Gene Overview
Target Gene: ADH1C
NCBI Official Symbol: ADH1C
Entrez ID: 126
Ensembl ID: ENSG00000248144
Gene Full Name: alcohol dehydrogenase 1C (class I), gamma polypeptide
Strand: -
Gene Locus: 4q23
External Links:

ADH1C Significantly Regulated by These T(co)Fs

T(co)Fs that Activate ADH1C   
T(co)Fs that Repress ADH1C
The Intensity of the Gene Regulated by T(co)Fs:
ADH1C-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
ADH1C HNF1B shRNA Ovary RMG2 7.08371 2.82451 0.0057 0.01676 DataSet_01_103
ADH1C FOXA1 siRNA Prostate LNCaP 0.50115 -0.99669 - - DataSet_01_104
ADH1C SPDEF shRNA Mammary_gland MCF7 0.42814 -1.22384 0.89321 0.99999 DataSet_01_107
ADH1C HOXA1 siRNA Lung_fibroblast IMR-90 1.83878 0.87875 0.09177 0.32814 DataSet_01_110
ADH1C TCF3 shRNA Mammary_gland MDA-MB468 0.49537 -1.01342 1.3975e-05 0.00064 DataSet_01_116
ADH1C ID1 siRNA Lung A549 4.60626 2.2036 0.22469 0.46275 DataSet_01_117
ADH1C ID1 siRNA Lung H1650 0.35198 -1.50643 0.06266 0.38813 DataSet_01_118
ADH1C ZIC2 siRNA Pancreas PANC1 3.0618 1.61438 - - DataSet_01_121
ADH1C FOXM1 siRNA Central_nervous_system U87 13.352 3.73898 - - DataSet_01_122
ADH1C ZNF85 siRNA Gastrointestinal_tissue GIST-T1 1.81242 0.85791 0.00053 0.00757 DataSet_01_126
ADH1C ZNF431 siRNA Gastrointestinal_tissue GIST-T1 1.93394 0.95154 0.00025 0.00343 DataSet_01_128
ADH1C POLR3A siRNA Mammary_gland MCF7 0.66154 -0.5961 - - DataSet_01_139
ADH1C ETV1 shRNA Prostate LNCaP 2.03327 1.0238 0.00012 0.00114 DataSet_01_161
ADH1C NFKB1 siRNA Peripheral_blood CD4+ T cells 0.63201 -0.66198 0.26189 0.77393 DataSet_01_167
ADH1C HOXB7 siRNA Pancreas Capan-1 1.52302 0.60694 0.01443 0.44057 DataSet_01_170
ADH1C TP53 siRNA Lung SAECs 0.35976 -1.47491 0.25967 0.66409 DataSet_01_175
ADH1C HSF1 shRNA Liver KYN2 0.50046 -0.99867 - - DataSet_01_178
ADH1C GATA2 siRNA Prostate LNCaP 0.3232 -1.62951 1.19547e-05 0.00023 DataSet_01_193
ADH1C CREB1 shRNA Parotid_gland H3118 MEC 5.17776 2.37233 0.9283 0.97443 DataSet_01_194
ADH1C CREB1 shRNA Parotid_gland HSY 1.7841 0.8352 0.43973 0.98055 DataSet_01_195
ADH1C TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.41961 -1.25289 - - DataSet_01_196
ADH1C TP63 siRNA Head_and_neck SCC-1 0.11215 -3.1565 - - DataSet_01_198
ADH1C TP63 siRNA Immortalized_keratinocyte HaCaT 2.5411 1.34545 - - DataSet_01_200
ADH1C HIC1 shRNA Mammary_gland HBL100 1.64858 0.72123 - - DataSet_01_205
ADH1C FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 4.22551 2.07913 - - DataSet_01_208
ADH1C FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 3.91882 1.97042 - - DataSet_01_209
ADH1C FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.33445 -1.58014 - - DataSet_01_210
ADH1C REST siRNA Prostate LNCaP 0.61835 -0.69351 0.01603 0.19375 DataSet_01_211
ADH1C KLF2 shRNA Bone_marrow RPMI8226 1.95615 0.96801 0.10954 0.71395 DataSet_01_226
ADH1C FOXA1 siRNA Prostate LNCaP 0.44182 -1.17847 0.0827 0.36746 DataSet_01_233
ADH1C NFYB siRNA Bone_marrow U2OS ER-HA-E2F1 2.36621 1.24258 0.03469 0.24816 DataSet_01_238
ADH1C TWIST1 shRNA Stomach CAF32 3.77261 1.91556 0.00027 0.01473 DataSet_01_253
ADH1C TWIST1 shRNA Stomach CAF 1.96651 0.97564 0.1059 0.59315 DataSet_01_254
ADH1C MSX1 siRNA Tooth Dental Pulp Cells 3.41308 1.77107 2.94893e-06 0.00013 DataSet_01_281
ADH1C SP3 siRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.83734 0.87762 0.26846 0.90406 DataSet_01_290
ADH1C SNAI2 siRNA Mammary_gland MCFDCIS 0.52467 -0.9305 0.16245 0.7047 DataSet_01_292
ADH1C POSTN shRNA Brain GSC272 0.33824 -1.56386 0.03933 0.53025 DataSet_01_293
ADH1C TFAP4 siRNA Brain BE(2)-C 0.19924 -2.32739 0.31997 0.51625 DataSet_01_295
ADH1C PTEN shRNA Skin A431 12.8095 3.67914 0.00642 0.084 DataSet_01_301
ADH1C PTEN shRNA Lung HCC827 0.20576 -2.28095 0.07452 0.56865 DataSet_01_302
ADH1C PTEN shRNA Mammary_gland SKBR3 0.25474 -1.9729 0.42431 0.78746 DataSet_01_303
ADH1C HOXC6 siRNA Prostate LNCaP 0.53976 -0.88961 0.7633 0.99927 DataSet_01_333
ADH1C REST siRNA Skin NHEK 1.61081 0.68778 0.17028 0.81455 DataSet_01_338
ADH1C GTF2B siRNA Cervix HeLa 0.56105 -0.8338 - - DataSet_01_362
ADH1C TAF15 shRNA Liver HepG2 1.625 0.70044 0.1819 0.2473 DataSet_02_106
ADH1C HNRNPUL1 shRNA Liver HepG2 9.75 3.2854 0.03748 0.08748 DataSet_02_109
ADH1C EWSR1 shRNA Liver HepG2 6.33333 2.66297 0.05812 0.14343 DataSet_02_122
ADH1C PRPF4 shRNA Liver HepG2 23.3333 4.54432 0.01559 0.06657 DataSet_02_128
ADH1C STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.177 1 DataSet_02_182
ADH1C AR siRNA Prostate abl cells 0.490566 -1.02748 0.15033439056409 0.999852161656754 DataSet_03_004
ADH1C ASCL1 siRNA Lung DMS79 0.254237 -1.97575 0.166289199156454 0.812944793881093 DataSet_03_016
ADH1C BCL6 siRNA Lymph OCI-Ly7 DLBCL 2.05598 1.03983 0.294508500443479 0.849474773782692 DataSet_03_025
ADH1C BCL6 siRNA Lymph Pfeiffer DLBCL 0.252917 -1.98327 0.0916317068857048 0.561907511900694 DataSet_03_026
ADH1C CEBPB siRNA Embryo hESC 0.147016 -2.76596 0.0151759031442324 0.263585039789825 DataSet_03_049
ADH1C GATA2 siRNA Uterus Decidual stromal cells 5.80551 2.53742 0.287513968142618 0.860164186220624 DataSet_03_100
ADH1C GATA4 siRNA Stomach YCC3 2.23836 1.16244 0.241922759345053 0.756412809511523 DataSet_03_107
ADH1C GATA6 siRNA Stomach AGS 2.10579 1.07436 0.320177274637626 0.779533089924947 DataSet_03_108
ADH1C HINFP siRNA Bone_marrow U2OS 2.07563 1.05355 0.000366910519067584 0.0172958766230471 DataSet_03_123
ADH1C IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 0.307867 -1.69962 0.581559302994034 0.999948959532916 DataSet_03_134
ADH1C KLF5 siRNA Stomach AGS 1.83725 0.877551 0.498281661465381 0.839000170718394 DataSet_03_149
ADH1C KLF5 siRNA Stomach KatoIII 1.79834 0.846663 0.403510889641983 0.784069003766692 DataSet_03_150
ADH1C KLF5 siRNA Stomach YCC3 0.246263 -2.02173 0.00296030162966961 0.0897356441451315 DataSet_03_151
ADH1C MAFB siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 1.50873 0.593333 0.0163559508879416 1 DataSet_03_155
ADH1C MEF2D shRNA Liver HuH7 0.518891 -0.946498 - - DataSet_03_162
ADH1C MEF2D siRNA Liver HuH7 0.511495 -0.967207 - - DataSet_03_163
ADH1C MYB siRNA Cord_Blood CD34+ progenitor cells 1.61052 0.687528 - - DataSet_03_170
ADH1C NR2F2 siRNA Uterus Primary eutopic stromal cells 2.06238 1.04431 0.103887357157346 0.99947668859931 DataSet_03_202
ADH1C PHB shRNA Embryo Embryonic stem cells (ESCs) 1.73204 0.792472 0.758750400477868 0.842737138569662 DataSet_03_211
ADH1C SOX11 siRNA Lung_fibroblast NHLF 1.60142 0.679349 0.0988481874724112 0.484414658150543 DataSet_03_237
ADH1C SOX2 siRNA Lung LK2 0.367993 -1.44225 - - DataSet_03_241
ADH1C SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 2.5 1.32193 - - DataSet_03_246
ADH1C SP1 siRNA Ovary OVSAYO 0.600984 -0.734603 0.0582254126735316 0.29499581192652 DataSet_03_251
ADH1C STAT3 CRISPR Embryo hESC 0.0799551 -3.64467 0.00399434508288587 0.0449989554288447 DataSet_03_258
ADH1C STAT6 siRNA Umbilical_vein HUVEC 0.271028 -1.88349 0.219384304806821 0.854767425175195 DataSet_03_264
ADH1C ZNF746 siRNA Colon HCT116 1.5305 0.614 - - DataSet_03_293
ADH1C CIZ1 CRISPR Liver HepG2 5.44444 2.44479 0.0359325249810583 0.228228780852589 DataSet_04_026
ADH1C E4F1 CRISPR Liver HepG2 2 1 0.0773859482420162 0.345647389521557 DataSet_04_028
ADH1C ERN1 CRISPR Liver HepG2 4.75 2.24793 0.00175087829825312 0.0615236264318229 DataSet_04_029
ADH1C FUBP1 shRNA Liver HepG2 2 1 0.0174759946380843 0.394621065851607 DataSet_04_030
ADH1C MECP2 CRISPR Liver HepG2 1.83333 0.874469 0.112469671416547 0.380662814418738 DataSet_04_031
ADH1C PAN2 CRISPR Liver HepG2 2.55556 1.35364 0.0625912296601943 0.203483207896963 DataSet_04_033
ADH1C SMAD2 CRISPR Liver HepG2 2.25 1.16992 0.224850798824843 0.725639395697324 DataSet_04_034
ADH1C SMAD5 CRISPR Liver HepG2 2.94444 1.55799 0.0591891679203948 0.435861334487992 DataSet_04_036
ADH1C SRPK2 CRISPR Liver HepG2 3.41667 1.77259 0.0027680572312795 0.112389276548355 DataSet_04_037
ADH1C WRN shRNA Liver HepG2 3 1.58496 0.0867720140406171 0.295758206892849 DataSet_04_038
ADH1C YBX1 CRISPR Liver HepG2 11.2632 3.49354 0.0034883256955972 0.972884761036538 DataSet_04_039
ADH1C ZNF574 CRISPR Liver HepG2 2.05556 1.03953 0.106793682512732 0.223950006765862 DataSet_04_041
ADH1C DDX20 CRISPR Liver HepG2 5.33333 2.41504 0.0346547971662376 0.119617778686207 DataSet_04_043
ADH1C APTX CRISPR Liver HepG2 11.2 3.48543 0.1791036146983 0.802252135883628 DataSet_04_069
ADH1C CNOT7 CRISPR Liver HepG2 1.625 0.70044 0.470037068237313 0.634853595257036 DataSet_04_045
ADH1C PAN2 CRISPR Liver HepG2 0.333333 -1.58496 0.766650791222066 0.873568327742526 DataSet_04_066
ADH1C RIOK2 CRISPR Liver HepG2 1.625 0.70044 0.313040281654338 1 DataSet_04_070
ADH1C SEPT11 CRISPR Liver HepG2 2.6 1.37851 0.00964514411210489 0.101484912829698 DataSet_04_068
ADH1C ABT1 shRNA Liver HepG2 3.75 1.90689 0.511171463733928 0.63724597058212 DataSet_04_052
ADH1C DDX1 shRNA Liver HepG2 1.875 0.906891 0.687557481752355 0.847627184507331 DataSet_04_057
ADH1C ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.618719447941421 0.768745225583854 DataSet_02_34
ADH1C LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.697756376664276 0.831961876116262 DataSet_02_35
ADH1C NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.66667 1.87447 0.433177159438787 0.662470068511527 DataSet_02_32
ADH1C TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.583333 -0.777608 0.730354449970345 0.838135799705298 DataSet_02_53
ADH1C CNOT3 shRNA Lung A549 2.94744 1.55946 2.643427e-01 0.8887602 DataSet_03_340
ADH1C DNMT1 siRNA Lung_fibroblast IMR-90 1.52229 0.606244 5.566030e-01 0.9999458 DataSet_03_317
ADH1C NFKBIZ knockout Colon Colon organoid 3.22161 1.68778 1.034067e-01 0.662888061 DataSet_03_323
ADH1C AEBP1 siRNA Umbilical_vein HUVEC 0.565627 -0.822077 3.716516e-03 0.563238092 DataSet_03_300
ADH1C SMARCA4 siRNA Colon HCT116 2.69983 1.43287 4.609812e-03 2.054125e-01 DataSet_03_301
ADH1C ELF3 CRISPR Bile_duct HBDEC2 0.620053 -0.689537 1.454196e-02 4.310594e-02 DataSet_03_304
ADH1C ELF3 knockdown Bile_duct HBDEC2 0.496574 -1.00992 3.958988e-03 4.254197e-02 DataSet_03_305
ADH1C HDAC5 siRNA Liver human hepatocytes 0.632648 -0.660525 3.834962e-05 1.026433e-03 DataSet_03_346
ADH1C SNAI2 shRNA Pancreas pancreatic cancer stem cells 0.626112 -0.675508 3.093728e-02 0.6330193 DataSet_03_306
ADH1C SNAI2 shRNA Pancreas KLM1 0.20503 -2.28609 3.153484e-03 0.12452976 DataSet_03_307
ADH1C BRCA1 siRNA Mammary_gland MCF7 0.480031 -1.0588 4.335961e-01 0.9999931 DataSet_03_308
ADH1C PARP1 siRNA Prostate LNCaP 1.80032 0.848251 4.319954e-02 0.249284879 DataSet_03_354
ADH1C NCOA2 siRNA Uterus endometrial stromal cells 2.60976 1.38391 0.3283104394 1 DataSet_03_360
ADH1C USP22 shRNA Liver PLC_PRF_5 cells 19.6 4.29278 1.106792e-02 0.12346630 DataSet_03_368
ADH1C E2F1 siRNA Nasopharynx HK1 2.66667 1.41504 3.571404e-01 9.722824e-01 DataSet_03_373
ADH1C KDM5A CRISPR Lung GLC16 3.98573 1.99484 4.327225e-01 0.593970164 DataSet_03_392
ADH1C ILF2 siRNA Stomach SGC-7901 0.333333 -1.58496 0.4343541649 0.64560645 DataSet_03_393
ADH1C BMI1 shRNA Bile_duct QBC-939 0.514416 -0.958992 5.889742e-01 0.7590999258 DataSet_03_395
ADH1C IKZF2 CRISPR Lymph CAR T Cell 0.330735 -1.59625 2.849111e-01 0.753482753 DataSet_03_397
ADH1C RELA CRISPR Brain T30 0.229141 -2.12569 0.4692998650 0.8455937 DataSet_03_399
ADH1C TFAP2A knockout Embryo H9 0.292308 -1.77444 4.310152e-02 0.13384705 DataSet_03_405
ADH1C E2F6 shRNA Liver HuH7 1.74592 0.803991 - - DataSet_03_412
ADH1C E2F1 siRNA Prostate LNCaP 1.54688 0.629357 5.293563e-01 0.8184360010 DataSet_03_413
ADH1C E2F2 siRNA Prostate LNCaP 0.515625 -0.955606 6.459607e-01 7.850809e-01 DataSet_03_414
ADH1C FOXK2 shRNA Ovary OVCAR-5 7.97436 2.99537 7.109438e-02 0.22433705 DataSet_03_419
ADH1C MAEL CRISPR Liver Alexander cells 71 6.14975 - - DataSet_03_423
ADH1C SUFU shRNA Mammary_gland HCC1954 cells 0.0909091 -3.45943 0.0342891886 0.4495022 DataSet_03_437
ADH1C FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 0.557377 -0.843274 5.806067e-01 0.96793390 DataSet_03_439
ADH1C PHF14 siRNA Mammary_gland MDA-MB-231 2.90909 1.54057 0.1798361298 0.5994811 DataSet_03_443
ADH1C RELB CRISPR Colon SW480 4 2 1.179162e-01 3.014054e-01 DataSet_03_449
ADH1C CBX2 siRNA Mammary_gland MDA-MB-231 1.73064 0.791309 1.626256e-01 3.422343e-01 DataSet_03_450
ADH1C HAND1 siRNA Placenta HPMVEC 0.333333 -1.58496 3.786723e-02 0.9463341 DataSet_03_459
ADH1C PARP1 knockout Embryo_kidney HEK293a 2.6 1.37851 3.212143e-01 4.808292e-01 DataSet_03_464
ADH1C EZH2 siRNA Prostate LNCaP 2.05556 1.03953 4.776115e-01 1.0000000 DataSet_03_475
Regulation Region
 
T(co)Fs that significantly regulate YBX1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of ADH1C
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines