Gene Overview
Target Gene: FXYD4
NCBI Official Symbol: FXYD4
Entrez ID: 53828
Ensembl ID: ENSG00000150201
Gene Full Name: FXYD domain containing ion transport regulator 4
Strand: +
Gene Locus: 10q11.21
External Links:

FXYD4 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate FXYD4   
T(co)Fs that Repress FXYD4
The Intensity of the Gene Regulated by T(co)Fs:
FXYD4-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
FXYD4 ID1 siRNA Lung A549 0.44536 -1.16696 0.56058 0.73973 DataSet_01_117
FXYD4 ID1 siRNA Lung H1650 1.61662 0.69298 0.04341 0.36866 DataSet_01_118
FXYD4 GATA3 siRNA Mammary_gland MCF7 0.5142 -0.9596 6.3214e-07 0.00011 DataSet_01_120
FXYD4 FOXM1 siRNA Central_nervous_system U87 5.66689 2.50256 - - DataSet_01_122
FXYD4 POLR3A siRNA Mammary_gland MCF7 3.30333 1.72392 - - DataSet_01_139
FXYD4 TFAP2C shRNA Mammary_gland MCF7 0.13504 -2.88849 3.51584e-17 9.23991e-15 DataSet_01_150
FXYD4 HSF1 shRNA Skin A375 0.44813 -1.158 0.28207 0.54673 DataSet_01_155
FXYD4 TP63 shRNA Bladder UC14 5.97698 2.57942 1.07091e-10 2.87805e-07 DataSet_01_183
FXYD4 GATA2 siRNA Prostate LNCaP 1.66063 0.73173 0.35513 0.4841 DataSet_01_193
FXYD4 CREB1 shRNA Parotid_gland H3118 MEC 0.56494 -0.82383 0.73189 0.8963 DataSet_01_194
FXYD4 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.63196 -0.6621 - - DataSet_01_197
FXYD4 TP63 siRNA Head_and_neck SCC-012 0.34719 -1.5262 - - DataSet_01_201
FXYD4 TP63 siRNA Head_and_neck SCC-6 1.55806 0.63975 - - DataSet_01_202
FXYD4 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.44245 -1.17642 - - DataSet_01_209
FXYD4 LIN28A siRNA Embryo H9 0.22705 -2.13895 0.00013 0.00353 DataSet_01_215
FXYD4 IRX1 shRNA Bone_marrow 143B 0.54089 -0.8866 0.0567 0.24607 DataSet_01_227
FXYD4 POSTN shRNA Brain GSC272 1.58325 0.66289 0.27221 0.63454 DataSet_01_293
FXYD4 TFAP4 siRNA Brain BE(2)-C 0.17739 -2.49499 0.32621 0.51625 DataSet_01_295
FXYD4 PTEN shRNA Skin A431 2.01273 1.00915 0.73245 0.84998 DataSet_01_301
FXYD4 PTEN shRNA Mammary_gland SKBR3 2.39441 1.25967 0.26957 0.71209 DataSet_01_303
FXYD4 SOX9 siRNA Prostate VCaP 6.4375 2.6865 0.03297 0.9316 DataSet_01_308
FXYD4 SOX9 siRNA Prostate VCaP 6.4375 2.6865 0.03297 0.9316 DataSet_01_309
FXYD4 ELK1 siRNA Mammary_gland MDA-MB-231 0.64111 -0.64137 - - DataSet_01_354
FXYD4 PAX3 shRNA Soft_tissue Rh30 1.59098 0.66991 - - DataSet_01_359
FXYD4 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 0.6 -0.73697 0.5019 0.58075 DataSet_02_143
FXYD4 ZFX siRNA Prostate C4-2B 1.625 0.70044 0.65196 0.74382 DataSet_02_172
FXYD4 LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 0.47541 -1.07276 0.86394 1 DataSet_02_175
FXYD4 CEBPZ siRNA Haematopoietic_and_lymphoid_tissue K562 2.4 1.26303 0.14979 1 DataSet_02_176
FXYD4 ZNF180 siRNA Haematopoietic_and_lymphoid_tissue K562 0.51852 -0.94753 0.7256 1 DataSet_02_177
FXYD4 VEZF1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.34821 -1.52195 0.11379 1 DataSet_02_179
FXYD4 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 0.57391 -0.8011 0.98197 1 DataSet_02_182
FXYD4 MAFK siRNA Haematopoietic_and_lymphoid_tissue K562 1.7 0.76553 0.25947 1 DataSet_02_183
FXYD4 BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.14023 1 DataSet_02_188
FXYD4 MAFG siRNA Haematopoietic_and_lymphoid_tissue K562 2.1 1.07039 0.16319 1 DataSet_02_189
FXYD4 LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.29508 -1.76081 0.52722 1 DataSet_02_191
FXYD4 MAX siRNA Haematopoietic_and_lymphoid_tissue K562 11.6 3.53605 0.01294 1 DataSet_02_192
FXYD4 TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.04918 -4.34577 0.24917 1 DataSet_02_194
FXYD4 CDAN1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.1348 1 DataSet_02_197
FXYD4 TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.36607 -1.4498 0.15866 1 DataSet_02_201
FXYD4 RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.12359 1 DataSet_02_204
FXYD4 E2F6 siRNA Haematopoietic_and_lymphoid_tissue K562 7.7 2.94486 0.03317 1 DataSet_02_205
FXYD4 AR siRNA Prostate LNCaP 0.284615 -1.81291 0.0251513292464993 1 DataSet_03_005
FXYD4 ASCL1 siRNA Lung DMS79 2.31818 1.21299 0.467631141114954 0.905404406577785 DataSet_03_016
FXYD4 FOXA1 siRNA Mammary_gland MCF7 3.43615 1.78079 1.8437162067681e-10 3.19829450388063e-07 DataSet_03_080
FXYD4 FOXA1 siRNA Mammary_gland MCF7 6.13478 2.61701 5.87207163360326e-19 4.0637084533188e-15 DataSet_03_081
FXYD4 FOXA1 siRNA Mammary_gland MCF7 6.13478 2.61701 5.87207163360326e-19 4.0637084533188e-15 DataSet_03_082
FXYD4 GATA2 siRNA Uterus Decidual stromal cells 0.380031 -1.39581 0.18231879633994 0.797392047110114 DataSet_03_100
FXYD4 GATA4 siRNA Stomach KatoIII 0.538157 -0.893901 0.219606812175315 0.914759953395016 DataSet_03_106
FXYD4 HNF4a siRNA Liver HepG2 4.53333 2.18057 0.165009121263111 0.779761191037938 DataSet_03_126
FXYD4 KDM3A siRNA Mammary_gland MCF7 0.666284 -0.585792 3.04471100184105e-05 0.00210006368783048 DataSet_03_146
FXYD4 KLF5 siRNA Colon SW480 0.56686 -0.818935 3.88185463535256e-05 0.0116155677566027 DataSet_03_148
FXYD4 KLF5 siRNA Stomach AGS 0.502873 -0.991734 0.0647615575877027 0.524780919415876 DataSet_03_149
FXYD4 KLF5 siRNA Stomach YCC3 0.599002 -0.739368 0.313334952414614 0.670766833859195 DataSet_03_151
FXYD4 MAF siRNA Lymph Lymphatic endothelial cells 0.651947 -0.617173 0.0159265258628453 0.816720674716982 DataSet_03_154
FXYD4 MEF2D siRNA Liver HuH7 0.371276 -1.42944 - - DataSet_03_163
FXYD4 MITF siRNA Skin SK-MEL-5 0.632633 -0.660559 0.0036429273316196 0.00945512677879679 DataSet_03_168
FXYD4 MTA2 siRNA Stomach SGC-7901 2.5034 1.32389 - - DataSet_03_169
FXYD4 MYC siRNA Colon HT29 21.5005 4.4263 - - DataSet_03_177
FXYD4 NCOR2 siRNA Mammary_gland MCF7 1.57138 0.65203 0.0281099843521898 0.999834929103349 DataSet_03_193
FXYD4 PBX1 siRNA Mammary_gland MCF7 0.57343 -0.802311 9.01548337433907e-05 0.2835943233808 DataSet_03_207
FXYD4 PBX1 siRNA Mammary_gland LTED 0.553058 -0.854498 0.000448649697901738 0.823349561355777 DataSet_03_208
FXYD4 PBX1 siRNA Mammary_gland MCF7 0.508781 -0.974884 7.46855280072422e-08 0.000172284576007106 DataSet_03_209
FXYD4 PRRX1 CRISPR Neuroblastoma 691-MES 1.54949 0.631797 0.24512996597894 0.896430549168743 DataSet_03_217
FXYD4 STAT3 CRISPR Embryo hESC 1.71338 0.776843 0.0276685889377196 0.0952829640258273 DataSet_03_258
FXYD4 STAT6 siRNA Umbilical_vein HUVEC 6.63158 2.72935 0.12679083282755 0.815789969199665 DataSet_03_264
FXYD4 TFAP2C siRNA Mammary_gland MCF7 2.77133 1.47058 0.0206813347303097 0.313736102282461 DataSet_03_274
FXYD4 TFE3 siRNA Kidney UOK257-2 0.589022 -0.763607 - - DataSet_03_275
FXYD4 RPS3 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.47368 1.30666 0.260048962626618 0.652516964233458 DataSet_04_017
FXYD4 SMAD5 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.58824 0.667425 0.53280919315087 0.776735129105939 DataSet_04_020
FXYD4 ACTN4 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.661538 -0.596103 0.47812871294673 0.682265139547566 DataSet_04_048
FXYD4 NPM1 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.2069 1.14202 0.147222515821324 0.313663297979939 DataSet_04_046
FXYD4 RIOK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.53333 1.34104 0.256344957471537 0.739715842617935 DataSet_04_076
FXYD4 SMG7 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.387755 -1.36678 0.20359560584145 0.556673667287025 DataSet_04_075
FXYD4 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.471698 -1.08406 0.294460099756006 0.557387452324265 DataSet_02_38
FXYD4 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.396226 -1.3356 0.103522665477015 0.207335939431827 DataSet_02_14
FXYD4 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.358491 -1.47999 0.176162328453563 0.326099844257081 DataSet_02_34
FXYD4 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.122642 -3.02748 0.0481116870149938 0.371881564709573 DataSet_02_32
FXYD4 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.396226 -1.3356 0.195333414929843 0.350847075876893 DataSet_02_53
FXYD4 SNAI2 shRNA Pancreas pancreatic cancer stem cells 0.632871 -0.660016 6.527105e-01 0.8607144 DataSet_03_306
FXYD4 SNAI2 shRNA Pancreas KLM1 0.43207 -1.21066 9.102433e-02 0.39602809 DataSet_03_307
FXYD4 PBX1 siRNA Mammary_gland MCF7 0.508781 -0.974884 1.002272e-07 2.093680e-04 DataSet_03_326
FXYD4 BRCA1 siRNA Mammary_gland MCF7 0.660526 -0.598313 4.002186e-01 0.9999931 DataSet_03_308
FXYD4 EZH2 shRNA Mammary_gland MCF7 1.54461 0.62724 3.223022e-02 2.652072e-01 DataSet_03_331
FXYD4 ETV5 knockdown Colon HT29 0.235294 -2.08746 2.678056e-02 0.188109471 DataSet_03_353
FXYD4 E2F1 siRNA Nasopharynx HK1 0.3 -1.73697 3.571404e-01 9.722824e-01 DataSet_03_373
FXYD4 SMARCA2 shRNA Lung NCI-H1944 0.610169 -0.712718 1.590232e-01 5.496809e-01 DataSet_03_377
FXYD4 ZBTB7A siRNA Stomach BGC823 2.1663 1.11523 - - DataSet_03_380
FXYD4 ILF2 siRNA Stomach SGC-7901 2.5 1.32193 0.7098309439 0.78197948 DataSet_03_393
FXYD4 CDK7 shRNA Bone_marrow D458 2 1 4.913884e-01 0.72090577 DataSet_03_404
FXYD4 TFAP2A knockout Embryo H9 0.5 -1 6.758596e-01 0.76331870 DataSet_03_405
FXYD4 SIRT1 siRNA Pancreas PANC1 2.13333 1.09311 5.883266e-01 0.725366147 DataSet_03_410
FXYD4 ZKSCAN3 CRISPR Colon HCT116 8.26316 3.04669 4.573344e-02 0.415288257 DataSet_03_415
FXYD4 FOXQ1 CRISPR Lymph Primary CD4+ T cells 0.333333 -1.58496 - - DataSet_03_422
FXYD4 FOXP3 CRISPR Peripheral_blood Naive Treg 1.6 0.678072 4.214654e-01 0.730375551 DataSet_03_427
FXYD4 EP300 knockout Pancreas HPAF-II orthotopic cells 0.628492 -0.670035 8.150665e-01 8.979718e-01 DataSet_03_436
FXYD4 CIC knockout Brain Immortalized Astrocyte Cells 0.642857 -0.63743 2.691413e-01 7.174618e-01 DataSet_03_438
FXYD4 PARP1 knockout Embryo_kidney HEK293a 3 1.58496 4.707577e-01 5.804848e-01 DataSet_03_464
FXYD4 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 2.13333 1.09311 0.3737511 0.7862139 DataSet_04_072
FXYD4 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 0.142857 -2.80735 0.3096695 0.469436764 DataSet_04_074
Regulation Region
 
T(co)Fs that significantly regulate PBX1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of FXYD4
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines