Gene Overview
Target Gene: LAIR2
NCBI Official Symbol: LAIR2
Entrez ID: 3904
Ensembl ID: ENSG00000167618
Gene Full Name: leukocyte associated immunoglobulin like receptor 2
Strand: +
Gene Locus: 19q13.42
External Links:

LAIR2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate LAIR2   
T(co)Fs that Repress LAIR2
The Intensity of the Gene Regulated by T(co)Fs:
LAIR2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
LAIR2 ID1 siRNA Lung A549 0.3679 -1.44263 0.56826 0.74576 DataSet_01_117
LAIR2 ZIC2 siRNA Pancreas PANC1 2.8835 1.52782 - - DataSet_01_121
LAIR2 FOXM1 siRNA Central_nervous_system U87 5.8495 2.54831 - - DataSet_01_122
LAIR2 ZNF708 siRNA Gastrointestinal_tissue GIST-T1 1.51508 0.59939 0.01105 0.07287 DataSet_01_130
LAIR2 IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 2.36777 1.24353 0.02533 0.48118 DataSet_01_137
LAIR2 POLR3A siRNA Mammary_gland MCF7 0.36164 -1.46739 - - DataSet_01_139
LAIR2 STAT1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 0.59642 -0.74561 0.04831 0.26595 DataSet_01_154
LAIR2 ELK1 siRNA Peripheral_blood CD4+ T cells 0.01137 -6.45896 0.3695 0.5952 DataSet_01_162
LAIR2 GATA3 siRNA Peripheral_blood CD4+ T cells 0.01135 -6.46164 0.37559 0.70465 DataSet_01_163
LAIR2 JUN siRNA Peripheral_blood CD4+ T cells 0.00747 -7.06472 0.20684 0.4543 DataSet_01_164
LAIR2 MAF siRNA Peripheral_blood CD4+ T cells 0.00677 -7.20571 0.19946 0.54056 DataSet_01_165
LAIR2 NFATC3 siRNA Peripheral_blood CD4+ T cells 0.0088 -6.82748 0.27055 0.57354 DataSet_01_166
LAIR2 NFKB1 siRNA Peripheral_blood CD4+ T cells 0.01087 -6.52304 0.3481 0.81442 DataSet_01_167
LAIR2 STAT3 siRNA Peripheral_blood CD4+ T cells 0.02523 -5.3087 0.81038 0.99999 DataSet_01_168
LAIR2 GABPA shRNA Prostate C4-2B 961.544 9.90921 0.23996 0.43934 DataSet_01_190
LAIR2 GABPA shRNA Prostate LNCaP 1241.79 10.2782 0.46335 0.7048 DataSet_01_191
LAIR2 GATA2 siRNA Prostate LNCaP 0.26559 -1.91274 0.18765 0.30786 DataSet_01_193
LAIR2 CREB1 shRNA Parotid_gland H3118 MEC 3.73799 1.90226 0.7322 0.8963 DataSet_01_194
LAIR2 CREB1 shRNA Parotid_gland HSY 3.1847 1.67116 0.47107 0.98114 DataSet_01_195
LAIR2 TP63 siRNA Immortalized_keratinocyte HaCaT 1.79875 0.84699 - - DataSet_01_200
LAIR2 TP63 siRNA Head_and_neck SCC-012 1.51995 0.60402 - - DataSet_01_201
LAIR2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 1.73672 0.79636 - - DataSet_01_209
LAIR2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.25939 -1.9468 - - DataSet_01_210
LAIR2 REST siRNA Prostate LNCaP 2.56086 1.35663 0.37859 0.66835 DataSet_01_211
LAIR2 BCLAF1 shRNA Colon RKO 2.18676 1.12879 - - DataSet_01_214
LAIR2 SNAI2 shRNA Skin Primary human keratinocytes 1.67523 0.74436 0.22457 0.36263 DataSet_01_225
LAIR2 TWIST1 shRNA Stomach CAF14 1.51148 0.59596 0.33125 0.99996 DataSet_01_252
LAIR2 TWIST1 shRNA Stomach CAF32 0.4755 -1.0725 0.22371 0.37726 DataSet_01_253
LAIR2 YBX1 shRNA Mammary_gland MDA 1.93526 0.95253 3.23265e-08 1.72246e-06 DataSet_01_255
LAIR2 YBX1 shRNA Mammary_gland MDA 1.9618 0.97218 1e-04 0.00189 DataSet_01_257
LAIR2 AR shRNA Prostate CWR22Pc 0.66368 -0.59144 0.30288 0.53466 DataSet_01_278
LAIR2 STAT5 shRNA Prostate CWR22Pc 2.15243 1.10596 0.02981 0.1077 DataSet_01_279
LAIR2 TP53 shRNA Haematopoietic_and_lymphoid_tissue JVM2 0.5369 -0.89728 1.15427e-08 6.66344e-07 DataSet_01_286
LAIR2 POSTN shRNA Brain GSC272 8.02812 3.00506 0.00353 0.47578 DataSet_01_293
LAIR2 TFAP4 siRNA Brain BE(2)-C 0.22513 -2.15115 0.40875 0.51625 DataSet_01_295
LAIR2 PTEN shRNA Skin A431 0.47474 -1.0748 0.35852 0.55571 DataSet_01_301
LAIR2 ARNT shRNA Embryo WA09/H9 1.97346 0.98072 0.13225 0.98102 DataSet_01_307
LAIR2 SOX9 siRNA Prostate VCaP 0.28922 -1.78978 0.00598 0.81045 DataSet_01_308
LAIR2 SOX9 siRNA Prostate VCaP 0.28922 -1.78978 0.00598 0.81045 DataSet_01_309
LAIR2 KLF4 siRNA Embryo HCE 6.53847 2.70895 0.72235 0.9211 DataSet_01_341
LAIR2 KLF7 siRNA Embryo HCE 3.7978 1.92517 0.50062 0.99985 DataSet_01_342
LAIR2 RBM17 shRNA Liver HepG2 0.48851 -1.03355 0.89874 0.95794 DataSet_02_100
LAIR2 RBFOX2 shRNA Liver HepG2 2.68966 1.42742 0.03687 0.65168 DataSet_02_101
LAIR2 SAFB2 shRNA Liver HepG2 1.9396 0.95576 0.06718 0.12959 DataSet_02_102
LAIR2 FIP1L1 shRNA Liver HepG2 9.32353 3.22088 0.00609 0.03214 DataSet_02_103
LAIR2 U2AF2 shRNA Liver HepG2 0.44737 -1.16046 0.45481 0.59779 DataSet_02_105
LAIR2 TAF15 shRNA Liver HepG2 0.50427 -0.98772 0.17054 0.23517 DataSet_02_106
LAIR2 SSB shRNA Liver HepG2 0.17857 -2.48543 0.01072 0.02815 DataSet_02_107
LAIR2 ZNF622 shRNA Liver HepG2 4.72 2.23879 0.00028 0.00594 DataSet_02_108
LAIR2 GTF2F1 shRNA Liver HepG2 1.77632 0.82889 0.02133 0.24986 DataSet_02_110
LAIR2 BCLAF1 shRNA Liver HepG2 4.59459 2.19994 0.00098 0.02512 DataSet_02_112
LAIR2 XRCC5 shRNA Liver HepG2 4.85526 2.27955 7.87057e-05 0.12055 DataSet_02_114
LAIR2 PCBP1 shRNA Liver HepG2 0.5641 -0.82597 0.19889 0.27008 DataSet_02_115
LAIR2 CEBPZ shRNA Liver HepG2 0.11765 -3.08746 0.83726 1 DataSet_02_118
LAIR2 PTBP1 shRNA Liver HepG2 3.77778 1.91754 0.01547 0.03107 DataSet_02_120
LAIR2 EWSR1 shRNA Liver HepG2 0.55319 -0.85415 0.28626 0.4124 DataSet_02_122
LAIR2 PCBP2 shRNA Liver HepG2 1.81579 0.8606 0.00304 0.05515 DataSet_02_123
LAIR2 FUS shRNA Liver HepG2 3.82895 1.93695 0.00018 0.0429 DataSet_02_124
LAIR2 SNRNP70 shRNA Liver HepG2 0.29536 -1.75946 0.00649 0.04403 DataSet_02_126
LAIR2 SRSF3 shRNA Liver HepG2 5.20675 2.38038 0.006 0.07392 DataSet_02_127
LAIR2 PRPF4 shRNA Liver HepG2 0.30769 -1.70044 0.03966 0.11081 DataSet_02_128
LAIR2 ASCL1 siRNA Lung DMS79 0.654971 -0.610498 0.511142940025697 0.912456625892934 DataSet_03_016
LAIR2 BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.582442 -0.779815 0.308687675433369 0.855071253901766 DataSet_03_025
LAIR2 CEBPB siRNA Embryo hESC 0.169843 -2.55772 0.00073421312818773 0.108255836739527 DataSet_03_049
LAIR2 GATA6 siRNA Stomach AGS 1.72064 0.78295 0.102637541373049 0.589894237021904 DataSet_03_108
LAIR2 GATA6 siRNA Stomach KatoIII 4.79466 2.26143 0.00895353988697231 0.379286503060899 DataSet_03_109
LAIR2 GFP siRNA Mammary_gland BT-20 cells 0.588235 -0.765535 0.0136242827123216 0.407041665414788 DataSet_03_111
LAIR2 HIF3A siRNA Liver Hep3B 1.61888 0.695 0.0261921136216277 1 DataSet_03_120
LAIR2 HIF3A siRNA Liver Hep3B 1.61888 0.695 0.0261921136216277 1 DataSet_03_121
LAIR2 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.57341 0.653893 0.932510046139531 0.999948959532916 DataSet_03_134
LAIR2 KLF5 siRNA Stomach KatoIII 33.1573 5.05125 0.000241885677746245 0.0620775107061253 DataSet_03_150
LAIR2 MEF2D shRNA Liver HuH7 1.65047 0.722874 - - DataSet_03_162
LAIR2 MYC siRNA Colon HT29 6.10594 2.61021 - - DataSet_03_177
LAIR2 PAX3 siRNA Mammary_gland MCF7 1.52887 0.61247 0.0534290890537244 0.919978041032696 DataSet_03_206
LAIR2 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.25775 -1.95595 0.0365516142472663 0.0880059157799145 DataSet_03_211
LAIR2 PRRX1 CRISPR Neuroblastoma 691-MES 0.304858 -1.71379 0.0078304309304972 0.89189998148014 DataSet_03_217
LAIR2 RELB siRNA Immortalized_keratinocyte HaCaT 0.66391 -0.590941 0.0028218834547702 0.0196900204279005 DataSet_03_227
LAIR2 SOX11 siRNA Lung_fibroblast NHLF 1.59356 0.672255 0.0561889890214934 0.343993009237626 DataSet_03_238
LAIR2 SOX2 siRNA Mammary_gland GSC-11 1.50627 0.590982 0.299231529087738 0.556460686016308 DataSet_03_245
LAIR2 SP1 siRNA Mammary_gland MDA-MB-231 0.600416 -0.735965 0.164875767698552 0.413972819854456 DataSet_03_250
LAIR2 STAT6 siRNA Umbilical_vein HUVEC 0.616279 -0.698344 0.382800782409997 0.890693953526314 DataSet_03_264
LAIR2 TFE3 siRNA Kidney UOK257-2 2.22458 1.15353 - - DataSet_03_275
LAIR2 ZNF746 siRNA Colon HCT116 2.22068 1.151 - - DataSet_03_293
LAIR2 E4F1 CRISPR Liver HepG2 1.85047 0.88789 0.0553642512524681 0.314567476713706 DataSet_04_028
LAIR2 NFX1 CRISPR Liver HepG2 4.10959 2.03899 0.00765200217625874 0.0311128947722166 DataSet_04_032
LAIR2 PAN2 CRISPR Liver HepG2 1.86316 0.89775 0.0712377170531975 0.217141236646098 DataSet_04_033
LAIR2 SMAD4 CRISPR Liver HepG2 0.532156 -0.91008 0.000378231269763529 0.0527443981287996 DataSet_04_035
LAIR2 YBX1 CRISPR Liver HepG2 0.0291698 -5.09938 0.230675822884736 0.972884761036538 DataSet_04_039
LAIR2 ZC3H8 shRNA Liver HepG2 1.64384 0.717066 0.0845414907251812 0.240899036327415 DataSet_04_040
LAIR2 CNOT7 CRISPR Liver HepG2 0.452657 -1.14351 0.000144287279008333 0.0110658006199607 DataSet_04_045
LAIR2 DNMT3B CRISPR Liver HepG2 2.14019 1.09774 0.00628680983634434 0.0952091843942027 DataSet_04_044
LAIR2 PAN2 CRISPR Liver HepG2 0.532155 -0.91008 5.45248021424616e-05 0.0146305632005086 DataSet_04_066
LAIR2 RIOK2 CRISPR Liver HepG2 0.644628 -0.633461 0.242274785645969 0.982788000984198 DataSet_04_070
LAIR2 ABT1 shRNA Liver HepG2 7.27397 2.86274 7.30829300137707e-05 0.00227893362349939 DataSet_04_052
LAIR2 CALR shRNA Liver HepG2 3.57047 1.83611 0.00163019539218845 0.0130602366242452 DataSet_04_053
LAIR2 CCAR1 shRNA Liver HepG2 1.80137 0.849094 0.0614325559969864 0.150280223255133 DataSet_04_054
LAIR2 CNOT7 shRNA Liver HepG2 3.51351 1.81291 0.000972758055192587 0.0066981752732178 DataSet_04_051
LAIR2 DDX1 shRNA Liver HepG2 2.79866 1.48474 0.0383662688615584 0.185617536849947 DataSet_04_057
LAIR2 PRPF6 shRNA Liver HepG2 1.90789 0.931982 0.119725095785404 0.293752653241535 DataSet_04_056
LAIR2 UBE2L3 shRNA Liver HepG2 7.89683 2.98127 0.00081188733313204 0.0105417412187932 DataSet_04_055
LAIR2 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.6875 0.754888 0.550784295302774 0.835152962849062 DataSet_02_75
LAIR2 CNOT3 shRNA Lung A549 0.291202 -1.77991 1.104944e-01 0.8830540 DataSet_03_340
LAIR2 SNAI2 shRNA Pancreas pancreatic cancer stem cells 1.73088 0.791501 1.135591e-01 0.6510154 DataSet_03_306
LAIR2 AEBP1 siRNA Central_nervous_system U87MG 0.415756 -1.26619 4.165442e-02 0.9964883 DataSet_03_338
LAIR2 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 4.18271 2.06444 5.642375e-02 1.015664e-01 DataSet_03_362
LAIR2 TPR shRNA Bone_marrow U2OS 1.76866 0.822659 9.795353e-02 4.643983e-01 DataSet_03_370
LAIR2 SMARCA2 shRNA Lung NCI-H1944 0.333333 -1.58496 3.372605e-01 6.547888e-01 DataSet_03_377
LAIR2 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 1.77704 0.829473 0.0052758852 0.8388073 DataSet_03_387
LAIR2 NFKBIA shRNA Bone_marrow U2OS 0.15037 -2.73341 5.703701e-01 0.87005461 DataSet_03_389
LAIR2 YY1 knockdown Liver HepG2 67.5833 6.0786 9.992785e-16 7.113637e-13 DataSet_03_390
LAIR2 IKZF2 shRNA Lymph Hut78 0.637802 -0.648819 3.182411e-01 0.73609286 DataSet_03_429
LAIR2 DAXX shRNA Mammary_gland MDA-MB-231 0.0684652 -3.86848 2.722552e-01 0.61257774 DataSet_03_441
LAIR2 PHF14 siRNA Mammary_gland MDA-MB-231 0.5 -1 0.0145491238 0.3034814 DataSet_03_443
LAIR2 CBX2 siRNA Mammary_gland MDA-MB-231 1.53703 0.620144 6.232204e-01 8.020085e-01 DataSet_03_450
LAIR2 OGT siRNA Embryo BeWo cells 1.53697 0.620087 1.469237e-02 0.40610183 DataSet_03_453
LAIR2 IRF2 shRNA Cord_Blood CD34+ cells 5.33333 2.41504 - - DataSet_03_460
LAIR2 TXNIP shRNA Cord_Blood CD34+ cells 2.33333 1.22239 - - DataSet_03_461
Regulation Region
 
T(co)Fs that significantly regulate YBX1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of LAIR2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines