Gene Overview
Target Gene: TMEM121
NCBI Official Symbol: TMEM121
Entrez ID: 80757
Ensembl ID: ENSG00000184986
Gene Full Name: transmembrane protein 121
Strand: +
Gene Locus: 14q32.33
External Links:

TMEM121 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate TMEM121   
T(co)Fs that Repress TMEM121
The Intensity of the Gene Regulated by T(co)Fs:
TMEM121-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
TMEM121 SPDEF shRNA Mammary_gland MCF7 1.53762 0.6207 0.83394 0.99999 DataSet_01_107
TMEM121 FOXM1 siRNA Central_nervous_system U87 0.3583 -1.48077 - - DataSet_01_122
TMEM121 IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.52627 0.61001 0.25088 0.99993 DataSet_01_137
TMEM121 ELK1 siRNA Peripheral_blood CD4+ T cells 0.05519 -4.17956 0.83384 0.92143 DataSet_01_162
TMEM121 GATA3 siRNA Peripheral_blood CD4+ T cells 0.02023 -5.62754 0.4685 0.76135 DataSet_01_163
TMEM121 JUN siRNA Peripheral_blood CD4+ T cells 0.03426 -4.86733 0.81694 0.91159 DataSet_01_164
TMEM121 MAF siRNA Peripheral_blood CD4+ T cells 0.02849 -5.13337 0.68981 0.87141 DataSet_01_165
TMEM121 NFATC3 siRNA Peripheral_blood CD4+ T cells 12.4724 3.64067 0.36078 0.66238 DataSet_01_166
TMEM121 NFKB1 siRNA Peripheral_blood CD4+ T cells 0.02254 -5.47158 0.53208 0.85272 DataSet_01_167
TMEM121 STAT3 siRNA Peripheral_blood CD4+ T cells 0.02009 -5.63745 0.45786 0.99183 DataSet_01_168
TMEM121 TP53 siRNA Lung SAECs 1.65844 0.72982 0.24107 0.65044 DataSet_01_175
TMEM121 GATA2 siRNA Prostate LNCaP 2.71992 1.44356 0.00112 0.00642 DataSet_01_193
TMEM121 TP63 siRNA Immortalized_keratinocyte HaCaT RG 2.31183 1.20903 - - DataSet_01_196
TMEM121 TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.51165 0.59613 - - DataSet_01_197
TMEM121 TP63 siRNA Head_and_neck SCC-1 0.19693 -2.34424 - - DataSet_01_198
TMEM121 TP63 siRNA Head_and_neck SCC-6 2.09953 1.07007 - - DataSet_01_202
TMEM121 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 5.08826 2.34717 - - DataSet_01_208
TMEM121 STAT5 shRNA Prostate CWR22Pc 0.65497 -0.61051 0.19996 0.37389 DataSet_01_279
TMEM121 MSX1 siRNA Tooth Dental Pulp Cells 0.27766 -1.84863 5.43268e-07 5.69141e-05 DataSet_01_281
TMEM121 POSTN shRNA Brain GSC272 3.39816 1.76475 0.2161 0.6072 DataSet_01_293
TMEM121 TFAP4 siRNA Brain BE(2)-C 0.12496 -3.00052 0.24861 0.51625 DataSet_01_295
TMEM121 PTEN shRNA Skin A431 1.53788 0.62094 0.44872 0.63304 DataSet_01_301
TMEM121 PTEN shRNA Mammary_gland SKBR3 1.77968 0.83162 0.28717 0.72106 DataSet_01_303
TMEM121 SOX9 siRNA Prostate VCaP 0.56158 -0.83243 0.02002 0.9316 DataSet_01_308
TMEM121 SOX9 siRNA Prostate VCaP 0.56158 -0.83243 0.02002 0.9316 DataSet_01_309
TMEM121 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 1.55923 0.64083 0.142 0.37197 DataSet_01_313
TMEM121 ELK3 shRNA Mammary_gland MDA-MB-231 1.74432 0.80267 0.00029 0.00131 DataSet_01_318
TMEM121 RBFOX2 shRNA Liver HepG2 2.84173 1.50677 0.19825 0.66758 DataSet_02_101
TMEM121 SAFB2 shRNA Liver HepG2 11.2308 3.48938 0.01354 0.04763 DataSet_02_102
TMEM121 FIP1L1 shRNA Liver HepG2 0.22298 -2.16498 0.04686 0.1047 DataSet_02_103
TMEM121 U2AF2 shRNA Liver HepG2 1.6962 0.76231 0.71214 0.80831 DataSet_02_105
TMEM121 TAF15 shRNA Liver HepG2 0.0995 -3.32912 0.03079 0.06203 DataSet_02_106
TMEM121 ZNF622 shRNA Liver HepG2 0.27941 -1.83954 0.00311 0.01396 DataSet_02_108
TMEM121 HNRNPUL1 shRNA Liver HepG2 3.38462 1.75899 0.26084 0.35524 DataSet_02_109
TMEM121 BCLAF1 shRNA Liver HepG2 4.04 2.01436 0.0318 0.09107 DataSet_02_112
TMEM121 XRCC5 shRNA Liver HepG2 0.27848 -1.84435 0.17389 0.36763 DataSet_02_114
TMEM121 PCBP1 shRNA Liver HepG2 1.78109 0.83276 0.03009 0.06546 DataSet_02_115
TMEM121 TARDBP shRNA Liver HepG2 0.49711 -1.00836 0.22938 0.32136 DataSet_02_116
TMEM121 SUB1 shRNA Liver HepG2 0.56962 -0.81193 0.63762 0.76957 DataSet_02_117
TMEM121 CEBPZ shRNA Liver HepG2 0.62093 -0.68751 0.00778 1 DataSet_02_118
TMEM121 RBM25 shRNA Liver HepG2 2.24378 1.16593 0.34077 0.44215 DataSet_02_119
TMEM121 PTBP1 shRNA Liver HepG2 1.99005 0.9928 0.0263 0.04632 DataSet_02_120
TMEM121 HNRNPLL shRNA Liver HepG2 0.44509 -1.16784 0.19652 0.27333 DataSet_02_125
TMEM121 SNRNP70 shRNA Liver HepG2 0.56647 -0.81992 0.23044 0.34401 DataSet_02_126
TMEM121 SRSF3 shRNA Liver HepG2 0.46243 -1.1127 0.17629 0.32482 DataSet_02_127
TMEM121 ZFX siRNA Prostate C4-2B 0.3252 -1.62059 8.43067e-05 0.00158 DataSet_02_172
TMEM121 MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.21612 1 DataSet_02_173
TMEM121 NFE2L2 siRNA Haematopoietic_and_lymphoid_tissue K562 4.2 2.07039 0.05279 1 DataSet_02_174
TMEM121 ZNF180 siRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.27776 1 DataSet_02_177
TMEM121 TBL1XR1 siRNA Haematopoietic_and_lymphoid_tissue K562 5 2.32193 0.67613 1 DataSet_02_178
TMEM121 VEZF1 siRNA Haematopoietic_and_lymphoid_tissue K562 5.8 2.53605 0.40288 1 DataSet_02_179
TMEM121 ATF3 siRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.66114 1 DataSet_02_180
TMEM121 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 2.25 1.16993 0.90955 1 DataSet_02_182
TMEM121 MAFK siRNA Haematopoietic_and_lymphoid_tissue K562 4.75 2.24793 0.97194 1 DataSet_02_183
TMEM121 CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.8 0.848 0.22316 1 DataSet_02_187
TMEM121 BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 6.25 2.64386 0.32542 1 DataSet_02_188
TMEM121 ARID3A siRNA Haematopoietic_and_lymphoid_tissue K562 2.4 1.26303 0.79697 1 DataSet_02_193
TMEM121 TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.24779 1 DataSet_02_194
TMEM121 LMNB1 siRNA Haematopoietic_and_lymphoid_tissue K562 12.5 3.64386 0.51917 1 DataSet_02_195
TMEM121 CHD2 siRNA Haematopoietic_and_lymphoid_tissue K562 1.75 0.80735 0.19439 0.31678 DataSet_02_196
TMEM121 E2F4 siRNA Haematopoietic_and_lymphoid_tissue K562 3.5 1.80735 0.84709 1 DataSet_02_200
TMEM121 BRCA1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.77778 1.47393 0.67809 1 DataSet_02_202
TMEM121 ZNF384 siRNA Haematopoietic_and_lymphoid_tissue K562 5.2 2.37851 0.42289 1 DataSet_02_203
TMEM121 RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 8 3 0.43492 1 DataSet_02_204
TMEM121 E2F6 siRNA Haematopoietic_and_lymphoid_tissue K562 3.25 1.70044 0.26554 1 DataSet_02_205
TMEM121 ZFX siRNA Mammary_gland MCF7 0.51349 -0.96159 0.0196 0.1243 DataSet_02_206
TMEM121 AR siRNA Prostate abl cells 0.353488 -1.50027 0.215514283881129 0.999852161656754 DataSet_03_004
TMEM121 AR siRNA Prostate LNCaP 1.65961 0.730846 0.668784691054144 1 DataSet_03_005
TMEM121 CEBPB siRNA Embryo hESC 0.595743 -0.747237 0.0645162457442318 0.40464104639382 DataSet_03_049
TMEM121 FOXF2 siRNA Mammary_gland MDA-MB-231 0.63089 -0.66454 - - DataSet_03_087
TMEM121 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 4.14842 2.05256 - - DataSet_03_096
TMEM121 GATA4 siRNA Stomach AGS 0.642464 -0.638313 0.354926984003077 0.889278530873529 DataSet_03_105
TMEM121 GATA4 siRNA Stomach YCC3 0.636884 -0.650898 0.0643219218715609 0.608729233820378 DataSet_03_107
TMEM121 GATA6 siRNA Stomach AGS 1.77606 0.828682 0.105177639165187 0.591436451862408 DataSet_03_108
TMEM121 GATA6 siRNA Stomach KatoIII 1.6779 0.746656 0.246782720234229 0.74661969919286 DataSet_03_109
TMEM121 GATA6 siRNA Stomach YCC3 0.596142 -0.746273 0.043163401763061 0.599938039267706 DataSet_03_110
TMEM121 HIC1 CRISPR Prostate PC3 1.96785 0.976617 - - DataSet_03_118
TMEM121 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 0.388487 -1.36406 0.146388927145601 0.999948959532916 DataSet_03_134
TMEM121 KLF5 siRNA Stomach AGS 0.660362 -0.59867 0.284127328750041 0.737125177538138 DataSet_03_149
TMEM121 KLF5 siRNA Stomach KatoIII 1.58078 0.660639 0.234738423464185 0.680854615606338 DataSet_03_150
TMEM121 MYC siRNA Colon HT29 1.83548 0.876161 - - DataSet_03_177
TMEM121 NR4A3 siRNA Pancreas 1.1B4 1.8424 0.88159 1.62350227016761e-05 0.000209371476977808 DataSet_03_203
TMEM121 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.571568 -0.807002 0.082168253482998 0.166557642250253 DataSet_03_211
TMEM121 PRRX1 CRISPR Neuroblastoma 691-MES 0.555323 -0.848601 0.498616677214941 0.93029070471583 DataSet_03_217
TMEM121 SOX11 siRNA Lung_fibroblast NHLF 0.556727 -0.844958 0.154306623106517 0.568093181345238 DataSet_03_237
TMEM121 SOX11 siRNA Lung_fibroblast NHLF 0.53163 -0.911507 0.00853636801541217 0.194079691413854 DataSet_03_238
TMEM121 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.596623 -0.745109 - - DataSet_03_246
TMEM121 SP1 siRNA Ovary OVSAYO 1.72989 0.790678 0.13373349124681 0.431905595851718 DataSet_03_251
TMEM121 STAT3 CRISPR Embryo hESC 2.04165 1.02974 0.0146724709739377 0.0741704691888433 DataSet_03_258
TMEM121 TFE3 siRNA Kidney UOK257-2 2.42447 1.27767 - - DataSet_03_275
TMEM121 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 139.656 7.12574 0.386060482908823 0.532772472172445 DataSet_04_014
TMEM121 E4F1 CRISPR Liver HepG2 0.313953 -1.67138 0.0486785534207923 0.303177989530464 DataSet_04_028
TMEM121 ERN1 CRISPR Liver HepG2 0.564885 -0.82397 0.0353354432267875 0.162673522510924 DataSet_04_029
TMEM121 NFX1 CRISPR Liver HepG2 0.285714 -1.80736 0.00829790433029045 0.0326019162333144 DataSet_04_032
TMEM121 SMAD4 CRISPR Liver HepG2 1.69091 0.757799 0.0847713697631398 0.215439344965125 DataSet_04_035
TMEM121 ACTN4 CRISPR Liver HepG2 0.204778 -2.28787 0.0376768343371962 0.109845559282202 DataSet_04_042
TMEM121 DDX20 CRISPR Liver HepG2 0.616794 -0.69714 0.0404007111593358 0.129842210697583 DataSet_04_043
TMEM121 PAN2 CRISPR Liver HepG2 1.69091 0.757799 0.063146104261051 0.169148484341085 DataSet_04_066
TMEM121 RIOK2 CRISPR Liver HepG2 0.571429 -0.807355 0.624777664373204 1 DataSet_04_070
TMEM121 SEPT11 CRISPR Liver HepG2 0.159016 -2.65275 0.000806690860737155 0.035320662711323 DataSet_04_068
TMEM121 CALR shRNA Liver HepG2 0.299296 -1.74036 0.0426308330197479 0.100154533469975 DataSet_04_053
TMEM121 CNOT7 shRNA Liver HepG2 0.44186 -1.17834 0.354883859275923 0.463469465594098 DataSet_04_051
TMEM121 DDX1 shRNA Liver HepG2 0.538462 -0.893085 0.39987903697152 0.635788225719709 DataSet_04_057
TMEM121 NPM1 shRNA Liver HepG2 0.347826 -1.52356 0.353173615976154 0.757162786560612 DataSet_04_058
TMEM121 YBX3 shRNA Liver HepG2 5.80769 2.53797 0.0167617889081222 0.0958620699275673 DataSet_02_98
TMEM121 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 4 2 0.75322833148921 0.867309401785622 DataSet_04_049
TMEM121 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.104167 -3.26303 0.0340455099632691 0.187192561395735 DataSet_02_38
TMEM121 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 5.11111 2.35364 0.082960364922362 0.4634167627885 DataSet_02_75
TMEM121 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.22917 1.1565 0.426765473174497 0.806696221696001 DataSet_02_45
TMEM121 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.5625 -0.830075 0.293178425247218 0.451362099021473 DataSet_02_47
TMEM121 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.153846 -2.70044 0.0763947376824557 0.464841605964485 DataSet_02_49
TMEM121 TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.182137203982719 0.345706475489559 DataSet_02_43
TMEM121 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.5625 -0.830075 0.231765621321662 0.373071844058532 DataSet_02_33
TMEM121 KDM5A shRNA Brain NCH644 1.62817 0.70325 7.878533e-05 0.246437943 DataSet_03_316
TMEM121 ELF3 CRISPR Bile_duct HBDEC2 3.11641 1.63989 1.816581e-04 1.817114e-03 DataSet_03_304
TMEM121 SNAI2 shRNA Pancreas KLM1 0.52386 -0.932746 1.010792e-02 0.16433532 DataSet_03_307
TMEM121 ZFX siRNA Prostate C4-2B 0.348536 -1.52062 3.332768e-06 7.741327e-05 DataSet_03_348
TMEM121 ZFX siRNA Mammary_gland MCF7 0.557738 -0.84234 3.618417e-04 7.478061e-03 DataSet_03_349
TMEM121 SKI CRISPR Blood HL60 0.340426 -1.55459 1.057736e-01 0.455952086 DataSet_03_351
TMEM121 TET1 CRISPR Mammary_gland Hs578T 0.352493 -1.50433 5.134080e-02 1.477084e-01 DataSet_03_355
TMEM121 CREBBP CRISPR Brain U5-NPC 2.71947 1.44332 0.3718308372 0.7490853 DataSet_03_356
TMEM121 PTPN14 CRISPR Brain U5-NPC 0.208424 -2.26241 1.458109e-03 0.16292674 DataSet_03_357
TMEM121 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 2.18837 1.12986 8.187079e-02 2.901274e-01 DataSet_03_359
TMEM121 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 0.475923 -1.0712 7.356290e-06 9.811516e-05 DataSet_03_362
TMEM121 MYC siRNA Peripheral_blood T lymphocyte 1.70888 0.773048 3.029473e-01 0.601723356 DataSet_03_363
TMEM121 TP53 knockout Stomach SNU1 0.64769 -0.626625 0.3982533428 0.9323630 DataSet_03_365
TMEM121 ZNF148 shRNA Mammary_gland MDA-MB-231 0.345091 -1.53495 1.286167e-02 0.081834450 DataSet_03_366
TMEM121 ABL1 shRNA Liver HuH7 0.616622 -0.697541 8.516146e-03 0.0268237911 DataSet_03_367
TMEM121 DNMT3A knockout Embryo_kidney HEK293T 0.60033 -0.736173 - - DataSet_03_369
TMEM121 ZFP36L1 siRNA Urinary_bladder J82 4.1 2.03562 - - DataSet_03_371
TMEM121 BHLHE40 shRNA Cervix HeLaS3 0.226891 -2.13993 2.313830e-01 0.84447131 DataSet_03_372
TMEM121 GLI1 siRNA Skeletal_muscle RMS13 0.198267 -2.33448 1.743099e-04 0.009286576 DataSet_03_375
TMEM121 NFKB2 siRNA Bone_marrow U2OS 0.615385 -0.70044 3.703002e-01 0.61000742 DataSet_03_381
TMEM121 TCF19 CRISPR Oral_squamous CAL27 5.75971 2.526 4.810644e-03 0.0476573120 DataSet_03_383
TMEM121 TRIM8 siRNA Mammary_gland MCF7 0.58831 -0.765351 4.980184e-04 0.0090609202 DataSet_03_388
TMEM121 NFKBIA shRNA Bone_marrow U2OS 0.176174 -2.50492 3.406459e-01 0.87005461 DataSet_03_389
TMEM121 JAZF1 siRNA Cervix HeLa Kyoto 1.63349 0.707954 4.855795e-01 0.871014933 DataSet_03_396
TMEM121 HMGA1 shRNA Bile_duct HUCCT1 2.44803 1.29162 9.140027e-02 0.332663791 DataSet_03_400
TMEM121 EHF shRNA Stomach MKN7 3.4708 1.79527 - - DataSet_03_402
TMEM121 TFAP2A knockout Embryo H9 2.54167 1.34577 1.640101e-03 0.03145781 DataSet_03_405
TMEM121 CHD1 shRNA Prostate LNCaP 1.72888 0.789838 1.155955e-01 6.390143e-01 DataSet_03_407
TMEM121 STRAP knockout Nerve SK-N-AS 2.24976 1.16978 - - DataSet_03_409
TMEM121 E2F1 siRNA Prostate LNCaP 0.548701 -0.865907 1.958013e-02 0.4026329797 DataSet_03_413
TMEM121 E2F2 siRNA Prostate LNCaP 0.613636 -0.704544 3.736546e-02 1.602306e-01 DataSet_03_414
TMEM121 ZKSCAN3 CRISPR Colon HCT116 1.95844 0.969706 4.680709e-02 0.417387863 DataSet_03_415
TMEM121 RUNX2 shRNA Cord_blood Natural Killer Cell 0.1875 -2.41504 6.162288e-01 0.873047677 DataSet_03_416
TMEM121 BRD4 CRISPR Lymph CD8+ T cells 0.590164 -0.760812 - - DataSet_03_420
TMEM121 MAEL CRISPR Liver Alexander cells 0.380165 -1.3953 - - DataSet_03_423
TMEM121 USP7 shRNA Skin xenograft cells 0.423436 -1.23978 0.25408601 0.4348960 DataSet_03_431
TMEM121 SUFU shRNA Mammary_gland HCC1954 cells 5.6 2.48543 0.0022481266 0.2904148 DataSet_03_437
TMEM121 CIC knockout Brain Immortalized Astrocyte Cells 0.373103 -1.42235 1.391811e-02 2.232177e-01 DataSet_03_438
TMEM121 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 2 1 1.597764e-01 0.90558273 DataSet_03_439
TMEM121 HMG20A siRNA Mammary_gland MDA-MB-231 2.14286 1.09954 0.0112466075 0.1695644 DataSet_03_442
TMEM121 PHF14 siRNA Mammary_gland MDA-MB-231 3.85714 1.94753 0.2337212461 0.5994811 DataSet_03_443
TMEM121 RELB CRISPR Colon SW480 2.50174 1.32293 5.046591e-04 1.507176e-02 DataSet_03_449
TMEM121 CBX2 siRNA Mammary_gland MDA-MB-231 0.40957 -1.28782 1.731475e-03 1.339160e-02 DataSet_03_450
TMEM121 CBX2 siRNA Mammary_gland MCF7 1.6463 0.719229 2.995780e-02 0.0721822617 DataSet_03_451
TMEM121 ZFP36L1 CRISPR Lung NCI-H1876 1.58881 0.667951 1.798740e-01 0.992381486 DataSet_03_454
TMEM121 SMARCA2 shRNA Lung HCC2302 0.631038 -0.664202 6.581751e-04 1.048116e-03 DataSet_03_455
TMEM121 TXNIP shRNA Cord_Blood CD34+ cells 1.65909 0.730393 - - DataSet_03_461
TMEM121 STAT3 shRNA Liver HepG2 2.10753 1.07555 3.332026e-02 0.2933802576 DataSet_03_465
TMEM121 SMARCA1 Cas13 Embryo_kidney HEK293T 0.538272 -0.893594 - - DataSet_03_466
TMEM121 SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 1.72346 0.785305 - - DataSet_03_467
TMEM121 EZH2 siRNA Umbilical_vein HUVEC 0.587156 -0.768184 9.385689e-03 0.136534204 DataSet_03_473
Regulation Region
 
T(co)Fs that significantly regulate RBM14 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of TMEM121
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines