Gene Overview
Target Gene: A2M
NCBI Official Symbol: A2M
Entrez ID: 2
Ensembl ID: ENSG00000175899
Gene Full Name: alpha-2-macroglobulin
Strand: -
Gene Locus: 12p13.31
External Links:

A2M Significantly Regulated by These T(co)Fs

T(co)Fs that Activate A2M   
T(co)Fs that Repress A2M
The Intensity of the Gene Regulated by T(co)Fs:
A2M-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
A2M HOXA1 siRNA Lung_fibroblast IMR-90 1.59788 0.67616 0.04851 0.23527 DataSet_01_110
A2M ZIC2 siRNA Pancreas PANC1 0.44475 -1.16893 - - DataSet_01_121
A2M FOXM1 siRNA Central_nervous_system U87 8.6272 3.10889 - - DataSet_01_122
A2M ZNF431 siRNA Gastrointestinal_tissue GIST-T1 4.51346 2.17423 9.28118e-09 3.39294e-05 DataSet_01_128
A2M ZNF665 siRNA Gastrointestinal_tissue GIST-T1 2.17749 1.12267 3.30415e-06 0.00079 DataSet_01_129
A2M ID1 shRNA Neuroepithelium GSC2 2.54872 1.34977 6.77977e-14 1.13844e-11 DataSet_01_133
A2M ID1 shRNA Neuroepithelium GSC8 0.14405 -2.79536 2.09033e-16 7.65821e-14 DataSet_01_134
A2M IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.55691 0.63869 0.58912 0.99993 DataSet_01_137
A2M MYBL2 shRNA Bone_marrow CD34+ BM cells 0.59905 -0.73926 0.04851 0.30697 DataSet_01_148
A2M TFAP2C shRNA Mammary_gland MCF7 1.88814 0.91697 1.01442e-06 5.92734e-06 DataSet_01_150
A2M HSF1 shRNA Skin A375 0.51264 -0.96398 0.01682 0.09366 DataSet_01_155
A2M ELK1 siRNA Peripheral_blood CD4+ T cells 1.85302 0.88987 0.02608 0.10012 DataSet_01_162
A2M GATA3 siRNA Peripheral_blood CD4+ T cells 0.64819 -0.6255 0.21523 0.55566 DataSet_01_163
A2M JUN siRNA Peripheral_blood CD4+ T cells 2.30737 1.20625 0.0028 0.03015 DataSet_01_164
A2M MAF siRNA Peripheral_blood CD4+ T cells 2.2473 1.16819 0.01343 0.12543 DataSet_01_165
A2M NFATC3 siRNA Peripheral_blood CD4+ T cells 3.54696 1.82658 0.00038 0.0143 DataSet_01_166
A2M ESRRG siRNA Placenta_tissue Trophoblast cells 0.58353 -0.77713 0.11632 0.4921 DataSet_01_173
A2M TP53 siRNA Lung SAECs 1.97639 0.98287 0.0017 0.15072 DataSet_01_175
A2M STAT3 siRNA Urothelial Scaber 0.66286 -0.59321 1.91806e-05 0.00076 DataSet_01_184
A2M CREB1 shRNA Parotid_gland H3118 MEC 0.53253 -0.90906 0.02465 0.24916 DataSet_01_194
A2M TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.71492 0.77814 - - DataSet_01_196
A2M TP63 siRNA Head_and_neck SCC-1 8.92381 3.15766 - - DataSet_01_198
A2M TP63 siRNA Immortalized_keratinocyte HaCaT 1.61911 0.6952 - - DataSet_01_200
A2M TP63 siRNA Head_and_neck SCC-6 0.56564 -0.82203 - - DataSet_01_202
A2M HIC1 shRNA Mammary_gland HBL100 0.5633 -0.82802 - - DataSet_01_205
A2M MITF shRNA Skin COLO829 2.06078 1.04319 0.00083 0.01959 DataSet_01_207
A2M FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 2.14455 1.10068 - - DataSet_01_208
A2M FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.39868 -1.32668 - - DataSet_01_209
A2M FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.24664 -2.0195 - - DataSet_01_210
A2M LIN28A siRNA Embryo H9 0.31682 -1.65829 8.11406e-05 0.00268 DataSet_01_215
A2M TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 6.87517 2.78139 2.45298e-06 0.00264 DataSet_01_217
A2M IRX1 shRNA Bone_marrow 143B 3.17797 1.66811 3.45121e-05 0.00753 DataSet_01_227
A2M FOXC2 siRNA Lymph Lymphatic endothelial cells 1.56733 0.64831 0.19556 0.82128 DataSet_01_236
A2M SMAD2 siRNA Liver Hep3B 1.97046 0.97853 - - DataSet_01_248
A2M SMAD3 siRNA Liver Hep3B 4.28355 2.09881 - - DataSet_01_249
A2M TWIST1 shRNA Stomach CAF32 2.32753 1.2188 0.01293 0.06092 DataSet_01_253
A2M TWIST1 shRNA Stomach CAF 1.5984 0.67662 0.46948 0.82679 DataSet_01_254
A2M MSX1 siRNA Tooth Dental Pulp Cells 4.75766 2.25025 2.17248e-06 0.00011 DataSet_01_281
A2M SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 0.62403 -0.68031 0.41075 0.92436 DataSet_01_290
A2M SNAI2 siRNA Mammary_gland MCFDCIS 0.59461 -0.74999 0.13904 0.68464 DataSet_01_292
A2M POSTN shRNA Brain GSC272 0.4611 -1.11686 0.11579 0.55804 DataSet_01_293
A2M TFAP4 siRNA Brain BE(2)-C 0.24377 -2.03639 0.39427 0.51625 DataSet_01_295
A2M NR2E1 shRNA Neuroepithelium PBT003 0.55923 -0.8385 0.2541 0.66467 DataSet_01_306
A2M FOXO1 shRNA Haematopoietic_and_lymphoid_tissue RS4;11 2.33164 1.22134 7.15948e-06 0.00969 DataSet_01_321
A2M AR shRNA Prostate CWR22Rv1 1.62736 0.70254 0.00597 0.05614 DataSet_01_323
A2M MYC siRNA Colon HCT116 1.52886 0.61246 0.00281 0.00713 DataSet_01_324
A2M HOXC6 siRNA Prostate LNCaP 4 2 0.35166 0.99927 DataSet_01_333
A2M PAX3 shRNA Soft_tissue Rh30 2.32394 1.21657 - - DataSet_01_359
A2M SOX17 siRNA Umbilical_vein HUVEC 0.21137 -2.24219 - - DataSet_01_360
A2M FIP1L1 shRNA Liver HepG2 0.42426 -1.23697 0.00041 0.01142 DataSet_02_103
A2M SSB shRNA Liver HepG2 1.93337 0.95112 0.00188 0.00997 DataSet_02_107
A2M ZNF622 shRNA Liver HepG2 1.59389 0.67255 0.00155 0.01015 DataSet_02_108
A2M HNRNPUL1 shRNA Liver HepG2 1.56509 0.64625 0.00695 0.03453 DataSet_02_109
A2M BCLAF1 shRNA Liver HepG2 1.85476 0.89123 0.0018 0.02671 DataSet_02_112
A2M TARDBP shRNA Liver HepG2 3.59436 1.84573 0.00196 0.01902 DataSet_02_116
A2M PTBP1 shRNA Liver HepG2 0.40029 -1.32088 5e-04 0.0061 DataSet_02_120
A2M EWSR1 shRNA Liver HepG2 0.62235 -0.6842 0.00198 0.04273 DataSet_02_122
A2M HNRNPLL shRNA Liver HepG2 2.35654 1.23667 0.00541 0.02405 DataSet_02_125
A2M SNRNP70 shRNA Liver HepG2 4.2446 2.08563 0.00122 0.03074 DataSet_02_126
A2M PRPF4 shRNA Liver HepG2 1.84566 0.88414 0.00184 0.03053 DataSet_02_128
A2M AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 9 3.16993 0.01743 0.12187 DataSet_02_132
A2M SRSF9 shRNA Haematopoietic_and_lymphoid_tissue K562 0.38462 -1.37851 0.05343 0.15947 DataSet_02_134
A2M PCBP2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.61538 0.69188 0.58744 0.71728 DataSet_02_135
A2M HNRNPK shRNA Haematopoietic_and_lymphoid_tissue K562 0.4359 -1.19794 0.22645 0.44324 DataSet_02_136
A2M RBM34 shRNA Haematopoietic_and_lymphoid_tissue K562 0.38462 -1.37851 0.05222 0.24655 DataSet_02_141
A2M RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 148 7.20945 0.01006 0.03736 DataSet_02_143
A2M CCAR2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.66667 0.73697 0.50636 0.80708 DataSet_02_146
A2M FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 11 3.45943 0.0176 0.10162 DataSet_02_147
A2M PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.07559 0.17856 DataSet_02_158
A2M RBM22 shRNA Haematopoietic_and_lymphoid_tissue K562 0.38462 -1.37851 0.139 0.25455 DataSet_02_168
A2M LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 0.21429 -2.22239 0.05696 1 DataSet_02_175
A2M LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.46429 -1.10692 0.23246 1 DataSet_02_191
A2M UBTF siRNA Haematopoietic_and_lymphoid_tissue K562 8.75 3.12928 0.03744 1 DataSet_02_198
A2M MAZ siRNA Haematopoietic_and_lymphoid_tissue K562 6.5 2.70044 0.03417 1 DataSet_02_199
A2M E2F4 siRNA Haematopoietic_and_lymphoid_tissue K562 0.21429 -2.22239 0.0706 1 DataSet_02_200
A2M ZFX siRNA Mammary_gland MCF7 2.22222 1.152 0.68557 0.83837 DataSet_02_206
A2M BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.50076 -0.997808 0.0662509539189782 0.735426122654401 DataSet_03_025
A2M BCL6 siRNA Lymph Pfeiffer DLBCL 1.95724 0.968823 0.0154200571828746 0.376616223935539 DataSet_03_026
A2M CEBPB siRNA Embryo hESC 2.0278 1.01991 0.387754330715747 0.730022184525615 DataSet_03_049
A2M ETS1 siRNA Fibroblasts WI38 0.57222 -0.805357 9.57096031678569e-06 0.000766585018657587 DataSet_03_073
A2M ETS1 siRNA Fibroblasts WI38 0.582703 -0.779167 4.53946847595798e-05 0.00237222777923134 DataSet_03_074
A2M FOXM1 siRNA Mammary_gland BT-20 cells 1.75 0.807355 0.064400074722646 0.50033384521145 DataSet_03_091
A2M FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.250877 -1.99495 - - DataSet_03_096
A2M GATA2 siRNA Uterus Decidual stromal cells 0.578962 -0.788459 0.0618963301402802 0.664863605747901 DataSet_03_100
A2M GATA2 siRNA Lymph Lymphatic endothelial cells 2.09509 1.06701 0.421630601011914 0.512617310996039 DataSet_03_101
A2M GATA4 siRNA Stomach AGS 1.89051 0.918773 0.177907929099069 0.82489141819264 DataSet_03_105
A2M GATA6 siRNA Stomach AGS 2.81169 1.49144 0.0567110739228166 0.498408403327351 DataSet_03_108
A2M GFP siRNA Mammary_gland BT-20 cells 2 1 0.0342818248215434 0.546410779049003 DataSet_03_111
A2M HIC1 CRISPR Prostate PC3 1.57122 0.651883 - - DataSet_03_118
A2M KLF5 siRNA Stomach KatoIII 2.12397 1.08676 0.0734550446323903 0.491706025197654 DataSet_03_150
A2M KLF5 siRNA Stomach YCC3 0.59622 -0.746084 0.237279241579784 0.604886403112842 DataSet_03_151
A2M MITF siRNA Skin MZ7 1.9026 0.927975 2.49111214712095e-09 8.19209903622882e-08 DataSet_03_165
A2M MITF siRNA Skin Ma-Mel-15 3.08467 1.62512 0.000304433265605719 0.0251418386923809 DataSet_03_166
A2M MITF siRNA Skin Ma-Mel-15 2.38034 1.25117 4.21229007894354e-05 0.00306948516130747 DataSet_03_167
A2M MYB siRNA Cord_Blood CD34+ progenitor cells 2.60991 1.384 - - DataSet_03_170
A2M MYC siRNA Central_nervous_system DAOY M2.1 1.63775 0.711716 7.5330655114378e-06 3.94984342978658e-05 DataSet_03_178
A2M RELA siRNA Fibroblasts WI38 1.76497 0.819643 1.25637851259597e-07 3.9960120054248e-05 DataSet_03_222
A2M RELA siRNA Fibroblasts WI38 1.77007 0.82381 4.0296899629531e-09 1.2665490757473e-06 DataSet_03_223
A2M SOX11 siRNA Lung_fibroblast NHLF 1.54589 0.628435 0.489932081005263 0.676160623301581 DataSet_03_237
A2M SOX11 siRNA Lung_fibroblast NHLF 1.64272 0.716089 0.476369702880606 0.801950843291554 DataSet_03_238
A2M SOX2 CRISPR Seminoma-like TCam-2 6.14584 2.61961 0.206647376241084 0.999580851453413 DataSet_03_244
A2M SP1 siRNA Ovary OVSAYO 4.24963 2.08734 0.00536855272804964 0.105917630196056 DataSet_03_251
A2M STAT1 knockout Liver Huh-7.5 0.553954 -0.852163 0.000632085905065295 0.0253094345945939 DataSet_03_257
A2M STAT3 CRISPR Embryo hESC 0.133047 -2.90999 0.033491884405351 0.103570248481608 DataSet_03_258
A2M TET1 siRNA Embryo NCCIT 0.114754 -3.12338 4.66055792130591e-08 0.000217247246943754 DataSet_03_269
A2M TET2 siRNA Embryo NCCIT 0.0967329 -3.36985 1.02845970228367e-07 0.000140654536654363 DataSet_03_270
A2M TET3 siRNA Embryo NCCIT 0.110739 -3.17476 3.05520620293454e-08 0.000178019227429488 DataSet_03_273
A2M TFAP2C siRNA Mammary_gland MCF7 0.656 -0.608231 0.0326689845053932 0.348152982019828 DataSet_03_274
A2M TFE3 siRNA Kidney UOK257-2 0.344584 -1.53708 - - DataSet_03_275
A2M CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 2.23077 1.15754 0.245485069008008 0.372734533665773 DataSet_04_002
A2M CHCHD3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.153846 -2.70044 0.276417904559214 0.915844825866729 DataSet_04_003
A2M CTCF CRISPR Haematopoietic_and_lymphoid_tissue K562 3.37097 1.75316 0.0416006502502445 0.356562365856881 DataSet_04_005
A2M E4F1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.306452 -1.70627 0.0935108945591181 0.531194801643782 DataSet_04_007
A2M ERN1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.0806452 -3.63227 0.000417195895759675 0.182184232729553 DataSet_04_009
A2M FUBP3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.444444 -1.16992 0.0632469993042515 0.748246762324488 DataSet_04_011
A2M SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.25641 -1.96347 0.22960439448141 0.377633619621068 DataSet_04_018
A2M SMAD5 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.241936 -2.04731 0.117295933606014 0.485137469051685 DataSet_04_020
A2M ZNF574 CRISPR Haematopoietic_and_lymphoid_tissue K562 8.08333 3.01495 0.0757999092456904 0.206677748735985 DataSet_04_023
A2M APTX CRISPR Liver HepG2 0.354839 -1.49477 0.0051063633884623 0.365462163133833 DataSet_04_025
A2M NFX1 CRISPR Liver HepG2 0.648398 -0.625048 0.00528395290887956 0.0254325471555627 DataSet_04_032
A2M SMAD4 CRISPR Liver HepG2 0.523141 -0.934727 0.00310745096161633 0.0722995622852713 DataSet_04_035
A2M PAN2 CRISPR Liver HepG2 0.523141 -0.934727 0.00065966081336088 0.0230488547319771 DataSet_04_066
A2M ABT1 shRNA Liver HepG2 2.94731 1.5594 2.05409706904921e-05 0.00134454088625359 DataSet_04_052
A2M ACTN4 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.483871 -1.04731 0.555864931454385 0.746068322847315 DataSet_04_048
A2M DDX20 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.472222 -1.08246 0.17777137562254 0.55774492038593 DataSet_04_050
A2M CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.037037 -4.75489 0.291597135455202 0.555443149472196 DataSet_02_38
A2M DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.518519 -0.947533 0.624497886377432 0.769276316479373 DataSet_02_14
A2M HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 12 3.58496 0.476486231120392 0.795995069879457 DataSet_02_75
A2M HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.037037 -4.75489 0.423094234090496 0.805594954180189 DataSet_02_45
A2M LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.444444 -1.16992 0.559982003581617 0.727637546081594 DataSet_02_35
A2M SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.89286 0.920566 0.641110419638257 0.914745122747674 DataSet_02_49
A2M TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.25926 1.17585 0.198535318489303 0.368478280670008 DataSet_02_43
A2M TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.037037 -4.75489 0.28377863757247 0.434802819900357 DataSet_02_33
A2M TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.481481 -1.05445 0.584528773240316 0.732840725996862 DataSet_02_53
A2M UBE2L3 shRNA Haematopoietic_and_lymphoid_tissue K562 7 2.80735 0.0707896209734503 0.252875419405312 DataSet_04_062
A2M SNAI2 shRNA Pancreas KLM1 1.53816 0.621208 3.422793e-01 0.66661906 DataSet_03_307
A2M EZH2 shRNA Mammary_gland MCF7 1.56383 0.64508 9.230949e-03 1.263849e-01 DataSet_03_331
A2M ETV5 knockdown Colon HT29 2.2 1.1375 6.544968e-01 0.800847465 DataSet_03_353
A2M TET1 CRISPR Mammary_gland Hs578T 2.41599 1.27262 3.575937e-01 5.507228e-01 DataSet_03_355
A2M RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 1.7956 0.844464 1.423799e-01 3.642729e-01 DataSet_03_359
A2M ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 1.50456 0.589341 6.475294e-01 7.268677e-01 DataSet_03_362
A2M TP53 knockout Stomach SNU1 0.48405 -1.04677 0.5292073861 0.9487047 DataSet_03_365
A2M USP22 shRNA Liver PLC_PRF_5 cells 0.493671 -1.01838 1.231557e-01 0.32829786 DataSet_03_368
A2M DNMT3A knockout Embryo_kidney HEK293T 6.19523 2.63116 - - DataSet_03_369
A2M TPR shRNA Bone_marrow U2OS 0.657581 -0.60476 1.706160e-01 5.913657e-01 DataSet_03_370
A2M ZFP36L1 siRNA Urinary_bladder J82 3.66667 1.87447 - - DataSet_03_371
A2M BHLHE40 shRNA Cervix HeLaS3 0.580645 -0.784271 7.174844e-02 0.84447131 DataSet_03_372
A2M ZNF213 siRNA Mammary_gland MCF7 0.000073049 -13.7408 7.627854e-02 5.057283e-01 DataSet_03_376
A2M EZH2 CRISPR Ovary SKOV3 0.2 -2.32193 6.351832e-01 0.7725665036 DataSet_03_378
A2M NFKB2 siRNA Bone_marrow U2OS 0.66034 -0.59872 5.225329e-02 0.29552408 DataSet_03_381
A2M DNMT1 siRNA Skin Human melanoma cells 3.61729 1.85491 9.259470e-10 2.592888e-06 DataSet_03_382
A2M YY1 shRNA Brain GSC1517 2.40816 1.26793 - - DataSet_03_384
A2M KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 2.32278 1.21585 0.6914794595 0.9421475 DataSet_03_387
A2M TRIM8 siRNA Mammary_gland MCF7 0.115385 -3.11548 1.931496e-01 0.3943868944 DataSet_03_388
A2M NFKBIA shRNA Bone_marrow U2OS 0.493937 -1.0176 9.309056e-03 0.87005461 DataSet_03_389
A2M YY1 knockdown Liver HepG2 2.00048 1.00035 2.828410e-07 5.025868e-06 DataSet_03_390
A2M ASXL1 CRISPR Embryo iPSC 0.354653 -1.49552 0.3139650694 0.8267144 DataSet_03_394
A2M HMGA1 shRNA Bile_duct HUCCT1 1.95727 0.968839 4.292461e-03 0.078106051 DataSet_03_400
A2M SUMO1 CRISPR Bone_marrow U2OS 0.564962 -0.823775 1.540535e-02 7.146566e-02 DataSet_03_401
A2M EHF shRNA Stomach MKN7 0.000868363 -10.1694 - - DataSet_03_402
A2M JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.84932 0.886998 4.238548e-04 0.2281987 DataSet_03_403
A2M CDK7 shRNA Bone_marrow D458 1.82283 0.866184 1.174541e-01 0.43106188 DataSet_03_404
A2M TFAP2A knockout Embryo H9 0.225807 -2.14684 4.803908e-02 0.14200289 DataSet_03_405
A2M SATB2 CRISPR Colon Colon organoid 0.2 -2.32193 2.748203e-01 0.95735254 DataSet_03_406
A2M MAP3K7 shRNA Prostate LNCaP 0.665328 -0.587863 3.770133e-02 1.742429e-01 DataSet_03_408
A2M STRAP knockout Nerve SK-N-AS 8.77839 3.13396 - - DataSet_03_409
A2M USP22 shRNA Liver HuH7 0.57538 -0.797414 - - DataSet_03_411
A2M E2F1 siRNA Prostate LNCaP 2.25 1.16992 4.281375e-01 0.7642299494 DataSet_03_413
A2M E2F2 siRNA Prostate LNCaP 6.75 2.75489 6.343754e-02 2.199137e-01 DataSet_03_414
A2M ZKSCAN3 CRISPR Colon HCT116 1.61539 0.691878 7.476944e-01 0.908244701 DataSet_03_415
A2M NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 5.5 2.45943 4.812130e-02 0.160180739 DataSet_03_418
A2M FOXQ1 CRISPR Lymph Primary CD4+ T cells 2.5 1.32193 - - DataSet_03_422
A2M LHX2 shRNA Bone_marrow ES-derived RPE cells 0.102564 -3.2854 2.646431e-03 3.168601e-01 DataSet_03_428
A2M STAT3 siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 0.518037 -0.948872 0.0121514181 1 DataSet_03_430
A2M USP7 shRNA Skin xenograft cells 0.510148 -0.971012 0.27988720 0.4350410 DataSet_03_431
A2M EP300 knockout Pancreas HPAF-II orthotopic cells 0.392045 -1.35091 6.184567e-01 7.680862e-01 DataSet_03_436
A2M CIC knockout Brain Immortalized Astrocyte Cells 2.52128 1.33415 1.164347e-02 2.045194e-01 DataSet_03_438
A2M FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 2.79019 1.48036 1.080291e-01 0.90558273 DataSet_03_439
A2M SETDB1 shRNA Colon HCT116 2.07201 1.05103 - - DataSet_03_440
A2M HMG20A siRNA Mammary_gland MDA-MB-231 1.78261 0.83399 0.1612269757 0.4209827 DataSet_03_442
A2M PURA siRNA Cervix HeLa 1.7931 0.842459 5.050015e-02 0.207822648 DataSet_03_444
A2M FOSL1 siRNA Prostate MSKPCa3 0.5 -1 0.3365328369 0.5560468 DataSet_03_445
A2M CAMTA1 knockout Embryo_kidney HEK293T 2 1 7.289713e-01 0.81166952 DataSet_03_448
A2M CBX2 siRNA Mammary_gland MDA-MB-231 0.41556 -1.26687 6.273898e-01 8.054776e-01 DataSet_03_450
A2M CBX2 siRNA Mammary_gland MCF7 1.61457 0.691153 7.082620e-01 0.8253434795 DataSet_03_451
A2M OGT siRNA Embryo BeWo cells 0.272727 -1.87447 5.399651e-01 0.82360205 DataSet_03_453
A2M SREBF2 siRNA Umbilical_vein HUVEC 0.533004 -0.907782 6.517885e-01 9.070437e-01 DataSet_03_457
A2M IRF2 shRNA Cord_Blood CD34+ cells 6 2.58496 - - DataSet_03_460
A2M SOX9 knockout Liver HuH7 2.19503 1.13424 1.411208e-04 2.590201e-03 DataSet_03_463
A2M SMARCA1 Cas13 Embryo_kidney HEK293T 3 1.58496 - - DataSet_03_466
A2M SMARCA1 shRNA Embryo_kidney HEK293T 2 1 - - DataSet_03_468
A2M CHCHD3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.153846 -2.70044 0.4195397 0.9305714 DataSet_04_071
A2M CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 2.23077 1.15754 0.2713642 0.42795502 DataSet_04_074
Regulation Region
 
T(co)Fs that significantly regulate ERN1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of A2M
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines