100A1 NONO shRNA Haematopoietic_and_lymphoid_tissue K562 2.01339 1.00962 0.00708 0.19424 DataSet_02_149
S100A1 AGO1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.51068 0.5952 0.05101 0.54875 DataSet_02_162
S100A1 U2AF1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.46977 -1.08999 0.02297 0.16359 DataSet_02_165
S100A1 RBM25 shRNA Haematopoietic_and_lymphoid_tissue K562 1.58756 0.66681 0.03097 0.20831 DataSet_02_166
S100A1 U2AF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.35197 -1.50646 0.0045 0.04914 DataSet_02_170
S100A1 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.60888 -0.71577 0.04247 0.23533 DataSet_02_171
S100A1 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 1.95036 0.96374 0.231 1 DataSet_02_190
S100A1 AR siRNA Prostate abl cells 0.631336 -0.663519 0.177685028114229 0.999852161656754 DataSet_03_004
S100A1 ASCL1 siRNA Lung DMS79 3.59259 1.84502 0.13237262962501 0.79963178393944 DataSet_03_016
S100A1 BCL6 siRNA Lymph Pfeiffer DLBCL 2.19741 1.13581 0.190948307290781 0.667902696556593 DataSet_03_026
S100A1 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.477984 -1.06497 - - DataSet_03_096
S100A1 GATA4 siRNA Stomach AGS 1.51468 0.599011 0.473981660531591 0.920869947863669 DataSet_03_105
S100A1 GATA6 siRNA Stomach KatoIII 1.96143 0.971907 0.0154242618442531 0.428989499117094 DataSet_03_109
S100A1 KLF5 siRNA Stomach KatoIII 3.5675 1.83491 0.0244195791816585 0.344632986903702 DataSet_03_150
S100A1 KLF5 siRNA Stomach YCC3 0.518199 -0.948423 0.224757778499149 0.590957952088281 DataSet_03_151
S100A1 MEF2D shRNA Liver HuH7 1.65902 0.730335 - - DataSet_03_162
S100A1 MYB siRNA Cord_Blood CD34+ progenitor cells 4.10949 2.03896 - - DataSet_03_170
S100A1 MYC siRNA Colon HT29 0.587623 -0.767036 - - DataSet_03_177
S100A1 MYCN siRNA Brain BE(2)C cells 0.610177 -0.7127 - - DataSet_03_188
S100A1 PRRX1 CRISPR Neuroblastoma 691-MES 0.235652 -2.08527 0.00234846451214966 0.878656003669909 DataSet_03_217
S100A1 SP1 siRNA Mammary_gland MDA-MB-231 0.455004 -1.13605 0.0646239411117523 0.413972819854456 DataSet_03_250
S100A1 STAT3 CRISPR Embryo hESC 0.491045 -1.02607 0.532144516275447 0.599247945287094 DataSet_03_258
S100A1 STAT6 siRNA Umbilical_vein HUVEC 4.24074 2.08432 0.174598309902355 0.837635960915423 DataSet_03_264
S100A1 TFAP2C siRNA Mammary_gland MCF7 2.39881 1.26232 0.0804313533915462 0.422053799964109 DataSet_03_274
S100A1 FUBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.81119 0.856937 0.0550065484702525 0.140303445008708 DataSet_04_010
S100A1 MARK2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.2062 1.14156 0.00277027818858214 0.0157158560998038 DataSet_04_012
S100A1 NUP35 shRNA Haematopoietic_and_lymphoid_tissue K562 1.69915 0.764817 0.0144369492503204 0.0404156943610806 DataSet_04_015
S100A1 YBX1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.516046 -0.95443 0.00750576341895491 0.419114200143896 DataSet_04_022
S100A1 ZNF574 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.477313 -1.06699 0.0233392289289632 0.131817619949159 DataSet_04_023
S100A1 ERN1 CRISPR Liver HepG2 0.663542 -0.591741 0.00486990561125134 0.0808543306181955 DataSet_04_029
S100A1 NFX1 CRISPR Liver HepG2 0.475247 -1.07325 0.000314524691123308 0.0109394908028065 DataSet_04_032
S100A1 YBX1 CRISPR Liver HepG2 0.624929 -0.678235 0.145690513916892 0.972884761036538 DataSet_04_039
S100A1 ZC3H8 shRNA Liver HepG2 0.60779 -0.718355 0.00709450184639066 0.0938241044784233 DataSet_04_040
S100A1 ACTN4 CRISPR Liver HepG2 0.491426 -1.02495 0.00128914565955187 0.0314387418505503 DataSet_04_042
S100A1 ABT1 shRNA Liver HepG2 0.31906 -1.6481 8.43597708750719e-06 0.00118215111124821 DataSet_04_052
S100A1 DDX1 shRNA Liver HepG2 1.55084 0.633051 0.00053408633937148 0.0452185962061524 DataSet_04_057
S100A1 YBX3 shRNA Liver HepG2 1.55771 0.639427 0.000884031027098686 0.0387149460915123 DataSet_02_98
S100A1 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.638088 -0.648174 0.0156514749852789 0.0572725465496952 DataSet_04_049
S100A1 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.653902 -0.612853 0.00630383115039583 0.0306075914839985 DataSet_02_35
S100A1 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.592988 -0.753926 0.0253065315584208 0.338760509826799 DataSet_02_32
S100A1 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.13686 1.09549 0.00842206196719419 0.0482168791278172 DataSet_04_060
S100A1 CCAR1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.68554 0.753211 0.0014956168735697 0.0399577482090427 DataSet_04_064
S100A1 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 2.34837 1.23166 0.000331988948907999 0.00441569710712164 DataSet_04_059
S100A1 UBE2L3 shRNA Haematopoietic_and_lymphoid_tissue K562 1.82318 0.866461 0.00013604173185992 0.0476722634566606 DataSet_04_062
S100A1 SMARCA4 siRNA Colon HCT116 0.564116 -0.825935 4.874520e-02 0.2215865 DataSet_03_302
S100A1 ELF3 CRISPR Bile_duct HBDEC2 0.588114 -0.765832 9.502633e-04 5.877586e-03 DataSet_03_304
S100A1 SNAI2 shRNA Pancreas KLM1 1.5972 0.675547 1.578881e-02 0.19168593 DataSet_03_307
S100A1 EZH2 shRNA Mammary_gland LM2 2.11638 1.0816 1.144328e-01 4.673582e-01 DataSet_03_350
S100A1 SKI CRISPR Blood HL60 0.4 -1.32193 4.929393e-01 0.733889837 DataSet_03_351
S100A1 ETV5 knockdown Colon HT29 0.470588 -1.08746 1.583153e-03 0.049972955 DataSet_03_353
S100A1 PARP1 siRNA Prostate LNCaP 0.635494 -0.654049 4.379559e-01 0.699201952 DataSet_03_354
S100A1 NCOA3 siRNA Mammary_gland MDA-MB-231 3.22476 1.68919 4.905587e-01 0.9006501 DataSet_03_361
S100A1 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 1.56957 0.650373 1.433517e-02 3.126496e-02 DataSet_03_362
S100A1 EP300 shRNA Mammary_gland MCF10AT 1.66667 0.736966 1.426511e-01 0.356605979 DataSet_03_364
S100A1 TP53 knockout Stomach SNU1 4.90901 2.29543 0.0219028714 0.9301241 DataSet_03_365
S100A1 ZNF148 shRNA Mammary_gland MDA-MB-231 1.69797 0.763807 1.105115e-01 0.286366733 DataSet_03_366
S100A1 ABL1 shRNA Liver HuH7 0.665269 -0.587989 1.379375e-03 0.0077119579 DataSet_03_367
S100A1 USP22 shRNA Liver PLC_PRF_5 cells 2.81481 1.49304 2.987882e-02 0.17589652 DataSet_03_368
S100A1 TPR shRNA Bone_marrow U2OS 2.93372 1.55273 6.966439e-02 3.956193e-01 DataSet_03_370
S100A1 ZFP36L1 siRNA Urinary_bladder J82 2.88889 1.53051 - - DataSet_03_371
S100A1 GLI1 siRNA Skeletal_muscle RMS13 0.587793 -0.766619 1.047074e-01 0.283184291 DataSet_03_375
S100A1 ZNF213 siRNA Mammary_gland MCF7 7.19258 2.84651 1.437038e-02 1.930076e-01 DataSet_03_376
S100A1 EZH2 CRISPR Ovary SKOV3 1.76129 0.816633 3.511440e-01 0.5299701142 DataSet_03_378
S100A1 DDX5 shRNA Stomach HGC-27 2.41756 1.27355 - - DataSet_03_379
S100A1 DNMT1 siRNA Skin Human melanoma cells 1.54684 0.629321 1.702652e-04 7.959949e-04 DataSet_03_382
S100A1 TCF19 CRISPR Oral_squamous CAL27 2.45868 1.29788 4.200862e-02 0.1903143467 DataSet_03_383
S100A1 YY1 shRNA Brain GSC1517 1.7193 0.78182 - - DataSet_03_384
S100A1 YY1 shRNA Brain GSC23 1.6129 0.68966 - - DataSet_03_385
S100A1 YY1 shRNA Brain GSC3028 0.636267 -0.652295 - - DataSet_03_386
S100A1 NFKBIA shRNA Bone_marrow U2OS 0.0107597 -6.53822 5.105869e-01 0.87005461 DataSet_03_389
S100A1 YY1 knockdown Liver HepG2 1.59658 0.674981 9.869482e-04 4.998258e-03 DataSet_03_390
S100A1 KDM5A CRISPR Lung GLC16 2.22595 1.15442 1.362139e-02 0.051798781 DataSet_03_392
S100A1 ILF2 siRNA Stomach SGC-7901 2.4 1.26303 0.2982696546 0.50235503 DataSet_03_393
S100A1 JAZF1 siRNA Cervix HeLa Kyoto 1.70344 0.768452 5.514848e-01 0.894077300 DataSet_03_396
S100A1 RELA CRISPR Brain T30 8.37564 3.0662 0.0113540495 0.8400824 DataSet_03_399
S100A1 EHF shRNA Stomach MKN7 70.514 6.13984 - - DataSet_03_402
S100A1 CDK7 shRNA Bone_marrow D458 0.172377 -2.53636 3.352385e-03 0.11520656 DataSet_03_404
S100A1 SIRT1 siRNA Pancreas PANC1 0.637809 -0.648803 2.346299e-02 0.083565635 DataSet_03_410
S100A1 E2F6 shRNA Liver HuH7 3.8801 1.95609 - - DataSet_03_412
S100A1 E2F1 siRNA Prostate LNCaP 0.333333 -1.58496 1.127864e-02 0.3187573797 DataSet_03_413
S100A1 ZKSCAN3 CRISPR Colon HCT116 0.375 -1.41504 3.036097e-03 0.132214808 DataSet_03_415
S100A1 FOXK2 shRNA Ovary OVCAR-5 4 2 7.978918e-02 0.24116688 DataSet_03_419
S100A1 FOXQ1 CRISPR Lymph Primary CD4+ T cells 0.5 -1 - - DataSet_03_422
S100A1 STAT5B CRISPR Embryo_kidney HEK293 0.5 -1 4.399425e-01 0.764657930 DataSet_03_424
S100A1 LHX2 shRNA Bone_marrow ES-derived RPE cells 0.428571 -1.22239 6.959590e-02 1.000000e+00 DataSet_03_428
S100A1 STAT3 siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 0.429319 -1.21988 0.0160091922 1 DataSet_03_430
S100A1 USP7 shRNA Skin xenograft cells 0.503557 -0.989772 0.27752112 0.4348960 DataSet_03_431
S100A1 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.4 -1.32193 - - DataSet_03_432
S100A1 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 2.125 1.08746 1.518373e-01 0.517945886 DataSet_03_434
S100A1 POU2AF1 CRISPR Lymph SUDHL4 3.84557 1.9432 6.736713e-04 0.010669842 DataSet_03_435
S100A1 EP300 knockout Pancreas HPAF-II orthotopic cells 0.242308 -2.04509 1.548871e-01 3.252501e-01 DataSet_03_436
S100A1 SUFU shRNA Mammary_gland HCC1954 cells 0.32 -1.64386 0.0563461884 0.5458359 DataSet_03_437
S100A1 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 2.71698 1.442 4.626190e-02 0.80985015 DataSet_03_439
S100A1 SETDB1 shRNA Colon HCT116 0.585037 -0.7734 - - DataSet_03_440
S100A1 RELB CRISPR Colon SW480 2.07692 1.05445 6.204933e-03 5.958859e-02 DataSet_03_449
S100A1 CBX2 siRNA Mammary_gland MDA-MB-231 2.63647 1.39861 1.959638e-01 3.881851e-01 DataSet_03_450
S100A1 CBX2 siRNA Mammary_gland MCF7 3.27619 1.71202 9.562206e-06 0.0004812612 DataSet_03_451
S100A1 OGT siRNA Embryo BeWo cells 1.54902 0.631355 1.129751e-01 0.63974818 DataSet_03_453
S100A1 PPARG siRNA Aortic_valve Valvular endothelial cell 1.70652 0.771059 8.884208e-02 4.596127e-01 DataSet_03_456
S100A1 SREBF2 siRNA Umbilical_vein HUVEC 0.50292 -0.991598 9.090596e-03 1.509835e-01 DataSet_03_457
S100A1 ARID1A shRNA Bile_duct MMNK1 0.377238 -1.40645 1.752283e-01 0.471325671 DataSet_03_458
S100A1 HAND1 siRNA Placenta HPMVEC 0.545455 -0.874469 1.515252e-01 0.9463341 DataSet_03_459
S100A1 SOX9 knockout Liver HuH7 4.33333 2.11548 2.741402e-02 8.956839e-02 DataSet_03_463
S100A1 SMARCA1 Cas13 Embryo_kidney HEK293T 0.333333 -1.58496 - - DataSet_03_466
S100A1 WHSC1 siRNA Prostate PC3 1.55856 0.640212 6.329892e-01 0.78388826 DataSet_03_471
S100A1 EZH2 siRNA Prostate LNCaP 1.63116 0.705894 - - DataSet_03_472
S100A1 EZH2 siRNA Umbilical_vein HUVEC 1.66667 0.736966 1.878141e-01 0.453911726 DataSet_03_473
Regulation Region
 
T(co)Fs that significantly regulate SOX2 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of S100A1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines