Gene Overview
Target Gene: GRM2
NCBI Official Symbol: GRM2
Entrez ID: 2912
Ensembl ID: ENSG00000164082
Gene Full Name: glutamate metabotropic receptor 2
Strand: +
Gene Locus: 3p21.2
External Links:

GRM2 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate GRM2   
T(co)Fs that Repress GRM2
The Intensity of the Gene Regulated by T(co)Fs:
GRM2-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
GRM2 ZIC2 siRNA Pancreas PANC1 1.55741 0.63915 - - DataSet_01_121
GRM2 ID1 shRNA Neuroepithelium GSC8 0.54354 -0.87954 5.53883e-10 2.49821e-09 DataSet_01_134
GRM2 POLR3A siRNA Mammary_gland MCF7 3.69947 1.88732 - - DataSet_01_139
GRM2 HSF1 shRNA Skin A375 0.39314 -1.34689 0.03057 0.13988 DataSet_01_155
GRM2 STAT3 siRNA Peripheral_blood CD4+ T cells 0.46227 -1.1132 0.11596 0.99183 DataSet_01_168
GRM2 HOXB7 siRNA Pancreas Capan-1 0.5835 -0.77719 0.09694 0.56934 DataSet_01_170
GRM2 TP53 siRNA Lung SAECs 2.57246 1.36315 0.05035 0.40719 DataSet_01_175
GRM2 GATA2 siRNA Prostate LNCaP 0.55406 -0.8519 0.00354 0.01553 DataSet_01_193
GRM2 CREB1 shRNA Parotid_gland H3118 MEC 1.73146 0.79199 0.28679 0.64869 DataSet_01_194
GRM2 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.3099 -1.69011 - - DataSet_01_196
GRM2 TP63 siRNA Immortalized_keratinocyte HaCaT RG 0.56313 -0.82846 - - DataSet_01_197
GRM2 TP63 siRNA Head_and_neck SCC-1 0.27058 -1.88588 - - DataSet_01_199
GRM2 TP63 siRNA Head_and_neck SCC-6 0.49726 -1.00793 - - DataSet_01_202
GRM2 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.5416 -0.8847 - - DataSet_01_210
GRM2 REST siRNA Prostate LNCaP 2.39483 1.25992 0.12956 0.40162 DataSet_01_211
GRM2 LIN28A siRNA Embryo H9 0.37462 -1.41651 0.00134 0.01484 DataSet_01_215
GRM2 KLF2 shRNA Bone_marrow RPMI8226 0.64867 -0.62444 0.10522 0.71331 DataSet_01_226
GRM2 IRX1 shRNA Bone_marrow 143B 0.60883 -0.71589 0.00765 0.09368 DataSet_01_227
GRM2 TWIST1 shRNA Stomach CAF32 0.50874 -0.97499 0.00259 0.02746 DataSet_01_253
GRM2 SNAI2 siRNA Mammary_gland MCFDCIS 1.69274 0.75936 0.03494 0.52487 DataSet_01_292
GRM2 POSTN shRNA Brain GSC272 1.75987 0.81547 0.22512 0.60941 DataSet_01_293
GRM2 TFAP4 siRNA Brain BE(2)-C 0.15248 -2.71329 0.29864 0.51625 DataSet_01_295
GRM2 PTEN shRNA Lung HCC827 1.50142 0.58633 0.39556 0.7765 DataSet_01_302
GRM2 SOX9 siRNA Prostate VCaP 0.54511 -0.87539 0.44766 0.94214 DataSet_01_308
GRM2 SOX9 siRNA Prostate VCaP 0.54511 -0.87539 0.44766 0.94214 DataSet_01_309
GRM2 HIF1A siRNA Oral_cavity OEC-M1 2.28886 1.19463 0.07091 0.85151 DataSet_01_348
GRM2 SAFB2 shRNA Liver HepG2 0.57143 -0.80735 0.08215 0.14971 DataSet_02_102
GRM2 TAF15 shRNA Liver HepG2 0.5 -1 0.21252 0.28086 DataSet_02_106
GRM2 SSB shRNA Liver HepG2 1.66667 0.73697 0.61421 0.67724 DataSet_02_107
GRM2 BCLAF1 shRNA Liver HepG2 4 2 0.03081 0.08926 DataSet_02_112
GRM2 PTBP1 shRNA Liver HepG2 0.6 -0.73697 0.05349 0.08141 DataSet_02_120
GRM2 RBM17 shRNA Haematopoietic_and_lymphoid_tissue K562 0.14286 -2.80735 0.0197 0.26029 DataSet_02_138
GRM2 CCAR2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.03509 0.47558 DataSet_02_146
GRM2 MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.76034 1 DataSet_02_173
GRM2 LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 4 2 0.27087 1 DataSet_02_175
GRM2 CEBPZ siRNA Haematopoietic_and_lymphoid_tissue K562 10 3.32193 0.03114 1 DataSet_02_176
GRM2 TBL1XR1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.0926 1 DataSet_02_178
GRM2 MAFK siRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.09267 1 DataSet_02_183
GRM2 BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 10 3.32193 0.17733 1 DataSet_02_188
GRM2 MAFG siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.17849 1 DataSet_02_189
GRM2 MAX siRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.09163 1 DataSet_02_192
GRM2 TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.81259 1 DataSet_02_194
GRM2 LMNB1 siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.19343 1 DataSet_02_195
GRM2 CDAN1 siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.19833 1 DataSet_02_197
GRM2 E2F4 siRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.8211 1 DataSet_02_200
GRM2 TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.11111 -3.16993 0.03333 1 DataSet_02_201
GRM2 BRCA1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.76542 1 DataSet_02_202
GRM2 RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.83425 1 DataSet_02_204
GRM2 E2F6 siRNA Haematopoietic_and_lymphoid_tissue K562 26 4.70044 0.43656 1 DataSet_02_205
GRM2 AR siRNA Prostate abl cells 0.62 -0.68966 0.335123709704571 0.999852161656754 DataSet_03_004
GRM2 ATF4 siRNA Skin A375 0.609714 -0.713796 0.0746079663684212 0.775512819201899 DataSet_03_018
GRM2 CEBPB siRNA Embryo hESC 0.542841 -0.881398 0.480289544276602 0.787253152244965 DataSet_03_049
GRM2 GATA2 siRNA Uterus Decidual stromal cells 0.539396 -0.890583 0.117454409558248 0.747751815518144 DataSet_03_100
GRM2 GATA4 siRNA Stomach AGS 1.68264 0.750727 0.141379545990422 0.79562735665868 DataSet_03_105
GRM2 GATA4 siRNA Stomach YCC3 1.57204 0.652643 0.0644469889128333 0.608920306487047 DataSet_03_107
GRM2 HNF4a siRNA Liver HepG2 0.459259 -1.12262 0.0346055711431061 0.604885684213422 DataSet_03_126
GRM2 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 1.70089 0.766287 0.50245804934673 0.999948959532916 DataSet_03_134
GRM2 KLF5 siRNA Stomach YCC3 0.636901 -0.650859 0.15739916432705 0.519189475019385 DataSet_03_151
GRM2 MEF2D shRNA Liver HuH7 3.36572 1.75092 - - DataSet_03_162
GRM2 MYB siRNA Cord_Blood CD34+ progenitor cells 2.19576 1.13472 - - DataSet_03_170
GRM2 SOX2 CRISPR Seminoma-like TCam-2 1.61986 0.695873 0.208586138635948 0.999580851453413 DataSet_03_244
GRM2 STAT3 CRISPR Embryo hESC 7.52738 2.91215 0.029493368119875 0.0979681724139433 DataSet_03_258
GRM2 STAT6 siRNA Umbilical_vein HUVEC 0.553531 -0.853265 0.666175250605842 0.954900357552075 DataSet_03_264
GRM2 TET2 siRNA Prostate LNCaP 1.56241 0.64377 - - DataSet_03_272
GRM2 TFAP2C siRNA Mammary_gland MCF7 0.646449 -0.629392 0.360607334680326 0.676527989818506 DataSet_03_274
GRM2 TFE3 siRNA Kidney UOK257-2 1.91924 0.940532 - - DataSet_03_275
GRM2 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 287.684 8.16834 0.00128891118174731 0.0144240576358051 DataSet_04_014
GRM2 CTCF CRISPR Liver HepG2 0.5 -1 0.128096294911839 0.87075549477253 DataSet_04_027
GRM2 FUBP1 shRNA Liver HepG2 0.636364 -0.652077 0.76158699503049 0.904261337051618 DataSet_04_030
GRM2 MECP2 CRISPR Liver HepG2 0.545455 -0.874469 0.585226945440491 0.783754274915452 DataSet_04_031
GRM2 PAN2 CRISPR Liver HepG2 4 2 0.0324905270975787 0.154817192287609 DataSet_04_033
GRM2 SMAD5 CRISPR Liver HepG2 6.33333 2.66297 0.00454673183139104 0.367798690114644 DataSet_04_036
GRM2 WRN shRNA Liver HepG2 0.545455 -0.874469 0.603822081268546 0.773357590755468 DataSet_04_038
GRM2 YBX1 CRISPR Liver HepG2 2.4 1.26303 0.259759787173927 0.972884761036538 DataSet_04_039
GRM2 ZNF574 CRISPR Liver HepG2 2.33333 1.22239 0.0520319171806686 0.14578086794285 DataSet_04_041
GRM2 DDX20 CRISPR Liver HepG2 1.63636 0.710493 0.373469133891096 0.519887693024649 DataSet_04_043
GRM2 APTX CRISPR Liver HepG2 0.5 -1 0.661564376575096 0.969929995678059 DataSet_04_069
GRM2 CHCHD3 CRISPR Liver HepG2 0.2 -2.32193 0.356261193681754 0.67899177834665 DataSet_04_067
GRM2 SEPT11 CRISPR Liver HepG2 2.8 1.48543 0.421463585419692 0.674080248074305 DataSet_04_068
GRM2 CALR shRNA Liver HepG2 0.333333 -1.58496 0.841347961511882 0.914540252275944 DataSet_04_053
GRM2 CCAR1 shRNA Liver HepG2 2 1 0.862349544664328 0.932017881290817 DataSet_04_054
GRM2 DDX1 shRNA Liver HepG2 0.571429 -0.807355 0.817586708576934 0.920707652816147 DataSet_04_057
GRM2 YBX3 shRNA Liver HepG2 2.28571 1.19265 0.540332312130831 0.714892696049715 DataSet_02_98
GRM2 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.83333 0.874469 0.606032164030321 0.754009054229395 DataSet_04_049
GRM2 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 4.05263 2.01886 0.367526854738048 0.622542005994332 DataSet_02_38
GRM2 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.15789 1.65896 0.14023275031269 0.260978568758356 DataSet_02_14
GRM2 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.21053 1.14439 0.378278736877406 0.557349438307065 DataSet_02_34
GRM2 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 4 2 0.328020060718413 0.698477149176385 DataSet_02_75
GRM2 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 8.73684 3.12711 0.0768395434475745 0.553341101868115 DataSet_02_45
GRM2 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 12.9737 3.69752 0.2305651199332 0.507490245244006 DataSet_02_32
GRM2 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.421053 -1.24793 0.332012584928583 0.492795127263206 DataSet_02_47
GRM2 SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.470588 -1.08746 0.628649876633448 0.908774970066088 DataSet_02_49
GRM2 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.105263 -3.24793 0.174381947569016 0.299795066760762 DataSet_02_33
GRM2 TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 3.73684 1.90182 0.323113892121004 0.493230443368067 DataSet_02_53
GRM2 UBE2L3 shRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.701973047620911 0.870151612401658 DataSet_04_062
GRM2 SMARCA4 siRNA Colon HCT116 2.30747 1.20631 4.086704e-02 6.817062e-01 DataSet_03_301
GRM2 ELF3 CRISPR Bile_duct HBDEC2 2.81137 1.49127 1.957385e-03 1.011306e-02 DataSet_03_304
GRM2 ACTR5 siRNA Muscle RD 0.20437 -2.29074 - - DataSet_03_343
GRM2 INO80 siRNA Muscle RD 0.0858016 -3.54285 - - DataSet_03_344
GRM2 BRCA1 siRNA Mammary_gland MCF7 2.50671 1.32579 2.247172e-02 0.9547597 DataSet_03_308
GRM2 EZH2 shRNA Mammary_gland LM2 0.332032 -1.59061 5.158809e-01 8.413562e-01 DataSet_03_350
GRM2 ETV5 knockdown Colon HT29 2.57143 1.36257 1.046452e-01 0.341791112 DataSet_03_353
GRM2 PARP1 siRNA Prostate LNCaP 0.471629 -1.08428 1.585477e-01 0.446405845 DataSet_03_354
GRM2 CREBBP CRISPR Brain U5-NPC 3 1.58496 0.5027345993 0.7550013 DataSet_03_356
GRM2 PTPN14 CRISPR Brain U5-NPC 0.0625 -4 1.927990e-03 0.17597795 DataSet_03_357
GRM2 TP53 CRISPR Brain U5-NPC 4 2 3.786759e-01 5.076721e-01 DataSet_03_358
GRM2 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 0.164503 -2.60381 2.549461e-01 4.950555e-01 DataSet_03_359
GRM2 NCOA3 siRNA Mammary_gland MDA-MB-231 1.745 0.80323 7.078171e-01 0.9695380 DataSet_03_361
GRM2 EP300 shRNA Mammary_gland MCF10AT 2.5 1.32193 3.824749e-01 0.526734721 DataSet_03_364
GRM2 TP53 knockout Stomach SNU1 1.71321 0.7767 0.6813841294 0.9786638 DataSet_03_365
GRM2 DNMT3A knockout Embryo_kidney HEK293T 0.512463 -0.964479 - - DataSet_03_369
GRM2 ZNF213 siRNA Mammary_gland MCF7 2.15651 1.1087 6.022084e-01 7.982940e-01 DataSet_03_376
GRM2 SMARCA2 shRNA Lung NCI-H1944 2.33333 1.22239 2.109874e-01 6.184909e-01 DataSet_03_377
GRM2 EZH2 CRISPR Ovary SKOV3 1.875 0.906891 3.992024e-01 0.5756207491 DataSet_03_378
GRM2 NFKB2 siRNA Bone_marrow U2OS 0.657895 -0.604071 8.510644e-02 0.34010088 DataSet_03_381
GRM2 DNMT1 siRNA Skin Human melanoma cells 0.273672 -1.86948 4.214489e-01 5.336387e-01 DataSet_03_382
GRM2 YY1 shRNA Brain GSC1517 0.636364 -0.652077 - - DataSet_03_384
GRM2 YY1 shRNA Brain GSC3028 0.327586 -1.61005 - - DataSet_03_386
GRM2 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 0.501316 -0.996208 0.7944221710 0.9641597 DataSet_03_387
GRM2 TRIM8 siRNA Mammary_gland MCF7 1.7 0.765535 5.742194e-01 0.7356972773 DataSet_03_388
GRM2 NFKBIA shRNA Bone_marrow U2OS 0.0417597 -4.58175 1.759668e-01 0.87005461 DataSet_03_389
GRM2 KDM5A CRISPR Lung GLC16 0.395692 -1.33755 9.757428e-04 0.015410943 DataSet_03_392
GRM2 ASXL1 CRISPR Embryo iPSC 1.6679 0.738033 0.2201429716 0.8187866 DataSet_03_394
GRM2 IKZF2 CRISPR Lymph CAR T Cell 1.63841 0.712297 5.992362e-01 0.891441726 DataSet_03_397
GRM2 TLE4 CRISPR Lymph CAR T Cell 1.5734 0.653889 4.464530e-01 0.72594150 DataSet_03_398
GRM2 RELA CRISPR Brain T30 0.239052 -2.06461 0.5221385033 0.8623714 DataSet_03_399
GRM2 EHF shRNA Stomach MKN7 0.0118085 -6.40404 - - DataSet_03_402
GRM2 CDK7 shRNA Bone_marrow D458 2.15 1.10434 1.667313e-01 0.50248141 DataSet_03_404
GRM2 TFAP2A knockout Embryo H9 1.59664 0.675038 3.622094e-02 0.12176866 DataSet_03_405
GRM2 SIRT1 siRNA Pancreas PANC1 0.5 -1 6.601058e-01 0.775228506 DataSet_03_410
GRM2 E2F6 shRNA Liver HuH7 0.387806 -1.36659 - - DataSet_03_412
GRM2 E2F2 siRNA Prostate LNCaP 0.594595 -0.750022 1.215583e-02 7.403887e-02 DataSet_03_414
GRM2 ZKSCAN3 CRISPR Colon HCT116 1.75 0.807355 1.228237e-01 0.520441131 DataSet_03_415
GRM2 FOXK2 shRNA Ovary OVCAR-5 2.5 1.32193 2.298122e-01 0.45139695 DataSet_03_419
GRM2 MAEL CRISPR Liver Alexander cells 3 1.58496 - - DataSet_03_423
GRM2 STAT5B CRISPR Embryo_kidney HEK293 0.6 -0.736966 8.600880e-02 0.570022797 DataSet_03_424
GRM2 IKZF2 shRNA Lymph Hut78 1.62257 0.698285 6.627571e-01 0.89537434 DataSet_03_429
GRM2 STAT3 siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 0.403846 -1.30812 0.1206770511 1 DataSet_03_430
GRM2 USP7 shRNA Skin xenograft cells 0.451613 -1.14684 0.24216389 0.4348960 DataSet_03_431
GRM2 POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 1.73696 0.796569 2.465470e-01 0.574894029 DataSet_03_434
GRM2 POU2AF1 CRISPR Lymph SUDHL4 1.80344 0.850755 7.722122e-02 0.173795074 DataSet_03_435
GRM2 EP300 knockout Pancreas HPAF-II orthotopic cells 0.262136 -1.93161 8.808691e-02 2.157797e-01 DataSet_03_436
GRM2 CIC knockout Brain Immortalized Astrocyte Cells 0.475 -1.074 5.837700e-02 4.129004e-01 DataSet_03_438
GRM2 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 1.5625 0.643856 2.563516e-01 0.90558273 DataSet_03_439
GRM2 CBX2 siRNA Mammary_gland MCF7 2.60897 1.38348 1.936735e-02 0.0511175828 DataSet_03_451
GRM2 ZFP36L1 CRISPR Lung NCI-H1876 0.548806 -0.865631 3.782768e-01 0.992381486 DataSet_03_454
GRM2 SREBF2 siRNA Umbilical_vein HUVEC 0.647717 -0.626565 1.785845e-01 6.175272e-01 DataSet_03_457
GRM2 HAND1 siRNA Placenta HPMVEC 0.642857 -0.63743 6.548290e-01 0.9463341 DataSet_03_459
GRM2 SOX9 knockout Liver HuH7 9 3.16992 1.417598e-01 2.858474e-01 DataSet_03_463
GRM2 PARP1 knockout Embryo_kidney HEK293a 3.15294 1.6567 6.011751e-04 3.032506e-03 DataSet_03_464
GRM2 LIN28A siRNA Mammary_gland MCF7M 0.603566 -0.728416 3.083567e-01 0.6874374 DataSet_03_469
GRM2 LIN28A siRNA Mammary_gland MCF7M 0.603566 -0.728416 3.083567e-01 0.6874374 DataSet_03_470
GRM2 WHSC1 siRNA Prostate PC3 1.78571 0.836501 3.573296e-01 0.57624612 DataSet_03_471
GRM2 EZH2 siRNA Prostate LNCaP 0.564969 -0.823755 - - DataSet_03_472
GRM2 EZH2 siRNA Umbilical_vein HUVEC 1.6087 0.685891 9.833477e-02 0.323009237 DataSet_03_473
GRM2 CREBBP CRISPR Lymph U2932 1.52632 0.610053 1.950932e-01 1.0000000 DataSet_03_474
GRM2 APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.7315326 0.9524161 DataSet_04_072
Regulation Region
 
T(co)Fs that significantly regulate SMAD5 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of GRM2
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines