Gene Overview
Target Gene: DLK1
NCBI Official Symbol: DLK1
Entrez ID: 8788
Ensembl ID: ENSG00000185559
Gene Full Name: delta like non-canonical Notch ligand 1
Strand: +
Gene Locus: 14q32.2
External Links:

DLK1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate DLK1   
T(co)Fs that Repress DLK1
The Intensity of the Gene Regulated by T(co)Fs:
DLK1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
DLK1 IRF2 shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 1.52361 0.60749 0.00071 0.04617 DataSet_01_100
DLK1 IRF6 shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 2.39043 1.25727 0.00073 0.01597 DataSet_01_101
DLK1 MYB shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 3.86779 1.95151 6.62303e-07 9.69019e-06 DataSet_01_102
DLK1 FOXO1 shRNA Bone EWS-FLI1 1.79354 0.84281 0.00076 0.05049 DataSet_01_106
DLK1 HOXA1 siRNA Lung_fibroblast IMR-90 4.14672 2.05197 0.00042 0.02066 DataSet_01_110
DLK1 ZIC2 siRNA Pancreas PANC1 2.84787 1.50988 - - DataSet_01_121
DLK1 ZNF43 siRNA Gastrointestinal_tissue GIST-T1 0.53126 -0.91252 0.00012 0.00747 DataSet_01_125
DLK1 ZNF254 siRNA Gastrointestinal_tissue GIST-T1 0.63672 -0.65127 0.00137 0.01591 DataSet_01_127
DLK1 SOX4 shRNA Parotid_gland ACC3 0.66372 -0.59136 0.11067 0.94878 DataSet_01_140
DLK1 TP53 siRNA Lung SAECs 2.16957 1.11741 0.01598 0.28711 DataSet_01_175
DLK1 GABPA shRNA Prostate C4-2B 459.815 8.84491 0.23913 0.43934 DataSet_01_190
DLK1 GABPA shRNA Prostate LNCaP 287.495 8.16739 0.46324 0.7048 DataSet_01_191
DLK1 CREB1 shRNA Parotid_gland H3118 MEC 9.11989 3.18902 0.14656 0.49696 DataSet_01_194
DLK1 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.13951 -2.84154 - - DataSet_01_196
DLK1 TP63 siRNA Head_and_neck SCC-1 0.16978 -2.55829 - - DataSet_01_198
DLK1 TP63 siRNA Head_and_neck SCC-1 0.31546 -1.66447 - - DataSet_01_199
DLK1 TP63 siRNA Head_and_neck SCC-6 1.62047 0.69641 - - DataSet_01_202
DLK1 ATF2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.31186 -1.68105 0.7265 0.98822 DataSet_01_206
DLK1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.42722 -1.22693 - - DataSet_01_209
DLK1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.28673 -1.80224 - - DataSet_01_210
DLK1 LIN28A siRNA Embryo H9 2.55738 1.35467 0.00737 0.04114 DataSet_01_215
DLK1 IRX1 shRNA Bone_marrow 143B 0.58304 -0.77833 0.11306 0.34388 DataSet_01_227
DLK1 STAT5 shRNA Haematopoietic_and_lymphoid_tissue K562 0.3267 -1.61397 1.18865e-05 0.00052 DataSet_01_239
DLK1 SMAD3 siRNA Liver Hep3B 1.9504 0.96377 - - DataSet_01_249
DLK1 TFAP4 siRNA Brain BE(2)-C 0.19023 -2.39416 0.32528 0.51625 DataSet_01_295
DLK1 PTEN shRNA Skin A431 2.04816 1.03433 0.11738 0.28897 DataSet_01_301
DLK1 SOX9 siRNA Prostate VCaP 0.53401 -0.90505 0.10177 0.9316 DataSet_01_308
DLK1 SOX9 siRNA Prostate VCaP 0.53401 -0.90505 0.10177 0.9316 DataSet_01_309
DLK1 HOXC6 siRNA Prostate LNCaP 0.5727 -0.80415 0.11512 0.99927 DataSet_01_333
DLK1 RBFOX2 shRNA Liver HepG2 1.65149 0.72377 0.30377 0.70852 DataSet_02_101
DLK1 FIP1L1 shRNA Liver HepG2 0.39675 -1.3337 0.00104 0.01449 DataSet_02_103
DLK1 HDGF shRNA Liver HepG2 2.02867 1.02053 0.00089 0.06383 DataSet_02_104
DLK1 HNRNPUL1 shRNA Liver HepG2 1.67983 0.74832 0.00175 0.02256 DataSet_02_109
DLK1 BCLAF1 shRNA Liver HepG2 2.2205 1.15088 0.00324 0.03057 DataSet_02_112
DLK1 XRCC5 shRNA Liver HepG2 0.62254 -0.68376 0.06222 0.22802 DataSet_02_114
DLK1 TARDBP shRNA Liver HepG2 2.61222 1.38528 0.00755 0.03216 DataSet_02_116
DLK1 SUB1 shRNA Liver HepG2 1.83594 0.87652 0.03621 0.18051 DataSet_02_117
DLK1 PTBP1 shRNA Liver HepG2 0.66647 -0.58539 0.00279 0.01068 DataSet_02_120
DLK1 PCBP2 shRNA Liver HepG2 0.63963 -0.64469 0.07606 0.20408 DataSet_02_123
DLK1 FUS shRNA Liver HepG2 0.55092 -0.86009 0.03547 0.14804 DataSet_02_124
DLK1 HNRNPLL shRNA Liver HepG2 2.78695 1.47869 0.0056 0.02442 DataSet_02_125
DLK1 SNRNP70 shRNA Liver HepG2 3.12387 1.64334 0.00377 0.03775 DataSet_02_126
DLK1 POLR2G shRNA Haematopoietic_and_lymphoid_tissue K562 0.63224 -0.66146 0.11059 0.72262 DataSet_02_130
DLK1 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.16875 -2.56705 7.8727e-05 0.02779 DataSet_02_131
DLK1 AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.50492 -0.98589 0.01402 0.1151 DataSet_02_132
DLK1 PCBP2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.55803 -0.84159 0.00445 0.0838 DataSet_02_135
DLK1 HNRNPK shRNA Haematopoietic_and_lymphoid_tissue K562 0.49557 -1.01284 0.00404 0.14525 DataSet_02_136
DLK1 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.42055 -1.24964 0.00647 0.14248 DataSet_02_140
DLK1 BCLAF1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.82943 0.8714 0.0015 0.08659 DataSet_02_142
DLK1 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.60947 -0.71437 0.02099 0.20927 DataSet_02_144
DLK1 ILF3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.41681 -1.26255 0.01171 0.24721 DataSet_02_148
DLK1 NONO shRNA Haematopoietic_and_lymphoid_tissue K562 2.10188 1.07168 0.00695 0.19424 DataSet_02_149
DLK1 RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 1.75345 0.81019 0.01587 0.23644 DataSet_02_151
DLK1 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.43808 -1.19074 0.01811 0.26498 DataSet_02_152
DLK1 FUS shRNA Haematopoietic_and_lymphoid_tissue K562 0.62549 -0.67693 0.03367 0.24616 DataSet_02_155
DLK1 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 1.6052 0.68276 0.02383 0.14655 DataSet_02_160
DLK1 AGO1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.5517 0.63385 0.03365 0.53443 DataSet_02_162
DLK1 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.39045 -1.3568 0.06205 0.29827 DataSet_02_163
DLK1 RBM22 shRNA Haematopoietic_and_lymphoid_tissue K562 1.64002 0.71371 0.00482 0.06105 DataSet_02_168
DLK1 U2AF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.55178 -0.85784 0.02443 0.09337 DataSet_02_170
DLK1 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.37708 -1.40708 0.01324 0.20625 DataSet_02_171
DLK1 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 0.24366 -2.03703 0.60811 1 DataSet_02_190
DLK1 AR siRNA Prostate abl cells 0.648438 -0.624961 0.251931236892389 0.999852161656754 DataSet_03_004
DLK1 ARID2 CRISPR Liver JHH4 1.73259 0.79293 0.706899786144313 1 DataSet_03_015
DLK1 ASCL1 siRNA Lung DMS79 0.368506 -1.44024 0.0315441521528916 0.633088021008633 DataSet_03_016
DLK1 CEBPB siRNA Embryo hESC 0.567814 -0.81651 0.420673096560295 0.753225744240664 DataSet_03_049
DLK1 GATA2 siRNA Uterus Decidual stromal cells 0.578512 -0.789581 0.0986830460603319 0.733930605781923 DataSet_03_100
DLK1 GATA4 siRNA Stomach YCC3 1.99134 0.993741 0.192917263202437 0.7257858468813 DataSet_03_107
DLK1 GATA6 siRNA Stomach AGS 2.36956 1.24462 0.0127142423910494 0.326556605216575 DataSet_03_108
DLK1 HIC1 CRISPR Prostate PC3 0.624395 -0.679469 - - DataSet_03_118
DLK1 KLF5 siRNA Stomach YCC3 2.60518 1.38138 0.00166903568523408 0.0701933774092467 DataSet_03_151
DLK1 MEF2D shRNA Liver HuH7 1.53831 0.621346 - - DataSet_03_162
DLK1 MEF2D siRNA Liver HuH7 0.432429 -1.20947 - - DataSet_03_163
DLK1 MITF siRNA Skin SK-MEL-5 0.631052 -0.66417 0.00406883327053292 0.0103214056175248 DataSet_03_168
DLK1 MYB siRNA Cord_Blood CD34+ progenitor cells 9.70041 3.27805 - - DataSet_03_170
DLK1 MYC siRNA Central_nervous_system DAOY M2.1 2.13263 1.09263 2.99788773434837e-06 1.88625167304758e-05 DataSet_03_178
DLK1 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.57214 -0.80556 0.00101258012425748 0.00568717797828454 DataSet_03_211
DLK1 SOX2 siRNA Embryo NTera-2 1.51345 0.597837 0.000353184638833558 0.0166447197908584 DataSet_03_243
DLK1 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 3.88889 1.95936 - - DataSet_03_246
DLK1 STAT6 siRNA Umbilical_vein HUVEC 1.79679 0.845423 0.210802455658868 0.852472382725311 DataSet_03_264
DLK1 TFAP2C siRNA Mammary_gland MCF7 1.87233 0.904837 0.189053560807933 0.540859800341884 DataSet_03_274
DLK1 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 0.0875417 -3.51389 0.00402098842013861 0.0281108236577543 DataSet_04_014
DLK1 ZNF574 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.464511 -1.10622 0.0219847001433094 0.129416639473374 DataSet_04_023
DLK1 NFX1 CRISPR Liver HepG2 0.597073 -0.74402 0.00386063345464414 0.0217432735850461 DataSet_04_032
DLK1 SMAD4 CRISPR Liver HepG2 0.602195 -0.731697 0.0014765151188551 0.0603611303910653 DataSet_04_035
DLK1 ZC3H8 shRNA Liver HepG2 2.21669 1.14841 0.00148417922956511 0.0720563168555107 DataSet_04_040
DLK1 ACTN4 CRISPR Liver HepG2 0.611872 -0.708698 0.0223745767560162 0.0834131312609844 DataSet_04_042
DLK1 PAN2 CRISPR Liver HepG2 0.602195 -0.731697 0.000211656340826011 0.016906233304564 DataSet_04_066
DLK1 ABT1 shRNA Liver HepG2 5.89194 2.55874 2.62511103161774e-05 0.00143333137512915 DataSet_04_052
DLK1 SMG5 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.654084 -0.612452 0.0602105466514261 0.486224109303412 DataSet_04_073
DLK1 SMG7 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.558787 -0.839629 0.0375048730314553 0.379819144629671 DataSet_04_075
DLK1 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.520421 -0.942249 0.00485629857321893 0.0292863323826216 DataSet_04_049
DLK1 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.564341 -0.825361 0.000397227538122918 0.119535699006184 DataSet_02_38
DLK1 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.460182 -1.11972 0.000320083364000149 0.00746438619291309 DataSet_02_14
DLK1 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.406772 -1.29771 3.93465162817605e-05 0.0104279029636139 DataSet_02_34
DLK1 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.369464 -1.4365 0.00202028036218917 0.365641857769697 DataSet_02_45
DLK1 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.428939 -1.22115 4.57259463060668e-05 0.0125682918939438 DataSet_02_35
DLK1 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.253982 -1.9772 0.00117134068640451 0.153070434855377 DataSet_02_32
DLK1 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.445739 -1.16573 6.05767101746837e-05 0.00993467045008745 DataSet_02_47
DLK1 TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.557708 -0.842417 0.000193239485076464 0.018946119864423 DataSet_02_43
DLK1 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.467819 -1.09598 0.000777687180328263 0.00906145311406845 DataSet_02_33
DLK1 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.561592 -0.832406 0.000137566116549809 0.0304078981610271 DataSet_02_53
DLK1 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.60798 0.685246 0.0234385661083304 0.0838097030949306 DataSet_04_060
DLK1 CCAR1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.54932 0.631633 0.0138945453587635 0.0780686969391611 DataSet_04_064
DLK1 CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 0.240445 -2.05622 4.37992624904576e-05 0.0320010022551457 DataSet_04_061
DLK1 PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 0.59602 -0.746566 0.0409532119642641 0.336719745667096 DataSet_04_065
DLK1 KDM5A shRNA Brain NCH644 1.50538 0.590125 7.518148e-02 0.543710922 DataSet_03_316
DLK1 ELF3 CRISPR Bile_duct HBDEC2 0.616483 -0.697867 3.474870e-05 6.379984e-04 DataSet_03_304
DLK1 ESR1 siRNA Mammary_gland MCF7 0.191575 -2.38402 1.262438e-02 0.0790903401 DataSet_03_352
DLK1 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 0.581629 -0.781828 9.545746e-02 3.080247e-01 DataSet_03_359
DLK1 DNMT3A knockout Embryo_kidney HEK293T 0.10863 -3.2025 - - DataSet_03_369
DLK1 E2F1 siRNA Nasopharynx HK1 0.5 -1 3.571404e-01 9.722824e-01 DataSet_03_373
DLK1 GLI1 siRNA Skeletal_muscle RMS13 0.519134 -0.94582 1.369240e-02 0.090126864 DataSet_03_375
DLK1 ZNF213 siRNA Mammary_gland MCF7 2.72097 1.44412 1.177571e-03 3.710346e-02 DataSet_03_376
DLK1 SMARCA2 shRNA Lung NCI-H1944 0.428571 -1.22239 3.020567e-01 6.547888e-01 DataSet_03_377
DLK1 YY1 shRNA Brain GSC1517 0.107143 -3.22239 - - DataSet_03_384
DLK1 TRIM8 siRNA Mammary_gland MCF7 0.325 -1.62149 7.699300e-02 0.2110441510 DataSet_03_388
DLK1 YY1 knockdown Liver HepG2 0.407056 -1.2967 1.385281e-08 3.936506e-07 DataSet_03_390
DLK1 KDM5A CRISPR Lung GLC16 0.51378 -0.960777 7.312089e-02 0.159726955 DataSet_03_392
DLK1 ASXL1 CRISPR Embryo iPSC 5.09769 2.34984 0.0069444633 0.8024343 DataSet_03_394
DLK1 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 3 1.58496 6.427975e-01 0.7479663 DataSet_03_403
DLK1 CDK7 shRNA Bone_marrow D458 2.8125 1.49185 6.668978e-02 0.34664727 DataSet_03_404
DLK1 TFAP2A knockout Embryo H9 0.316281 -1.66072 3.805986e-04 0.02020034 DataSet_03_405
DLK1 SIRT1 siRNA Pancreas PANC1 2 1 7.116235e-01 0.810503864 DataSet_03_410
DLK1 USP22 shRNA Liver HuH7 0.286842 -1.80167 - - DataSet_03_411
DLK1 ZKSCAN3 CRISPR Colon HCT116 5 2.32193 2.996320e-02 0.348352270 DataSet_03_415
DLK1 USP7 shRNA Skin xenograft cells 0.551613 -0.858272 0.49654104 0.6232835 DataSet_03_431
DLK1 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 7.04206 2.816 9.103470e-04 0.19183308 DataSet_03_439
DLK1 CBX2 siRNA Mammary_gland MDA-MB-231 1.67208 0.741643 4.830578e-01 6.974089e-01 DataSet_03_450
DLK1 CBX2 siRNA Mammary_gland MCF7 1.70564 0.770311 5.270333e-01 0.6906401388 DataSet_03_451
DLK1 OGT siRNA Embryo BeWo cells 0.0769231 -3.70044 2.583114e-01 0.66237450 DataSet_03_453
DLK1 ZFP36L1 CRISPR Lung NCI-H1876 0.385565 -1.37495 3.107417e-01 0.992381486 DataSet_03_454
DLK1 SMARCA2 shRNA Lung HCC2302 0.115546 -3.11346 5.783036e-07 1.618683e-06 DataSet_03_455
DLK1 ARID1A shRNA Bile_duct MMNK1 0.498251 -1.00505 6.094703e-01 0.780892330 DataSet_03_458
DLK1 HAND1 siRNA Placenta HPMVEC 0.513253 -0.962258 1.593665e-01 0.9463341 DataSet_03_459
DLK1 TXNIP shRNA Cord_blood ST3 0.0487805 -4.35755 3.286269e-03 0.0984853801 DataSet_03_462
DLK1 SOX9 knockout Liver HuH7 2.72727 1.44746 2.874989e-04 4.116960e-03 DataSet_03_463
DLK1 PARP1 knockout Embryo_kidney HEK293a 0.423841 -1.2384 4.084652e-02 1.000809e-01 DataSet_03_464
Regulation Region
 
T(co)Fs that significantly regulate OGT by the evidences of both expression and ChIP-seq/motif
Expression Atlas of DLK1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines