Gene Overview
Target Gene: AKR1C3
NCBI Official Symbol: AKR1C3
Entrez ID: 8644
Ensembl ID: ENSG00000196139
Gene Full Name: aldo-keto reductase family 1 member C3
Strand: +
Gene Locus: 10p15.1
External Links:

AKR1C3 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate AKR1C3   
T(co)Fs that Repress AKR1C3
The Intensity of the Gene Regulated by T(co)Fs:
AKR1C3-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
AKR1C3 FOXA1 shRNA Prostate 22RV1 0.35522 -1.49322 - - DataSet_01_105
AKR1C3 SPDEF shRNA Mammary_gland MCF7 4.21165 2.07439 0.33903 0.99999 DataSet_01_107
AKR1C3 ARID1A shRNA Ovary IOSE80pc 0.57367 -0.8017 - - DataSet_01_109
AKR1C3 HOXA1 siRNA Lung_fibroblast IMR-90 2.41206 1.27026 0.00209 0.04704 DataSet_01_110
AKR1C3 GABPA siRNA Lung A549 0.60466 -0.7258 9.50325e-08 1.8797e-06 DataSet_01_113
AKR1C3 ID1 siRNA Lung H1650 1.55492 0.63684 0.24391 0.58984 DataSet_01_118
AKR1C3 GATA3 siRNA Mammary_gland MCF7 0.52998 -0.91599 1.02967e-05 0.00063 DataSet_01_120
AKR1C3 ZIC2 siRNA Pancreas PANC1 1.50155 0.58645 - - DataSet_01_121
AKR1C3 FOXM1 siRNA Central_nervous_system U87 21.7676 4.44411 - - DataSet_01_122
AKR1C3 ID1 shRNA Neuroepithelium GSC2 1.51179 0.59626 6.61135e-09 5.42091e-08 DataSet_01_133
AKR1C3 ID1 shRNA Neuroepithelium GSC8 0.60803 -0.71778 2.24583e-07 4.70778e-07 DataSet_01_134
AKR1C3 IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 5.59304 2.48363 1.55212e-05 0.00341 DataSet_01_137
AKR1C3 IKZF1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 3.32318 1.73256 0.00257 0.66217 DataSet_01_138
AKR1C3 TFAP2C shRNA Mammary_gland MCF7 0.17608 -2.5057 1.4596e-15 1.88815e-13 DataSet_01_150
AKR1C3 STAT1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 0.47053 -1.08764 0.02525 0.1954 DataSet_01_154
AKR1C3 ETV1 shRNA Prostate LNCaP 1.92554 0.94526 0.00528 0.02308 DataSet_01_161
AKR1C3 ELK1 siRNA Peripheral_blood CD4+ T cells 0.567 -0.81857 0.13179 0.29428 DataSet_01_162
AKR1C3 MAF siRNA Peripheral_blood CD4+ T cells 0.64946 -0.62268 0.28773 0.64584 DataSet_01_165
AKR1C3 ESRRG siRNA Placenta_tissue Trophoblast cells 2.21327 1.14618 0.01675 0.17605 DataSet_01_173
AKR1C3 NR5A2 siRNA Mammary_gland MCF7 2.07224 1.05119 1.6036e-06 0.00019 DataSet_01_182
AKR1C3 TP63 shRNA Bladder UC14 3.9129 1.96824 3.77924e-09 1.68589e-06 DataSet_01_183
AKR1C3 CREB1 shRNA Parotid_gland HSY 0.65545 -0.60943 0.3929 0.97459 DataSet_01_195
AKR1C3 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.35259 -1.50395 - - DataSet_01_196
AKR1C3 TP63 siRNA Head_and_neck SCC-1 0.23387 -2.09622 - - DataSet_01_198
AKR1C3 TP63 siRNA Head_and_neck SCC-012 0.4892 -1.0315 - - DataSet_01_201
AKR1C3 TP63 siRNA Head_and_neck SCC-6 0.46728 -1.09765 - - DataSet_01_202
AKR1C3 XBP1 shRNA Mammary_gland T47D 3.87724 1.95503 2.04996e-07 0.00011 DataSet_01_203
AKR1C3 ATF2 siRNA Haematopoietic_and_lymphoid_tissue K562 2.4293 1.28054 0.15181 0.98802 DataSet_01_206
AKR1C3 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.34818 -1.5221 - - DataSet_01_209
AKR1C3 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.30394 -1.71812 - - DataSet_01_210
AKR1C3 LIN28A siRNA Embryo H9 4.56622 2.191 5.65632e-05 0.00221 DataSet_01_215
AKR1C3 TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 0.64155 -0.64038 0.02526 0.09577 DataSet_01_217
AKR1C3 PTEN shRNA Mammary_gland MCF10A 0.52315 -0.9347 4.33783e-06 1e-04 DataSet_01_218
AKR1C3 ATM shRNA Mammary_gland MCF10A 0.0363 -4.78403 2.70702e-05 0.00032 DataSet_01_219
AKR1C3 HIF1A shRNA Liver HuH7 0.61945 -0.69094 - - DataSet_01_224
AKR1C3 SNAI2 shRNA Skin Primary human keratinocytes 2.40874 1.26828 0.04366 0.11749 DataSet_01_225
AKR1C3 KLF2 shRNA Bone_marrow RPMI8226 2.53024 1.33928 0.00498 0.41961 DataSet_01_226
AKR1C3 IRX1 shRNA Bone_marrow 143B 0.51788 -0.9493 0.01607 0.13286 DataSet_01_227
AKR1C3 ESR2 siRNA Mammary_gland BT549 1.75727 0.81333 4.29586e-05 0.00076 DataSet_01_229
AKR1C3 FOXA1 siRNA Prostate LNCaP 2.17811 1.12308 0.00513 0.12746 DataSet_01_233
AKR1C3 FOXC2 siRNA Lymph Lymphatic endothelial cells 0.47107 -1.08598 0.13066 0.77378 DataSet_01_236
AKR1C3 ARNT shRNA Embryo hESC HSF1 2.07421 1.05256 0.36658 0.99999 DataSet_01_240
AKR1C3 EGR2 siRNA Muscle A673 0.61747 -0.69555 0.01493 0.4838 DataSet_01_242
AKR1C3 EGR2 siRNA Neuroepithelium SK-N-MC 0.52901 -0.91863 0.00662 0.55024 DataSet_01_243
AKR1C3 ETS1 siRNA Haematopoietic_and_lymphoid_tissue ALLSIL 0.64983 -0.62187 0.00504 0.25101 DataSet_01_244
AKR1C3 TWIST1 shRNA Stomach CAF14 3.13011 1.64622 0.0799 0.99996 DataSet_01_252
AKR1C3 TWIST1 shRNA Stomach CAF32 4.30921 2.10742 0.00104 0.01981 DataSet_01_253
AKR1C3 TWIST1 shRNA Stomach CAF 3.67265 1.87682 0.01759 0.52717 DataSet_01_254
AKR1C3 YBX1 shRNA Mammary_gland MDA 0.32404 -1.62577 5.11193e-10 7.9796e-08 DataSet_01_255
AKR1C3 YBX1 shRNA Mammary_gland MDA 0.34555 -1.53302 1.40799e-07 4.01312e-05 DataSet_01_257
AKR1C3 TLX1 shRNA Haematopoietic_and_lymphoid_tissue ALLSIL 0.58144 -0.78231 0.04943 0.99999 DataSet_01_263
AKR1C3 MEF2A shRNA Fetal_spinal_cord SPC04 1.53396 0.61726 0.00843 0.89906 DataSet_01_265
AKR1C3 HES1 shRNA Haematopoietic_and_lymphoid_tissue_Blood CUTLL1 1.53507 0.6183 7.62092e-05 0.00155 DataSet_01_266
AKR1C3 MSX1 siRNA Tooth Dental Pulp Cells 1.64187 0.71534 0.00036 0.00241 DataSet_01_281
AKR1C3 ZIC5 siRNA Skin A375 1.73012 0.79087 - - DataSet_01_284
AKR1C3 ZIC5 siRNA Skin SK-MEL-28 0.64759 -0.62684 - - DataSet_01_285
AKR1C3 NFYA shRNA Lung H322 0.57612 -0.79555 0.00819 0.03626 DataSet_01_288
AKR1C3 POSTN shRNA Brain GSC272 0.46117 -1.11663 0.08752 0.54319 DataSet_01_293
AKR1C3 TFAP4 siRNA Brain BE(2)-C 0.07756 -3.68851 0.15771 0.51625 DataSet_01_295
AKR1C3 ARID1B shRNA Liver IRM90 1.56705 0.64805 4.18592e-06 5e-04 DataSet_01_298
AKR1C3 PTEN shRNA Mammary_gland SKBR3 2.99201 1.58112 0.16426 0.66744 DataSet_01_303
AKR1C3 HOXA5 shRNA Mammary_gland MCF10A 2.18196 1.12562 0.01409 0.65306 DataSet_01_305
AKR1C3 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 1.61132 0.68824 0.09226 0.34824 DataSet_01_313
AKR1C3 ARNT siRNA Upper_aerodigestive_tract HSC3 0.27613 -1.85657 - - DataSet_01_315
AKR1C3 ELK3 shRNA Mammary_gland MDA-MB-231 0.33297 -1.58655 1.93296e-06 4.88322e-05 DataSet_01_318
AKR1C3 HNF4G shRNA Prostate 22RV1 0.29081 -1.78183 0.0028 0.13062 DataSet_01_320
AKR1C3 FOXO1 shRNA Haematopoietic_and_lymphoid_tissue RS4;11 1.64905 0.72163 0.0237 0.13504 DataSet_01_321
AKR1C3 MYC siRNA Colon HCT116 4.5313 2.17992 0.00017 0.00069 DataSet_01_324
AKR1C3 HOXC6 siRNA Prostate LNCaP 4.6253 2.20955 0.14685 0.99927 DataSet_01_333
AKR1C3 ETV4 shRNA Prostate PC3 1.58207 0.66181 - - DataSet_01_356
AKR1C3 SOX17 siRNA Umbilical_vein HUVEC 2.40067 1.26344 - - DataSet_01_360
AKR1C3 FIP1L1 shRNA Liver HepG2 0.48606 -1.0408 0.00433 0.02757 DataSet_02_103
AKR1C3 U2AF2 shRNA Liver HepG2 0.64148 -0.64052 0.66233 0.764 DataSet_02_113
AKR1C3 PTBP1 shRNA Liver HepG2 0.56058 -0.83502 0.0019 0.00886 DataSet_02_120
AKR1C3 SNRNP70 shRNA Liver HepG2 1.99334 0.99518 0.00692 0.04495 DataSet_02_126
AKR1C3 AGO2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.6594 -0.60077 0.15796 0.31716 DataSet_02_132
AKR1C3 SRSF7 shRNA Haematopoietic_and_lymphoid_tissue K562 0.62342 -0.68173 0.04024 0.26384 DataSet_02_133
AKR1C3 HNRNPK shRNA Haematopoietic_and_lymphoid_tissue K562 1.51582 0.6001 0.0149 0.16276 DataSet_02_136
AKR1C3 RBFOX2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.60232 -0.73141 0.1892 0.5399 DataSet_02_139
AKR1C3 TAF15 shRNA Haematopoietic_and_lymphoid_tissue K562 1.71719 0.78005 0.48536 0.69148 DataSet_02_140
AKR1C3 PTBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.68665 0.75416 0.07661 0.2846 DataSet_02_144
AKR1C3 FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.09036 1.06375 0.02857 0.12136 DataSet_02_147
AKR1C3 ILF3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.53668 -0.89787 0.02756 0.27888 DataSet_02_148
AKR1C3 SAFB2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.51351 -0.96153 0.01809 0.42628 DataSet_02_150
AKR1C3 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 1.84663 0.88489 0.11598 0.40378 DataSet_02_152
AKR1C3 SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 1.81614 0.86088 0.07308 0.40467 DataSet_02_154
AKR1C3 FUS shRNA Haematopoietic_and_lymphoid_tissue K562 2.4988 1.32124 0.00208 0.22733 DataSet_02_155
AKR1C3 PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 1.88696 0.91606 0.2209 0.3495 DataSet_02_158
AKR1C3 SUB1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.06278 1.04459 0.02201 0.66851 DataSet_02_161
AKR1C3 ZFX siRNA Prostate C4-2B 2.61111 1.38466 0.00331 0.01431 DataSet_02_172
AKR1C3 RAD21 siRNA Haematopoietic_and_lymphoid_tissue K562 0.60973 -0.71375 0.28737 1 DataSet_02_190
AKR1C3 AR siRNA Mammary_gland MCF7 1.79871 0.846967 9.44027642828007e-06 0.000749007265613788 DataSet_03_006
AKR1C3 AR siRNA Prostate VCaP 1.6219 0.697682 1.84226474153894e-06 0.00155980538516079 DataSet_03_007
AKR1C3 AR siRNA Prostate VCaP 1.52626 0.61 0.00104372173443271 0.140275231008176 DataSet_03_010
AKR1C3 AR siRNA Prostate LNCaP 6.61659 2.72609 3.8206156667837e-06 1.70159300206674e-05 DataSet_03_011
AKR1C3 ATR siRNA Mammary_gland MCF7 0.457569 -1.12794 0.111107054080412 0.999819450785634 DataSet_03_020
AKR1C3 BCL6 siRNA Central_nervous_system U87 2.00809 1.00582 0.000412915255718265 0.0343747063266803 DataSet_03_027
AKR1C3 BRCA2 siRNA Mammary_gland MCF7 0.646997 -0.628169 0.3413121201585 0.999441861952364 DataSet_03_029
AKR1C3 CEBPB siRNA Mammary_gland MCF7 0.489984 -1.02919 0.139788968380166 0.993756826434039 DataSet_03_048
AKR1C3 CEBPB siRNA Embryo hESC 0.526763 -0.924775 0.821548771433706 0.946977216971352 DataSet_03_049
AKR1C3 CEBPD siRNA Mammary_gland MCF7 0.444291 -1.17042 0.10061192058096 0.999848455332859 DataSet_03_050
AKR1C3 CENPF siRNA Mammary_gland MCF7 1.90146 0.92711 0.176794492948196 0.999662524742916 DataSet_03_052
AKR1C3 CHEK1 siRNA Mammary_gland MCF7 0.589026 -0.763598 0.255166269006612 0.999587656258211 DataSet_03_053
AKR1C3 CREBBP siRNA Mammary_gland MCF7 0.562474 -0.830142 0.22014761640144 0.966455540764243 DataSet_03_055
AKR1C3 CTNNB1 siRNA Mammary_gland MCF7 1.98661 0.990312 0.152927952480261 0.999436862066063 DataSet_03_058
AKR1C3 E2F5 siRNA Mammary_gland MCF7 2.07659 1.05422 0.131908935071673 0.999540347732068 DataSet_03_062
AKR1C3 E2F7 siRNA Upper_aerodigestive_tract SCC25 3.61435 1.85373 3.71844881748365e-10 6.60012764079335e-07 DataSet_03_063
AKR1C3 ERF siRNA Mammary_gland MCF7 0.636563 -0.651626 0.324883954446051 0.999855523449227 DataSet_03_067
AKR1C3 ESR1 siRNA Mammary_gland MCF7 0.3531 -1.50185 1.11759983922063e-05 0.00240825411317276 DataSet_03_071
AKR1C3 FOS siRNA Mammary_gland MCF7 0.518688 -0.947062 0.168908786187508 0.999966427400474 DataSet_03_079
AKR1C3 FOXA1 siRNA Mammary_gland MCF7 4.7576 2.25023 4.33034126453865e-19 3.74596171088916e-15 DataSet_03_081
AKR1C3 FOXA1 siRNA Mammary_gland MCF7 4.7576 2.25023 4.33034126453865e-19 3.74596171088916e-15 DataSet_03_082
AKR1C3 FOXA1 siRNA Prostate LNCaP 1.7241 0.785847 7.46660561603648e-06 0.000333831546171231 DataSet_03_083
AKR1C3 FOXC1 siRNA Mammary_gland MCF7 0.445332 -1.16705 0.101409217280388 0.999669928105298 DataSet_03_084
AKR1C3 FOXF2 siRNA Mammary_gland MCF10A 2.8122 1.4917 - - DataSet_03_086
AKR1C3 FOXJ2 siRNA Mammary_gland MCF7 0.54131 -0.885472 0.194356641567138 0.999965704179325 DataSet_03_088
AKR1C3 FOXM1 siRNA Aorta Vascular smooth muscle cells 0.665358 -0.587798 - - DataSet_03_090
AKR1C3 FOXP1 siRNA Mammary_gland MCF7 0.552315 -0.856436 0.20753010869963 0.999975993110711 DataSet_03_099
AKR1C3 GATA2 siRNA Uterus Decidual stromal cells 0.301642 -1.72909 0.279611486296905 0.855104396266006 DataSet_03_100
AKR1C3 GATA3 siRNA Mammary_gland MCF7 0.565775 -0.821701 0.224340835391829 0.999831535534034 DataSet_03_102
AKR1C3 GATA3 siRNA Mammary_gland MCF7 0.346029 -1.53103 4.85514514843617e-06 0.00330273628695482 DataSet_03_103
AKR1C3 GATA6 siRNA Stomach AGS 0.636184 -0.652484 0.241543496177855 0.732683066218161 DataSet_03_108
AKR1C3 GFP siRNA Upper_aerodigestive_tract SCC25 2.1718 1.11889 1.72562356519402e-07 5.48494282695807e-05 DataSet_03_112
AKR1C3 HDAC3 siRNA Mammary_gland MCF7 0.535702 -0.900497 0.187842862662309 0.99997791025972 DataSet_03_114
AKR1C3 HDAC5 siRNA Mammary_gland MCF7 2.26991 1.18263 0.0977801972895307 0.999966625300244 DataSet_03_115
AKR1C3 HIF1A siRNA Mammary_gland MCF7 0.507049 -0.979804 0.156674642277075 0.999966843283762 DataSet_03_119
AKR1C3 HOXC4 siRNA Skin Fibroblast 0.629066 -0.668716 0.000157758643501606 0.0334893532665188 DataSet_03_128
AKR1C3 HSF2 siRNA Mammary_gland MCF7 2.01947 1.01398 0.144797221203468 0.990969613280381 DataSet_03_130
AKR1C3 HTATIP siRNA Prostate LNCaP 1.97332 0.980623 6.22167852356575e-06 5.89019565140856e-05 DataSet_03_131
AKR1C3 HTATIP2 siRNA Prostate LNCaP 6.10581 2.61018 0.0309863890328011 0.0467833716769742 DataSet_03_132
AKR1C3 ID1 siRNA Mammary_gland MCF7 0.526821 -0.924615 0.177804433444742 0.999926480273844 DataSet_03_133
AKR1C3 JARID1A siRNA Autonomic_ganglia SKNBE2 1.69375 0.760217 0.00442512837144771 0.215786126410629 DataSet_03_135
AKR1C3 JARID1A siRNA Brain NB1691 1.74638 0.804367 0.0547557241940535 0.547529103219286 DataSet_03_136
AKR1C3 KLF5 siRNA Stomach KatoIII 0.537839 -0.894754 0.000437200375899895 0.0718339660695207 DataSet_03_150
AKR1C3 LHX9 siRNA Skin Fibroblast 0.542255 -0.882955 9.90112411973166e-07 0.00155726680359525 DataSet_03_152
AKR1C3 MAX siRNA Mammary_gland MCF7 0.616952 -0.696769 0.29507468022009 0.999907009675999 DataSet_03_158
AKR1C3 MCM2 siRNA Mammary_gland MCF7 0.507346 -0.978959 0.15697964912242 0.999925560383539 DataSet_03_161
AKR1C3 MEF2D shRNA Liver HuH7 0.183814 -2.44368 - - DataSet_03_162
AKR1C3 MITF siRNA Skin Ma-Mel-15 3.97689 1.99164 0.000363678106807015 0.0282837193110048 DataSet_03_166
AKR1C3 MITF siRNA Skin Ma-Mel-15 2.30529 1.20495 0.0154386709269847 0.175230935789723 DataSet_03_167
AKR1C3 MYB siRNA Cord_Blood CD34+ progenitor cells 0.328237 -1.60719 - - DataSet_03_170
AKR1C3 MYB siRNA Prostate DU145 1.86004 0.895333 6.9170965865e-06 0.00451595049219005 DataSet_03_171
AKR1C3 MYB siRNA Prostate PC-3M 1.87211 0.904667 4.46653764649108e-09 5.9442744478417e-06 DataSet_03_173
AKR1C3 MYB siRNA Prostate VCaP 0.640972 -0.641667 0.00149284596075555 0.0538160406123087 DataSet_03_174
AKR1C3 NCOA3 siRNA Prostate LNCaP 1.71622 0.779234 0.0866063345688048 0.27045281118924 DataSet_03_191
AKR1C3 NCOR2 siRNA Mammary_gland MCF7 0.539138 -0.891275 0.191816900723046 0.999834929103349 DataSet_03_193
AKR1C3 NMI siRNA Mammary_gland MCF7 0.471102 -1.08589 0.122547050355189 0.714335498100033 DataSet_03_199
AKR1C3 OSR1 siRNA Skin Fibroblast 0.595362 -0.748161 1.66245989555821e-05 0.00200906910572283 DataSet_03_204
AKR1C3 PAX3 siRNA Mammary_gland MCF7 0.479967 -1.05899 0.0768010268792212 0.919978041032696 DataSet_03_206
AKR1C3 PCNA siRNA Mammary_gland MCF7 2.74402 1.45629 0.0516280495977633 0.999448838103647 DataSet_03_210
AKR1C3 PHB shRNA Embryo Embryonic stem cells (ESCs) 0.471398 -1.08498 0.000180469424144517 0.00180747089528162 DataSet_03_211
AKR1C3 POLR2A siRNA Mammary_gland MCF7 0.647863 -0.62624 0.263051469255822 0.999513313282531 DataSet_03_213
AKR1C3 PRRX1 CRISPR Neuroblastoma 691-MES 0.282546 -1.82344 0.194292393172253 0.89189998148014 DataSet_03_217
AKR1C3 RBL2 siRNA Mammary_gland MCF7 0.571496 -0.807186 0.231717890853504 0.999927471951507 DataSet_03_220
AKR1C3 RELA siRNA Mammary_gland MCF7 0.647902 -0.626153 0.34275464930286 0.999993711976373 DataSet_03_224
AKR1C3 RELB siRNA Immortalized_keratinocyte HaCaT 14.1444 3.82216 6.3170660279635e-10 7.43479995576847e-08 DataSet_03_227
AKR1C3 SMAD7 siRNA Mammary_gland MCF7 0.528003 -0.921382 0.179120511210137 0.99858912864726 DataSet_03_234
AKR1C3 SOX2 siRNA Mammary_gland GSC-11 0.654809 -0.610853 0.0908579383895211 0.28726706004603 DataSet_03_245
AKR1C3 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.0300752 -5.05528 - - DataSet_03_246
AKR1C3 SOX4 siRNA Mammary_gland MDA-LM2 0.340212 -1.5555 0.00384943370386026 0.270044492597122 DataSet_03_247
AKR1C3 SP1 siRNA Ovary OVSAYO 0.360412 -1.47228 0.00413405243133793 0.0981290883010731 DataSet_03_251
AKR1C3 STAT1 siRNA Mammary_gland MCF7 0.612701 -0.706745 0.288802809149348 0.999890411872485 DataSet_03_256
AKR1C3 STAT3 siRNA Prostate LNCaP 2.31233 1.20935 0.0313079568462346 0.0569459687518125 DataSet_03_262
AKR1C3 STAT5B siRNA Mammary_gland MCF7 1.7414 0.800247 0.235318814739957 0.999932708473107 DataSet_03_263
AKR1C3 STAT6 siRNA Umbilical_vein HUVEC 0.65983 -0.599834 0.074960302348456 0.789771205947014 DataSet_03_264
AKR1C3 TCEA1 siRNA Mammary_gland MCF7 1.52443 0.608273 0.355759690181347 0.999762252994287 DataSet_03_266
AKR1C3 TET2 siRNA Prostate DU145 1.52623 0.60997 - - DataSet_03_271
AKR1C3 TP63 siRNA Skin Primary neonatal keratinocytes 0.231855 -2.10871 0.0125012822085579 0.0566349929343769 DataSet_03_281
AKR1C3 TP63 siRNA Foreskin Neonatal foreskin keratinocytes 5.67778 2.50533 7.94817689345929e-05 0.710683149277425 DataSet_03_282
AKR1C3 TWIST2 siRNA Skin Fibroblast 0.624221 -0.679871 7.78826180071195e-05 0.0109995687684994 DataSet_03_284
AKR1C3 WT1 siRNA Mammary_gland MCF7 0.590604 -0.759736 0.257339786132021 0.999957852801679 DataSet_03_285
AKR1C3 ZNF263 siRNA Cervix HeLaS3 1.64028 0.713938 0.00110761128507732 0.0340309554255641 DataSet_03_290
AKR1C3 ZNF746 siRNA Colon HCT116 2.07053 1.05 - - DataSet_03_293
AKR1C3 ZNF750 siRNA Skin Primary neonatal keratinocytes 0.348632 -1.52022 5.56013864903654e-05 0.0142783656484272 DataSet_03_294
AKR1C3 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 0.569028 -0.813429 0.2302477235545 0.375146985736331 DataSet_04_014
AKR1C3 SMAD5 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.634476 -0.656363 0.0283087487022147 0.395800493182546 DataSet_04_020
AKR1C3 CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 2.12456 1.08716 0.0384679776826807 0.147363769452081 DataSet_04_061
AKR1C3 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 0.427114 -1.22731 0.00545321889744168 0.0193272489326061 DataSet_04_059
AKR1C3 PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 2.39292 1.25877 0.00415653929944114 0.216445920582559 DataSet_04_065
AKR1C3 KDM5A shRNA Brain NCH644 1.94228 0.95775 1.445068e-03 0.313477886 DataSet_03_316
AKR1C3 ZNF598 knockout Cervix HeLa 0.00983549 -6.66779 2.214466e-04 0.5632019 DataSet_03_299
AKR1C3 AEBP1 siRNA Umbilical_vein HUVEC 1.57012 0.650878 5.327027e-01 0.999982779 DataSet_03_300
AKR1C3 SMARCA4 siRNA Colon HCT116 0.598697 -0.740102 7.600301e-03 0.1330646 DataSet_03_302
AKR1C3 ELF3 CRISPR Bile_duct HBDEC2 2.45247 1.29424 4.552002e-04 3.443499e-03 DataSet_03_304
AKR1C3 ELF3 knockdown Bile_duct HBDEC2 1.56895 0.649803 1.671520e-03 2.607902e-02 DataSet_03_305
AKR1C3 HDAC5 siRNA Liver human hepatocytes 0.613932 -0.70385 3.788710e-07 6.134632e-05 DataSet_03_346
AKR1C3 INO80 siRNA Muscle RD 2.44984 1.29269 - - DataSet_03_344
AKR1C3 EZH2 knockdown Colon HCT116 1.5738 0.654251 0.710964536 0.9997630 DataSet_03_334
AKR1C3 DNMT1 shRNA Lung hTERT-immortalised adult fibroblasts 1.74139 0.800238 4.691984e-03 1.707335e-01 DataSet_03_311
AKR1C3 TET1 CRISPR Mammary_gland MDA-MB-231 0.0872276 -3.51907 4.374095e-07 7.341190e-05 DataSet_03_347
AKR1C3 ZFX siRNA Prostate C4-2B 5.12437 2.35737 2.284198e-03 6.476463e-03 DataSet_03_348
AKR1C3 SKI CRISPR Blood HL60 5.68966 2.50834 1.350596e-03 0.088078123 DataSet_03_351
AKR1C3 ESR1 siRNA Mammary_gland MCF7 0.618065 -0.69417 1.819976e-02 0.0995113238 DataSet_03_352
AKR1C3 ETV5 knockdown Colon HT29 2.75143 1.46018 9.719217e-02 0.329221277 DataSet_03_353
AKR1C3 PARP1 siRNA Prostate LNCaP 2.98865 1.57949 3.717444e-01 0.647122293 DataSet_03_354
AKR1C3 CREBBP CRISPR Brain U5-NPC 0.4 -1.32193 0.8182230439 0.8890638 DataSet_03_356
AKR1C3 TP53 CRISPR Brain U5-NPC 4.1 2.03562 2.423202e-01 3.759099e-01 DataSet_03_358
AKR1C3 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 1.51667 0.600908 3.857973e-05 2.927738e-04 DataSet_03_362
AKR1C3 MYC siRNA Peripheral_blood T lymphocyte 1.64396 0.717177 1.558590e-01 0.407864976 DataSet_03_363
AKR1C3 EP300 shRNA Mammary_gland MCF10AT 2.33069 1.22076 6.679838e-03 0.058146896 DataSet_03_364
AKR1C3 TP53 knockout Stomach SNU1 0.461713 -1.11493 0.0975510654 0.9301241 DataSet_03_365
AKR1C3 USP22 shRNA Liver PLC_PRF_5 cells 2.59091 1.37346 1.178425e-01 0.32097262 DataSet_03_368
AKR1C3 ZNF213 siRNA Mammary_gland MCF7 1.95482 0.967036 4.642540e-01 7.067350e-01 DataSet_03_376
AKR1C3 EZH2 CRISPR Ovary SKOV3 8.82727 3.14197 2.537180e-06 0.0008177305 DataSet_03_378
AKR1C3 DDX5 shRNA Stomach HGC-27 3.57143 1.8365 - - DataSet_03_379
AKR1C3 NFKB2 siRNA Bone_marrow U2OS 1.99708 0.997895 1.716524e-02 0.17928694 DataSet_03_381
AKR1C3 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 2.40954 1.26875 0.0197030112 0.8388073 DataSet_03_387
AKR1C3 NFKBIA shRNA Bone_marrow U2OS 0.358028 -1.48186 1.354833e-01 0.87005461 DataSet_03_389
AKR1C3 KDM5A CRISPR Lung GLC16 5.86128 2.55122 8.057419e-04 0.014921520 DataSet_03_392
AKR1C3 ASXL1 CRISPR Embryo iPSC 0.624538 -0.679139 0.9932518928 0.9989345 DataSet_03_394
AKR1C3 BMI1 shRNA Bile_duct QBC-939 2.44092 1.28742 6.799857e-06 0.0006980907 DataSet_03_395
AKR1C3 IKZF2 CRISPR Lymph CAR T Cell 0.477334 -1.06693 8.767831e-03 0.271769499 DataSet_03_397
AKR1C3 TLE4 CRISPR Lymph CAR T Cell 0.293598 -1.76808 6.824717e-04 0.06869266 DataSet_03_398
AKR1C3 RELA CRISPR Brain T30 0.546758 -0.871026 0.2749197897 0.8400824 DataSet_03_399
AKR1C3 CDK7 shRNA Bone_marrow D458 4.75 2.24793 1.844536e-02 0.21419239 DataSet_03_404
AKR1C3 TFAP2A knockout Embryo H9 0.590164 -0.760812 1.466024e-02 0.07782985 DataSet_03_405
AKR1C3 CHD1 shRNA Prostate LNCaP 0.189791 -2.39752 2.490218e-02 3.524945e-01 DataSet_03_407
AKR1C3 MAP3K7 shRNA Prostate LNCaP 0.487238 -1.0373 9.509250e-01 9.780291e-01 DataSet_03_408
AKR1C3 SIRT1 siRNA Pancreas PANC1 1.81818 0.862496 4.519884e-01 0.615127473 DataSet_03_410
AKR1C3 USP22 shRNA Liver HuH7 2.15725 1.10919 - - DataSet_03_411
AKR1C3 E2F6 shRNA Liver HuH7 0.47719 -1.06736 - - DataSet_03_412
AKR1C3 E2F1 siRNA Prostate LNCaP 0.537634 -0.895303 2.970771e-01 0.7226289181 DataSet_03_413
AKR1C3 ZKSCAN3 CRISPR Colon HCT116 2.30672 1.20584 2.378824e-02 0.323017727 DataSet_03_415
AKR1C3 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 0.5 -1 9.517175e-02 0.251604276 DataSet_03_418
AKR1C3 FOXK2 shRNA Ovary OVCAR-5 0.375 -1.41504 1.159053e-01 0.30535956 DataSet_03_419
AKR1C3 PRDM1 CRISPR Lymph CD8+ T cells 0.504951 -0.985786 - - DataSet_03_421
AKR1C3 FOXP3 CRISPR Peripheral_blood Naive Treg 0.625709 -0.676436 2.588913e-01 0.617015738 DataSet_03_427
AKR1C3 USP7 shRNA Skin xenograft cells 0.509317 -0.973365 0.29035485 0.4384136 DataSet_03_431
AKR1C3 PLAG1 shRNA Cord_blood Lin-CD34+ HSPCs 0.375 -1.41504 - - DataSet_03_432
AKR1C3 EP300 knockout Pancreas HPAF-II orthotopic cells 0.593294 -0.75318 3.948511e-07 5.005954e-05 DataSet_03_436
AKR1C3 SUFU shRNA Mammary_gland HCC1954 cells 1.87492 0.906829 0.1083709870 0.6455297 DataSet_03_437
AKR1C3 CIC knockout Brain Immortalized Astrocyte Cells 5.73558 2.51994 1.293775e-02 2.139655e-01 DataSet_03_438
AKR1C3 SETDB1 shRNA Colon HCT116 12.7711 3.67481 - - DataSet_03_440
AKR1C3 DAXX shRNA Mammary_gland MDA-MB-231 1.67062 0.740385 1.052724e-02 0.11537367 DataSet_03_441
AKR1C3 PURA siRNA Cervix HeLa 6 2.58496 4.965766e-01 0.655028958 DataSet_03_444
AKR1C3 CBX2 siRNA Mammary_gland MDA-MB-231 0.452278 -1.14472 4.933110e-04 5.567696e-03 DataSet_03_450
AKR1C3 ZFP36L1 CRISPR Lung NCI-H1876 2.5128 1.32929 1.257627e-01 0.992381486 DataSet_03_454
AKR1C3 SMARCA2 shRNA Lung HCC2302 0.13784 -2.85894 1.894280e-05 3.834990e-05 DataSet_03_455
AKR1C3 ARID1A shRNA Bile_duct MMNK1 0.65794 -0.603971 4.315482e-01 0.637765925 DataSet_03_458
AKR1C3 IRF2 shRNA Cord_Blood CD34+ cells 1.77201 0.825383 - - DataSet_03_460
AKR1C3 TXNIP shRNA Cord_blood ST3 0.43949 -1.1861 1.722094e-02 0.1941473862 DataSet_03_462
AKR1C3 SOX9 knockout Liver HuH7 4.63158 2.2115 6.861180e-04 7.057504e-03 DataSet_03_463
AKR1C3 STAT3 shRNA Liver HepG2 1.97306 0.980433 7.195933e-03 0.1208095864 DataSet_03_465
AKR1C3 LIN28A siRNA Mammary_gland MCF7M 1.61451 0.691097 6.226784e-01 0.9060554 DataSet_03_469
AKR1C3 LIN28A siRNA Mammary_gland MCF7M 1.61451 0.691097 6.226784e-01 0.9060554 DataSet_03_470
AKR1C3 CREBBP CRISPR Lymph U2932 1.75 0.807355 6.540405e-01 1.0000000 DataSet_03_474
Regulation Region
 
T(co)Fs that significantly regulate MCM2 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of AKR1C3
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines