Gene Overview
Target Gene: GADD45A
NCBI Official Symbol: GADD45A
Entrez ID: 1647
Ensembl ID: ENSG00000116717
Gene Full Name: growth arrest and DNA damage inducible alpha
Strand: +
Gene Locus: 1p31.3
External Links:

GADD45A Significantly Regulated by These T(co)Fs

T(co)Fs that Activate GADD45A   
T(co)Fs that Repress GADD45A
The Intensity of the Gene Regulated by T(co)Fs:
GADD45A-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
GADD45A FOXO1 shRNA Bone EWS-FLI1 1.78202 0.83351 0.00083 0.05127 DataSet_01_106
GADD45A HOXA1 siRNA Lung_fibroblast IMR-90 0.65195 -0.61717 0.03535 0.20107 DataSet_01_110
GADD45A TCF3 shRNA Mammary_gland MDA-MB468 2.6222 1.39078 0.00013 0.00293 DataSet_01_116
GADD45A ZIC2 siRNA Pancreas PANC1 6.90411 2.78746 - - DataSet_01_121
GADD45A FOXM1 siRNA Central_nervous_system U87 2.622 1.39067 - - DataSet_01_122
GADD45A ZNF431 siRNA Gastrointestinal_tissue GIST-T1 1.59166 0.67053 0.00022 0.00312 DataSet_01_128
GADD45A ID1 shRNA Neuroepithelium GSC2 1.61259 0.68938 3.68556e-10 5.22986e-09 DataSet_01_133
GADD45A SPDEF shRNA Mammary_gland MCF7 4.19067 2.06718 6.98518e-06 0.00504 DataSet_01_135
GADD45A IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 2.67358 1.41877 0.00802 0.26898 DataSet_01_137
GADD45A SOX4 shRNA Parotid_gland ACC3 1.93292 0.95079 0.42859 0.98575 DataSet_01_140
GADD45A TFAP2C shRNA Mammary_gland MCF7 1.51035 0.59488 4.70072e-09 6.35712e-08 DataSet_01_150
GADD45A TAL1 shRNA Umbilical_cord_blood ECFCs 1.69926 0.76491 0.00645 0.33889 DataSet_01_152
GADD45A MYCN siRNA Autonomic_ganglia SKNBE2 0.49389 -1.01773 0.04998 0.27613 DataSet_01_160
GADD45A ELK1 siRNA Peripheral_blood CD4+ T cells 0.00115 -9.76259 0.13318 0.29652 DataSet_01_162
GADD45A GATA3 siRNA Peripheral_blood CD4+ T cells 3.86902 1.95197 0.22986 0.57284 DataSet_01_163
GADD45A JUN siRNA Peripheral_blood CD4+ T cells 0.00107 -9.86684 0.12495 0.33084 DataSet_01_164
GADD45A MAF siRNA Peripheral_blood CD4+ T cells 0.00083 -10.2372 0.09657 0.38318 DataSet_01_165
GADD45A NFATC3 siRNA Peripheral_blood CD4+ T cells 0.0012 -9.70594 0.13619 0.38963 DataSet_01_166
GADD45A NFKB1 siRNA Peripheral_blood CD4+ T cells 5.82689 2.54273 0.05976 0.62884 DataSet_01_167
GADD45A STAT3 siRNA Peripheral_blood CD4+ T cells 0.00195 -9.00312 0.21171 0.99183 DataSet_01_168
GADD45A ESRRG siRNA Placenta_tissue Trophoblast cells 1.82256 0.86596 0.10879 0.47389 DataSet_01_173
GADD45A HSF1 shRNA Liver KYN2 2.39343 1.25908 - - DataSet_01_178
GADD45A TP63 shRNA Bladder UC14 0.54108 -0.88609 0.00067 0.00624 DataSet_01_183
GADD45A STAT3 siRNA Urothelial Scaber 1.76125 0.8166 4.26357e-07 4.92674e-05 DataSet_01_184
GADD45A GABPA shRNA Prostate C4-2B 2577.09 11.3315 0.23386 0.43934 DataSet_01_190
GADD45A GABPA shRNA Prostate LNCaP 1659.76 10.6968 0.46176 0.7048 DataSet_01_191
GADD45A CREB1 shRNA Parotid_gland H3118 MEC 0.61701 -0.69662 0.11187 0.44181 DataSet_01_194
GADD45A TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.89977 0.92582 - - DataSet_01_196
GADD45A TP63 siRNA Head_and_neck SCC-012 0.4805 -1.0574 - - DataSet_01_201
GADD45A LIN28A siRNA Embryo H9 4.25969 2.09075 7.33796e-05 0.00254 DataSet_01_215
GADD45A ERG siRNA Prostate VCaP 0.64333 -0.63636 0.001 0.02075 DataSet_01_216
GADD45A ATM shRNA Mammary_gland MCF10A 4.0683 2.02443 2.8988e-07 9.26747e-06 DataSet_01_219
GADD45A YBX1 shRNA Mammary_gland MDA 2.32016 1.21422 0.00251 0.01794 DataSet_01_257
GADD45A YBX1 shRNA Mammary_gland MDA 0.52513 -0.92924 0.01092 0.11652 DataSet_01_258
GADD45A HES1 shRNA Haematopoietic_and_lymphoid_tissue_Blood CUTLL1 1.58329 0.66293 0.00035 0.00436 DataSet_01_266
GADD45A SIX4 siRNA Ovary PEO1 0.66321 -0.59246 0.01652 0.09481 DataSet_01_269
GADD45A ZIC5 siRNA Skin A375 1.79989 0.84791 - - DataSet_01_284
GADD45A NFYA shRNA Lung H322 0.53843 -0.89316 0.00011 0.0018 DataSet_01_288
GADD45A POSTN shRNA Brain GSC272 0.55095 -0.86001 0.15753 0.57653 DataSet_01_293
GADD45A TFAP4 siRNA Brain BE(2)-C 0.23898 -2.06503 0.39196 0.51625 DataSet_01_295
GADD45A SOX9 siRNA Prostate VCaP 0.47523 -1.0733 0.10705 0.9316 DataSet_01_308
GADD45A SOX9 siRNA Prostate VCaP 0.47523 -1.0733 0.10705 0.9316 DataSet_01_309
GADD45A ERG siRNA Cervix HeLa 12.0794 3.59448 1.172e-09 1.72007e-08 DataSet_01_316
GADD45A ELK3 shRNA Mammary_gland MDA-MB-231 0.45648 -1.13137 1.83569e-05 0.00019 DataSet_01_318
GADD45A MYC siRNA Colon HCT116 2.15171 1.10549 3.35569e-05 0.00017 DataSet_01_324
GADD45A TP63 shRNA Head_and_neck FaDU 0.43961 -1.18569 1.56277e-07 5.04209e-05 DataSet_01_327
GADD45A TP63 shRNA Head_and_neck FaDU 0.43961 -1.18569 1.56277e-07 5.04209e-05 DataSet_01_330
GADD45A TCF7L1 shRNA Colon HCT116 1.5938 0.67247 0.00437 0.0539 DataSet_01_346
GADD45A HIF1A siRNA Oral_cavity OEC-M1 0.38119 -1.39144 0.04176 0.85151 DataSet_01_348
GADD45A PAX3 shRNA Soft_tissue Rh30 1.50724 0.5919 - - DataSet_01_359
GADD45A GTF2B siRNA Cervix HeLa 2.22844 1.15603 - - DataSet_01_362
GADD45A FIP1L1 shRNA Liver HepG2 2.2252 1.15394 0.00245 0.02099 DataSet_02_103
GADD45A U2AF2 shRNA Liver HepG2 2.03387 1.02423 0.00563 0.05884 DataSet_02_105
GADD45A TAF15 shRNA Liver HepG2 1.81487 0.85987 0.00063 0.01075 DataSet_02_106
GADD45A U2AF2 shRNA Liver HepG2 2.17389 1.12028 0.00169 0.0514 DataSet_02_113
GADD45A PTBP1 shRNA Liver HepG2 1.86217 0.89698 0.00154 0.00811 DataSet_02_120
GADD45A EWSR1 shRNA Liver HepG2 1.81937 0.86344 0.00552 0.05081 DataSet_02_122
GADD45A SNRNP70 shRNA Liver HepG2 1.75964 0.81528 0.04944 0.12091 DataSet_02_126
GADD45A SRSF3 shRNA Liver HepG2 2.25114 1.17066 0.00596 0.07366 DataSet_02_127
GADD45A PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.25737 1.17465 0.00135 0.02779 DataSet_02_131
GADD45A PCBP2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.50306 0.5879 0.00932 0.0941 DataSet_02_135
GADD45A DROSHA shRNA Haematopoietic_and_lymphoid_tissue K562 0.60173 -0.73281 0.13021 0.51719 DataSet_02_145
GADD45A RBM22 shRNA Haematopoietic_and_lymphoid_tissue K562 1.53148 0.61493 0.00804 0.06809 DataSet_02_168
GADD45A ZFX siRNA Prostate C4-2B 1.61812 0.69432 0.00016 0.00213 DataSet_02_172
GADD45A CHD2 siRNA Haematopoietic_and_lymphoid_tissue K562 2.02973 1.02129 0.0328 0.14256 DataSet_02_196
GADD45A ZFX siRNA Mammary_gland MCF7 1.6989 0.7646 0.00063 0.02716 DataSet_02_206
GADD45A AR siRNA Mammary_gland MCF7 1.52771 0.611367 0.000209681546277283 0.00560780337670227 DataSet_03_006
GADD45A BCL6 siRNA Central_nervous_system U87 1.62676 0.701998 0.000114340307568532 0.0149259992191994 DataSet_03_027
GADD45A CHEK1 siRNA Mammary_gland MCF7 2.40593 1.2666 0.000239988647985332 0.999587656258211 DataSet_03_053
GADD45A FOXA1 siRNA Mammary_gland MCF7 2.09154 1.06457 5.34273549191372e-07 4.65730816976017e-05 DataSet_03_080
GADD45A FOXA1 siRNA Mammary_gland MCF7 1.64319 0.716498 3.72716952131685e-11 2.85326371187181e-09 DataSet_03_081
GADD45A FOXA1 siRNA Mammary_gland MCF7 1.64319 0.716498 3.72716952131685e-11 2.85326371187181e-09 DataSet_03_082
GADD45A FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.656118 -0.607973 - - DataSet_03_096
GADD45A GATA2 siRNA Lymph Lymphatic endothelial cells 1.65247 0.724625 0.00241999707660208 0.00757147600204215 DataSet_03_101
GADD45A GATA3 siRNA Mammary_gland MCF7 1.53364 0.616959 0.190634024468286 0.338849585555808 DataSet_03_103
GADD45A HIC1 CRISPR Prostate PC3 0.568898 -0.813759 - - DataSet_03_118
GADD45A HMGA2 siRNA Mammary_gland MDA-MB-231 0.538927 -0.891839 0.0206622023305636 0.668831985856449 DataSet_03_125
GADD45A JUN siRNA Fibroblasts WI38 1.88931 0.917857 0.0249249029787484 0.105505560736523 DataSet_03_140
GADD45A JUN siRNA Fibroblasts WI38 1.88931 0.917857 0.0249139302654417 0.10530261092765 DataSet_03_141
GADD45A MAFB siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 1.5874 0.666667 0.0242616192543255 1 DataSet_03_155
GADD45A MEF2D shRNA Liver HuH7 1.77638 0.82894 - - DataSet_03_162
GADD45A MEF2D siRNA Liver HuH7 2.58173 1.36834 - - DataSet_03_163
GADD45A MITF siRNA Skin Ma-Mel-15 1.71793 0.780674 0.00391220116169247 0.0760642429901709 DataSet_03_167
GADD45A MITF siRNA Skin SK-MEL-5 0.561463 -0.832737 0.000273091234380051 0.00121547959238395 DataSet_03_168
GADD45A MYC siRNA Central_nervous_system DAOY M2.1 1.63512 0.709393 2.9791615397126e-06 1.87758274570653e-05 DataSet_03_178
GADD45A MYCN siRNA Autonomic_ganglia SKNBE2 0.493892 -1.01773 0.0484239904000428 0.283402784384685 DataSet_03_185
GADD45A NR4A3 siRNA Pancreas 1.1B4 0.642057 -0.639226 0.050767417981143 0.10991251538485 DataSet_03_203
GADD45A PHB shRNA Embryo Embryonic stem cells (ESCs) 10.9011 3.4464 1.16712838508654e-06 0.000157963532369056 DataSet_03_211
GADD45A RELB siRNA Pancreas MIA PaCa-2 0.570932 -0.80861 0.0441924981973814 0.199650039830659 DataSet_03_225
GADD45A RELB shRNA Ovary SKOV3 1.71298 0.776507 0.393393285035212 0.999733815028798 DataSet_03_226
GADD45A RELB siRNA Immortalized_keratinocyte HaCaT 24.2846 4.60197 2.72499882320437e-11 7.14321282428164e-09 DataSet_03_227
GADD45A SOX2 siRNA Lung H520 1.84933 0.887003 - - DataSet_03_240
GADD45A SOX2 CRISPR Seminoma-like TCam-2 0.320679 -1.6408 0.0227963717529925 0.999580851453413 DataSet_03_244
GADD45A SOX2 siRNA Mammary_gland GSC-11 0.652928 -0.615004 8.8686014053593e-05 0.00632519680542854 DataSet_03_245
GADD45A SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.568798 -0.814011 - - DataSet_03_246
GADD45A SP1 siRNA Mammary_gland MDA-MB-231 5.09695 2.34963 0.119915025036197 0.413972819854456 DataSet_03_250
GADD45A STAT3 CRISPR Embryo hESC 0.496407 -1.0104 0.0335557442062988 0.103570248481608 DataSet_03_258
GADD45A TP53 knockout Haematopoietic_and_lymphoid_tissue MM1S 0.430938 -1.21445 0.0957261578642514 0.994828053448528 DataSet_03_279
GADD45A TP63 siRNA Skin Primary neonatal keratinocytes 0.351773 -1.50728 4.53823548737374e-05 0.00209990362134783 DataSet_03_281
GADD45A NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 0.136619 -2.87177 0.00901009887681152 0.0464237675699532 DataSet_04_014
GADD45A NFX1 CRISPR Liver HepG2 2.96005 1.56562 0.000192864041606998 0.0107080024071796 DataSet_04_032
GADD45A ACTN4 CRISPR Liver HepG2 1.51958 0.603675 0.0225812955977372 0.0837228543809784 DataSet_04_042
GADD45A CNOT7 CRISPR Liver HepG2 0.492941 -1.02051 3.01110357069615e-05 0.00960341421474169 DataSet_04_045
GADD45A ABT1 shRNA Liver HepG2 1.84187 0.881169 0.000267793286085261 0.00407334232399789 DataSet_04_052
GADD45A CALR shRNA Liver HepG2 1.64468 0.717808 0.000593954163582224 0.00776219368970713 DataSet_04_053
GADD45A ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.61585 0.692294 0.00164112424258969 0.0181688335502187 DataSet_02_34
GADD45A MBD5 siRNA Bile_duct HCCC-9810 0.618263 -0.693707 1.717696e-06 0.0014988895 DataSet_03_295
GADD45A KDM5A shRNA Brain NCH644 1.55079 0.633 7.621898e-02 0.543776728 DataSet_03_316
GADD45A TET1 siRNA Lung A549 0.639741 -0.64444 - - DataSet_03_318
GADD45A TET1 siRNA Lung A549 0.639741 -0.64444 - - DataSet_03_320
GADD45A EZH2 knockdown Uterus Ishikawa (ISK) cell 3.81937 1.93333 - - DataSet_03_324
GADD45A SMARCA4 siRNA Colon HCT116 1.57331 0.653799 2.026515e-01 9.892536e-01 DataSet_03_301
GADD45A NSD2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.32946 1.21999 2.632850e-09 2.614842e-06 DataSet_03_303
GADD45A ELF3 CRISPR Bile_duct HBDEC2 0.469537 -1.09069 4.134309e-05 7.104629e-04 DataSet_03_304
GADD45A SNAI2 shRNA Pancreas KLM1 1.63308 0.707599 7.001313e-02 0.35360159 DataSet_03_307
GADD45A EZH2 siRNA Prostate LNCaP 0.602317 -0.731405 0.0154505013 0.9997152 DataSet_03_328
GADD45A EZH2 siRNA Prostate LNCaP 0.602317 -0.731405 0.0154505013 0.9997152 DataSet_03_330
GADD45A LITAF siRNA Lymph VAL 0.605934 -0.722768 7.869913e-02 0.602102297 DataSet_03_310
GADD45A EZH2 shRNA Mammary_gland MCF7 0.545569 -0.874165 6.870456e-05 3.993022e-03 DataSet_03_331
GADD45A EZH2 knockdown Colon HCT116 1.61469 0.69126 0.097606868 0.8488990 DataSet_03_334
GADD45A ARID3B CRISPR Colon HCT15 2.62271 1.39106 - - DataSet_03_335
GADD45A ZFX siRNA Prostate C4-2B 1.64252 0.71591 1.120124e-04 6.678152e-04 DataSet_03_348
GADD45A ZFX siRNA Mammary_gland MCF7 1.70227 0.767462 9.401559e-06 9.221981e-04 DataSet_03_349
GADD45A SKI CRISPR Blood HL60 2.57208 1.36294 2.265966e-03 0.102039778 DataSet_03_351
GADD45A PARP1 siRNA Prostate LNCaP 1.72258 0.784572 3.256944e-03 0.081955200 DataSet_03_354
GADD45A TET1 CRISPR Mammary_gland Hs578T 1.50654 0.59124 9.691064e-03 4.769862e-02 DataSet_03_355
GADD45A CREBBP CRISPR Brain U5-NPC 2.36656 1.24279 0.3555523035 0.7490853 DataSet_03_356
GADD45A RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 0.657782 -0.604318 3.994021e-01 6.383384e-01 DataSet_03_359
GADD45A ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 3.53458 1.82154 1.107413e-09 2.050560e-06 DataSet_03_362
GADD45A MYC siRNA Peripheral_blood T lymphocyte 1.66441 0.735011 5.207114e-04 0.015385462 DataSet_03_363
GADD45A TP53 knockout Stomach SNU1 0.123124 -3.02181 0.1773637324 0.9301241 DataSet_03_365
GADD45A ZNF148 shRNA Mammary_gland MDA-MB-231 0.613038 -0.705952 4.615675e-03 0.050917153 DataSet_03_366
GADD45A DNMT3A knockout Embryo_kidney HEK293T 0.431245 -1.21342 - - DataSet_03_369
GADD45A GLI1 siRNA Skeletal_muscle RMS13 1.99221 0.994373 5.960122e-04 0.016612477 DataSet_03_375
GADD45A ZNF213 siRNA Mammary_gland MCF7 1.63216 0.706781 1.379787e-03 4.125152e-02 DataSet_03_376
GADD45A DDX5 shRNA Stomach HGC-27 2.33403 1.22282 - - DataSet_03_379
GADD45A NFKB2 siRNA Bone_marrow U2OS 2.12902 1.09019 5.342022e-03 0.10464299 DataSet_03_381
GADD45A YY1 shRNA Brain GSC1517 1.60572 0.683223 - - DataSet_03_384
GADD45A TRIM8 siRNA Mammary_gland MCF7 1.66833 0.738403 2.690152e-03 0.0227083472 DataSet_03_388
GADD45A YY1 knockdown Liver HepG2 2.15566 1.10813 2.544778e-10 1.314170e-08 DataSet_03_390
GADD45A ILF2 siRNA Stomach SGC-7901 2.45647 1.29659 0.2629171896 0.46114469 DataSet_03_393
GADD45A RELA CRISPR Brain T30 1.7362 0.795932 0.2092365902 0.8400824 DataSet_03_399
GADD45A HMGA1 shRNA Bile_duct HUCCT1 1.93223 0.950269 9.232417e-03 0.117173956 DataSet_03_400
GADD45A CDK7 shRNA Bone_marrow D458 2.43357 1.28308 6.217671e-02 0.34008487 DataSet_03_404
GADD45A TFAP2A knockout Embryo H9 0.57918 -0.787915 2.575493e-03 0.03775961 DataSet_03_405
GADD45A USP22 shRNA Liver HuH7 3.77587 1.91681 - - DataSet_03_411
GADD45A E2F2 siRNA Prostate LNCaP 1.77762 0.829951 2.260332e-04 5.644063e-03 DataSet_03_414
GADD45A FOXQ1 CRISPR Lymph Primary CD4+ T cells 1.624 0.699554 - - DataSet_03_422
GADD45A MAEL CRISPR Liver Alexander cells 0.368839 -1.43894 - - DataSet_03_423
GADD45A STAT5B CRISPR Embryo_kidney HEK293 1.97262 0.98011 9.965189e-04 0.164099515 DataSet_03_424
GADD45A FOXP3 CRISPR Peripheral_blood Naive Treg 1.9881 0.991387 4.102985e-01 0.721755305 DataSet_03_427
GADD45A USP7 shRNA Skin xenograft cells 0.472363 -1.08203 0.26514146 0.4348960 DataSet_03_431
GADD45A POU2AF1 CRISPR Lymph SUDHL4 0.633861 -0.657762 1.727093e-03 0.015560792 DataSet_03_435
GADD45A EP300 knockout Pancreas HPAF-II orthotopic cells 0.634764 -0.655707 2.823251e-04 3.259587e-03 DataSet_03_436
GADD45A SETDB1 shRNA Colon HCT116 2.61186 1.38507 - - DataSet_03_440
GADD45A HMG20A siRNA Mammary_gland MDA-MB-231 1.5377 0.620777 0.0799495835 0.2956273 DataSet_03_442
GADD45A CAMTA1 knockout Embryo_kidney HEK293T 2.13517 1.09435 1.314835e-03 0.05587999 DataSet_03_448
GADD45A CBX2 siRNA Mammary_gland MDA-MB-231 0.658866 -0.601943 1.530884e-03 1.222610e-02 DataSet_03_450
GADD45A CBX2 siRNA Mammary_gland MCF7 0.636576 -0.651595 9.594936e-02 0.1832474730 DataSet_03_451
GADD45A SMARCA2 shRNA Lung HCC2302 0.197225 -2.34209 1.571924e-11 1.710363e-10 DataSet_03_455
GADD45A SREBF2 siRNA Umbilical_vein HUVEC 0.592294 -0.755615 3.361655e-02 2.953854e-01 DataSet_03_457
GADD45A IRF2 shRNA Cord_Blood CD34+ cells 2.00179 1.00129 - - DataSet_03_460
GADD45A TXNIP shRNA Cord_Blood CD34+ cells 1.74325 0.80178 - - DataSet_03_461
GADD45A TXNIP shRNA Cord_blood ST3 1.63118 0.705911 3.726573e-02 0.2668050560 DataSet_03_462
GADD45A PARP1 knockout Embryo_kidney HEK293a 2.50598 1.32537 2.457687e-09 1.006104e-07 DataSet_03_464
GADD45A SMARCA1 Cas13 Embryo_kidney HEK293T 4.28725 2.10005 - - DataSet_03_466
GADD45A SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 4.30791 2.10699 - - DataSet_03_467
GADD45A SMARCA1 shRNA Embryo_kidney HEK293T 1.58006 0.659975 - - DataSet_03_468
GADD45A WHSC1 siRNA Prostate PC3 0.453648 -1.14035 1.588919e-04 0.06953019 DataSet_03_471
Regulation Region
 
T(co)Fs that significantly regulate SOX2 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of GADD45A
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines