Gene Overview
Target Gene: NKG7
NCBI Official Symbol: NKG7
Entrez ID: 4818
Ensembl ID: ENSG00000105374
Gene Full Name: natural killer cell granule protein 7
Strand: -
Gene Locus: 19q13.41
External Links:

NKG7 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate NKG7   
T(co)Fs that Repress NKG7
The Intensity of the Gene Regulated by T(co)Fs:
NKG7-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
NKG7 IRF2 shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 2.91979 1.54587 0.04943 0.29825 DataSet_01_100
NKG7 IRF6 shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 2.71405 1.44045 0.01658 0.0978 DataSet_01_101
NKG7 MYB shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 6.50245 2.70098 1.56538e-12 1.04496e-09 DataSet_01_102
NKG7 ZIC2 siRNA Pancreas PANC1 0.61585 -0.69934 - - DataSet_01_121
NKG7 FOXM1 siRNA Central_nervous_system U87 0.62127 -0.6867 - - DataSet_01_122
NKG7 IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.84895 0.88671 0.121 0.9262 DataSet_01_137
NKG7 IKZF1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.79462 0.84368 0.13741 0.99993 DataSet_01_138
NKG7 ELK1 siRNA Peripheral_blood CD4+ T cells 6.50054 2.70056 0.22851 0.43498 DataSet_01_162
NKG7 GATA3 siRNA Peripheral_blood CD4+ T cells 0.01112 -6.49057 0.79986 0.9087 DataSet_01_163
NKG7 JUN siRNA Peripheral_blood CD4+ T cells 0.02188 -5.51455 0.79372 0.89969 DataSet_01_164
NKG7 MAF siRNA Peripheral_blood CD4+ T cells 5.7033 2.5118 0.24368 0.59943 DataSet_01_165
NKG7 NFATC3 siRNA Peripheral_blood CD4+ T cells 0.01664 -5.90953 0.96954 0.98646 DataSet_01_166
NKG7 NFKB1 siRNA Peripheral_blood CD4+ T cells 0.01136 -6.46036 0.80845 0.92338 DataSet_01_167
NKG7 STAT3 siRNA Peripheral_blood CD4+ T cells 0.00847 -6.88292 0.62453 0.99183 DataSet_01_168
NKG7 TP53 siRNA Lung SAECs 2.10714 1.07529 0.12075 0.52484 DataSet_01_175
NKG7 CREB1 shRNA Parotid_gland HSY 0.13067 -2.936 0.1908 0.86533 DataSet_01_195
NKG7 TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.88235 0.91254 - - DataSet_01_196
NKG7 TP63 siRNA Head_and_neck SCC-1 0.31193 -1.68072 - - DataSet_01_198
NKG7 TP63 siRNA Head_and_neck SCC-6 0.65663 -0.60686 - - DataSet_01_202
NKG7 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 7.05738 2.81913 - - DataSet_01_208
NKG7 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 5.76134 2.5264 - - DataSet_01_210
NKG7 REST siRNA Prostate LNCaP 0.00605 -7.36964 2.96727e-05 0.01759 DataSet_01_211
NKG7 KLF2 shRNA Bone_marrow RPMI8226 1.69266 0.7593 0.74639 0.96414 DataSet_01_226
NKG7 FOXO3 siRNA Pancreas PANC1 0.47499 -1.07402 - - DataSet_01_267
NKG7 TP53 shRNA Haematopoietic_and_lymphoid_tissue JVM2 1.86866 0.902 4.36893e-07 1.34944e-05 DataSet_01_286
NKG7 POSTN shRNA Brain GSC272 12.5242 3.64665 0.19787 0.59847 DataSet_01_293
NKG7 TFAP4 siRNA Brain BE(2)-C 0.20467 -2.28861 0.37871 0.51625 DataSet_01_295
NKG7 PTEN shRNA Skin A431 0.60761 -0.71879 0.62289 0.77233 DataSet_01_301
NKG7 PTEN shRNA Mammary_gland SKBR3 1.94946 0.96308 0.0339 0.53766 DataSet_01_303
NKG7 MYC siRNA Colon HCT116 1.94493 0.95972 0.04162 0.06901 DataSet_01_324
NKG7 GTF2B siRNA Cervix HeLa 0.40691 -1.29721 - - DataSet_01_362
NKG7 FIP1L1 shRNA Liver HepG2 1.83333 0.87447 0.07382 0.14198 DataSet_02_103
NKG7 HNRNPUL1 shRNA Liver HepG2 0.52083 -0.94111 0.11326 0.18869 DataSet_02_109
NKG7 GTF2F1 shRNA Liver HepG2 7.25 2.85798 0.00297 0.20753 DataSet_02_110
NKG7 BCLAF1 shRNA Liver HepG2 2.33333 1.22239 0.05001 0.12136 DataSet_02_112
NKG7 XRCC5 shRNA Liver HepG2 7.5 2.90689 0.14562 0.33489 DataSet_02_114
NKG7 CEBPZ shRNA Liver HepG2 2 1 1 1 DataSet_02_118
NKG7 RBM25 shRNA Liver HepG2 0.375 -1.41504 0.09734 0.16973 DataSet_02_119
NKG7 PTBP1 shRNA Liver HepG2 0.5 -1 0.2328 0.28301 DataSet_02_120
NKG7 RBM34 shRNA Liver HepG2 2.125 1.08746 0.06982 0.43538 DataSet_02_121
NKG7 FUS shRNA Liver HepG2 12 3.58496 0.2517 0.44283 DataSet_02_124
NKG7 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.43243 -1.20945 0.95385 0.97971 DataSet_02_131
NKG7 SRSF9 shRNA Haematopoietic_and_lymphoid_tissue K562 0.43243 -1.20945 0.95471 0.98357 DataSet_02_134
NKG7 HNRNPK shRNA Haematopoietic_and_lymphoid_tissue K562 0.21622 -2.20945 0.47688 0.66592 DataSet_02_136
NKG7 YBX3 shRNA Haematopoietic_and_lymphoid_tissue K562 2.12 1.08406 0.83286 0.9461 DataSet_02_153
NKG7 SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 0.46 -1.12029 0.44019 0.6925 DataSet_02_154
NKG7 GTF2F1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.16 -2.64386 0.37977 0.99879 DataSet_02_157
NKG7 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 4.2 2.07039 0.0353 0.16814 DataSet_02_160
NKG7 EWSR1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.26 -1.94342 0.1529 0.37344 DataSet_02_167
NKG7 RBM22 shRNA Haematopoietic_and_lymphoid_tissue K562 0.27027 -1.88753 0.63141 0.73276 DataSet_02_168
NKG7 ZFX siRNA Prostate C4-2B 0.53383 -0.90554 0.05074 0.10635 DataSet_02_172
NKG7 MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.46667 1.30256 0.88308 1 DataSet_02_173
NKG7 NFE2L2 siRNA Haematopoietic_and_lymphoid_tissue K562 1.78788 0.83825 0.72514 1 DataSet_02_174
NKG7 LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 3.07547 1.62081 0.13682 1 DataSet_02_175
NKG7 CEBPZ siRNA Haematopoietic_and_lymphoid_tissue K562 4.28302 2.09863 0.53837 1 DataSet_02_176
NKG7 ZNF180 siRNA Haematopoietic_and_lymphoid_tissue K562 2.6 1.37851 0.99786 1 DataSet_02_177
NKG7 ATF3 siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.99466 1 DataSet_02_180
NKG7 ZMIZ1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.51111 -0.96829 0.05362 1 DataSet_02_181
NKG7 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 1.74545 0.8036 0.52591 1 DataSet_02_182
NKG7 KAT2B siRNA Haematopoietic_and_lymphoid_tissue K562 3.90909 1.96683 0.56462 1 DataSet_02_184
NKG7 BHLHE40 siRNA Haematopoietic_and_lymphoid_tissue K562 2.27451 1.18556 0.22802 1 DataSet_02_186
NKG7 CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 4.54902 2.18556 0.01595 1 DataSet_02_187
NKG7 BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.88679 1.52947 0.54475 1 DataSet_02_188
NKG7 MAFG siRNA Haematopoietic_and_lymphoid_tissue K562 0.4717 -1.08406 0.93843 1 DataSet_02_189
NKG7 LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 2.0566 1.04026 0.28064 1 DataSet_02_191
NKG7 MAX siRNA Haematopoietic_and_lymphoid_tissue K562 3.77358 1.91594 0.1095 1 DataSet_02_192
NKG7 ARID3A siRNA Haematopoietic_and_lymphoid_tissue K562 2.4382 1.28582 0.27228 1 DataSet_02_193
NKG7 TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.79245 0.84194 0.41482 1 DataSet_02_194
NKG7 LMNB1 siRNA Haematopoietic_and_lymphoid_tissue K562 3.58491 1.84194 0.24393 1 DataSet_02_195
NKG7 CHD2 siRNA Haematopoietic_and_lymphoid_tissue K562 2.9 1.53605 0.01263 0.12618 DataSet_02_196
NKG7 CDAN1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.5283 1.33817 0.38721 1 DataSet_02_197
NKG7 E2F4 siRNA Haematopoietic_and_lymphoid_tissue K562 0.41509 -1.26849 0.89249 1 DataSet_02_200
NKG7 TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.98684 0.99048 0.12724 1 DataSet_02_201
NKG7 BRCA1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.86667 0.90046 0.78172 1 DataSet_02_202
NKG7 ZNF384 siRNA Haematopoietic_and_lymphoid_tissue K562 0.19481 -2.3599 0.04776 1 DataSet_02_203
NKG7 RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.37288 -1.42321 0.81846 1 DataSet_02_204
NKG7 E2F6 siRNA Haematopoietic_and_lymphoid_tissue K562 2.54717 1.3489 0.05955 1 DataSet_02_205
NKG7 CEBPB siRNA Embryo hESC 0.501782 -0.994869 0.126610505990292 0.503400315524265 DataSet_03_049
NKG7 GATA4 siRNA Stomach KatoIII 0.404497 -1.3058 0.0792069236511922 0.881974118394822 DataSet_03_106
NKG7 GATA6 siRNA Stomach KatoIII 0.525965 -0.926962 0.191342714317051 0.70203806846035 DataSet_03_109
NKG7 GATA6 siRNA Stomach YCC3 1.65366 0.725664 0.495394025287453 0.907733887335487 DataSet_03_110
NKG7 HOXB7 siRNA Mammary_gland MCF7 1.62815 0.703231 0.00301245520566376 0.999977683706165 DataSet_03_127
NKG7 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 5.51345 2.46296 0.240222797964726 0.999948959532916 DataSet_03_134
NKG7 KLF5 siRNA Stomach AGS 0.642683 -0.63782 0.416472081124298 0.806249143281483 DataSet_03_149
NKG7 KLF5 siRNA Stomach KatoIII 0.361701 -1.46713 0.0418088683307212 0.413222749293368 DataSet_03_150
NKG7 KLF5 siRNA Stomach YCC3 1.88492 0.914505 0.0754274431062035 0.393485194345944 DataSet_03_151
NKG7 MITF siRNA Skin SK-MEL-5 0.563418 -0.827722 0.000275442297867263 0.00122266845647699 DataSet_03_168
NKG7 MYB siRNA Cord_Blood CD34+ progenitor cells 1.57885 0.658876 - - DataSet_03_170
NKG7 MYC siRNA Colon HT29 0.245315 -2.02729 - - DataSet_03_177
NKG7 NR2F2 siRNA Uterus Primary eutopic stromal cells 2.50894 1.32708 0.412200775371237 0.99947668859931 DataSet_03_202
NKG7 RELB siRNA Immortalized_keratinocyte HaCaT 0.168812 -2.56651 7.80717783867159e-09 5.28657470790048e-07 DataSet_03_227
NKG7 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.513172 -0.962486 - - DataSet_03_246
NKG7 SP1 siRNA Ovary OVSAYO 0.622446 -0.68398 0.0528104994402688 0.280892688781543 DataSet_03_251
NKG7 STAT6 siRNA Umbilical_vein HUVEC 3.60976 1.8519 0.164327555876462 0.835278631521068 DataSet_03_264
NKG7 TFAP2C siRNA Mammary_gland MCF7 2.3642 1.24135 0.583137085925859 0.812303231434395 DataSet_03_274
NKG7 ZNF165 siRNA Mammary_gland SUM159 1.71818 0.780877 0.804314298771306 0.999998167536832 DataSet_03_288
NKG7 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 63.9749 5.99943 0.190080076483467 0.32918095072914 DataSet_04_014
NKG7 RPS3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.380952 -1.39232 0.144377031500268 0.553967066795594 DataSet_04_017
NKG7 MECP2 CRISPR Liver HepG2 2.13043 1.09115 0.135445847259278 0.408676746757011 DataSet_04_031
NKG7 SRPK2 CRISPR Liver HepG2 2 1 0.165397118056144 0.361934450336878 DataSet_04_037
NKG7 DDX20 CRISPR Liver HepG2 0.608696 -0.716207 0.456978356221659 0.599080195707689 DataSet_04_043
NKG7 APTX CRISPR Liver HepG2 0.333333 -1.58496 0.525213899223947 0.938998918152006 DataSet_04_069
NKG7 CNOT7 CRISPR Liver HepG2 0.285714 -1.80735 0.393650711397367 0.562699211931026 DataSet_04_045
NKG7 PAN2 CRISPR Liver HepG2 0.0238095 -5.39232 0.0195796988533113 0.085390700895404 DataSet_04_066
NKG7 CALR shRNA Liver HepG2 0.130435 -2.9386 0.290587912328918 0.428454065316423 DataSet_04_053
NKG7 CCAR1 shRNA Liver HepG2 0.290323 -1.78427 0.245156705897377 0.395839675829995 DataSet_04_054
NKG7 CNOT7 shRNA Liver HepG2 0.442308 -1.17688 0.194825284406232 0.285320932979735 DataSet_04_051
NKG7 PRPF6 shRNA Liver HepG2 3 1.58496 0.318547018656935 0.535483878898948 DataSet_04_056
NKG7 NPM1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.0851064 -3.55459 0.16559365201016 0.337192400277716 DataSet_04_046
NKG7 SMG7 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.478261 -1.06413 0.614101574966811 0.862333705201514 DataSet_04_075
NKG7 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.196347 -2.34852 0.0249461819090398 0.166794530199569 DataSet_02_38
NKG7 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.0821918 -3.60486 0.0114423497113432 0.0413441807249637 DataSet_02_14
NKG7 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.187215 -2.41724 0.0149643875437661 0.0584780516330778 DataSet_02_34
NKG7 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.26923 1.70895 0.073827227704423 0.449381017006031 DataSet_02_75
NKG7 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.484018 -1.04687 0.177858391001505 0.665305902000238 DataSet_02_45
NKG7 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.410959 -1.28293 0.0887168439329008 0.189904345163947 DataSet_02_35
NKG7 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.59589 -0.746881 0.351098415855608 0.598187432110265 DataSet_02_32
NKG7 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.404762 -1.30485 0.233987659799082 0.648443577907437 DataSet_02_49
NKG7 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.356164 -1.48938 0.056053469253531 0.123635497989591 DataSet_02_33
NKG7 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.26484 -1.91681 0.0292717914163752 0.0995905918589391 DataSet_02_53
NKG7 CCAR1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.04 1.02857 0.301220053390226 0.491472562633433 DataSet_04_064
NKG7 DDX1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.595923137572827 0.884263887578574 DataSet_04_063
NKG7 UBE2L3 shRNA Haematopoietic_and_lymphoid_tissue K562 1.55556 0.63743 0.638495913140828 0.834389269735531 DataSet_04_062
NKG7 SMARCA4 siRNA Colon HCT116 1.59011 0.669125 3.519201e-01 9.892536e-01 DataSet_03_301
NKG7 SMARCA4 siRNA Colon HCT116 0.56339 -0.827795 1.160545e-01 0.3493303 DataSet_03_302
NKG7 ELF3 CRISPR Bile_duct HBDEC2 0.281742 -1.82755 3.888843e-05 6.873259e-04 DataSet_03_304
NKG7 BRCA1 siRNA Mammary_gland MCF7 2.2758 1.18637 5.209972e-01 0.9999931 DataSet_03_308
NKG7 ESR1 siRNA Mammary_gland MCF7 0.108696 -3.20163 1.253788e-02 0.0786869683 DataSet_03_352
NKG7 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 0.122912 -3.02431 4.642139e-03 1.031383e-01 DataSet_03_359
NKG7 TP53 knockout Stomach SNU1 0.65238 -0.616215 0.4884075172 0.9432710 DataSet_03_365
NKG7 USP22 shRNA Liver PLC_PRF_5 cells 10.5 3.39232 2.658534e-02 0.16910410 DataSet_03_368
NKG7 TPR shRNA Bone_marrow U2OS 1.63897 0.71279 7.943241e-01 9.573402e-01 DataSet_03_370
NKG7 E2F1 siRNA Nasopharynx HK1 0.307692 -1.70044 7.562568e-01 1.000000e+00 DataSet_03_373
NKG7 GLI1 siRNA Skeletal_muscle RMS13 0.473776 -1.07772 2.961741e-02 0.141950308 DataSet_03_375
NKG7 ZBTB7A siRNA Stomach BGC823 0.509718 -0.972227 - - DataSet_03_380
NKG7 YY1 knockdown Liver HepG2 7 2.80735 1.625618e-02 5.200768e-02 DataSet_03_390
NKG7 ASXL1 CRISPR Embryo iPSC 1.78377 0.834926 0.0998306876 0.8094451 DataSet_03_394
NKG7 RELA CRISPR Brain T30 1.50622 0.590933 0.7133724247 0.9241599 DataSet_03_399
NKG7 TFAP2A knockout Embryo H9 0.571429 -0.807355 4.341305e-01 0.55822433 DataSet_03_405
NKG7 FOXK2 shRNA Ovary OVCAR-5 2 1 1.527881e-01 0.37172465 DataSet_03_419
NKG7 FOXQ1 CRISPR Lymph Primary CD4+ T cells 2.74045 1.45441 - - DataSet_03_422
NKG7 FOXP3 CRISPR Peripheral_blood Naive Treg 0.24311 -2.04032 7.076804e-01 0.862334927 DataSet_03_427
NKG7 STAT3 siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 2.08009 1.05665 0.0907160390 1 DataSet_03_430
NKG7 USP7 shRNA Skin xenograft cells 0.388889 -1.36257 0.02559044 0.4348960 DataSet_03_431
NKG7 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 6.33333 2.66297 4.193458e-02 0.441119773 DataSet_03_434
NKG7 SUFU shRNA Mammary_gland HCC1954 cells 3 1.58496 0.0720050937 0.5870672 DataSet_03_437
NKG7 CIC knockout Brain Immortalized Astrocyte Cells 0.6 -0.736966 2.573476e-01 7.052370e-01 DataSet_03_438
NKG7 SETDB1 shRNA Colon HCT116 2.48641 1.31406 - - DataSet_03_440
NKG7 FOSL1 siRNA Prostate MSKPCa3 0.333333 -1.58496 0.1881657188 0.5297688 DataSet_03_445
NKG7 RELB CRISPR Colon SW480 2.25 1.16992 1.281331e-02 8.983430e-02 DataSet_03_449
NKG7 ZFP36L1 CRISPR Lung NCI-H1876 0.322633 -1.63203 2.740459e-01 0.992381486 DataSet_03_454
NKG7 IRF2 shRNA Cord_Blood CD34+ cells 1.7242 0.785924 - - DataSet_03_460
NKG7 PARP1 knockout Embryo_kidney HEK293a 2 1 6.082383e-01 7.047880e-01 DataSet_03_464
NKG7 EZH2 siRNA Prostate LNCaP 0.452584 -1.14374 - - DataSet_03_472
Regulation Region
 
T(co)Fs that significantly regulate REST by the evidences of both expression and ChIP-seq/motif
Expression Atlas of NKG7
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines