Gene Overview
Target Gene: MMP7
NCBI Official Symbol: MMP7
Entrez ID: 4316
Ensembl ID: ENSG00000137673
Gene Full Name: matrix metallopeptidase 7
Strand: -
Gene Locus: 11q22.2
External Links:

MMP7 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate MMP7   
T(co)Fs that Repress MMP7
The Intensity of the Gene Regulated by T(co)Fs:
MMP7-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
MMP7 HNF1B shRNA Ovary RMG2 0.56298 -0.82883 1.97754e-10 1.06834e-08 DataSet_01_103
MMP7 FOXA1 siRNA Prostate LNCaP 4.10053 2.03581 - - DataSet_01_104
MMP7 TCF3 shRNA Mammary_gland MDA-MB468 0.46463 -1.10584 0.00051 0.00751 DataSet_01_116
MMP7 ID1 siRNA Lung A549 2.83187 1.50176 7e-04 0.08908 DataSet_01_117
MMP7 ZIC2 siRNA Pancreas PANC1 0.61517 -0.70094 - - DataSet_01_121
MMP7 FOXM1 siRNA Central_nervous_system U87 1.70804 0.77234 - - DataSet_01_122
MMP7 ZNF431 siRNA Gastrointestinal_tissue GIST-T1 1.51408 0.59845 0.00049 0.00526 DataSet_01_128
MMP7 SOX4 shRNA Parotid_gland ACC3 0.63463 -0.65601 0.03222 0.94635 DataSet_01_140
MMP7 TAL1 shRNA Umbilical_cord_blood ECFCs 0.65966 -0.60021 0.59697 0.96295 DataSet_01_152
MMP7 HSF1 shRNA Skin A375 1.58738 0.66665 0.63387 0.81936 DataSet_01_155
MMP7 ZFX shRNA Central_nervous_system DAOY 0.53471 -0.90318 0.03305 0.99991 DataSet_01_157
MMP7 ETV1 shRNA Prostate LNCaP 0.09988 -3.32361 3.05814e-15 1.01965e-11 DataSet_01_161
MMP7 ELK1 siRNA Peripheral_blood CD4+ T cells 0.05369 -4.21913 1.31313e-08 1.16529e-05 DataSet_01_162
MMP7 GATA3 siRNA Peripheral_blood CD4+ T cells 0.37647 -1.4094 0.00027 0.03393 DataSet_01_163
MMP7 JUN siRNA Peripheral_blood CD4+ T cells 0.1132 -3.14305 8.59561e-08 5.78662e-05 DataSet_01_164
MMP7 MAF siRNA Peripheral_blood CD4+ T cells 0.08009 -3.6423 2.75682e-08 2.44643e-05 DataSet_01_165
MMP7 NFATC3 siRNA Peripheral_blood CD4+ T cells 0.09194 -3.44309 3.12814e-07 0.00032 DataSet_01_166
MMP7 NFKB1 siRNA Peripheral_blood CD4+ T cells 0.6121 -0.70815 0.03047 0.47056 DataSet_01_167
MMP7 ESRRG siRNA Placenta_tissue Trophoblast cells 1.67991 0.74838 0.05284 0.33208 DataSet_01_173
MMP7 ETV1 shRNA Prostate LNCaP 0.58044 -0.78478 0.00175 0.6693 DataSet_01_179
MMP7 STAT3 siRNA Urothelial Scaber 0.46851 -1.09386 2.78594e-08 7.63427e-06 DataSet_01_184
MMP7 GABPA shRNA Prostate C4-2B 733.006 9.51768 0.23793 0.43934 DataSet_01_190
MMP7 GABPA shRNA Prostate LNCaP 1752.75 10.7754 0.45641 0.7048 DataSet_01_191
MMP7 GATA2 siRNA Prostate LNCaP 0.49618 -1.01106 0.04208 0.10403 DataSet_01_193
MMP7 CREB1 shRNA Parotid_gland H3118 MEC 4.45338 2.1549 0.12365 0.4608 DataSet_01_194
MMP7 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.54473 -0.87638 - - DataSet_01_196
MMP7 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.62489 -0.67832 - - DataSet_01_210
MMP7 REST siRNA Prostate LNCaP 2.6516 1.40686 0.00322 0.12829 DataSet_01_211
MMP7 LIN28A siRNA Embryo H9 1.66565 0.73609 0.03147 0.10208 DataSet_01_215
MMP7 ATM shRNA Mammary_gland MCF10A 0.54954 -0.86371 4.28294e-09 3.5565e-07 DataSet_01_219
MMP7 SNAI2 shRNA Skin Primary human keratinocytes 0.37685 -1.40794 0.00197 0.01966 DataSet_01_225
MMP7 IRX1 shRNA Bone_marrow 143B 5.69435 2.50953 0.00813 0.0958 DataSet_01_227
MMP7 MYC siRNA White_adipose_tissue Adipose stem cells 0.64123 -0.64109 0.03035 0.15968 DataSet_01_231
MMP7 FOXA1 siRNA Prostate LNCaP 5.415 2.43696 6.35051e-07 0.00127 DataSet_01_233
MMP7 FOXP1 siRNA Prostate LNCaP 1.96631 0.97549 0.04056 0.37914 DataSet_01_234
MMP7 TWIST1 shRNA Stomach CAF32 3.14611 1.65357 0.00909 0.04941 DataSet_01_253
MMP7 TWIST1 shRNA Stomach CAF 1.95417 0.96656 0.10142 0.59035 DataSet_01_254
MMP7 SIX4 siRNA Ovary PEO1 2.02061 1.01479 0.01242 0.07883 DataSet_01_269
MMP7 TP53 shRNA Haematopoietic_and_lymphoid_tissue JVM2 0.5421 -0.88336 5.79726e-07 1.68409e-05 DataSet_01_286
MMP7 SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 2.05093 1.03628 0.10374 0.87301 DataSet_01_290
MMP7 SNAI2 siRNA Mammary_gland MCFDCIS 0.49975 -1.00071 0.0235 0.4899 DataSet_01_292
MMP7 RELB siRNA Lung A549 0.1934 -2.37036 0.00682 0.07404 DataSet_01_294
MMP7 TFAP4 siRNA Brain BE(2)-C 0.12972 -2.94651 0.23856 0.51625 DataSet_01_295
MMP7 PTEN shRNA Lung HCC827 0.56341 -0.82775 0.03748 0.53762 DataSet_01_302
MMP7 PTEN shRNA Mammary_gland SKBR3 1.54316 0.62589 0.85296 0.95409 DataSet_01_303
MMP7 ARNT siRNA Upper_aerodigestive_tract HSC3 0.02893 -5.11144 - - DataSet_01_315
MMP7 MYC siRNA Colon HCT116 3.1105 1.63714 1.41681e-08 2.65993e-07 DataSet_01_324
MMP7 TP63 shRNA Immortalized_keratinocyte HaCaT 7.83538 2.97 1.31532e-09 6.97393e-07 DataSet_01_325
MMP7 TP63 shRNA Head_and_neck FaDU 2.52781 1.33789 3.8023e-08 2.76118e-05 DataSet_01_327
MMP7 TP63 shRNA Immortalized_keratinocyte HaCaT 7.83538 2.97 1.31532e-09 6.97393e-07 DataSet_01_328
MMP7 TP63 shRNA Head_and_neck FaDU 2.52781 1.33789 3.8023e-08 2.76118e-05 DataSet_01_330
MMP7 HOXC6 siRNA Prostate LNCaP 1.61095 0.68791 0.60964 0.99927 DataSet_01_333
MMP7 SMAD2 siRNA Pancreas BxPC-3 0.57362 -0.80183 - - DataSet_01_351
MMP7 ELK1 siRNA Mammary_gland MDA-MB-231 0.5636 -0.82727 - - DataSet_01_354
MMP7 NFYA siRNA Mammary_gland MDA-MB-231 0.51875 -0.94688 - - DataSet_01_355
MMP7 ETV4 shRNA Prostate PC3 0.62553 -0.67684 - - DataSet_01_356
MMP7 CDX2 siRNA Colon COLO320 56.8853 5.82998 - - DataSet_01_357
MMP7 SOX17 siRNA Umbilical_vein HUVEC 0.36898 -1.43839 - - DataSet_01_360
MMP7 RBM17 shRNA Liver HepG2 0.36842 -1.44057 0.0085 0.26816 DataSet_02_100
MMP7 FIP1L1 shRNA Liver HepG2 4.73333 2.24286 0.00023 0.01016 DataSet_02_103
MMP7 HDGF shRNA Liver HepG2 1.875 0.90689 0.5576 0.70539 DataSet_02_104
MMP7 TAF15 shRNA Liver HepG2 0.21739 -2.20163 0.03219 0.06403 DataSet_02_106
MMP7 HNRNPUL1 shRNA Liver HepG2 0.53846 -0.89308 0.55221 0.63559 DataSet_02_109
MMP7 GTF2F1 shRNA Liver HepG2 4.38095 2.13124 0.06368 0.33657 DataSet_02_110
MMP7 RBM39 shRNA Liver HepG2 0.21053 -2.24793 0.04161 0.24361 DataSet_02_111
MMP7 BCLAF1 shRNA Liver HepG2 2.3125 1.20945 0.09911 0.19143 DataSet_02_112
MMP7 PCBP1 shRNA Liver HepG2 2.13043 1.09115 0.01016 0.03324 DataSet_02_115
MMP7 TARDBP shRNA Liver HepG2 3 1.58496 0.47128 0.56196 DataSet_02_116
MMP7 SUB1 shRNA Liver HepG2 2.90476 1.53842 0.4747 0.642 DataSet_02_117
MMP7 RBM25 shRNA Liver HepG2 0.52174 -0.9386 0.09508 0.16686 DataSet_02_119
MMP7 PTBP1 shRNA Liver HepG2 2.65217 1.40718 0.18974 0.23672 DataSet_02_120
MMP7 RBM34 shRNA Liver HepG2 0.57143 -0.80735 0.00278 0.39494 DataSet_02_121
MMP7 EWSR1 shRNA Liver HepG2 4.0625 2.02237 0.14833 0.26207 DataSet_02_122
MMP7 FUS shRNA Liver HepG2 2 1 0.03935 0.15544 DataSet_02_124
MMP7 HNRNPLL shRNA Liver HepG2 3 1.58496 0.46425 0.54652 DataSet_02_125
MMP7 SNRNP70 shRNA Liver HepG2 3 1.58496 0.04313 0.11093 DataSet_02_126
MMP7 SRSF3 shRNA Liver HepG2 15 3.90689 0.01324 0.09092 DataSet_02_127
MMP7 ARID1A siRNA Mammary_gland MDA-MB-157 0.415067 -1.26858 - - DataSet_03_014
MMP7 ARID2 CRISPR Liver JHH4 0.168404 -2.57 0.45811579115977 1 DataSet_03_015
MMP7 ATF4 siRNA Skin A375 0.634543 -0.656211 0.112382372606205 0.775512819201899 DataSet_03_018
MMP7 BCL6 siRNA Lymph OCI-Ly7 DLBCL 2.08089 1.0572 0.328926112394514 0.862022868680042 DataSet_03_025
MMP7 BCL6 siRNA Lymph Pfeiffer DLBCL 1.81337 0.858677 0.29097231058586 0.738860856676454 DataSet_03_026
MMP7 E2F7 siRNA Upper_aerodigestive_tract SCC25 1.57449 0.654884 1.27831567870314e-06 4.38352056324367e-05 DataSet_03_063
MMP7 GATA4 siRNA Stomach YCC3 1.59819 0.676437 0.00649195918829133 0.455031891080592 DataSet_03_107
MMP7 GATA6 siRNA Stomach AGS 2.17757 1.12272 0.0204131439091465 0.370533639021432 DataSet_03_108
MMP7 GATA6 siRNA Stomach KatoIII 2.09174 1.0647 0.00621704466072459 0.328366102751198 DataSet_03_109
MMP7 GATA6 siRNA Stomach YCC3 3.05572 1.61151 0.000625756512181738 0.162784938010937 DataSet_03_110
MMP7 HNF4a siRNA Liver HepG2 0.61 -0.713119 0.240452092631665 0.826637571985823 DataSet_03_126
MMP7 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 2.10096 1.07105 0.0878419355512049 0.926812735269085 DataSet_03_134
MMP7 Klf4 siRNA Skin Primary neonatal keratinocytes 3.56119 1.83236 0.000448384140519782 0.0054888403408456 DataSet_03_147
MMP7 KLF5 siRNA Stomach YCC3 2.87713 1.52463 9.56939182654369e-05 0.0218131768425056 DataSet_03_151
MMP7 MEF2D shRNA Liver HuH7 1.56052 0.642027 - - DataSet_03_162
MMP7 MYB siRNA Cord_Blood CD34+ progenitor cells 4.0559 2.02002 - - DataSet_03_170
MMP7 MYC siRNA Colon HT29 2.74771 1.45823 - - DataSet_03_177
MMP7 MYC siRNA Central_nervous_system DAOY M2.1 11.3902 3.50973 8.04159473509184e-10 1.38364040534198e-07 DataSet_03_178
MMP7 PHB shRNA Embryo Embryonic stem cells (ESCs) 1.57567 0.655965 0.502559314404778 0.641454789192236 DataSet_03_211
MMP7 SOX11 siRNA Lung_fibroblast NHLF 0.512257 -0.96506 0.309239732647573 0.612273876569061 DataSet_03_237
MMP7 SOX2 siRNA Mammary_gland GSC-11 0.588187 -0.765652 0.454103362407879 0.683854284986169 DataSet_03_245
MMP7 SPIB siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly3 0.506314 -0.981894 3.3655539911185e-06 0.00507671870295067 DataSet_03_253
MMP7 STAT3 CRISPR Embryo hESC 0.16527 -2.5971 0.334690012248891 0.410119220777467 DataSet_03_258
MMP7 STAT6 siRNA Umbilical_vein HUVEC 1.68293 0.750973 0.743046395886564 0.965732158535753 DataSet_03_264
MMP7 TFAP2C siRNA Mammary_gland MCF7 0.142321 -2.81278 0.00268488665198572 0.202971247000628 DataSet_03_274
MMP7 E4F1 CRISPR Liver HepG2 2.13636 1.09516 0.126587349814631 0.410460793987786 DataSet_04_028
MMP7 FUBP1 shRNA Liver HepG2 1.6 0.678072 0.264711897924692 0.61785116721909 DataSet_04_030
MMP7 MECP2 CRISPR Liver HepG2 1.53333 0.616671 0.270045288663273 0.552692343382081 DataSet_04_031
MMP7 PAN2 CRISPR Liver HepG2 2.8 1.48543 0.0330244293307786 0.155439259434504 DataSet_04_033
MMP7 SMAD2 CRISPR Liver HepG2 1.51429 0.598637 0.043668305972759 0.592551633437875 DataSet_04_034
MMP7 SMAD5 CRISPR Liver HepG2 1.8 0.847997 0.158601239259733 0.553657882496824 DataSet_04_036
MMP7 WRN shRNA Liver HepG2 2.06667 1.04731 0.124485642057554 0.346254233817431 DataSet_04_038
MMP7 ZNF574 CRISPR Liver HepG2 1.8 0.847997 0.470709817977914 0.604071758216631 DataSet_04_041
MMP7 DDX20 CRISPR Liver HepG2 2.2 1.1375 0.114111563629822 0.241772584196378 DataSet_04_043
MMP7 APTX CRISPR Liver HepG2 0.375 -1.41504 0.658392669276982 0.969929995678059 DataSet_04_069
MMP7 CHCHD3 CRISPR Liver HepG2 6 2.58496 0.309376954098338 0.647963708652716 DataSet_04_067
MMP7 CNOT7 CRISPR Liver HepG2 0.514286 -0.959358 0.0560153999050717 0.142818110094507 DataSet_04_045
MMP7 RIOK2 CRISPR Liver HepG2 0.354839 -1.49476 0.452364530058089 1 DataSet_04_070
MMP7 CCAR1 shRNA Liver HepG2 0.571429 -0.807355 0.640059593550472 0.775221254685834 DataSet_04_054
MMP7 CNOT7 shRNA Liver HepG2 0.148649 -2.75002 0.0209692368712151 0.0496727765619247 DataSet_04_051
MMP7 DDX1 shRNA Liver HepG2 1.53846 0.621488 0.607507561858679 0.794999805870027 DataSet_04_057
MMP7 UBE2L3 shRNA Liver HepG2 2.70588 1.4361 0.145362132209037 0.263933205461633 DataSet_04_055
MMP7 YBX3 shRNA Liver HepG2 0.538462 -0.893085 0.629554701556671 0.78276379504733 DataSet_02_98
MMP7 EZH2 shRNA Colon SW480 0.428432 -1.22286 - - DataSet_03_298
MMP7 NFKBIZ knockout Colon Colon organoid 0.252356 -1.98647 4.693844e-02 0.635642994 DataSet_03_323
MMP7 AEBP1 siRNA Umbilical_vein HUVEC 1.67279 0.742254 5.994793e-01 0.999982779 DataSet_03_300
MMP7 ELF3 CRISPR Bile_duct HBDEC2 2.02625 1.01881 5.589889e-03 2.216174e-02 DataSet_03_304
MMP7 ELF3 knockdown Bile_duct HBDEC2 0.399345 -1.32429 1.006975e-04 7.022536e-03 DataSet_03_305
MMP7 SNAI2 shRNA Pancreas KLM1 3.57196 1.83672 8.822084e-03 0.16110703 DataSet_03_307
MMP7 PRMT1 shRNA Lung A549 3.99724 1.999 - - DataSet_03_342
MMP7 SKI CRISPR Blood HL60 0.333333 -1.58496 4.042893e-02 0.351527891 DataSet_03_351
MMP7 ETV5 knockdown Colon HT29 1.55033 0.63257 2.219010e-01 0.524958833 DataSet_03_353
MMP7 PARP1 siRNA Prostate LNCaP 0.656086 -0.608044 3.900944e-01 0.661610340 DataSet_03_354
MMP7 TET1 CRISPR Mammary_gland Hs578T 7.31996 2.87183 4.063050e-02 1.251407e-01 DataSet_03_355
MMP7 CREBBP CRISPR Brain U5-NPC 4.28571 2.09954 0.0643061463 0.7490853 DataSet_03_356
MMP7 PTPN14 CRISPR Brain U5-NPC 0.625 -0.678072 5.184410e-01 0.71384811 DataSet_03_357
MMP7 TP53 CRISPR Brain U5-NPC 11.5714 3.5325 1.977971e-03 1.623145e-01 DataSet_03_358
MMP7 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 3.36078 1.7488 4.109384e-01 6.483786e-01 DataSet_03_359
MMP7 EP300 shRNA Mammary_gland MCF10AT 0.277778 -1.848 6.467866e-03 0.057183235 DataSet_03_364
MMP7 EZH2 CRISPR Ovary SKOV3 12.04 3.58976 3.408289e-05 0.0030989911 DataSet_03_378
MMP7 NFKB2 siRNA Bone_marrow U2OS 0.21875 -2.19265 2.567044e-03 0.08020911 DataSet_03_381
MMP7 TCF19 CRISPR Oral_squamous CAL27 2.25565 1.17354 1.019023e-04 0.0063488181 DataSet_03_383
MMP7 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 5.60676 2.48717 0.1159075203 0.8388073 DataSet_03_387
MMP7 NFKBIA shRNA Bone_marrow U2OS 0.0441703 -4.50078 8.710328e-02 0.87005461 DataSet_03_389
MMP7 YY1 knockdown Liver HepG2 8.75 3.12928 5.263440e-02 1.385377e-01 DataSet_03_390
MMP7 ILF2 siRNA Stomach SGC-7901 5.25 2.39232 0.2383545284 0.42975591 DataSet_03_393
MMP7 SUMO1 CRISPR Bone_marrow U2OS 0.156627 -2.6746 1.042007e-04 3.770589e-03 DataSet_03_401
MMP7 EHF shRNA Stomach MKN7 0.00889818 -6.81227 - - DataSet_03_402
MMP7 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 1.88889 0.917538 5.562851e-01 0.6736206 DataSet_03_403
MMP7 SATB2 CRISPR Colon Colon organoid 1.56746 0.648431 2.071107e-01 0.95735254 DataSet_03_406
MMP7 CHD1 shRNA Prostate LNCaP 0.290794 -1.78193 2.068233e-06 1.304616e-03 DataSet_03_407
MMP7 SIRT1 siRNA Pancreas PANC1 2.7807 1.47545 8.497342e-03 0.046135240 DataSet_03_410
MMP7 E2F2 siRNA Prostate LNCaP 2.72 1.44361 1.458596e-04 4.398718e-03 DataSet_03_414
MMP7 ZKSCAN3 CRISPR Colon HCT116 0.329897 -1.59991 7.845555e-02 0.450513929 DataSet_03_415
MMP7 FOXK2 shRNA Ovary OVCAR-5 0.0102273 -6.61143 3.500069e-04 0.08266460 DataSet_03_419
MMP7 BRD4 CRISPR Lymph CD8+ T cells 0.322581 -1.63227 - - DataSet_03_420
MMP7 PRDM1 CRISPR Lymph CD8+ T cells 7.48387 2.90378 - - DataSet_03_421
MMP7 IKZF2 shRNA Lymph Hut78 1.55778 0.639489 4.447459e-01 0.78539383 DataSet_03_429
MMP7 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.348837 -1.51937 - - DataSet_03_432
MMP7 EP300 knockout Pancreas HPAF-II orthotopic cells 0.603592 -0.728355 1.634402e-02 6.073566e-02 DataSet_03_436
MMP7 PURA siRNA Cervix HeLa 3.35 1.74416 1.524086e-02 0.112582739 DataSet_03_444
MMP7 ZFP36L1 CRISPR Lung NCI-H1876 1.69959 0.765188 6.237092e-02 0.912695735 DataSet_03_454
MMP7 SREBF2 siRNA Umbilical_vein HUVEC 0.473669 -1.07805 1.574523e-02 1.994861e-01 DataSet_03_457
MMP7 ARID1A shRNA Bile_duct MMNK1 0.630273 -0.665951 6.093482e-01 0.780784393 DataSet_03_458
MMP7 IRF2 shRNA Cord_Blood CD34+ cells 2.5 1.32193 - - DataSet_03_460
MMP7 TXNIP shRNA Cord_Blood CD34+ cells 9.1 3.18587 - - DataSet_03_461
MMP7 PARP1 knockout Embryo_kidney HEK293a 0.376238 -1.41028 5.148478e-01 6.227489e-01 DataSet_03_464
MMP7 STAT3 shRNA Liver HepG2 4.10345 2.03684 3.916917e-04 0.0236469527 DataSet_03_465
MMP7 EZH2 siRNA Prostate LNCaP 0.603065 -0.729614 - - DataSet_03_472
Regulation Region
 
T(co)Fs that significantly regulate MYC by the evidences of both expression and ChIP-seq/motif
Expression Atlas of MMP7
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines