Gene Overview
| Target Gene: | Alas2 |
| NCBI Official Symbol: | Alas2 |
| Entrez ID: | 11656 |
| Ensembl ID: | ENSMUSG00000025270 |
| Gene Full Name: | aminolevulinic acid synthase 2, erythroid |
| Strand: | + |
| Gene Locus: | X F3|X 68.46 cM |
| External Links: |
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Alas2 Significantly Regulated by These T(co)Fs
T(co)Fs
that Activate Alas2
T(co)Fs
that Repress Alas2
The Intensity of the Gene Regulated by T(co)Fs:
Alas2-T(co)F Pairs
| Target Gene |
T(co)F | Knock -Method |
Tissue Type | Biosample Name |
Fold Change |
Log2FC | P-value | Corrected _P |
Dataset ID |
|---|---|---|---|---|---|---|---|---|---|
| Alas2 | Ahr | knockout | Lung | Lung | 2.38172 | 1.252 | 0.356606602824836 | 0.999996968611848 | DataSet_11_003 |
| Alas2 | Bcl6 | knockout | Bone_marrow | Bone marrow-derived macrophages | 0.533333 | -0.906891 | 0.176818450434155 | 0.55727818285708 | DataSet_11_014 |
| Alas2 | Cbfb | knockdown | Peripheral_blood | Peripheral CD4+CD25hi cells | 1.86176 | 0.896667 | 0.191311065148827 | 0.98383223421716 | DataSet_11_017 |
| Alas2 | Cebpb | knockout | Mammary_gland | Mammary epithlial cells (MECs) | 0.418994 | -1.255 | 0.244451302103614 | 0.999788745984441 | DataSet_11_020 |
| Alas2 | Dmrt1 | knockout | Ovary | Ovary | 0.602335 | -0.731362 | 0.0856232641689642 | 0.336555866624729 | DataSet_11_030 |
| Alas2 | Dmrt1 | knockout | Ovary | Ovary | 0.602335 | -0.731362 | 0.0856232641689642 | 0.336555866624729 | DataSet_11_031 |
| Alas2 | Elf5 | knockout | Mammary_gland | Mammary gland | 2.93888 | 1.55527 | 0.0306267719201151 | 0.274281044105476 | DataSet_11_035 |
| Alas2 | Irf6 | knockout | Skin | Skin | 0.513802 | -0.960717 | 0.00599648866942857 | 0.108230720629416 | DataSet_11_062 |
| Alas2 | Lhx8 | knockout | Ovary | Ovary | 2.72535 | 1.44644 | 0.0318264073294416 | 0.104315978890637 | DataSet_11_070 |
| Alas2 | Mafg | knockout | Embryo | Whole embryo | 0.467066 | -1.0983 | 0.180738347494384 | 1 | DataSet_11_073 |
| Alas2 | Mbd2 | knockout | Lymph | GFP+ BM leukemia cells | 0.502852 | -0.991793 | 0.00118600657391166 | 0.0123426805566993 | DataSet_11_076 |
| Alas2 | Mkx | knockout | Tooth | PDL | 0.584063 | -0.775805 | 0.66216331691754 | 0.999970897748702 | DataSet_11_083 |
| Alas2 | Neurod1 | knockout | Eye | Pineal gland | 0.635997 | -0.652909 | 0.0797222369123148 | 0.450874521249639 | DataSet_11_087 |
| Alas2 | Neurod1 | knockout | Eye | Pineal gland | 0.615027 | -0.701277 | 0.149227160783583 | 0.9983937273602 | DataSet_11_089 |
| Alas2 | Nrf1 | knockdown | Liver | Liver | 1.85809 | 0.893821 | 0.0446793548338792 | 0.10950901761008 | DataSet_11_096 |
| Alas2 | Pitx2 | knockout | Eye | Cornea | 0.406363 | -1.29916 | 0.308740528065219 | 0.680110606452178 | DataSet_11_103 |
| Alas2 | Plagl2 | knockout | Intestine | Small intestine | 1.66112 | 0.732154 | 0.0914041609280867 | 0.354389772571993 | DataSet_11_104 |
| Alas2 | Prdm1 | knockout | Intestine | Mid-intestine | 1.58707 | 0.666365 | 6.77573553008752e-05 | 0.000409443642325895 | DataSet_11_106 |
| Alas2 | Rest | knockout | Brain | Brain | 1.56823 | 0.649134 | 0.507029286557122 | 1 | DataSet_11_113 |
| Alas2 | Runx1 | knockout | Mammary_gland | Luminal epithelial cells | 0.578593 | -0.78938 | 0.0159420356025547 | 0.999784944667092 | DataSet_11_117 |
| Alas2 | Sall4 | shRNA | Embryo | ES cells | 0.59375 | -0.752073 | 0.186593920555775 | 0.999840995136314 | DataSet_11_123 |
| Alas2 | Smad1 | knockout | Lung | Lung left lobe | 0.555714 | -0.847585 | 0.0859645787064116 | 0.542998753027287 | DataSet_11_126 |
| Alas2 | Smad4 | siRNA | Brain | bEnd3 | 6.89842 | 2.78627 | - | - | DataSet_11_127 |
| Alas2 | Snai1 | knockout | Embryo | Embryoid body | 0.0584166 | -4.09748 | - | - | DataSet_11_129 |
| Alas2 | Snai1 | knockout | Embryo | Embryonic stem cells (ESCs) | 0.541111 | -0.886004 | 0.173314366479777 | 0.999994003527217 | DataSet_11_132 |
| Alas2 | Sox11 | knockout | Eye | Retina | 2.44286 | 1.28857 | - | - | DataSet_11_137 |
| Alas2 | Spdef | knockout | Colon | Colon | 0.28921 | -1.78981 | 0.292730052230053 | 0.997507742354799 | DataSet_11_146 |
| Alas2 | Spdef | knockout | Stomach | Stomach | 0.606438 | -0.721569 | 0.250176556781728 | 0.89599660996714 | DataSet_11_147 |
| Alas2 | Srf | knockout | Aorta | Aorta | 1.73508 | 0.795 | 0.0421317068742883 | 0.993526315825099 | DataSet_11_148 |
| Alas2 | Stat3 | knockout | Lung | Lung typeII cells | 0.637887 | -0.648627 | 0.320522350993413 | 0.814921847249123 | DataSet_11_151 |
| Alas2 | Stat4 | knockout | Lymph | Lamina propria lymphocytes | 1.63607 | 0.71023 | 0.145545480126539 | 0.924261066168849 | DataSet_11_152 |
| Alas2 | Stat6 | knockout | Bone_marrow | Bone marrow-derived macrophages | 0.576557 | -0.794464 | 0.146698903085417 | 0.323792907193215 | DataSet_11_153 |
| Alas2 | Tsc22d4 | shRNA | Adipose_tissue | Abdominal fat | 1.75827 | 0.814152 | 0.242191198927535 | 0.730776401653086 | DataSet_11_170 |
| Alas2 | Tsc22d4 | shRNA | Adipose_tissue | Abdominal fat | 1.82685 | 0.869357 | 0.0320970887511313 | 0.339943531073952 | DataSet_11_171 |
| Alas2 | Vdr | knockout | Bone_marrow | Bone marrow-derived macrophages | 0.648193 | -0.625505 | 0.536156388539871 | 0.999827445128963 | DataSet_11_174 |
| Alas2 | Vdr | knockout | Skin | Skin | 0.572011 | -0.805885 | - | - | DataSet_11_176 |
| Alas2 | Wt1 | knockout | Oviduct | Oviduct | 0.664898 | -0.588795 | 0.863917511402156 | 0.984599454203641 | DataSet_11_180 |
| Alas2 | Yy1 | knockout | Muscle | Skeletal muscle | 0.618085 | -0.694124 | 0.00599850933809565 | 0.022458653318989 | DataSet_11_182 |
| Alas2 | Yy1 | knockout | White_adipose_tissue | Subcutaneous white adipose tissue | 1.51919 | 0.603306 | 0.0352100185309064 | 0.445326586875231 | DataSet_11_184 |
| Alas2 | Dnmt1 | siRNA | Pituitary_gland | AtT-20 | 1.87689 | 0.90834 | 2.093238e-01 | 0.9999923 | DataSet_11_187 |
| Alas2 | Cpeb1 | siRNA | Neuron | Neuro-2a | 4.22414 | 2.07866 | - | - | DataSet_11_189 |
| Alas2 | Mapk9 | knockout | Knee | Mouse total knee | 0.433182 | -1.20695 | 2.671749e-02 | 0.179828714 | DataSet_11_237 |
| Alas2 | Dnmt1 | shRNA | Embryo | Embryonic fibroblasts | 0.644526 | -0.633689 | - | - | DataSet_11_196 |
| Alas2 | Ezh2 | knockout | Bone_marrow | CD45.2+LSK cells | 1.874 | 0.906119 | - | - | DataSet_11_220 |
| Alas2 | Dnmt3a | siRNA | Peritoneum | peritoneal macrophages | 2.54728 | 1.34896 | - | - | DataSet_11_222 |
| Alas2 | Smarca4 | shRNA | Embryo | ES cells | 0.542011 | -0.883606 | - | - | DataSet_11_224 |
| Alas2 | Smarca4 | shRNA | Embryo | ES cells | 0.542011 | -0.883606 | - | - | DataSet_11_225 |
| Alas2 | Rag1 | knockout | Bone | Mice fractured callus | 0.0517834 | -4.27137 | 2.107998e-12 | 5.162208e-09 | DataSet_11_230 |
| Alas2 | Ncl | siRNA | Embryo | ES cells | 2 | 1 | 2.897784e-01 | 0.6109283876 | DataSet_11_240 |
| Alas2 | Dnmt3a | siRNA | Embryo | iPSC | 0.491451 | -1.02488 | - | - | DataSet_11_241 |
| Alas2 | Lin28a | knockout | Heart | Heart | 0.659776 | -0.599952 | 0.1025789966 | 0.8777652 | DataSet_11_243 |
| Alas2 | Twist1 | knockout | Bone_marrow | stromal cells | 4.61761 | 2.20715 | - | - | DataSet_11_244 |
| Alas2 | Kdm2a | CRISPR | Embryo | ES cells | 1.875 | 0.906891 | 0.0697488377 | 1.0000000 | DataSet_11_251 |
| Alas2 | Zbp1 | siRNA | Bone_marrow | bone marrow-derived mesenchymal stem_progenitor cells | 1.94243 | 0.957861 | 2.342430e-01 | 0.430407009 | DataSet_11_252 |
| Alas2 | Fubp1 | shRNA | Bone_marrow | BM cells | 2.83462 | 1.50315 | 1.707776e-03 | 0.141069053 | DataSet_11_262 |
| Alas2 | Bcl3 | knockout | Bone | Osteoblast | 0.565217 | -0.823122 | 6.491251e-02 | 7.008336e-01 | DataSet_11_263 |
| Alas2 | Nsd2 | knockout | Bone_marrow | Bone marrow immature B cells | 0.469514 | -1.09076 | 3.926010e-05 | 0.02477520 | DataSet_11_267 |
| Alas2 | Dux | knockout | Embryo | Embryo | 3.25533 | 1.70281 | 4.305660e-01 | 6.122658e-01 | DataSet_11_269 |
| Alas2 | Myc | CRISPR | Skeletal_muscle | muscle stem cells | 0.0149387 | -6.0648 | 9.123123e-01 | 1.00000000 | DataSet_11_272 |
| Alas2 | Dux | knockout | Embryo | Embryo | 3.25533 | 1.70281 | 4.305732e-01 | 6.122909e-01 | DataSet_11_273 |
| Alas2 | Lin28b | knockout | Bone_marrow | Bone marrow immature B cells | 0.125 | -3 | 2.266121e-01 | 0.9643594 | DataSet_11_274 |
| Alas2 | Myod1 | CRISPR | Skeletal_muscle | myoblast | 1.52455 | 0.60838 | 4.894813e-01 | 6.495634e-01 | DataSet_11_275 |
| Alas2 | Gsk3b | CRISPR | Neuron | mPFC D2 neurons | 0.612695 | -0.70676 | 6.105171e-01 | 0.90799148 | DataSet_11_277 |
| Alas2 | Dnmt1 | knockout | Cortex | mature Pvergic cortical interneurons | 1.78882 | 0.839008 | 3.383788e-02 | 0.6936949 | DataSet_11_283 |
| Alas2 | Setd2 | knockout | Kidney | primary renal tubular epithelial (RTE) cells | 0.62069 | -0.688056 | - | - | DataSet_11_285 |
| Alas2 | Irf8 | knockout | Brain | mice brain | 2.57118 | 1.36243 | 4.468965e-04 | 2.792240e-01 | DataSet_11_292 |
| Alas2 | Phf8 | knockout | prostate | Prostate | 0.461228 | -1.11645 | 0.0171502304 | 0.1692446 | DataSet_11_298 |
| Alas2 | Arid2 | knockout | Muscle | LSK | 5.54545 | 2.47131 | 6.904107e-06 | 1.549080e-03 | DataSet_11_301 |
| Alas2 | Esr1 | knockout | Liver | Liver | 1.85824 | 0.89394 | 7.406999e-03 | 1.0000000 | DataSet_11_307 |
| Alas2 | Myc | CRISPR | Skeletal_muscle | quiescent muscle stem cell | 0.23096 | -2.11429 | 4.495815e-03 | 0.12839644 | DataSet_11_310 |
| Alas2 | Suz12 | knockout | Lung | Alveolar macrophage | 6.29032 | 2.65313 | 7.616656e-01 | 0.9361406612 | DataSet_11_311 |
| Alas2 | Suz12 | knockout | Lung | Alveolar macrophage | 5.17647 | 2.37197 | 2.417609e-02 | 9.187807e-02 | DataSet_11_312 |
| Alas2 | Actl6a | knockout | Nerve | sciatic nerve | 3.73325 | 1.90043 | 1.256026e-02 | 0.159876399 | DataSet_11_314 |
| Alas2 | Satb2 | knockout | Colon | Intestine epithelium | 2.7 | 1.43296 | 6.064553e-01 | 0.7847958829 | DataSet_11_316 |
| Alas2 | Arid1b | knockout | Bone_marrow | bone marrow leukemia cells | 1.50943 | 0.594008 | 2.154727e-01 | 0.6105745618 | DataSet_11_317 |
| Alas2 | Arid2 | knockout | Bone_marrow | bone marrow leukemia cells | 1.97248 | 0.980008 | 5.493847e-01 | 0.8269554 | DataSet_11_318 |
| Alas2 | Gata2 | knockout | Brain | Pituitary gland | 3.42857 | 1.77761 | 0.176509863 | 0.9730581 | DataSet_11_322 |
| Alas2 | Setdb1 | shRNA | Neuron | NE-4C | 0.153639 | -2.70238 | - | - | DataSet_11_323 |
| Alas2 | Prmt1 | siRNA | Adipose_tissue | 3T3-L1 cells | 1.64474 | 0.717857 | 2.783439e-02 | 0.9832045 | DataSet_11_325 |
| Alas2 | Dnmt1 | knockout | Brain | Cortex | 0.568753 | -0.814125 | 3.191422e-02 | 0.2905609679 | DataSet_11_329 |
| Alas2 | Dnmt3a | knockout | Brain | Cortex | 1.80118 | 0.848944 | 2.665014e-01 | 0.8486878 | DataSet_11_330 |
| Alas2 | Ezh2 | shRNA | Brain | SVZ derived neural stem cells | 2.31944 | 1.21378 | 2.767407e-01 | 5.927129e-01 | DataSet_11_332 |
| Alas2 | Atrx | knockout | Embryo | ES cells | 0.5 | -1 | - | - | DataSet_11_335 |
| Alas2 | Dnmt3a | knockout | Peritoneum | peritoneal macrophages | 2.04974 | 1.03544 | - | - | DataSet_11_336 |
| Alas2 | Dnmt3a | siRNA | Heart | embryonic cardiomyocytes | 0.625 | -0.678072 | 1.579425e-01 | 0.69832724 | DataSet_11_337 |
| Alas2 | Gtf2ird1 | knockout | Lip | Lip | 0.618483 | -0.693193 | 7.638208e-02 | 4.412126e-01 | DataSet_11_339 |
| Alas2 | Hnrnpk | siRNA | Embryo | ES cells | 2.84349 | 1.50766 | 4.038492e-02 | 0.077536589 | DataSet_11_342 |
| Alas2 | Pcbp1 | shRNA | Thymus | Th1 | 0.6 | -0.736966 | 2.750851e-01 | 0.47636835 | DataSet_11_343 |
Regulation Region
Expression Atlas of Alas2