Gene Overview
Target Gene: PTPN14
NCBI Official Symbol: PTPN14
Entrez ID: 5784
Ensembl ID: ENSG00000152104
Gene Full Name: protein tyrosine phosphatase non-receptor type 14
Strand: -
Gene Locus: 1q32.3-q41
External Links:

PTPN14 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate PTPN14   
T(co)Fs that Repress PTPN14
The Intensity of the Gene Regulated by T(co)Fs:
PTPN14-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
PTPN14 HNF1B shRNA Ovary RMG2 0.65033 -0.62076 2.95643e-08 7.03903e-07 DataSet_01_103
PTPN14 SPDEF shRNA Mammary_gland MCF7 0.54541 -0.87458 0.77791 0.99999 DataSet_01_107
PTPN14 ZIC2 siRNA Pancreas PANC1 2.25926 1.17585 - - DataSet_01_121
PTPN14 GATA3 siRNA Peripheral_blood CD4+ T cells 0.57314 -0.80305 0.31894 0.66294 DataSet_01_163
PTPN14 JUN siRNA Peripheral_blood CD4+ T cells 0.59527 -0.74837 0.37595 0.63724 DataSet_01_164
PTPN14 MAF siRNA Peripheral_blood CD4+ T cells 0.60144 -0.73352 0.39417 0.73733 DataSet_01_165
PTPN14 TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.59891 0.67709 - - DataSet_01_196
PTPN14 XBP1 shRNA Mammary_gland T47D 1.56584 0.64693 0.00033 0.00269 DataSet_01_203
PTPN14 XBP1 shRNA Mammary_gland MDA-MB-231 0.48377 -1.04761 0.00019 0.00757 DataSet_01_204
PTPN14 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.44724 -1.16089 - - DataSet_01_210
PTPN14 REST siRNA Prostate LNCaP 0.65813 -0.60355 0.0042 0.14256 DataSet_01_211
PTPN14 LIN28A siRNA Embryo H9 1.55717 0.63892 0.01905 0.07363 DataSet_01_215
PTPN14 TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 0.54028 -0.88822 0.00034 0.00881 DataSet_01_217
PTPN14 SNAI2 shRNA Skin Primary human keratinocytes 0.66304 -0.59283 0.00449 0.03029 DataSet_01_225
PTPN14 MYC siRNA White_adipose_tissue Adipose stem cells 1.60508 0.68264 1.04328e-05 0.00076 DataSet_01_231
PTPN14 MSX1 siRNA Tooth Dental Pulp Cells 1.56231 0.64368 8.41493e-05 0.00091 DataSet_01_281
PTPN14 SNAI2 siRNA Mammary_gland MCFDCIS 2.19224 1.1324 0.00912 0.41744 DataSet_01_292
PTPN14 TFAP4 siRNA Brain BE(2)-C 0.19464 -2.36115 0.32977 0.51625 DataSet_01_295
PTPN14 ELK3 shRNA Mammary_gland MDA-MB-231 0.36704 -1.44599 0.00047 0.0019 DataSet_01_318
PTPN14 MYC siRNA Colon HCT116 2.18621 1.12843 7.05369e-07 6.3173e-06 DataSet_01_324
PTPN14 HOXC6 siRNA Prostate LNCaP 0.65205 -0.61693 0.07225 0.99927 DataSet_01_333
PTPN14 TCF7L1 shRNA Colon HCT116 1.57233 0.6529 0.00161 0.02908 DataSet_01_346
PTPN14 HIF1A siRNA Oral_cavity OEC-M1 0.54679 -0.87094 0.05323 0.85151 DataSet_01_348
PTPN14 CDX2 siRNA Colon COLO320 0.34475 -1.53639 - - DataSet_01_357
PTPN14 FIP1L1 shRNA Liver HepG2 1.78929 0.83938 0.00142 0.01668 DataSet_02_103
PTPN14 U2AF2 shRNA Liver HepG2 1.72315 0.78505 0.01172 0.07393 DataSet_02_105
PTPN14 TAF15 shRNA Liver HepG2 2.32302 1.216 0.00107 0.01165 DataSet_02_106
PTPN14 U2AF2 shRNA Liver HepG2 1.85217 0.88922 0.0142 0.07785 DataSet_02_113
PTPN14 PCBP1 shRNA Liver HepG2 1.68041 0.74882 0.00084 0.01339 DataSet_02_115
PTPN14 RBM25 shRNA Liver HepG2 1.91753 0.93925 0.00052 0.02139 DataSet_02_119
PTPN14 PTBP1 shRNA Liver HepG2 2.16838 1.11662 0.00046 0.00603 DataSet_02_120
PTPN14 FUS shRNA Liver HepG2 1.93317 0.95097 0.00753 0.08141 DataSet_02_124
PTPN14 HNRNPLL shRNA Liver HepG2 0.62342 -0.68173 0.00858 0.03092 DataSet_02_125
PTPN14 SRSF3 shRNA Liver HepG2 1.61234 0.68916 0.00312 0.06874 DataSet_02_127
PTPN14 RBFOX2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.6 -0.73697 0.15355 0.51542 DataSet_02_139
PTPN14 BCLAF1 shRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.48537 0.64648 DataSet_02_142
PTPN14 CCAR2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 1 1 DataSet_02_146
PTPN14 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.11765 -3.08746 0.28811 0.43614 DataSet_02_147
PTPN14 ILF3 shRNA Haematopoietic_and_lymphoid_tissue K562 8 3 0.06929 0.34254 DataSet_02_148
PTPN14 NONO shRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.05493 0.23625 DataSet_02_149
PTPN14 SAFB2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.23077 -2.11548 0.03413 0.45882 DataSet_02_150
PTPN14 RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 0.09091 -3.45943 0.42828 0.60474 DataSet_02_151
PTPN14 YBX3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.48118 0.80112 DataSet_02_153
PTPN14 SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.83894 0.92953 DataSet_02_154
PTPN14 HNRNPUL1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.09091 -3.45943 0.40525 0.69268 DataSet_02_156
PTPN14 GTF2F1 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.09341 0.92135 DataSet_02_157
PTPN14 PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 1 1 DataSet_02_158
PTPN14 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.01221 0.1247 DataSet_02_160
PTPN14 SUB1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.08577 0.71289 DataSet_02_161
PTPN14 LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 1.75 0.80735 0.62824 1 DataSet_02_175
PTPN14 CEBPZ siRNA Haematopoietic_and_lymphoid_tissue K562 0.22917 -2.12553 0.89292 1 DataSet_02_176
PTPN14 ZNF180 siRNA Haematopoietic_and_lymphoid_tissue K562 1.83333 0.87447 0.1016 1 DataSet_02_177
PTPN14 VEZF1 siRNA Haematopoietic_and_lymphoid_tissue K562 22.5 4.49185 0.2225 1 DataSet_02_179
PTPN14 ATF3 siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.01313 1 DataSet_02_180
PTPN14 BHLHE40 siRNA Haematopoietic_and_lymphoid_tissue K562 16 4 0.00095 1 DataSet_02_186
PTPN14 CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 1 1 DataSet_02_187
PTPN14 BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.08333 -3.58496 0.42449 1 DataSet_02_188
PTPN14 MAFG siRNA Haematopoietic_and_lymphoid_tissue K562 0.08333 -3.58496 0.43912 1 DataSet_02_189
PTPN14 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.54834 1 DataSet_02_190
PTPN14 LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 6.25 2.64386 0.42785 1 DataSet_02_191
PTPN14 MAX siRNA Haematopoietic_and_lymphoid_tissue K562 0.10417 -3.26303 0.13968 1 DataSet_02_192
PTPN14 LMNB1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.10417 -3.26303 0.14698 1 DataSet_02_195
PTPN14 CDAN1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.125 -3 0.18029 1 DataSet_02_197
PTPN14 UBTF siRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 1 1 DataSet_02_198
PTPN14 TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.6 -0.73697 0.07074 1 DataSet_02_201
PTPN14 ZNF384 siRNA Haematopoietic_and_lymphoid_tissue K562 2.66667 1.41504 0.04747 1 DataSet_02_203
PTPN14 ASCL1 siRNA Lung DMS79 0.364964 -1.45418 0.0395615163712916 0.646808950312483 DataSet_03_016
PTPN14 ATF4 siRNA Skin A375 0.459555 -1.12169 0.067619018192127 0.775512819201899 DataSet_03_018
PTPN14 BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.619649 -0.690476 0.310762175550426 0.855071253901766 DataSet_03_025
PTPN14 FLI1 siRNA Haematopoietic_and_lymphoid_tissue THP-1 0.535349 -0.901447 0.000113240939688817 0.0377605883524114 DataSet_03_078
PTPN14 FOXM1 siRNA Aorta Vascular smooth muscle cells 3.45017 1.78667 - - DataSet_03_090
PTPN14 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.68914 0.756288 0.202327275780382 0.999948959532916 DataSet_03_134
PTPN14 Klf4 siRNA Skin Primary neonatal keratinocytes 0.635917 -0.653089 0.00194288602463808 0.0142283384726201 DataSet_03_147
PTPN14 MITF siRNA Skin Ma-Mel-15 1.93821 0.954723 0.0148076880010106 0.251150865584696 DataSet_03_166
PTPN14 MYB siRNA Cord_Blood CD34+ progenitor cells 1.93332 0.951077 - - DataSet_03_170
PTPN14 MYC siRNA Central_nervous_system DAOY M2.1 2.06088 1.04326 1.9843829761617e-07 2.53301109884742e-06 DataSet_03_178
PTPN14 PHB shRNA Embryo Embryonic stem cells (ESCs) 1.76605 0.820529 0.000389097517307989 0.00294921481879751 DataSet_03_211
PTPN14 RELB siRNA Pancreas MIA PaCa-2 0.55039 -0.861472 0.000176758213184294 0.0152259505664257 DataSet_03_225
PTPN14 RELB siRNA Immortalized_keratinocyte HaCaT 1.63197 0.706612 0.000500234272275668 0.0047072373477446 DataSet_03_227
PTPN14 SOX2 siRNA Lung LK2 0.583343 -0.777584 - - DataSet_03_241
PTPN14 STAT3 siRNA Prostate DU145 1.59415 0.672783 1.06785043377023e-05 0.00304267120306505 DataSet_03_260
PTPN14 ZNF750 siRNA Skin Primary neonatal keratinocytes 0.653156 -0.614501 0.00359217766025062 0.0494768133747338 DataSet_03_294
PTPN14 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 8.4 3.07039 0.0200665743249629 0.475344159608796 DataSet_04_001
PTPN14 CIZ1 CRISPR Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.00331407993810455 0.0257225348314739 DataSet_04_004
PTPN14 E4F1 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.25 1.16992 0.305421245690732 0.687911626567786 DataSet_04_007
PTPN14 EIF2AK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.66667 0.736966 0.89469914638128 0.955542116393077 DataSet_04_008
PTPN14 MECP2 CRISPR Haematopoietic_and_lymphoid_tissue K562 4.5 2.16992 0.000310778795842095 0.254793036316993 DataSet_04_013
PTPN14 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 166.269 7.37738 0.0129010814820246 0.0582300739774306 DataSet_04_014
PTPN14 RPS3 CRISPR Haematopoietic_and_lymphoid_tissue K562 4 2 0.0472302359063195 0.419640340175443 DataSet_04_017
PTPN14 SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.555556 -0.847997 0.42404071577355 0.567436351533313 DataSet_04_018
PTPN14 SMAD4 CRISPR Haematopoietic_and_lymphoid_tissue K562 8 3 0.00844884610828975 0.109261362911569 DataSet_04_019
PTPN14 SMAD5 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.25 1.16992 0.30469175398855 0.629387144466949 DataSet_04_020
PTPN14 XRCC5 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.75 0.807355 0.017144960982607 0.191465447007942 DataSet_04_021
PTPN14 ANXA2 CRISPR Liver HepG2 2.75 1.45943 0.629802668795046 0.889502042761693 DataSet_04_024
PTPN14 APTX CRISPR Liver HepG2 3.25 1.70044 0.0540960127489253 0.464065532601871 DataSet_04_025
PTPN14 ZNF574 CRISPR Liver HepG2 0.649891 -0.621731 0.00240360856479407 0.0567277196215169 DataSet_04_041
PTPN14 CCAR1 shRNA Liver HepG2 1.88777 0.916685 0.00420950763694039 0.0305414939649627 DataSet_04_054
PTPN14 UBE2L3 shRNA Liver HepG2 2.19797 1.13617 0.00206353968010866 0.0161636281847264 DataSet_04_055
PTPN14 ACTN4 CRISPR Haematopoietic_and_lymphoid_tissue K562 5.5 2.45943 0.291799163143637 0.500364486388453 DataSet_04_048
PTPN14 DDX20 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.375 -1.41504 0.627020684919216 0.88325338681902 DataSet_04_050
PTPN14 NPM1 CRISPR Haematopoietic_and_lymphoid_tissue K562 3.75 1.90689 0.2204896286054 0.404050779239921 DataSet_04_046
PTPN14 RIOK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 2 1 0.924715060360641 0.990760854897555 DataSet_04_076
PTPN14 SEPT11 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.77042327680321 1 DataSet_04_077
PTPN14 SMG5 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.6 -0.736966 0.850570881072367 0.974967299465354 DataSet_04_073
PTPN14 SMG7 CRISPR Haematopoietic_and_lymphoid_tissue K562 3.2 1.67807 0.466323253602428 0.773961999628856 DataSet_04_075
PTPN14 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 2 1 0.60306365269735 0.752404845801191 DataSet_04_049
PTPN14 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 4 2 0.301649069048475 0.563948069227997 DataSet_02_38
PTPN14 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.38462 1.25376 0.161875611908708 0.290476689667209 DataSet_02_14
PTPN14 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 9.15385 3.19438 0.0299560082742717 0.480607566711255 DataSet_02_45
PTPN14 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.61538 0.691878 0.623143374908563 0.777279107739273 DataSet_02_35
PTPN14 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 5.65385 2.49923 0.0797263376136412 0.403591581431273 DataSet_02_32
PTPN14 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.125 -3 0.179179723218436 0.595806980620071 DataSet_02_49
PTPN14 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2 1 0.249227808035429 0.414791418922281 DataSet_02_53
PTPN14 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 10 3.32193 0.594725233664998 0.71817682135187 DataSet_04_059
PTPN14 UBE2L3 shRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.642385450708532 0.837484523036692 DataSet_04_062
PTPN14 EZH2 knockdown Uterus Ishikawa (ISK) cell 2.8219 1.49667 - - DataSet_03_324
PTPN14 EZH2 knockdown Colon HCT116 2.7498 1.45933 0.100342204 0.8488990 DataSet_03_334
PTPN14 SKI CRISPR Blood HL60 0.276753 -1.85333 1.003351e-03 0.080922187 DataSet_03_351
PTPN14 PARP1 siRNA Prostate LNCaP 3.93403 1.97601 4.421302e-03 0.094142070 DataSet_03_354
PTPN14 CREBBP CRISPR Brain U5-NPC 1.66428 0.734896 0.4343818269 0.7490853 DataSet_03_356
PTPN14 TP53 CRISPR Brain U5-NPC 1.61517 0.691684 4.636084e-01 5.867315e-01 DataSet_03_358
PTPN14 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 12.1002 3.59696 8.730814e-08 1.042713e-05 DataSet_03_362
PTPN14 MYC siRNA Peripheral_blood T lymphocyte 1.87786 0.909088 6.326855e-01 0.817705606 DataSet_03_363
PTPN14 DNMT3A knockout Embryo_kidney HEK293T 1.56784 0.648782 - - DataSet_03_369
PTPN14 ZFP36L1 siRNA Urinary_bladder J82 1.97625 0.982769 - - DataSet_03_371
PTPN14 E2F1 siRNA Nasopharynx HK1 0.447301 -1.16068 2.319951e-02 2.061165e-01 DataSet_03_373
PTPN14 GLI1 siRNA Skeletal_muscle RMS13 1.60963 0.686728 4.281288e-02 0.176128248 DataSet_03_375
PTPN14 NFKB2 siRNA Bone_marrow U2OS 0.628046 -0.671059 1.404416e-01 0.45217318 DataSet_03_381
PTPN14 YY1 knockdown Liver HepG2 1.82639 0.868994 5.579560e-06 6.298775e-05 DataSet_03_390
PTPN14 KDM5A CRISPR Lung GLC16 2.72099 1.44413 1.248454e-02 0.049328455 DataSet_03_392
PTPN14 ILF2 siRNA Stomach SGC-7901 2.2058 1.14131 0.0206840725 0.08165351 DataSet_03_393
PTPN14 TLE4 CRISPR Lymph CAR T Cell 1.64453 0.717672 1.259376e-01 0.40779547 DataSet_03_398
PTPN14 EHF shRNA Stomach MKN7 8.95293 3.16236 - - DataSet_03_402
PTPN14 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.54508 0.627684 2.840692e-02 0.3239928 DataSet_03_403
PTPN14 CDK7 shRNA Bone_marrow D458 2.57273 1.3633 1.075763e-02 0.17089333 DataSet_03_404
PTPN14 MAP3K7 shRNA Prostate LNCaP 1.5575 0.639234 2.654611e-03 3.665562e-02 DataSet_03_408
PTPN14 USP22 shRNA Liver HuH7 6.16099 2.62316 - - DataSet_03_411
PTPN14 E2F6 shRNA Liver HuH7 2.39157 1.25796 - - DataSet_03_412
PTPN14 RUNX2 shRNA Cord_blood Natural Killer Cell 0.568608 -0.814493 2.955128e-01 0.793390621 DataSet_03_416
PTPN14 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 6.26316 2.64689 8.509957e-04 0.010960229 DataSet_03_418
PTPN14 BRD4 CRISPR Lymph CD8+ T cells 0.565934 -0.821294 - - DataSet_03_420
PTPN14 PRDM1 CRISPR Lymph CD8+ T cells 5.09615 2.34941 - - DataSet_03_421
PTPN14 MAEL CRISPR Liver Alexander cells 0.491503 -1.02473 - - DataSet_03_423
PTPN14 FOXP3 CRISPR Peripheral_blood Naive Treg 1.98031 0.98573 7.454891e-02 0.368715480 DataSet_03_427
PTPN14 USP7 shRNA Skin xenograft cells 0.448789 -1.15589 0.26390633 0.4348960 DataSet_03_431
PTPN14 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 8.67267 3.11648 1.153037e-03 0.128166202 DataSet_03_434
PTPN14 POU2AF1 CRISPR Lymph SUDHL4 1.61074 0.687722 2.124417e-01 0.385884017 DataSet_03_435
PTPN14 DAXX shRNA Mammary_gland MDA-MB-231 0.505541 -0.984101 5.221871e-03 0.08702037 DataSet_03_441
PTPN14 CBX2 siRNA Mammary_gland MCF7 1.96233 0.972564 1.784557e-02 0.0479586032 DataSet_03_451
PTPN14 SMARCA2 shRNA Lung HCC2302 0.21881 -2.19225 9.767439e-08 3.310343e-07 DataSet_03_455
PTPN14 TXNIP shRNA Cord_Blood CD34+ cells 2.97059 1.57075 - - DataSet_03_461
PTPN14 SOX9 knockout Liver HuH7 0.40264 -1.31244 3.869713e-05 1.301429e-03 DataSet_03_463
PTPN14 STAT3 shRNA Liver HepG2 1.74766 0.805427 1.577123e-02 0.1920188356 DataSet_03_465
PTPN14 SMARCA1 Cas13 Embryo_kidney HEK293T 0.336999 -1.56918 - - DataSet_03_466
PTPN14 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 2.16559 1.11476 - - DataSet_03_467
PTPN14 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 8.4 3.07039 0.100872 0.5318382 DataSet_04_072
Regulation Region
 
T(co)Fs that significantly regulate POLR2G by the evidences of both expression and ChIP-seq/motif
Expression Atlas of PTPN14
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines