Gene Overview
Target Gene: IGFBP1
NCBI Official Symbol: IGFBP1
Entrez ID: 3484
Ensembl ID: ENSG00000146678
Gene Full Name: insulin like growth factor binding protein 1
Strand: +
Gene Locus: 7p12.3
External Links:

IGFBP1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate IGFBP1   
T(co)Fs that Repress IGFBP1
The Intensity of the Gene Regulated by T(co)Fs:
IGFBP1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
IGFBP1 HNF1B shRNA Ovary RMG2 0.5007 -0.99799 2.67198e-05 0.00021 DataSet_01_103
IGFBP1 GABPA siRNA Lung A549 1.53126 0.61471 1.88021e-05 0.00012 DataSet_01_113
IGFBP1 ARID1A siRNA Oesophagus OE33 1.59022 0.66923 7.62483e-05 0.01597 DataSet_01_114
IGFBP1 ID1 siRNA Lung A549 1.71751 0.78032 0.09161 0.30083 DataSet_01_117
IGFBP1 ID1 siRNA Lung H1650 2.37542 1.24818 0.0013 0.32206 DataSet_01_118
IGFBP1 ZIC2 siRNA Pancreas PANC1 5.11568 2.35493 - - DataSet_01_121
IGFBP1 FOXM1 siRNA Central_nervous_system U87 14.0761 3.81518 - - DataSet_01_122
IGFBP1 SOX4 shRNA Parotid_gland ACC3 2.06579 1.04669 0.03678 0.94635 DataSet_01_140
IGFBP1 SF1 siRNA Adrenal_gland H295R/TR 1.52684 0.61055 0.00029 0.00512 DataSet_01_146
IGFBP1 STAT1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 0.43567 -1.19868 0.05145 0.27271 DataSet_01_154
IGFBP1 JUN siRNA Mammary_gland BT549 0.61411 -0.70342 0.0018 0.08417 DataSet_01_172
IGFBP1 TP53 siRNA Lung SAECs 1.63429 0.70866 0.09159 0.4794 DataSet_01_175
IGFBP1 HSF1 shRNA Liver KYN2 0.17776 -2.49197 - - DataSet_01_178
IGFBP1 GABPA shRNA Prostate C4-2B 594.817 9.2163 0.23833 0.43934 DataSet_01_190
IGFBP1 GABPA shRNA Prostate LNCaP 592.45 9.21055 0.46579 0.7048 DataSet_01_191
IGFBP1 CREB1 shRNA Parotid_gland H3118 MEC 4.49517 2.16838 0.48197 0.78161 DataSet_01_194
IGFBP1 CREB1 shRNA Parotid_gland HSY 0.43174 -1.21176 0.55368 0.98114 DataSet_01_195
IGFBP1 TP63 siRNA Immortalized_keratinocyte HaCaT RG 1.5974 0.67573 - - DataSet_01_196
IGFBP1 TP63 siRNA Head_and_neck SCC-1 13 3.70044 - - DataSet_01_198
IGFBP1 TP63 siRNA Head_and_neck SCC-1 0.4013 -1.31724 - - DataSet_01_199
IGFBP1 TP63 siRNA Head_and_neck SCC-012 1.84292 0.88199 - - DataSet_01_201
IGFBP1 TP63 siRNA Head_and_neck SCC-6 2.58499 1.37016 - - DataSet_01_202
IGFBP1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 4.64791 2.21658 - - DataSet_01_208
IGFBP1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 0.26266 -1.92873 - - DataSet_01_209
IGFBP1 SNAI2 shRNA Skin Primary human keratinocytes 0.53986 -0.88933 0.00304 0.02463 DataSet_01_225
IGFBP1 TWIST1 shRNA Stomach CAF32 0.37792 -1.40385 0.00603 0.03941 DataSet_01_253
IGFBP1 TWIST1 shRNA Stomach CAF 0.55549 -0.84818 0.06262 0.56128 DataSet_01_254
IGFBP1 YBX1 shRNA Mammary_gland MDA 0.63278 -0.66024 0.01369 0.06343 DataSet_01_257
IGFBP1 YBX1 shRNA Mammary_gland MDA 0.64223 -0.63884 7.79655e-13 7.72922e-11 DataSet_01_259
IGFBP1 FOXO3 siRNA Pancreas PANC1 0.4575 -1.12815 - - DataSet_01_267
IGFBP1 SF1 siRNA Endometrial_tissue OsisHESC 0.14564 -2.77949 4e-04 0.01209 DataSet_01_271
IGFBP1 STAT5 shRNA Prostate CWR22Pc 1.73541 0.79527 0.08773 0.21629 DataSet_01_279
IGFBP1 MSX1 siRNA Tooth Dental Pulp Cells 0.47394 -1.07722 0.35915 0.49623 DataSet_01_281
IGFBP1 POSTN shRNA Brain GSC272 2.78411 1.47722 0.1448 0.5679 DataSet_01_293
IGFBP1 TFAP4 siRNA Brain BE(2)-C 0.3177 -1.65426 0.47344 0.5198 DataSet_01_295
IGFBP1 SOX17 siRNA Umbilical_vein HUVEC 1.7849 0.83585 0.05422 0.99998 DataSet_01_300
IGFBP1 PTEN shRNA Skin A431 0.66559 -0.58729 0.85235 0.92118 DataSet_01_301
IGFBP1 PTEN shRNA Mammary_gland SKBR3 2.08097 1.05726 0.42718 0.78929 DataSet_01_303
IGFBP1 BRD4 siRNA Ovary Ovcar8 0.57507 -0.79818 0.00279 0.01576 DataSet_01_311
IGFBP1 OVOL2 siRNA Corneal_epithelial Corneal epithelial cells 0.66408 -0.59057 0.12055 0.35886 DataSet_01_313
IGFBP1 ARNT siRNA Upper_aerodigestive_tract HSC3 0.18158 -2.46129 - - DataSet_01_315
IGFBP1 ELK3 shRNA Mammary_gland MDA-MB-231 0.01098 -6.50904 4.2195e-09 4.92425e-06 DataSet_01_318
IGFBP1 NFE2L2 siRNA Lung A549 0.34839 -1.52122 4.63895e-08 8.39695e-06 DataSet_01_335
IGFBP1 GATA3 siRNA Oral_cavity OEC-M1 1.68642 0.75397 0.16977 0.99787 DataSet_01_347
IGFBP1 ZNF24 siRNA Embryo_kidney HEK293 1.83198 0.8734 - - DataSet_01_353
IGFBP1 ELK1 siRNA Mammary_gland MDA-MB-231 0.61884 -0.69236 - - DataSet_01_354
IGFBP1 SOX17 siRNA Umbilical_vein HUVEC 0.51681 -0.95229 - - DataSet_01_360
IGFBP1 RBM17 shRNA Liver HepG2 0.32446 -1.62387 0.00244 0.26816 DataSet_02_100
IGFBP1 FIP1L1 shRNA Liver HepG2 0.31421 -1.67021 0.00056 0.01231 DataSet_02_103
IGFBP1 U2AF2 shRNA Liver HepG2 0.45673 -1.1306 0.00029 0.04454 DataSet_02_105
IGFBP1 TAF15 shRNA Liver HepG2 0.20096 -2.31501 0.00019 0.01075 DataSet_02_106
IGFBP1 SSB shRNA Liver HepG2 0.00855 -6.86954 8.14849e-05 0.00367 DataSet_02_107
IGFBP1 HNRNPUL1 shRNA Liver HepG2 0.57405 -0.80076 0.00157 0.0223 DataSet_02_109
IGFBP1 RBM39 shRNA Liver HepG2 0.61767 -0.69509 0.04735 0.25082 DataSet_02_111
IGFBP1 BCLAF1 shRNA Liver HepG2 1.79987 0.84789 0.00331 0.03078 DataSet_02_112
IGFBP1 U2AF2 shRNA Liver HepG2 0.16389 -2.6092 0.00926 0.0682 DataSet_02_113
IGFBP1 PCBP1 shRNA Liver HepG2 0.64481 -0.63305 0.00334 0.01933 DataSet_02_115
IGFBP1 SUB1 shRNA Liver HepG2 2.3343 1.22299 0.00126 0.12645 DataSet_02_117
IGFBP1 PTBP1 shRNA Liver HepG2 0.23441 -2.09288 6e-04 0.00619 DataSet_02_120
IGFBP1 EWSR1 shRNA Liver HepG2 0.14702 -2.76591 0.00122 0.04273 DataSet_02_122
IGFBP1 FUS shRNA Liver HepG2 0.10254 -3.2858 6.50163e-05 0.0429 DataSet_02_124
IGFBP1 HNRNPLL shRNA Liver HepG2 1.65093 0.72328 0.09661 0.15655 DataSet_02_125
IGFBP1 SNRNP70 shRNA Liver HepG2 2.33656 1.22438 0.08992 0.17685 DataSet_02_126
IGFBP1 PRPF4 shRNA Liver HepG2 0.28701 -1.80085 0.00426 0.03833 DataSet_02_128
IGFBP1 RBM17 shRNA Haematopoietic_and_lymphoid_tissue K562 0.53846 -0.89308 0.28651 0.56563 DataSet_02_138
IGFBP1 AR siRNA Prostate LNCaP 0.579853 -0.786242 0.634677472972184 1 DataSet_03_005
IGFBP1 ARID1A siRNA Mammary_gland MDA-MB-157 3.37173 1.75349 - - DataSet_03_014
IGFBP1 ASCL1 siRNA Lung DMS79 2.26984 1.18259 0.0380714722104735 0.642640307745226 DataSet_03_016
IGFBP1 BCL6 siRNA Central_nervous_system U87 0.395549 -1.33807 5.71937407003627e-05 0.0094489506659923 DataSet_03_027
IGFBP1 CEBPB siRNA Embryo hESC 0.396479 -1.33468 0.11990413267808 0.494276722074848 DataSet_03_049
IGFBP1 ESR1 siRNA Uterus Endometrial stromal cells 0.571767 -0.8065 - - DataSet_03_069
IGFBP1 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.348585 -1.52042 - - DataSet_03_096
IGFBP1 GATA2 siRNA Uterus Decidual stromal cells 0.439548 -1.18591 0.80702097094974 0.981782919484572 DataSet_03_100
IGFBP1 GATA4 siRNA Liver HUH6 0.631192 -0.66385 0.0265680838277619 0.609530293655674 DataSet_03_104
IGFBP1 GATA4 siRNA Stomach AGS 2.58765 1.37164 0.0884377677268546 0.737361633436096 DataSet_03_105
IGFBP1 GATA4 siRNA Stomach YCC3 1.8806 0.911195 0.00205416706090183 0.388702606296578 DataSet_03_107
IGFBP1 HMGA2 siRNA Mammary_gland MDA-MB-231 0.54645 -0.871837 0.0296823192330751 0.732422277303185 DataSet_03_125
IGFBP1 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 0.533767 -0.905718 0.275950433679327 0.999948959532916 DataSet_03_134
IGFBP1 KLF5 siRNA Stomach AGS 2.61483 1.38672 0.252758449758716 0.717520260562023 DataSet_03_149
IGFBP1 KLF5 siRNA Stomach KatoIII 0.497462 -1.00734 0.135168599129951 0.583780617103926 DataSet_03_150
IGFBP1 KLF5 siRNA Stomach YCC3 2.23493 1.16023 0.00101316319118425 0.0540069763728957 DataSet_03_151
IGFBP1 MEF2D shRNA Liver HuH7 0.600119 -0.73668 - - DataSet_03_162
IGFBP1 MEF2D siRNA Liver HuH7 5.06245 2.33984 - - DataSet_03_163
IGFBP1 MITF siRNA Skin SK-MEL-5 1.69559 0.761786 0.000839719490186827 0.00294435246761697 DataSet_03_168
IGFBP1 MYC siRNA Colon HT29 1.72377 0.785569 - - DataSet_03_177
IGFBP1 SOX11 siRNA Lung_fibroblast NHLF 1.57976 0.659708 0.156968957062 0.531686913411013 DataSet_03_238
IGFBP1 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 5.08333 2.34577 - - DataSet_03_246
IGFBP1 SP1 siRNA Mammary_gland MDA-MB-231 1.55878 0.640415 0.283983997799695 0.493471734346519 DataSet_03_250
IGFBP1 STAT3 CRISPR Embryo hESC 0.521653 -0.938837 0.717354744653073 0.765680541444627 DataSet_03_258
IGFBP1 STAT3 siRNA Ovary SKOV3 0.455417 -1.13474 9.19744797795641e-09 7.3993803129151e-05 DataSet_03_261
IGFBP1 STAT6 siRNA Umbilical_vein HUVEC 0.627358 -0.672638 0.303122148042192 0.875511876160132 DataSet_03_264
IGFBP1 TFE3 siRNA Kidney UOK257-2 0.308665 -1.69589 - - DataSet_03_275
IGFBP1 ZNF746 siRNA Colon HCT116 2.48975 1.316 - - DataSet_03_293
IGFBP1 ERN1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.0571429 -4.12928 0.00172690453933458 0.365632788373658 DataSet_04_009
IGFBP1 SMAD5 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.142857 -2.80735 0.00799432336040671 0.394951331771279 DataSet_04_020
IGFBP1 APTX CRISPR Liver HepG2 0.0857143 -3.54432 0.00541797182663293 0.369587415942144 DataSet_04_025
IGFBP1 SMAD4 CRISPR Liver HepG2 0.232665 -2.10368 0.000164733975861025 0.0527443981287996 DataSet_04_035
IGFBP1 ZNF574 CRISPR Liver HepG2 0.611145 -0.710414 0.000746315305881485 0.0542183280723296 DataSet_04_041
IGFBP1 ACTN4 CRISPR Liver HepG2 0.645906 -0.630604 0.0273495444794107 0.0916567489040369 DataSet_04_042
IGFBP1 CNOT7 CRISPR Liver HepG2 1.87182 0.904442 4.17909288794705e-05 0.00960341421474169 DataSet_04_045
IGFBP1 DNMT3B CRISPR Liver HepG2 0.607732 -0.718492 0.00371105189032418 0.0809866136665049 DataSet_04_044
IGFBP1 PAN2 CRISPR Liver HepG2 0.232665 -2.10368 1.52349323276405e-05 0.0134929239906341 DataSet_04_066
IGFBP1 ABT1 shRNA Liver HepG2 0.17796 -2.49038 1.29670207836348e-05 0.00122689332263789 DataSet_04_052
IGFBP1 CALR shRNA Liver HepG2 1.63581 0.710009 0.000233716506810649 0.00498013645532069 DataSet_04_053
IGFBP1 CCAR1 shRNA Liver HepG2 0.130384 -2.93916 6.06299531895646e-07 0.00325046241701876 DataSet_04_054
IGFBP1 CNOT7 shRNA Liver HepG2 0.46217 -1.1135 0.00238207853767091 0.0112731745343277 DataSet_04_051
IGFBP1 PRPF6 shRNA Liver HepG2 0.073712 -3.76196 4.31331047353903e-05 0.0270009206802023 DataSet_04_056
IGFBP1 UBE2L3 shRNA Liver HepG2 1.50869 0.593296 0.00171119944559888 0.014652184410916 DataSet_04_055
IGFBP1 YBX3 shRNA Liver HepG2 1.56623 0.647294 0.00100241540166717 0.039575617400155 DataSet_02_98
IGFBP1 RIOK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.555556 -0.847997 0.760601712277121 0.962586640255164 DataSet_04_076
IGFBP1 MBD5 siRNA Bile_duct HCCC-9810 0.655719 -0.608851 7.261877e-04 0.0261711296 DataSet_03_295
IGFBP1 CNOT3 shRNA Lung A549 2.06357 1.04514 1.269298e-02 0.8678906 DataSet_03_340
IGFBP1 EZH2 siRNA Uterus Hec-1A 3.1163 1.63983 3.847184e-08 9.552381e-05 DataSet_03_314
IGFBP1 NFKBIZ knockout Colon Colon organoid 0.365522 -1.45197 5.474236e-02 0.649358825 DataSet_03_323
IGFBP1 AEBP1 siRNA Umbilical_vein HUVEC 0.610383 -0.712214 5.891217e-02 0.563238092 DataSet_03_300
IGFBP1 SNAI2 shRNA Pancreas pancreatic cancer stem cells 0.583237 -0.777846 1.377778e-02 0.5763430 DataSet_03_306
IGFBP1 SNAI2 shRNA Pancreas KLM1 2.63027 1.39521 6.523807e-02 0.34282736 DataSet_03_307
IGFBP1 PRMT1 shRNA Lung A549 2.08574 1.06056 - - DataSet_03_342
IGFBP1 AEBP1 siRNA Central_nervous_system U87MG 2.34609 1.23026 1.347339e-01 0.9999434 DataSet_03_338
IGFBP1 BRCA1 siRNA Mammary_gland MCF7 2.01606 1.01154 3.637886e-02 0.9999931 DataSet_03_308
IGFBP1 EZH2 knockdown Colon HCT116 0.479084 -1.06165 0.050534568 0.8488990 DataSet_03_334
IGFBP1 BCL3 siRNA Central_nervous_system U87 0.431665 -1.21202 4.540175e-09 2.972396e-06 DataSet_03_336
IGFBP1 TET1 CRISPR Mammary_gland MDA-MB-231 2.92679 1.54932 1.816925e-04 4.059430e-03 DataSet_03_347
IGFBP1 ETV5 knockdown Colon HT29 3 1.58496 2.987563e-01 0.527308910 DataSet_03_353
IGFBP1 TET1 CRISPR Mammary_gland Hs578T 3.01628 1.59277 1.277861e-02 5.732536e-02 DataSet_03_355
IGFBP1 ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 7.54286 2.91511 7.705032e-04 2.797481e-03 DataSet_03_362
IGFBP1 ZNF148 shRNA Mammary_gland MDA-MB-231 0.36108 -1.46961 2.990775e-04 0.020123630 DataSet_03_366
IGFBP1 ABL1 shRNA Liver HuH7 0.424896 -1.23482 4.542996e-03 0.0171101896 DataSet_03_367
IGFBP1 BHLHE40 shRNA Cervix HeLaS3 1.61539 0.691878 5.349512e-01 0.91660371 DataSet_03_372
IGFBP1 SMARCA2 shRNA Lung NCI-H1944 0.591996 -0.75634 2.123462e-03 1.477741e-01 DataSet_03_377
IGFBP1 EZH2 CRISPR Ovary SKOV3 1.51813 0.6023 5.466938e-02 0.2047370389 DataSet_03_378
IGFBP1 TCF19 CRISPR Oral_squamous CAL27 2.92407 1.54797 3.311926e-01 0.6355227679 DataSet_03_383
IGFBP1 NFKBIA shRNA Bone_marrow U2OS 0.0125224 -6.31935 4.853387e-01 0.87005461 DataSet_03_389
IGFBP1 ILF2 siRNA Stomach SGC-7901 1.69231 0.758992 0.6134003061 0.68964791 DataSet_03_393
IGFBP1 EHF shRNA Stomach MKN7 0.00434028 -7.84799 - - DataSet_03_402
IGFBP1 SATB2 CRISPR Colon Colon organoid 1.61871 0.69484 4.672476e-01 0.97591228 DataSet_03_406
IGFBP1 MAP3K7 shRNA Prostate LNCaP 1.86667 0.900464 2.942335e-02 1.525473e-01 DataSet_03_408
IGFBP1 SIRT1 siRNA Pancreas PANC1 0.2 -2.32193 5.926433e-02 0.152742832 DataSet_03_410
IGFBP1 USP22 shRNA Liver HuH7 0.077389 -3.69173 - - DataSet_03_411
IGFBP1 E2F6 shRNA Liver HuH7 2.71586 1.44141 - - DataSet_03_412
IGFBP1 MAEL CRISPR Liver Alexander cells 0.41656 -1.2634 - - DataSet_03_423
IGFBP1 EP300 knockout Pancreas HPAF-II orthotopic cells 0.407459 -1.29527 4.222371e-02 1.233835e-01 DataSet_03_436
IGFBP1 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 0.25 -2 5.286831e-02 0.85020957 DataSet_03_439
IGFBP1 FOSL1 siRNA Prostate MSKPCa3 0.25 -2 0.0102114654 0.3072825 DataSet_03_445
IGFBP1 RELB CRISPR Colon SW480 0.353659 -1.49957 9.934708e-01 1.000000e+00 DataSet_03_449
IGFBP1 CBX2 siRNA Mammary_gland MDA-MB-231 0.390818 -1.35543 8.821682e-04 8.327648e-03 DataSet_03_450
IGFBP1 CBX2 siRNA Mammary_gland MCF7 2.42237 1.27642 6.264961e-01 0.7704718055 DataSet_03_451
IGFBP1 SMARCA2 shRNA Lung HCC2302 0.00746518 -7.06561 7.927813e-09 3.608873e-08 DataSet_03_455
IGFBP1 PPARG siRNA Aortic_valve Valvular endothelial cell 1.52785 0.611498 1.126548e-03 3.504508e-02 DataSet_03_456
IGFBP1 ARID1A shRNA Bile_duct MMNK1 0.269925 -1.88937 3.331043e-02 0.194519820 DataSet_03_458
IGFBP1 SOX9 knockout Liver HuH7 0.53125 -0.912537 1.069217e-01 2.301118e-01 DataSet_03_463
IGFBP1 PARP1 knockout Embryo_kidney HEK293a 9.8 3.29278 1.710946e-04 1.048816e-03 DataSet_03_464
IGFBP1 STAT3 shRNA Liver HepG2 11.16 3.48027 2.097789e-06 0.0017267344 DataSet_03_465
Regulation Region
 
T(co)Fs that significantly regulate ERN1 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of IGFBP1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines