Gene Overview
Target Gene: CEACAM6
NCBI Official Symbol: CEACAM6
Entrez ID: 4680
Ensembl ID: ENSG00000086548
Gene Full Name: carcinoembryonic antigen related cell adhesion molecule 6
Strand: +
Gene Locus: 19q13.2
External Links:

CEACAM6 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate CEACAM6   
T(co)Fs that Repress CEACAM6
The Intensity of the Gene Regulated by T(co)Fs:
CEACAM6-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
CEACAM6 IRF2 shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 3.46608 1.79331 0.00317 0.0866 DataSet_01_100
CEACAM6 IRF6 shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 3.67026 1.87588 0.00209 0.02936 DataSet_01_101
CEACAM6 MYB shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 13.3465 3.73839 6.79736e-15 2.17801e-11 DataSet_01_102
CEACAM6 SPDEF shRNA Mammary_gland MCF7 0.26913 -1.89361 0.27235 0.99999 DataSet_01_107
CEACAM6 ID1 siRNA Lung H1650 0.64954 -0.62251 0.33873 0.66832 DataSet_01_118
CEACAM6 GATA3 siRNA Mammary_gland MCF7 2.13913 1.09702 5.47009e-06 0.00043 DataSet_01_120
CEACAM6 FOXM1 siRNA Central_nervous_system U87 1.96444 0.97412 - - DataSet_01_122
CEACAM6 SPDEF shRNA Mammary_gland MCF7 0.42508 -1.23418 0.00027 0.02403 DataSet_01_135
CEACAM6 IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 0.60478 -0.72551 0.16449 0.99971 DataSet_01_137
CEACAM6 ZFX shRNA Haematopoietic_and_lymphoid_tissue NOMO-1 4.11761 2.04181 0.23243 0.99999 DataSet_01_144
CEACAM6 TFAP2C shRNA Mammary_gland MCF7 0.15479 -2.69165 1.27133e-14 1.19643e-12 DataSet_01_150
CEACAM6 HSF1 shRNA Liver KYN2 1.68016 0.7486 - - DataSet_01_178
CEACAM6 NR5A2 siRNA Mammary_gland MCF7 4.32484 2.11265 3.7121e-14 6.18843e-10 DataSet_01_182
CEACAM6 TP63 shRNA Bladder UC14 1.93327 0.95104 0.00017 0.00224 DataSet_01_183
CEACAM6 SPDEF siRNA Mammary_gland MCF7 1.95684 0.96852 3.56972e-05 0.03655 DataSet_01_189
CEACAM6 CREB1 shRNA Parotid_gland H3118 MEC 4.54584 2.18455 0.19986 0.56353 DataSet_01_194
CEACAM6 XBP1 shRNA Mammary_gland T47D 4.26011 2.09089 1.5306e-07 0.00011 DataSet_01_203
CEACAM6 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 0.44609 -1.16459 - - DataSet_01_208
CEACAM6 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 4.04905 2.01758 - - DataSet_01_209
CEACAM6 PTEN shRNA Mammary_gland MCF10A 0.66304 -0.59284 1.15081e-05 0.00022 DataSet_01_218
CEACAM6 ATM shRNA Mammary_gland MCF10A 0.36524 -1.45308 0.00361 0.01666 DataSet_01_219
CEACAM6 FOXM1 siRNA Mammary_gland MCF7 4.36002 2.12434 0.00528 0.22768 DataSet_01_223
CEACAM6 SNAI2 shRNA Skin Primary human keratinocytes 22.3727 4.48367 1.22512e-05 0.00444 DataSet_01_225
CEACAM6 FOXP1 siRNA Prostate LNCaP 1.65702 0.7286 0.00762 0.24494 DataSet_01_234
CEACAM6 GATA6 siRNA Colon HT29 2.85566 1.51383 - - DataSet_01_247
CEACAM6 SOX4 shRNA Mammary_gland MDA-MB-231 1.52801 0.61165 0.04757 0.26427 DataSet_01_260
CEACAM6 SF1 siRNA Endometrial_tissue OsisHESC 0.56707 -0.81839 0.00455 0.03767 DataSet_01_271
CEACAM6 AR shRNA Prostate CWR22Pc 5.08805 2.34711 0.00219 0.02416 DataSet_01_278
CEACAM6 NFYA shRNA Lung H322 1.75834 0.81421 0.05076 0.1402 DataSet_01_288
CEACAM6 SNAI2 siRNA Mammary_gland MCFDCIS 2.22341 1.15277 0.00574 0.41265 DataSet_01_292
CEACAM6 RELB siRNA Lung A549 0.5714 -0.80744 0.0845 0.34074 DataSet_01_294
CEACAM6 TFAP4 siRNA Brain BE(2)-C 0.16489 -2.60045 0.30529 0.51625 DataSet_01_295
CEACAM6 ARNT siRNA Upper_aerodigestive_tract HSC3 0.22694 -2.13964 - - DataSet_01_315
CEACAM6 HNF4G shRNA Prostate 22RV1 0.63576 -0.65345 1.05675e-05 0.00324 DataSet_01_320
CEACAM6 TP63 shRNA Head_and_neck FaDU 1.9357 0.95286 4.00385e-05 0.0012 DataSet_01_327
CEACAM6 TP63 shRNA Head_and_neck FaDU 1.9357 0.95286 4.00385e-05 0.0012 DataSet_01_330
CEACAM6 KLF4 siRNA Embryo HCE 0.57544 -0.79727 0.00027 0.05424 DataSet_01_339
CEACAM6 KLF4 siRNA Embryo HCE 2.17557 1.1214 0.16267 0.62671 DataSet_01_341
CEACAM6 GATA3 siRNA Oral_cavity OEC-M1 0.46778 -1.09609 0.20318 0.99787 DataSet_01_347
CEACAM6 HIF1A siRNA Oral_cavity OEC-M1 1.62551 0.7009 0.11698 0.85151 DataSet_01_348
CEACAM6 ZNF24 siRNA Embryo_kidney HEK293 0.49377 -1.0181 - - DataSet_01_353
CEACAM6 ETV4 shRNA Prostate PC3 5.8479 2.54792 - - DataSet_01_356
CEACAM6 ABL1 siRNA Mammary_gland MCF7 1.64172 0.715211 0.321100902782665 0.976385569407162 DataSet_03_001
CEACAM6 AR siRNA Prostate LNCaP 1.6712 0.740881 0.187002666759553 1 DataSet_03_005
CEACAM6 ARID1A siRNA Oral_cavity SAS cells 1.5674 0.648375 0.347331471509788 0.824061028827408 DataSet_03_013
CEACAM6 ARID2 CRISPR Liver JHH4 0.659814 -0.599869 0.72085939159062 1 DataSet_03_015
CEACAM6 BCL6 siRNA Lymph OCI-Ly7 DLBCL 1.74715 0.804999 0.262975673102544 0.840427715619185 DataSet_03_025
CEACAM6 BRCA1 siRNA Mammary_gland MCF7 0.570134 -0.810628 0.265876850059855 0.999850583334387 DataSet_03_028
CEACAM6 CEBPA siRNA Mammary_gland MCF7 1.96302 0.973072 0.190593783078673 0.999962793175751 DataSet_03_047
CEACAM6 CEBPB siRNA Mammary_gland MCF7 1.50682 0.591505 0.406107007812779 0.993756826434039 DataSet_03_048
CEACAM6 CEBPD siRNA Mammary_gland MCF7 1.70423 0.769117 0.288835154676241 0.999848455332859 DataSet_03_050
CEACAM6 CENPF siRNA Mammary_gland MCF7 2.69383 1.42966 0.0719765954696512 0.999662524742916 DataSet_03_052
CEACAM6 CTNNB1 siRNA Mammary_gland MCF7 2.25273 1.17168 0.125230906579803 0.999436862066063 DataSet_03_058
CEACAM6 E2F1 siRNA Mammary_gland MCF7 2.84432 1.50808 0.0608360312457039 0.999927373439084 DataSet_03_061
CEACAM6 E2F5 siRNA Mammary_gland MCF7 2.51974 1.33328 0.088541634592908 0.999540347732068 DataSet_03_062
CEACAM6 ESRRA siRNA Mammary_gland MCF7 0.490884 -1.02655 0.17039837478372 0.999964003642835 DataSet_03_072
CEACAM6 FOXA1 siRNA Mammary_gland MCF7 0.182819 -2.45152 6.87027399246724e-10 6.14594045785319e-07 DataSet_03_080
CEACAM6 FOXA1 siRNA Mammary_gland MCF7 0.536742 -0.897699 2.68371935055004e-12 2.92019047068341e-10 DataSet_03_081
CEACAM6 FOXA1 siRNA Mammary_gland MCF7 0.536742 -0.897699 2.68371935055004e-12 2.92019047068341e-10 DataSet_03_082
CEACAM6 GATA2 siRNA Uterus Decidual stromal cells 1.57977 0.659712 0.286426873432 0.859842713370722 DataSet_03_100
CEACAM6 GATA3 siRNA Mammary_gland MCF7 5.93759 2.56988 0.00719038382265678 0.999831535534034 DataSet_03_102
CEACAM6 HDAC5 siRNA Mammary_gland MCF7 2.27654 1.18684 0.121234566810282 0.999966625300244 DataSet_03_115
CEACAM6 HOXB7 siRNA Mammary_gland MCF7 0.586658 -0.769407 0.288668884333735 0.999977683706165 DataSet_03_127
CEACAM6 HSF2 siRNA Mammary_gland MCF7 2.58997 1.37294 0.0813057729488701 0.990969613280381 DataSet_03_130
CEACAM6 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 0.616789 -0.697152 0.328118117216583 0.999948959532916 DataSet_03_134
CEACAM6 KDM3A siRNA Mammary_gland MCF7 0.108407 -3.20547 1.56445916377714e-07 0.000215154383202793 DataSet_03_146
CEACAM6 Klf4 siRNA Skin Primary neonatal keratinocytes 0.0763159 -3.71187 8.00753128688489e-06 0.000636722087614765 DataSet_03_147
CEACAM6 KLF5 siRNA Stomach AGS 0.277061 -1.85172 5.17811425192007e-06 0.0186886773542215 DataSet_03_149
CEACAM6 KLF5 siRNA Stomach YCC3 0.448853 -1.15569 3.44499749777176e-05 0.0138613422571264 DataSet_03_151
CEACAM6 MEF2D shRNA Liver HuH7 1.51872 0.602858 - - DataSet_03_162
CEACAM6 MITF siRNA Skin Ma-Mel-15 1.54348 0.626183 0.249214620803422 0.704560953393716 DataSet_03_166
CEACAM6 MITF siRNA Skin SK-MEL-5 0.546566 -0.871531 0.000155287078103736 0.000784911594426364 DataSet_03_168
CEACAM6 MTA2 siRNA Stomach SGC-7901 0.627209 -0.672982 - - DataSet_03_169
CEACAM6 MYB siRNA Cord_Blood CD34+ progenitor cells 0.323744 -1.62707 - - DataSet_03_170
CEACAM6 MYB siRNA Prostate VCaP 0.173419 -2.52767 4.47805245465722e-07 0.00112957567124373 DataSet_03_174
CEACAM6 MYC siRNA Colon HT29 2.44085 1.28738 - - DataSet_03_177
CEACAM6 PAX3 siRNA Mammary_gland MCF7 0.511785 -0.966391 0.104110576668778 0.919978041032696 DataSet_03_206
CEACAM6 PCNA siRNA Mammary_gland MCF7 2.38896 1.25638 0.104447947359258 0.999448838103647 DataSet_03_210
CEACAM6 PRRX1 CRISPR Neuroblastoma 691-MES 1.51508 0.599392 0.128088993075348 0.89189998148014 DataSet_03_217
CEACAM6 RB1 siRNA Mammary_gland MCF7 2.15562 1.1081 0.143402385512079 0.999890290262508 DataSet_03_219
CEACAM6 SOX11 siRNA Lung_fibroblast NHLF 0.349689 -1.51586 0.337637550788874 0.612273876569061 DataSet_03_237
CEACAM6 SOX11 siRNA Lung_fibroblast NHLF 0.326614 -1.61434 0.302086581090531 0.658262815901604 DataSet_03_238
CEACAM6 SOX2 siRNA Lung LK2 0.211707 -2.23986 - - DataSet_03_241
CEACAM6 SOX2 siRNA Mammary_gland GSC-11 1.52427 0.608123 0.182220465258286 0.428873164791024 DataSet_03_245
CEACAM6 SP100 siRNA Mammary_gland MCF7 0.502276 -0.993446 0.182652367948853 0.999952086018951 DataSet_03_252
CEACAM6 STAT3 CRISPR Embryo hESC 0.0893796 -3.48391 0.0672013145991728 0.145708900407695 DataSet_03_258
CEACAM6 STAT5B siRNA Mammary_gland MCF7 2.5926 1.3744 0.0810506999796425 0.999932708473107 DataSet_03_263
CEACAM6 TCEA1 siRNA Mammary_gland MCF7 2.17649 1.122 0.139225495949033 0.999762252994287 DataSet_03_266
CEACAM6 TFAP2C siRNA Mammary_gland MCF7 1.52102 0.605035 0.0888616257316591 0.43372916118588 DataSet_03_274
CEACAM6 TP53 siRNA Mammary_gland MCF7 3.00584 1.58777 0.0513170897260427 0.999938217444253 DataSet_03_277
CEACAM6 TP63 siRNA Skin Primary neonatal keratinocytes 0.21994 -2.18482 3.86993676532307e-05 0.00197239708379088 DataSet_03_281
CEACAM6 TP63 siRNA Foreskin Neonatal foreskin keratinocytes 0.662259 -0.594533 0.0533033825632267 0.731077588222791 DataSet_03_282
CEACAM6 ZNF750 siRNA Skin Primary neonatal keratinocytes 0.118739 -3.07413 0.00125811937999761 0.0331666725932848 DataSet_03_294
CEACAM6 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.804335846298837 0.919103259263859 DataSet_02_38
CEACAM6 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.723556024191044 0.841940496382433 DataSet_02_14
CEACAM6 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.857421784791219 0.974990364842182 DataSet_02_45
CEACAM6 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.58333 0.662965 0.814882794106256 0.909406355942749 DataSet_02_32
CEACAM6 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.726797657070185 0.844483032321424 DataSet_02_33
CEACAM6 TET1 siRNA Lung A549 2.0195 1.014 - - DataSet_03_318
CEACAM6 TET1 siRNA Lung A549 2.0195 1.014 - - DataSet_03_320
CEACAM6 NFKBIZ knockout Colon Colon organoid 0.500552 -0.998407 4.712890e-01 0.803742302 DataSet_03_323
CEACAM6 ELF3 CRISPR Bile_duct HBDEC2 0.522561 -0.936329 2.968972e-05 5.844805e-04 DataSet_03_304
CEACAM6 ELF3 knockdown Bile_duct HBDEC2 2.34299 1.22835 9.065024e-04 1.957887e-02 DataSet_03_305
CEACAM6 SNAI2 shRNA Pancreas pancreatic cancer stem cells 1.55733 0.639075 4.552712e-02 0.6360924 DataSet_03_306
CEACAM6 SNAI2 shRNA Pancreas KLM1 0.19763 -2.33913 1.676507e-02 0.19571585 DataSet_03_307
CEACAM6 EZH2 shRNA Mammary_gland MCF7 4.4863 2.16552 6.642626e-08 2.537645e-05 DataSet_03_331
CEACAM6 SKI CRISPR Blood HL60 3 1.58496 3.108157e-01 0.615851377 DataSet_03_351
CEACAM6 ESR1 siRNA Mammary_gland MCF7 2.71301 1.4399 3.556844e-04 0.0131578190 DataSet_03_352
CEACAM6 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 4.95572 2.30909 5.160364e-01 7.367543e-01 DataSet_03_359
CEACAM6 MYC siRNA Peripheral_blood T lymphocyte 1.68764 0.755006 7.096950e-01 0.862569192 DataSet_03_363
CEACAM6 TP53 knockout Stomach SNU1 0.471133 -1.0858 0.6358873163 0.9728713 DataSet_03_365
CEACAM6 TPR shRNA Bone_marrow U2OS 2.03666 1.0262 3.149218e-01 7.460530e-01 DataSet_03_370
CEACAM6 E2F1 siRNA Nasopharynx HK1 0.147541 -2.76081 2.126378e-01 8.404068e-01 DataSet_03_373
CEACAM6 NFKBIA shRNA Bone_marrow U2OS 0.00294118 -8.40939 5.996435e-01 0.87005461 DataSet_03_389
CEACAM6 ILF2 siRNA Stomach SGC-7901 0.25 -2 0.3518317636 0.55149413 DataSet_03_393
CEACAM6 TLE4 CRISPR Lymph CAR T Cell 0.0482894 -4.37215 2.801853e-01 0.63443366 DataSet_03_398
CEACAM6 HMGA1 shRNA Bile_duct HUCCT1 2.63158 1.39593 5.184202e-03 0.086139584 DataSet_03_400
CEACAM6 EHF shRNA Stomach MKN7 2.02155 1.01546 - - DataSet_03_402
CEACAM6 CHD1 shRNA Prostate LNCaP 0.00261454 -8.57923 1.382865e-01 6.694942e-01 DataSet_03_407
CEACAM6 MAP3K7 shRNA Prostate LNCaP 0.00286962 -8.44493 1.860097e-01 4.142452e-01 DataSet_03_408
CEACAM6 SIRT1 siRNA Pancreas PANC1 0.373684 -1.42011 5.456937e-02 0.144607066 DataSet_03_410
CEACAM6 E2F6 shRNA Liver HuH7 0.465611 -1.1028 - - DataSet_03_412
CEACAM6 E2F1 siRNA Prostate LNCaP 2 1 4.387083e-01 0.7707699809 DataSet_03_413
CEACAM6 E2F2 siRNA Prostate LNCaP 4.33333 2.11548 2.792112e-02 1.309606e-01 DataSet_03_414
CEACAM6 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 2.42873 1.2802 3.184744e-04 0.006357415 DataSet_03_418
CEACAM6 MAEL CRISPR Liver Alexander cells 0.166667 -2.58496 - - DataSet_03_423
CEACAM6 NFE2L1 knockout Lung A549 82.1521 6.36023 6.744662e-03 2.095783e-01 DataSet_03_433
CEACAM6 SUFU shRNA Mammary_gland HCC1954 cells 0.235812 -2.08429 0.0356851319 0.4591926 DataSet_03_437
CEACAM6 RELB CRISPR Colon SW480 0.267327 -1.90332 7.131944e-01 8.289690e-01 DataSet_03_449
CEACAM6 CBX2 siRNA Mammary_gland MCF7 0.105614 -3.24312 4.224059e-07 0.0002614853 DataSet_03_451
CEACAM6 SMARCA2 shRNA Lung HCC2302 21.7394 4.44224 7.574457e-07 2.062093e-06 DataSet_03_455
CEACAM6 IRF2 shRNA Cord_Blood CD34+ cells 2.03698 1.02643 - - DataSet_03_460
CEACAM6 PARP1 knockout Embryo_kidney HEK293a 5 2.32193 1.950866e-02 5.479890e-02 DataSet_03_464
Regulation Region
 
T(co)Fs that significantly regulate SP100 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of CEACAM6
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines