Gene Overview
Target Gene: RNASE1
NCBI Official Symbol: RNASE1
Entrez ID: 6035
Ensembl ID: ENSG00000129538
Gene Full Name: ribonuclease A family member 1, pancreatic
Strand: -
Gene Locus: 14q11.2
External Links:

RNASE1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate RNASE1   
T(co)Fs that Repress RNASE1
The Intensity of the Gene Regulated by T(co)Fs:
RNASE1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
RNASE1 IRF6 shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 0.60736 -0.71937 0.00022 0.00849 DataSet_01_101
RNASE1 MYB shRNA Fetal_liver Primary CD34+ hematopoietic stem/progenitor cells (HSPCs) 0.54716 -0.86996 1.03024e-07 2.38518e-06 DataSet_01_102
RNASE1 SPDEF shRNA Mammary_gland MCF7 0.59649 -0.74542 0.90184 0.99999 DataSet_01_107
RNASE1 HOXA1 siRNA Lung_fibroblast IMR-90 3.02641 1.59761 0.07821 0.3025 DataSet_01_110
RNASE1 ID1 siRNA Lung H1650 1.56365 0.64492 0.22673 0.57478 DataSet_01_118
RNASE1 ZIC2 siRNA Pancreas PANC1 1.67184 0.74144 - - DataSet_01_121
RNASE1 FOXM1 siRNA Central_nervous_system U87 9.98486 3.31974 - - DataSet_01_122
RNASE1 ELK1 siRNA Peripheral_blood CD4+ T cells 3.47704 1.79786 5.10402e-07 0.00016 DataSet_01_162
RNASE1 GATA3 siRNA Peripheral_blood CD4+ T cells 2.12608 1.08819 0.00016 0.02914 DataSet_01_163
RNASE1 JUN siRNA Peripheral_blood CD4+ T cells 694.586 9.44001 0.02606 0.12846 DataSet_01_164
RNASE1 MAF siRNA Peripheral_blood CD4+ T cells 1.61061 0.68761 0.00405 0.06116 DataSet_01_165
RNASE1 NFATC3 siRNA Peripheral_blood CD4+ T cells 2.21831 1.14946 6.10742e-05 0.00631 DataSet_01_166
RNASE1 NFKB1 siRNA Peripheral_blood CD4+ T cells 1.61677 0.69312 0.0043 0.19002 DataSet_01_167
RNASE1 HOXB7 siRNA Pancreas Capan-1 0.64048 -0.64279 0.01095 0.43018 DataSet_01_170
RNASE1 ESRRG siRNA Placenta_tissue Trophoblast cells 0.31588 -1.66257 0.04661 0.31015 DataSet_01_173
RNASE1 GABPA shRNA Prostate C4-2B 1356.24 10.4054 0.24029 0.43934 DataSet_01_190
RNASE1 GABPA shRNA Prostate LNCaP 618.618 9.27291 0.45929 0.7048 DataSet_01_191
RNASE1 CREB1 shRNA Parotid_gland H3118 MEC 0.60526 -0.72438 0.51333 0.79881 DataSet_01_194
RNASE1 TP63 siRNA Head_and_neck SCC-012 2.04444 1.03171 - - DataSet_01_201
RNASE1 TP63 siRNA Head_and_neck SCC-6 2.63894 1.39996 - - DataSet_01_202
RNASE1 ATF2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.6155 -0.70017 0.55505 0.98802 DataSet_01_206
RNASE1 MITF shRNA Skin COLO829 1.6202 0.69617 0.03842 0.16886 DataSet_01_207
RNASE1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 2.60842 1.38317 - - DataSet_01_209
RNASE1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.14186 -2.81749 - - DataSet_01_210
RNASE1 LIN28A siRNA Embryo H9 3.1915 1.67423 0.00115 0.01345 DataSet_01_215
RNASE1 TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 0.57701 -0.79334 0.00051 0.01039 DataSet_01_217
RNASE1 SNAI2 shRNA Skin Primary human keratinocytes 1.63834 0.71223 0.12999 0.24873 DataSet_01_225
RNASE1 KLF2 shRNA Bone_marrow RPMI8226 0.65893 -0.6018 0.12889 0.73652 DataSet_01_226
RNASE1 FOXA1 siRNA Prostate LNCaP 1.55894 0.64056 0.01708 0.21122 DataSet_01_233
RNASE1 STAT5 shRNA Haematopoietic_and_lymphoid_tissue K562 1.78606 0.83678 0.00084 0.0064 DataSet_01_239
RNASE1 SF1 siRNA Endometrial_tissue OsisHESC 0.50003 -0.99992 0.00014 0.00869 DataSet_01_271
RNASE1 TFAP4 siRNA Brain BE(2)-C 0.21063 -2.24724 0.36087 0.51625 DataSet_01_295
RNASE1 MYC siRNA Colon HCT116 2.0433 1.0309 7.6171e-07 6.7308e-06 DataSet_01_324
RNASE1 TCF7L1 shRNA Colon HCT116 1.559 0.64062 0.00147 0.02749 DataSet_01_346
RNASE1 SOX17 siRNA Umbilical_vein HUVEC 0.55377 -0.85263 - - DataSet_01_360
RNASE1 GTF2B siRNA Cervix HeLa 0.46252 -1.1124 - - DataSet_01_362
RNASE1 HNRNPUL1 shRNA Liver HepG2 0.59459 -0.75002 0.62954 0.70526 DataSet_02_109
RNASE1 BCLAF1 shRNA Liver HepG2 5.61538 2.48938 0.08397 0.1708 DataSet_02_112
RNASE1 XRCC5 shRNA Liver HepG2 2.09091 1.06413 0.06937 0.23684 DataSet_02_114
RNASE1 PTBP1 shRNA Liver HepG2 8.44444 3.078 0.09668 0.13248 DataSet_02_120
RNASE1 FUS shRNA Liver HepG2 69.4546 6.118 0.00097 0.05046 DataSet_02_124
RNASE1 HNRNPLL shRNA Liver HepG2 3.7931 1.92338 0.02292 0.0559 DataSet_02_125
RNASE1 SNRNP70 shRNA Liver HepG2 0.58621 -0.77052 0.276 0.39199 DataSet_02_126
RNASE1 SRSF3 shRNA Liver HepG2 0.51724 -0.95109 0.17765 0.32628 DataSet_02_127
RNASE1 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 1.55174 0.63388 0.38811 0.6617 DataSet_02_129
RNASE1 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.52417 -0.93189 0.00394 0.03326 DataSet_02_131
RNASE1 SRSF9 shRNA Haematopoietic_and_lymphoid_tissue K562 1.67119 0.74088 0.00508 0.08928 DataSet_02_134
RNASE1 RBFOX2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.09011 1.06358 0.02457 0.45829 DataSet_02_139
RNASE1 BCLAF1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.28151 1.18999 0.00539 0.09655 DataSet_02_142
RNASE1 RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 3.39142 1.76189 0.00102 0.02038 DataSet_02_143
RNASE1 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.97111 0.97901 0.01606 0.19832 DataSet_02_144
RNASE1 DROSHA shRNA Haematopoietic_and_lymphoid_tissue K562 1.83797 0.87811 0.0518 0.51061 DataSet_02_145
RNASE1 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 3.91201 1.96791 0.00164 0.08322 DataSet_02_147
RNASE1 ILF3 shRNA Haematopoietic_and_lymphoid_tissue K562 2.49065 1.31652 0.01045 0.24295 DataSet_02_148
RNASE1 NONO shRNA Haematopoietic_and_lymphoid_tissue K562 1.52341 0.60731 0.06066 0.24454 DataSet_02_149
RNASE1 RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 2.87257 1.52234 0.01141 0.23644 DataSet_02_151
RNASE1 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 3.16746 1.66333 0.00701 0.24113 DataSet_02_152
RNASE1 SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 2.25816 1.17515 0.01572 0.37537 DataSet_02_154
RNASE1 FUS shRNA Haematopoietic_and_lymphoid_tissue K562 2.19073 1.13141 0.04729 0.26032 DataSet_02_155
RNASE1 HNRNPUL1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.22286 1.15242 0.0234 0.51515 DataSet_02_156
RNASE1 GTF2F1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.56195 0.64335 0.05036 0.87116 DataSet_02_157
RNASE1 PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.7225 0.78451 0.00941 0.08226 DataSet_02_158
RNASE1 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 2.29021 1.19548 0.00153 0.11467 DataSet_02_160
RNASE1 SSB shRNA Haematopoietic_and_lymphoid_tissue K562 2.41623 1.27276 0.03576 0.22243 DataSet_02_164
RNASE1 U2AF1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.55684 0.63862 0.04865 0.19871 DataSet_02_165
RNASE1 RBM25 shRNA Haematopoietic_and_lymphoid_tissue K562 1.67349 0.74286 0.03564 0.2159 DataSet_02_166
RNASE1 EWSR1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.67763 0.74643 0.01743 0.22555 DataSet_02_167
RNASE1 U2AF2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.7635 0.81844 0.02117 0.08756 DataSet_02_170
RNASE1 CTCF siRNA Haematopoietic_and_lymphoid_tissue K562 1.54009 0.62301 0.36618 1 DataSet_02_185
RNASE1 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 1.96911 0.97754 0.26892 1 DataSet_02_190
RNASE1 CHD2 siRNA Haematopoietic_and_lymphoid_tissue K562 2.39728 1.2614 0.02391 0.13588 DataSet_02_196
RNASE1 RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.81838 0.86266 0.26338 1 DataSet_02_204
RNASE1 ZFX siRNA Mammary_gland MCF7 0.41135 -1.28157 0.03373 0.16617 DataSet_02_206
RNASE1 AR siRNA Prostate LNCaP 2.38652 1.25491 0.0463648632030448 1 DataSet_03_005
RNASE1 ASCL1 siRNA Lung DMS79 1.52083 0.604862 0.813544808260622 0.967558920413212 DataSet_03_016
RNASE1 ATF4 siRNA Skin A375 0.572273 -0.805224 0.0325878912653667 0.775512819201899 DataSet_03_018
RNASE1 BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.399743 -1.32286 0.0846271590912234 0.754632591407822 DataSet_03_025
RNASE1 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 3.01692 1.59308 - - DataSet_03_096
RNASE1 GATA4 siRNA Stomach YCC3 1.62041 0.696362 0.232813686432505 0.751241302294127 DataSet_03_107
RNASE1 GFP siRNA Mammary_gland BT-20 cells 0.636364 -0.652077 0.132318750333529 0.667337491633893 DataSet_03_111
RNASE1 KLF5 siRNA Stomach AGS 1.51387 0.598239 0.175253819703429 0.654218490894285 DataSet_03_149
RNASE1 KLF5 siRNA Stomach KatoIII 0.567287 -0.817849 0.298503921607658 0.726241344462048 DataSet_03_150
RNASE1 KLF5 siRNA Stomach YCC3 2.23855 1.16256 0.0878120298930132 0.415788065916752 DataSet_03_151
RNASE1 MYB siRNA Cord_Blood CD34+ progenitor cells 2.41422 1.27155 - - DataSet_03_170
RNASE1 MYC siRNA Colon HT29 11.2028 3.48579 - - DataSet_03_177
RNASE1 NR2F2 siRNA Uterus Primary eutopic stromal cells 1.57946 0.659432 0.120160082896196 0.99947668859931 DataSet_03_202
RNASE1 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.476412 -1.06972 0.105485432355967 0.202274598217344 DataSet_03_211
RNASE1 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 1.93333 0.95109 - - DataSet_03_246
RNASE1 STAT3 CRISPR Embryo hESC 0.359186 -1.4772 0.0716435101469652 0.151549292078674 DataSet_03_258
RNASE1 FUBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 6.52718 2.70646 0.00442745597105875 0.060027293904898 DataSet_04_010
RNASE1 MARK2 shRNA Haematopoietic_and_lymphoid_tissue K562 3.45664 1.78937 0.00160843475641419 0.0133165718438212 DataSet_04_012
RNASE1 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 2.60821 1.38306 0.76197071690234 0.840499099964739 DataSet_04_014
RNASE1 SMAD2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.3009 -1.73265 0.00296351672738716 0.0786343354168621 DataSet_04_018
RNASE1 YBX1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.494704 -1.01536 0.0594384214802289 0.510328569526742 DataSet_04_022
RNASE1 ZNF574 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.215312 -2.2155 0.000521457501569393 0.113567209536072 DataSet_04_023
RNASE1 PAN2 CRISPR Liver HepG2 13 3.70044 0.117092518716222 0.254076082096252 DataSet_04_066
RNASE1 ABT1 shRNA Liver HepG2 0.473684 -1.078 0.61919717428954 0.734465890918402 DataSet_04_052
RNASE1 CCAR1 shRNA Liver HepG2 5.26316 2.39593 0.000319249232013562 0.0116090218289223 DataSet_04_054
RNASE1 DDX1 shRNA Liver HepG2 0.324324 -1.62449 0.189332768759876 0.417584108904471 DataSet_04_057
RNASE1 ACTN4 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.514003 -0.960153 0.000384549199644714 0.0485642197229718 DataSet_04_048
RNASE1 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.75749 1.46335 0.000350946698808651 0.00756770086275561 DataSet_02_14
RNASE1 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.64843 1.40514 0.000201645769478551 0.0109270781186903 DataSet_02_34
RNASE1 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.58115 0.660971 0.419954024627809 0.804634237529921 DataSet_02_45
RNASE1 ABT1 shRNA Haematopoietic_and_lymphoid_tissue K562 7.17619 2.84322 0.000378616665488765 0.0167279545044846 DataSet_04_060
RNASE1 CCAR1 shRNA Haematopoietic_and_lymphoid_tissue K562 3.89328 1.96099 0.000450218755097879 0.0366438790055592 DataSet_04_064
RNASE1 CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 6.55351 2.71227 0.000312028701818571 0.0366179587666743 DataSet_04_061
RNASE1 DDX1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.90181 0.927371 0.0120561340513697 0.422525650067192 DataSet_04_063
RNASE1 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 1.9909 0.993418 0.00231353659055719 0.0111711938145934 DataSet_04_059
RNASE1 PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 1.65661 0.728232 0.010230195868976 0.250438848513914 DataSet_04_065
RNASE1 UBE2L3 shRNA Haematopoietic_and_lymphoid_tissue K562 2.19821 1.13633 2.00777119583335e-05 0.0267384730309782 DataSet_04_062
RNASE1 SMARCA4 siRNA Colon HCT116 0.458198 -1.12596 2.819419e-03 0.1301247 DataSet_03_302
RNASE1 SNAI2 shRNA Pancreas pancreatic cancer stem cells 1.89014 0.918492 3.739115e-02 0.6330193 DataSet_03_306
RNASE1 SNAI2 shRNA Pancreas KLM1 0.337351 -1.56768 3.221307e-04 0.07366544 DataSet_03_307
RNASE1 AEBP1 siRNA Central_nervous_system U87MG 0.568605 -0.8145 1.644324e-01 0.9999434 DataSet_03_338
RNASE1 BRCA1 siRNA Mammary_gland MCF7 2.29692 1.1997 2.255507e-01 0.9999931 DataSet_03_308
RNASE1 ETV5 knockdown Colon HT29 0.322176 -1.63408 6.331847e-04 0.039947336 DataSet_03_353
RNASE1 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 1.72436 0.786065 3.835680e-01 6.236944e-01 DataSet_03_359
RNASE1 NCOA3 siRNA Mammary_gland MDA-MB-231 0.608925 -0.715665 7.724658e-02 0.5529974 DataSet_03_361
RNASE1 ZNF148 shRNA Mammary_gland MDA-MB-231 1.79649 0.845177 7.662216e-01 0.883201940 DataSet_03_366
RNASE1 DNMT3A knockout Embryo_kidney HEK293T 10.8809 3.44373 - - DataSet_03_369
RNASE1 NFKB2 siRNA Bone_marrow U2OS 0.5 -1 4.810225e-01 0.70022749 DataSet_03_381
RNASE1 DNMT1 siRNA Skin Human melanoma cells 2.33753 1.22499 1.244940e-07 1.246066e-05 DataSet_03_382
RNASE1 TCF19 CRISPR Oral_squamous CAL27 0.581554 -0.782016 1.862270e-02 0.1127217855 DataSet_03_383
RNASE1 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 1.61046 0.687475 0.5180387123 0.8948242 DataSet_03_387
RNASE1 NFKBIA shRNA Bone_marrow U2OS 0.146051 -2.77546 1.075557e-01 0.87005461 DataSet_03_389
RNASE1 SUMO1 CRISPR Bone_marrow U2OS 1.52727 0.610958 8.313702e-02 2.058605e-01 DataSet_03_401
RNASE1 EHF shRNA Stomach MKN7 0.323898 -1.62639 - - DataSet_03_402
RNASE1 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 2.69291 1.42917 2.205306e-04 0.2090579 DataSet_03_403
RNASE1 TFAP2A knockout Embryo H9 0.170455 -2.55254 2.543116e-04 0.01905946 DataSet_03_405
RNASE1 CHD1 shRNA Prostate LNCaP 0.031746 -4.97728 3.702771e-01 8.497211e-01 DataSet_03_407
RNASE1 MAP3K7 shRNA Prostate LNCaP 0.0142857 -6.12928 1.441661e-01 3.640240e-01 DataSet_03_408
RNASE1 SIRT1 siRNA Pancreas PANC1 0.508475 -0.975752 6.176690e-01 0.748062366 DataSet_03_410
RNASE1 E2F6 shRNA Liver HuH7 2.66489 1.41408 - - DataSet_03_412
RNASE1 ZKSCAN3 CRISPR Colon HCT116 1.58645 0.665805 7.476500e-01 0.908244701 DataSet_03_415
RNASE1 RUNX2 shRNA Cord_blood Natural Killer Cell 0.4 -1.32193 8.068823e-01 0.949526315 DataSet_03_416
RNASE1 FOXK2 shRNA Ovary OVCAR-5 0.0292479 -5.09552 8.075043e-03 0.09617284 DataSet_03_419
RNASE1 LHX2 shRNA Bone_marrow ES-derived RPE cells 0.640961 -0.641692 4.903712e-01 1.000000e+00 DataSet_03_428
RNASE1 USP7 shRNA Skin xenograft cells 0.392611 -1.34883 0.27367532 0.4348960 DataSet_03_431
RNASE1 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.5 -1 6.820104e-01 0.804994933 DataSet_03_434
RNASE1 SUFU shRNA Mammary_gland HCC1954 cells 0.363207 -1.46113 0.0341599467 0.4485730 DataSet_03_437
RNASE1 SETDB1 shRNA Colon HCT116 4.10798 2.03843 - - DataSet_03_440
RNASE1 RELB CRISPR Colon SW480 3.42857 1.77761 5.572387e-04 1.592085e-02 DataSet_03_449
RNASE1 CBX2 siRNA Mammary_gland MDA-MB-231 0.499817 -1.00053 5.766976e-01 7.676134e-01 DataSet_03_450
RNASE1 CBX2 siRNA Mammary_gland MCF7 0.296203 -1.75534 2.385465e-02 0.0603061162 DataSet_03_451
RNASE1 HAND1 siRNA Placenta HPMVEC 0.375 -1.41504 2.927815e-01 0.9463341 DataSet_03_459
RNASE1 SOX9 knockout Liver HuH7 4 2 5.666182e-01 6.817893e-01 DataSet_03_463
RNASE1 EZH2 siRNA Prostate LNCaP 9.14286 3.19265 1.864439e-01 1.0000000 DataSet_03_475
Regulation Region
 
T(co)Fs that significantly regulate FUS by the evidences of both expression and ChIP-seq/motif
Expression Atlas of RNASE1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines