Gene Overview
Target Gene: UPK3A
NCBI Official Symbol: UPK3A
Entrez ID: 7380
Ensembl ID: ENSG00000100373
Gene Full Name: uroplakin 3A
Strand: +
Gene Locus: 22q13.31
External Links:

UPK3A Significantly Regulated by These T(co)Fs

T(co)Fs that Activate UPK3A   
T(co)Fs that Repress UPK3A
The Intensity of the Gene Regulated by T(co)Fs:
UPK3A-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
UPK3A SPDEF shRNA Mammary_gland MCF7 2.00319 1.0023 0.5483 0.99999 DataSet_01_107
UPK3A BRD4 shRNA Embryo_kidney HEK293 2.09217 1.065 - - DataSet_01_119
UPK3A FOXM1 siRNA Central_nervous_system U87 3.03724 1.60276 - - DataSet_01_122
UPK3A IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.56713 0.64812 0.22493 0.99993 DataSet_01_137
UPK3A SOX4 shRNA Parotid_gland ACC3 0.62973 -0.6672 0.20807 0.96805 DataSet_01_140
UPK3A HSF1 shRNA Skin A375 0.41379 -1.27302 0.00242 0.02382 DataSet_01_155
UPK3A ELK1 siRNA Peripheral_blood CD4+ T cells 0.65443 -0.6117 0.36075 0.58681 DataSet_01_162
UPK3A GATA3 siRNA Peripheral_blood CD4+ T cells 2.9423 1.55694 0.00157 0.07379 DataSet_01_163
UPK3A JUN siRNA Peripheral_blood CD4+ T cells 0.557 -0.84425 0.16232 0.38774 DataSet_01_164
UPK3A NFKB1 siRNA Peripheral_blood CD4+ T cells 2.5018 1.32297 0.01604 0.35365 DataSet_01_167
UPK3A STAT3 siRNA Peripheral_blood CD4+ T cells 0.64348 -0.63604 0.23819 0.99183 DataSet_01_168
UPK3A GATA2 siRNA Prostate LNCaP 1.75087 0.80807 0.00013 0.00127 DataSet_01_193
UPK3A CREB1 shRNA Parotid_gland H3118 MEC 2.46697 1.30274 0.27852 0.64159 DataSet_01_194
UPK3A TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.82353 0.86673 - - DataSet_01_196
UPK3A TP63 siRNA Head_and_neck SCC-012 2.88462 1.52838 - - DataSet_01_201
UPK3A LIN28A siRNA Embryo H9 1.53592 0.6191 0.0233 0.08368 DataSet_01_215
UPK3A TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 0.56497 -0.82375 0.00402 0.03046 DataSet_01_217
UPK3A TWIST1 shRNA Stomach CAF32 1.54576 0.62832 0.41266 0.56577 DataSet_01_253
UPK3A STAT5 shRNA Prostate CWR22Pc 0.40282 -1.31179 2.96921e-05 0.00435 DataSet_01_279
UPK3A ESRRA shRNA Embryo_kidney 293T 2.28022 1.18917 0.09566 0.70248 DataSet_01_280
UPK3A MSX1 siRNA Tooth Dental Pulp Cells 1.56145 0.64289 0.0576 0.12158 DataSet_01_281
UPK3A TFAP4 siRNA Brain BE(2)-C 0.14896 -2.74702 0.26516 0.51625 DataSet_01_295
UPK3A SOX7 siRNA Umbilical_vein HUVEC 1.79014 0.84008 0.04911 0.89788 DataSet_01_299
UPK3A PTEN shRNA Skin A431 1.56524 0.64639 0.01259 0.10318 DataSet_01_301
UPK3A PTEN shRNA Mammary_gland SKBR3 1.88989 0.9183 0.10411 0.61502 DataSet_01_303
UPK3A SOX9 siRNA Prostate VCaP 0.64454 -0.63366 0.26856 0.93253 DataSet_01_308
UPK3A SOX9 siRNA Prostate VCaP 0.64454 -0.63366 0.26856 0.93253 DataSet_01_309
UPK3A ARNT siRNA Upper_aerodigestive_tract HSC3 4.63003 2.21102 - - DataSet_01_315
UPK3A MYC siRNA Colon HCT116 2.48367 1.31247 0.05837 0.09203 DataSet_01_324
UPK3A HOXC6 siRNA Prostate LNCaP 0.57442 -0.79981 0.66185 0.99927 DataSet_01_333
UPK3A ZNF24 siRNA Embryo_kidney HEK293 0.64292 -0.6373 - - DataSet_01_353
UPK3A ELK1 siRNA Mammary_gland MDA-MB-231 0.65085 -0.6196 - - DataSet_01_354
UPK3A ETV4 shRNA Prostate PC3 2.20182 1.1387 - - DataSet_01_356
UPK3A CDX2 siRNA Colon COLO320 0.41687 -1.26233 - - DataSet_01_357
UPK3A RBM17 shRNA Liver HepG2 0.56328 -0.82809 0.04226 0.28809 DataSet_02_100
UPK3A SAFB2 shRNA Liver HepG2 2.85088 1.51141 0.00127 0.02332 DataSet_02_102
UPK3A FIP1L1 shRNA Liver HepG2 0.14882 -2.74834 0.00013 0.0094 DataSet_02_103
UPK3A U2AF2 shRNA Liver HepG2 0.64914 -0.62339 0.0071 0.06284 DataSet_02_105
UPK3A TAF15 shRNA Liver HepG2 2.95967 1.56543 0.00359 0.01757 DataSet_02_106
UPK3A SSB shRNA Liver HepG2 0.51304 -0.96286 0.02929 0.05724 DataSet_02_107
UPK3A ZNF622 shRNA Liver HepG2 0.36335 -1.46055 0.00095 0.00835 DataSet_02_108
UPK3A GTF2F1 shRNA Liver HepG2 0.60343 -0.72875 0.01466 0.23107 DataSet_02_110
UPK3A BCLAF1 shRNA Liver HepG2 2.92042 1.54618 0.00197 0.02682 DataSet_02_112
UPK3A U2AF2 shRNA Liver HepG2 0.41439 -1.27093 0.14366 0.27285 DataSet_02_113
UPK3A RBM25 shRNA Liver HepG2 0.43463 -1.20214 0.00094 0.02139 DataSet_02_119
UPK3A PTBP1 shRNA Liver HepG2 2.32615 1.21794 2e-04 0.00582 DataSet_02_120
UPK3A EWSR1 shRNA Liver HepG2 0.38115 -1.39155 0.00063 0.04098 DataSet_02_122
UPK3A PCBP2 shRNA Liver HepG2 0.37257 -1.42441 0.04563 0.15468 DataSet_02_123
UPK3A FUS shRNA Liver HepG2 0.552 -0.85726 0.0093 0.08674 DataSet_02_124
UPK3A HNRNPLL shRNA Liver HepG2 2.50691 1.32591 0.03055 0.06792 DataSet_02_125
UPK3A SNRNP70 shRNA Liver HepG2 0.3894 -1.36067 0.0424 0.11013 DataSet_02_126
UPK3A SRSF3 shRNA Liver HepG2 0.22811 -2.13219 0.02586 0.1164 DataSet_02_127
UPK3A PRPF4 shRNA Liver HepG2 0.60434 -0.72656 0.05982 0.14236 DataSet_02_128
UPK3A ABL1 siRNA Mammary_gland MCF7 1.61285 0.689616 0.0755110008766154 0.976385569407162 DataSet_03_001
UPK3A AR siRNA Prostate abl cells 1.82143 0.86507 0.0951471095939379 0.999852161656754 DataSet_03_004
UPK3A AR siRNA Prostate LNCaP 2.3454 1.22984 0.0894098591526929 1 DataSet_03_005
UPK3A ASCL1 siRNA Lung DMS79 0.3 -1.73697 0.0152581046659089 0.604357868059899 DataSet_03_016
UPK3A ATF4 siRNA Skin A375 0.632105 -0.661764 0.154377050838996 0.775512819201899 DataSet_03_018
UPK3A BRCA1 siRNA Mammary_gland MCF7 1.54097 0.623835 0.100766296912476 0.999850583334387 DataSet_03_028
UPK3A CEBPA siRNA Mammary_gland MCF7 0.590111 -0.760942 0.0552785505903826 0.999962793175751 DataSet_03_047
UPK3A CEBPB siRNA Embryo hESC 0.645706 -0.63105 0.19241992274934 0.576662333570269 DataSet_03_049
UPK3A CENPF siRNA Mammary_gland MCF7 0.583824 -0.776394 0.0516832036684537 0.999662524742916 DataSet_03_052
UPK3A CTNNB1 siRNA Mammary_gland MCF7 0.53901 -0.891616 0.0314844031185592 0.999436862066063 DataSet_03_058
UPK3A E2F1 siRNA Mammary_gland MCF7 0.585193 -0.773017 0.0524478802406746 0.999927373439084 DataSet_03_061
UPK3A E2F5 siRNA Mammary_gland MCF7 0.63201 -0.661981 0.085242303886109 0.999540347732068 DataSet_03_062
UPK3A FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.437371 -1.19307 - - DataSet_03_096
UPK3A GATA4 siRNA Stomach YCC3 2.14535 1.10122 0.161884029989541 0.70079883948279 DataSet_03_107
UPK3A GATA6 siRNA Stomach YCC3 0.577445 -0.792244 0.170951510449681 0.777966167629148 DataSet_03_110
UPK3A HDAC5 siRNA Mammary_gland MCF7 0.646559 -0.629147 0.0984471613897613 0.999966625300244 DataSet_03_115
UPK3A HIC1 CRISPR Prostate PC3 3.36806 1.75192 - - DataSet_03_118
UPK3A HNF4a siRNA Liver HepG2 0.332692 -1.58774 0.0441197926601771 0.628561914510616 DataSet_03_126
UPK3A HSF2 siRNA Mammary_gland MCF7 0.557291 -0.843497 0.0386701524251427 0.990969613280381 DataSet_03_130
UPK3A IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 0.485295 -1.04307 0.0810838919401518 0.919224197425053 DataSet_03_134
UPK3A MEF2D siRNA Liver HuH7 2.56425 1.35854 - - DataSet_03_163
UPK3A MYB siRNA Cord_Blood CD34+ progenitor cells 2.99215 1.58118 - - DataSet_03_170
UPK3A MYC siRNA Colon HT29 36.9614 5.20795 - - DataSet_03_177
UPK3A PCNA siRNA Mammary_gland MCF7 0.649819 -0.62189 0.101628956249067 0.999448838103647 DataSet_03_210
UPK3A PHB shRNA Embryo Embryonic stem cells (ESCs) 0.556829 -0.844694 0.0694241257586567 0.146029437442154 DataSet_03_211
UPK3A SOX11 siRNA Lung_fibroblast NHLF 0.666546 -0.585224 0.307552197951912 0.612273876569061 DataSet_03_237
UPK3A SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 2.85714 1.51457 - - DataSet_03_246
UPK3A SP1 siRNA Mammary_gland MDA-MB-231 0.435699 -1.1986 0.126974086727943 0.413972819854456 DataSet_03_250
UPK3A SP100 siRNA Mammary_gland MCF7 2.40477 1.2659 0.00701372793909858 0.999952086018951 DataSet_03_252
UPK3A SRF siRNA Prostate LNCaP 0.513363 -0.961947 0.0186543338801284 0.0962266794126204 DataSet_03_254
UPK3A STAT3 CRISPR Embryo hESC 0.282395 -1.82421 0.000237701686081673 0.0121669705388723 DataSet_03_258
UPK3A TCEA1 siRNA Mammary_gland MCF7 0.496182 -1.01106 0.0191097739368786 0.999762252994287 DataSet_03_266
UPK3A TP53 siRNA Mammary_gland MCF7 0.530823 -0.913697 0.0286727819987041 0.999938217444253 DataSet_03_277
UPK3A ZNF746 siRNA Colon HCT116 0.610897 -0.711 - - DataSet_03_293
UPK3A NFX1 CRISPR Liver HepG2 0.535596 -0.900783 0.0257170538870229 0.0647367464646577 DataSet_04_032
UPK3A ACTN4 CRISPR Liver HepG2 0.327065 -1.61235 0.00106579019901489 0.0314049003592783 DataSet_04_042
UPK3A CHCHD3 CRISPR Liver HepG2 0.565436 -0.822564 0.00318018264434983 0.462359872902174 DataSet_04_067
UPK3A ABT1 shRNA Liver HepG2 0.43543 -1.19949 0.00229086257870838 0.0136782412164215 DataSet_04_052
UPK3A CALR shRNA Liver HepG2 0.398593 -1.32701 0.000208486759595191 0.00482064480014651 DataSet_04_053
UPK3A CNOT7 shRNA Liver HepG2 0.515094 -0.957091 0.00720838711591572 0.0230136147248096 DataSet_04_051
UPK3A YBX3 shRNA Liver HepG2 2.39631 1.26081 0.000480819299583529 0.0334995062512868 DataSet_02_98
UPK3A SMG7 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.8 0.847997 0.770822817762681 0.939350458234872 DataSet_04_075
UPK3A SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.4 1.26303 0.615422960156405 0.762293458856824 DataSet_04_049
UPK3A CNOT3 shRNA Lung A549 0.638438 -0.647381 4.834785e-02 0.8830540 DataSet_03_340
UPK3A SNAI2 shRNA Pancreas pancreatic cancer stem cells 2.36317 1.24072 1.184414e-02 0.5642287 DataSet_03_306
UPK3A BRCA1 siRNA Mammary_gland MCF7 0.517642 -0.949974 6.152368e-03 0.7791568 DataSet_03_308
UPK3A EZH2 knockdown Colon HCT116 1.99191 0.994151 0.296807295 0.9236228 DataSet_03_334
UPK3A SKI CRISPR Blood HL60 0.635821 -0.653308 1.096617e-01 0.465031967 DataSet_03_351
UPK3A ESR1 siRNA Mammary_gland MCF7 1.6173 0.693585 3.065648e-02 0.1363975359 DataSet_03_352
UPK3A ETV5 knockdown Colon HT29 0.555556 -0.847997 2.063034e-01 0.503422104 DataSet_03_353
UPK3A RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 1.87295 0.905312 9.691478e-02 3.097549e-01 DataSet_03_359
UPK3A ZNF148 shRNA Mammary_gland MDA-MB-231 0.205095 -2.28564 3.134955e-02 0.133190842 DataSet_03_366
UPK3A ABL1 shRNA Liver HuH7 0.643767 -0.63539 3.549239e-02 0.0769992233 DataSet_03_367
UPK3A TRIM8 siRNA Mammary_gland MCF7 0.244898 -2.02975 1.849914e-02 0.0788226983 DataSet_03_388
UPK3A YY1 knockdown Liver HepG2 0.556818 -0.844722 2.205910e-04 1.397098e-03 DataSet_03_390
UPK3A BMI1 shRNA Bile_duct QBC-939 2.76813 1.46891 1.935571e-01 0.3835016688 DataSet_03_395
UPK3A TFAP2A knockout Embryo H9 0.384615 -1.37851 9.232215e-02 0.21037994 DataSet_03_405
UPK3A SATB2 CRISPR Colon Colon organoid 1.70796 0.772278 7.819389e-01 1.00000000 DataSet_03_406
UPK3A ZKSCAN3 CRISPR Colon HCT116 0.27027 -1.88752 4.469818e-01 0.720043327 DataSet_03_415
UPK3A NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 0.632732 -0.660334 3.178977e-02 0.121947277 DataSet_03_418
UPK3A FOXQ1 CRISPR Lymph Primary CD4+ T cells 5 2.32193 - - DataSet_03_422
UPK3A MAEL CRISPR Liver Alexander cells 6.4 2.67807 - - DataSet_03_423
UPK3A LHX2 shRNA Bone_marrow ES-derived RPE cells 0.181818 -2.45943 6.212064e-02 1.000000e+00 DataSet_03_428
UPK3A NFE2L1 knockout Lung A549 0.253371 -1.98067 4.465306e-01 9.984904e-01 DataSet_03_433
UPK3A EP300 knockout Pancreas HPAF-II orthotopic cells 1.86328 0.897846 1.715082e-01 3.496552e-01 DataSet_03_436
UPK3A SUFU shRNA Mammary_gland HCC1954 cells 0.333333 -1.58496 0.0085071006 0.3673014 DataSet_03_437
UPK3A CIC knockout Brain Immortalized Astrocyte Cells 5.5 2.45943 3.353250e-02 3.269701e-01 DataSet_03_438
UPK3A HMG20A siRNA Mammary_gland MDA-MB-231 3 1.58496 0.1826890867 0.4402072 DataSet_03_442
UPK3A PHF14 siRNA Mammary_gland MDA-MB-231 2 1 0.2974755825 0.5994811 DataSet_03_443
UPK3A RELB CRISPR Colon SW480 5.27273 2.39855 2.717477e-04 1.152132e-02 DataSet_03_449
UPK3A CBX2 siRNA Mammary_gland MCF7 0.6242 -0.67992 9.187801e-02 0.1768007559 DataSet_03_451
UPK3A ZFP36L1 CRISPR Lung NCI-H1876 0.59405 -0.751344 4.761124e-01 0.992381486 DataSet_03_454
UPK3A EZH2 siRNA Prostate LNCaP 0.519582 -0.944578 - - DataSet_03_472
Regulation Region
 
T(co)Fs that significantly regulate SP100 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of UPK3A
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines