Gene Overview
Target Gene: SERPINA1
NCBI Official Symbol: SERPINA1
Entrez ID: 5265
Ensembl ID: ENSG00000197249
Gene Full Name: serpin family A member 1
Strand: -
Gene Locus: 14q32.13
External Links:

SERPINA1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate SERPINA1   
T(co)Fs that Repress SERPINA1
The Intensity of the Gene Regulated by T(co)Fs:
SERPINA1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
SERPINA1 IRF6 shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 1.50066 0.5856 0.02147 0.11425 DataSet_01_101
SERPINA1 MYB shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 2.11846 1.08302 1.2941e-08 4.61078e-07 DataSet_01_102
SERPINA1 HNF1B shRNA Ovary RMG2 1.57615 0.6564 0.00731 0.02034 DataSet_01_103
SERPINA1 SPDEF shRNA Mammary_gland MCF7 0.60212 -0.73187 0.70116 0.99999 DataSet_01_107
SERPINA1 TCF3 shRNA Mammary_gland MDA-MB468 1.79351 0.84278 5.31326e-06 0.00031 DataSet_01_116
SERPINA1 ID1 siRNA Lung A549 3.69222 1.88449 0.00048 0.08908 DataSet_01_117
SERPINA1 ZIC2 siRNA Pancreas PANC1 0.55185 -0.85765 - - DataSet_01_121
SERPINA1 FOXM1 siRNA Central_nervous_system U87 4.63342 2.21208 - - DataSet_01_122
SERPINA1 SF1 siRNA Adrenal_gland H295R/TR 1.52035 0.6044 0.00012 0.00294 DataSet_01_146
SERPINA1 MYBL2 shRNA Bone_marrow CD34+ BM cells 0.50651 -0.98133 0.00111 0.12951 DataSet_01_148
SERPINA1 HSF1 shRNA Skin A375 0.3885 -1.364 5.78483e-06 0.00028 DataSet_01_155
SERPINA1 ZFX shRNA Central_nervous_system DAOY 0.50371 -0.98934 0.04373 0.99991 DataSet_01_157
SERPINA1 ELK1 siRNA Peripheral_blood CD4+ T cells 3.88647 1.95846 1.91975e-06 0.00032 DataSet_01_162
SERPINA1 JUN siRNA Peripheral_blood CD4+ T cells 3.95738 1.98455 1.65784e-06 0.00041 DataSet_01_164
SERPINA1 MAF siRNA Peripheral_blood CD4+ T cells 2.97723 1.57397 1.28228e-05 0.00181 DataSet_01_165
SERPINA1 NFATC3 siRNA Peripheral_blood CD4+ T cells 2.96442 1.56775 0.00019 0.01091 DataSet_01_166
SERPINA1 GABPA shRNA Prostate C4-2B 865.153 9.75681 0.23749 0.43934 DataSet_01_190
SERPINA1 GABPA shRNA Prostate LNCaP 759.878 9.56962 0.46528 0.7048 DataSet_01_191
SERPINA1 CREB1 shRNA Parotid_gland H3118 MEC 0.42411 -1.23749 0.11505 0.44721 DataSet_01_194
SERPINA1 TP63 siRNA Immortalized_keratinocyte HaCaT 1.56925 0.65008 - - DataSet_01_200
SERPINA1 XBP1 shRNA Mammary_gland T47D 0.60621 -0.72211 0.00011 0.00138 DataSet_01_203
SERPINA1 LIN28A siRNA Embryo H9 1.86678 0.90055 0.00385 0.0278 DataSet_01_215
SERPINA1 FOXM1 siRNA Mammary_gland MCF7 0.63806 -0.64824 0.50102 0.90018 DataSet_01_223
SERPINA1 FOXA1 siRNA Prostate LNCaP 1.98798 0.9913 0.03991 0.29313 DataSet_01_233
SERPINA1 TWIST1 shRNA Stomach CAF14 1.52407 0.60793 0.03284 0.99996 DataSet_01_252
SERPINA1 SOX4 shRNA Mammary_gland MDA-MB-231 2.70777 1.4371 2.72465e-05 0.00489 DataSet_01_260
SERPINA1 FOXO3 siRNA Pancreas PANC1 1.77232 0.82564 - - DataSet_01_267
SERPINA1 TP53 shRNA Haematopoietic_and_lymphoid_tissue JVM2 0.55058 -0.86097 2.424e-07 8.39067e-06 DataSet_01_286
SERPINA1 TFAP4 siRNA Brain BE(2)-C 0.21882 -2.1922 0.38839 0.51625 DataSet_01_295
SERPINA1 PTEN shRNA Mammary_gland SKBR3 0.60044 -0.7359 0.0683 0.589 DataSet_01_303
SERPINA1 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 1.82188 0.86542 0.08499 0.34462 DataSet_01_313
SERPINA1 ELK3 shRNA Mammary_gland MDA-MB-231 0.41892 -1.25525 0.02693 0.05137 DataSet_01_318
SERPINA1 MYC siRNA Colon HCT116 4.26037 2.09098 6.04523e-14 1.12018e-10 DataSet_01_324
SERPINA1 KLF4 siRNA Embryo HCE 2.39579 1.2605 0.00014 0.04401 DataSet_01_339
SERPINA1 KLF7 siRNA Embryo HCE 0.43813 -1.19056 0.14484 0.6419 DataSet_01_340
SERPINA1 PAX3 shRNA Soft_tissue Rh30 1.56933 0.65015 - - DataSet_01_359
SERPINA1 GTF2B siRNA Cervix HeLa 0.63387 -0.65774 - - DataSet_01_362
SERPINA1 SSB shRNA Liver HepG2 1.60664 0.68405 0.00082 0.00694 DataSet_02_107
SERPINA1 BCLAF1 shRNA Liver HepG2 2.83552 1.50361 0.00019 0.02312 DataSet_02_112
SERPINA1 PCBP1 shRNA Liver HepG2 1.69975 0.76532 0.00059 0.01339 DataSet_02_115
SERPINA1 TARDBP shRNA Liver HepG2 1.65428 0.7262 0.00817 0.03358 DataSet_02_116
SERPINA1 CEBPZ shRNA Liver HepG2 1.63388 0.7083 0.73534 1 DataSet_02_118
SERPINA1 HNRNPLL shRNA Liver HepG2 2.59507 1.37577 0.00095 0.01259 DataSet_02_125
SERPINA1 SNRNP70 shRNA Liver HepG2 1.99826 0.99874 0.0078 0.04759 DataSet_02_126
SERPINA1 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 50.4 5.65535 0.00022 0.02038 DataSet_02_143
SERPINA1 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.33333 1.22239 0.07949 0.35531 DataSet_02_152
SERPINA1 ZFX siRNA Prostate C4-2B 31 4.9542 0.13171 0.21996 DataSet_02_172
SERPINA1 MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 6.33333 2.66297 0.83683 1 DataSet_02_173
SERPINA1 LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 0.0303 -5.04439 0.14104 1 DataSet_02_175
SERPINA1 CEBPZ siRNA Haematopoietic_and_lymphoid_tissue K562 2.33333 1.22239 0.15712 1 DataSet_02_176
SERPINA1 ZMIZ1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.66667 1.41504 0.03516 1 DataSet_02_181
SERPINA1 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 0.16667 -2.58496 0.047 1 DataSet_02_182
SERPINA1 CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 5.25 2.39232 0.03895 1 DataSet_02_187
SERPINA1 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.37977 1 DataSet_02_190
SERPINA1 LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.21212 -2.23704 0.81922 1 DataSet_02_191
SERPINA1 MAX siRNA Haematopoietic_and_lymphoid_tissue K562 10.3333 3.36923 0.4232 1 DataSet_02_192
SERPINA1 TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.39394 -1.34395 0.44545 1 DataSet_02_194
SERPINA1 MAZ siRNA Haematopoietic_and_lymphoid_tissue K562 11.25 3.49185 0.01341 1 DataSet_02_199
SERPINA1 E2F4 siRNA Haematopoietic_and_lymphoid_tissue K562 0.30303 -1.72247 0.96824 1 DataSet_02_200
SERPINA1 CEBPB siRNA Embryo hESC 0.636256 -0.652321 0.214604053153597 0.597614660224442 DataSet_03_049
SERPINA1 E2F1 siRNA Mammary_gland MCF7 1.63359 0.708049 0.0591753657870321 0.999927373439084 DataSet_03_061
SERPINA1 E2F5 siRNA Mammary_gland MCF7 1.66223 0.733116 0.0527472310334686 0.999540347732068 DataSet_03_062
SERPINA1 HDAC5 siRNA Mammary_gland MCF7 1.52551 0.609294 0.0933100705804809 0.999966625300244 DataSet_03_115
SERPINA1 HINFP siRNA Bone_marrow hTERT-RPE1 0.623857 -0.680712 0.000842912768021295 0.0690833973753528 DataSet_03_122
SERPINA1 HSF2 siRNA Mammary_gland MCF7 1.88672 0.915882 0.0232078345150622 0.990969613280381 DataSet_03_130
SERPINA1 MEF2D shRNA Liver HuH7 0.618668 -0.692763 - - DataSet_03_162
SERPINA1 MYB siRNA Cord_Blood CD34+ progenitor cells 1.85643 0.892533 - - DataSet_03_170
SERPINA1 MYC siRNA Colon HT29 3.10144 1.63294 - - DataSet_03_177
SERPINA1 MYC siRNA Central_nervous_system DAOY M2.1 2.4952 1.31916 8.9005709260418e-08 1.47896570578763e-06 DataSet_03_178
SERPINA1 NPAT siRNA Bone_marrow U2OS 0.589012 -0.763631 3.75273339377224e-05 0.00511441085077909 DataSet_03_201
SERPINA1 PCNA siRNA Mammary_gland MCF7 1.60152 0.679438 0.0675026764453071 0.999448838103647 DataSet_03_210
SERPINA1 PRRX1 CRISPR Neuroblastoma 691-MES 0.499313 -1.00198 0.304227913114076 0.901120477612808 DataSet_03_217
SERPINA1 RB1 siRNA Mammary_gland MCF7 1.76856 0.822573 0.0351345222190763 0.999890290262508 DataSet_03_219
SERPINA1 RELB siRNA Immortalized_keratinocyte HaCaT 1.56089 0.642374 0.00100260547224774 0.00830949809597999 DataSet_03_227
SERPINA1 SOX11 siRNA Lung_fibroblast NHLF 2.75907 1.46418 0.174497548213137 0.578274929476723 DataSet_03_237
SERPINA1 SOX11 siRNA Lung_fibroblast NHLF 3.6135 1.85339 0.00662296858053567 0.187139246354892 DataSet_03_238
SERPINA1 SOX2 CRISPR Seminoma-like TCam-2 4.06066 2.02171 0.0875720937526097 0.999580851453413 DataSet_03_244
SERPINA1 SP1 siRNA Mammary_gland MDA-MB-231 0.612932 -0.7062 0.134343404787143 0.413972819854456 DataSet_03_250
SERPINA1 STAT3 CRISPR Embryo hESC 0.4323 -1.2099 0.361061111444217 0.43696931395591 DataSet_03_258
SERPINA1 STAT5B siRNA Mammary_gland MCF7 1.57933 0.659316 0.0740661262870821 0.999932708473107 DataSet_03_263
SERPINA1 TCEA1 siRNA Mammary_gland MCF7 1.50952 0.59409 0.10009371848086 0.999762252994287 DataSet_03_266
SERPINA1 ZNF165 siRNA Mammary_gland SUM159 2.80645 1.48875 0.540243849669063 0.999998167536832 DataSet_03_288
SERPINA1 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 2.66667 1.41504 0.168201131403768 0.671828078113708 DataSet_04_001
SERPINA1 E4F1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.026738 -5.22497 0.0035839320086011 0.460888933881103 DataSet_04_007
SERPINA1 ERN1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.0320856 -4.96193 6.89474936994995e-06 0.0705648732380784 DataSet_04_009
SERPINA1 SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.602273 -0.731511 0.944380540528611 0.966170005534418 DataSet_04_018
SERPINA1 SMAD5 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.0534759 -4.22497 0.00164301095590315 0.392743003922383 DataSet_04_020
SERPINA1 APTX CRISPR Liver HepG2 0.0481283 -4.37697 0.000689898619544686 0.226894515042161 DataSet_04_025
SERPINA1 CALR shRNA Liver HepG2 1.91712 0.938939 0.000116560847110844 0.00379871874597755 DataSet_04_053
SERPINA1 CNOT7 shRNA Liver HepG2 0.286257 -1.80462 9.18736831373359e-06 0.00151371793725214 DataSet_04_051
SERPINA1 DDX1 shRNA Liver HepG2 1.63073 0.705519 0.000333540323835947 0.0429589673467077 DataSet_04_057
SERPINA1 YBX3 shRNA Liver HepG2 1.87456 0.90655 0.000161296975430236 0.0291150790830575 DataSet_02_98
SERPINA1 RIOK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.566667 -0.819428 0.65571010066099 0.930758356385663 DataSet_04_076
SERPINA1 SMG5 CRISPR Haematopoietic_and_lymphoid_tissue K562 3.75 1.90689 0.442832785487471 0.781767050033682 DataSet_04_073
SERPINA1 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.647059 -0.628031 0.753345800930886 0.957041289742236 DataSet_02_49
SERPINA1 EZH2 shRNA Colon SW480 0.386839 -1.3702 - - DataSet_03_298
SERPINA1 DNMT1 siRNA Lung_fibroblast IMR-90 0.659495 -0.600567 4.910230e-01 0.9999458 DataSet_03_317
SERPINA1 EZH2 knockdown Uterus Ishikawa (ISK) cell 1.57371 0.654167 - - DataSet_03_324
SERPINA1 SMARCA4 siRNA Colon HCT116 0.32603 -1.61692 1.124401e-03 0.1301247 DataSet_03_302
SERPINA1 ELF3 CRISPR Bile_duct HBDEC2 2.5161 1.33119 5.618366e-05 8.583181e-04 DataSet_03_304
SERPINA1 SNAI2 shRNA Pancreas KLM1 0.305828 -1.70921 4.739431e-04 0.08465563 DataSet_03_307
SERPINA1 EZH2 shRNA Mammary_gland MCF7 1.90323 0.92845 2.255903e-04 9.614750e-03 DataSet_03_331
SERPINA1 TET1 CRISPR Mammary_gland MDA-MB-231 4.0868 2.03097 1.751673e-01 3.763531e-01 DataSet_03_347
SERPINA1 SKI CRISPR Blood HL60 14.4286 3.85086 1.574718e-03 0.090982843 DataSet_03_351
SERPINA1 ETV5 knockdown Colon HT29 2.28097 1.18965 3.084039e-01 0.527308910 DataSet_03_353
SERPINA1 TET1 CRISPR Mammary_gland Hs578T 0.488066 -1.03485 5.943210e-01 7.570815e-01 DataSet_03_355
SERPINA1 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 0.197602 -2.33933 1.689040e-02 1.721791e-01 DataSet_03_359
SERPINA1 NCOA2 siRNA Uterus endometrial stromal cells 0.65 -0.621488 0.2797314868 1 DataSet_03_360
SERPINA1 MYC siRNA Peripheral_blood T lymphocyte 1.64719 0.72001 8.096288e-01 0.917824964 DataSet_03_363
SERPINA1 EP300 shRNA Mammary_gland MCF10AT 0.31831 -1.6515 6.194076e-04 0.019179932 DataSet_03_364
SERPINA1 TP53 knockout Stomach SNU1 0.539121 -0.89132 0.7970550431 0.9984297 DataSet_03_365
SERPINA1 ZNF148 shRNA Mammary_gland MDA-MB-231 1.63901 0.712822 2.101318e-02 0.106210518 DataSet_03_366
SERPINA1 BHLHE40 shRNA Cervix HeLaS3 0.318182 -1.65208 5.132233e-01 0.91042936 DataSet_03_372
SERPINA1 HNRNPU siRNA Colon RKO 0.133149 -2.90888 - - DataSet_03_374
SERPINA1 ZNF213 siRNA Mammary_gland MCF7 0.642724 -0.63773 4.757936e-01 7.121864e-01 DataSet_03_376
SERPINA1 EZH2 CRISPR Ovary SKOV3 0.383871 -1.38131 1.023947e-03 0.0213490945 DataSet_03_378
SERPINA1 DDX5 shRNA Stomach HGC-27 0.636364 -0.652077 - - DataSet_03_379
SERPINA1 ZBTB7A siRNA Stomach BGC823 2.1663 1.11524 - - DataSet_03_380
SERPINA1 NFKB2 siRNA Bone_marrow U2OS 1.91848 0.939962 5.701202e-02 0.30687814 DataSet_03_381
SERPINA1 DNMT1 siRNA Skin Human melanoma cells 2.01522 1.01094 7.835543e-02 1.297329e-01 DataSet_03_382
SERPINA1 TCF19 CRISPR Oral_squamous CAL27 4.03308 2.01188 4.459233e-05 0.0044280488 DataSet_03_383
SERPINA1 YY1 shRNA Brain GSC1517 2.2 1.1375 - - DataSet_03_384
SERPINA1 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 2.43334 1.28294 0.6103321813 0.9196521 DataSet_03_387
SERPINA1 TRIM8 siRNA Mammary_gland MCF7 2.39412 1.25949 8.423603e-02 0.2248805129 DataSet_03_388
SERPINA1 ILF2 siRNA Stomach SGC-7901 2.75 1.45943 0.7615352183 0.82692065 DataSet_03_393
SERPINA1 ASXL1 CRISPR Embryo iPSC 0.596211 -0.746105 0.9157604735 0.9810968 DataSet_03_394
SERPINA1 HMGA1 shRNA Bile_duct HUCCT1 0.4 -1.32193 4.099009e-01 0.621746859 DataSet_03_400
SERPINA1 SUMO1 CRISPR Bone_marrow U2OS 0.281854 -1.82698 1.139091e-06 1.812747e-04 DataSet_03_401
SERPINA1 EHF shRNA Stomach MKN7 6.2561 2.64526 - - DataSet_03_402
SERPINA1 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.93902 0.955331 4.466048e-02 0.3239928 DataSet_03_403
SERPINA1 CHD1 shRNA Prostate LNCaP 0.190298 -2.39366 1.880554e-03 8.933871e-02 DataSet_03_407
SERPINA1 MAP3K7 shRNA Prostate LNCaP 0.447761 -1.1592 2.998529e-01 5.332857e-01 DataSet_03_408
SERPINA1 STRAP knockout Nerve SK-N-AS 0.32782 -1.60902 - - DataSet_03_409
SERPINA1 SIRT1 siRNA Pancreas PANC1 0.129032 -2.9542 3.795996e-03 0.030596736 DataSet_03_410
SERPINA1 USP22 shRNA Liver HuH7 0.308787 -1.69532 - - DataSet_03_411
SERPINA1 E2F1 siRNA Prostate LNCaP 0.51282 -0.963474 4.014004e-02 0.5066243911 DataSet_03_413
SERPINA1 E2F2 siRNA Prostate LNCaP 0.307692 -1.70044 2.637352e-03 2.691187e-02 DataSet_03_414
SERPINA1 ZKSCAN3 CRISPR Colon HCT116 0.480399 -1.0577 9.057056e-02 0.460921997 DataSet_03_415
SERPINA1 FOXK2 shRNA Ovary OVCAR-5 0.176773 -2.50003 1.023952e-03 0.08266460 DataSet_03_419
SERPINA1 BRD4 CRISPR Lymph CD8+ T cells 5.5 2.45943 - - DataSet_03_420
SERPINA1 PRDM1 CRISPR Lymph CD8+ T cells 9.5 3.24793 - - DataSet_03_421
SERPINA1 MAEL CRISPR Liver Alexander cells 2.97959 1.57512 - - DataSet_03_423
SERPINA1 IKZF2 shRNA Lymph Hut78 1.86913 0.90237 6.705233e-01 0.89721059 DataSet_03_429
SERPINA1 USP7 shRNA Skin xenograft cells 0.474527 -1.07544 0.26857914 0.4348960 DataSet_03_431
SERPINA1 POU2AF1 CRISPR Lymph SUDHL4 24.177 4.59556 8.328833e-05 0.005917891 DataSet_03_435
SERPINA1 EP300 knockout Pancreas HPAF-II orthotopic cells 1.87948 0.910335 1.379404e-05 4.593122e-04 DataSet_03_436
SERPINA1 CIC knockout Brain Immortalized Astrocyte Cells 0.294118 -1.76553 1.538096e-01 6.198478e-01 DataSet_03_438
SERPINA1 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 2.93216 1.55197 1.439442e-04 0.11912039 DataSet_03_439
SERPINA1 SETDB1 shRNA Colon HCT116 4.42028 2.14414 - - DataSet_03_440
SERPINA1 DAXX shRNA Mammary_gland MDA-MB-231 59.927 5.90513 4.602031e-03 0.08323804 DataSet_03_441
SERPINA1 HMG20A siRNA Mammary_gland MDA-MB-231 0.353801 -1.49899 0.0269066836 0.2080997 DataSet_03_442
SERPINA1 PHF14 siRNA Mammary_gland MDA-MB-231 0.332602 -1.58813 0.0209124643 0.3462252 DataSet_03_443
SERPINA1 CBX2 siRNA Mammary_gland MDA-MB-231 1.51262 0.597054 7.547274e-04 7.428134e-03 DataSet_03_450
SERPINA1 CBX2 siRNA Mammary_gland MCF7 0.551259 -0.859198 4.727218e-02 0.1037271617 DataSet_03_451
SERPINA1 ZFP36L1 CRISPR Lung NCI-H1876 27.6249 4.7879 3.962511e-02 0.798545827 DataSet_03_454
SERPINA1 PPARG siRNA Aortic_valve Valvular endothelial cell 0.620179 -0.689243 3.194105e-04 1.535067e-02 DataSet_03_456
SERPINA1 SOX9 knockout Liver HuH7 1.59649 0.674899 4.809879e-03 2.558631e-02 DataSet_03_463
SERPINA1 PARP1 knockout Embryo_kidney HEK293a 0.5 -1 6.340901e-02 1.413049e-01 DataSet_03_464
SERPINA1 EZH2 siRNA Prostate LNCaP 0.246334 -2.02131 - - DataSet_03_472
SERPINA1 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 2.66667 1.41504 0.07728267 0.5005831 DataSet_04_072
Regulation Region
 
T(co)Fs that significantly regulate ERN1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of SERPINA1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines