Gene Overview
Target Gene: LHX1
NCBI Official Symbol: LHX1
Entrez ID: 3975
Ensembl ID: ENSG00000273706
Gene Full Name: LIM homeobox 1
Strand: +
Gene Locus: 17q12
External Links:

LHX1 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate LHX1   
T(co)Fs that Repress LHX1
The Intensity of the Gene Regulated by T(co)Fs:
LHX1-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
LHX1 SPDEF shRNA Mammary_gland MCF7 1.95976 0.97068 0.74035 0.99999 DataSet_01_107
LHX1 HOXA1 siRNA Lung_fibroblast IMR-90 3.37363 1.7543 0.0625 0.26973 DataSet_01_110
LHX1 FOXM1 siRNA Central_nervous_system U87 1.87694 0.90838 - - DataSet_01_122
LHX1 IKZF2 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 1.87988 0.91064 0.03042 0.53743 DataSet_01_137
LHX1 IKZF1 shRNA Haematopoietic_and_lymphoid_tissue JURKAT 2.0505 1.03597 0.02661 0.99993 DataSet_01_138
LHX1 LIN28B siRNA Embryo_kidney HEK293 1.63526 0.70952 0.00937 0.05646 DataSet_01_153
LHX1 ELK1 siRNA Peripheral_blood CD4+ T cells 1.61208 0.68893 0.08207 0.21339 DataSet_01_162
LHX1 GATA3 siRNA Peripheral_blood CD4+ T cells 1.81297 0.85836 0.06804 0.39623 DataSet_01_163
LHX1 MAF siRNA Peripheral_blood CD4+ T cells 1.77838 0.83056 0.05541 0.28591 DataSet_01_165
LHX1 NFATC3 siRNA Peripheral_blood CD4+ T cells 2.35943 1.23844 0.01515 0.11579 DataSet_01_166
LHX1 NFKB1 siRNA Peripheral_blood CD4+ T cells 2.15291 1.10629 0.02129 0.39668 DataSet_01_167
LHX1 HOXB7 siRNA Pancreas MIA PaCa-2 1.59563 0.67413 0.04497 0.61361 DataSet_01_169
LHX1 TP53 siRNA Lung SAECs 2.66 1.41143 0.07518 0.45312 DataSet_01_175
LHX1 CREB1 shRNA Parotid_gland HSY 0.57871 -0.78909 0.96802 0.99682 DataSet_01_195
LHX1 TP63 siRNA Head_and_neck SCC-1 1.97696 0.98328 - - DataSet_01_198
LHX1 TP63 siRNA Immortalized_keratinocyte HaCaT 6.725 2.74953 - - DataSet_01_200
LHX1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly10 2.32356 1.21634 - - DataSet_01_208
LHX1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 4.67481 2.22491 - - DataSet_01_209
LHX1 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.55783 -0.8421 - - DataSet_01_210
LHX1 LIN28A siRNA Embryo H9 9.43669 3.23828 1.05546e-06 0.00028 DataSet_01_215
LHX1 ATM shRNA Mammary_gland MCF10A 2.05211 1.0371 2.81523e-09 2.62144e-07 DataSet_01_219
LHX1 SNAI2 shRNA Skin Primary human keratinocytes 2.14869 1.10345 0.05659 0.14131 DataSet_01_225
LHX1 KLF2 shRNA Bone_marrow RPMI8226 2.89184 1.53199 0.07231 0.66669 DataSet_01_226
LHX1 IRX1 shRNA Bone_marrow 143B 0.38786 -1.3664 6.43464e-06 0.00433 DataSet_01_227
LHX1 TWIST1 shRNA Stomach CAF14 1.54302 0.62575 0.2828 0.99996 DataSet_01_252
LHX1 STAT5 shRNA Prostate CWR22Pc 1.71285 0.7764 0.02012 0.08285 DataSet_01_279
LHX1 ESRRA shRNA Embryo_kidney 293T 0.62137 -0.68648 0.03181 0.63839 DataSet_01_280
LHX1 ZIC5 siRNA Skin A375 4.57544 2.19391 - - DataSet_01_284
LHX1 NFYA shRNA Lung H322 1.65739 0.72891 2.18027e-05 0.00071 DataSet_01_288
LHX1 POSTN shRNA Brain GSC272 5.84164 2.54637 0.11967 0.55804 DataSet_01_293
LHX1 TFAP4 siRNA Brain BE(2)-C 0.12583 -2.99041 0.2536 0.51625 DataSet_01_295
LHX1 SOX7 siRNA Umbilical_vein HUVEC 6.24784 2.64336 0.00986 0.89788 DataSet_01_299
LHX1 SOX17 siRNA Umbilical_vein HUVEC 2.32189 1.2153 0.0191 0.99998 DataSet_01_300
LHX1 PTEN shRNA Skin A431 0.58471 -0.77421 0.36376 0.56003 DataSet_01_301
LHX1 PTEN shRNA Lung HCC827 0.42197 -1.2448 0.38609 0.77139 DataSet_01_302
LHX1 PTEN shRNA Mammary_gland SKBR3 1.67437 0.74362 0.57984 0.85477 DataSet_01_303
LHX1 SOX9 siRNA Prostate VCaP 0.35507 -1.49381 0.01851 0.9316 DataSet_01_308
LHX1 SOX9 siRNA Prostate VCaP 0.35507 -1.49381 0.01851 0.9316 DataSet_01_309
LHX1 ARNT siRNA Upper_aerodigestive_tract HSC3 0.42451 -1.23614 - - DataSet_01_315
LHX1 ELK3 shRNA Mammary_gland MDA-MB-231 4.07033 2.02515 6.65209e-07 2.76834e-05 DataSet_01_318
LHX1 MYC siRNA Colon HCT116 1.61482 0.69138 3.01128e-05 0.00015 DataSet_01_324
LHX1 GATA3 siRNA Oral_cavity OEC-M1 2.34665 1.2306 0.02268 0.74579 DataSet_01_347
LHX1 SOX2 siRNA Embryo Undifferentiated hESCs 2.14979 1.10419 - - DataSet_01_350
LHX1 CDX2 siRNA Colon COLO320 0.37154 -1.42843 - - DataSet_01_357
LHX1 GTF2B siRNA Cervix HeLa 0.59498 -0.74909 - - DataSet_01_362
LHX1 FIP1L1 shRNA Liver HepG2 0.33333 -1.58496 0.00076 0.01347 DataSet_02_103
LHX1 SRSF3 shRNA Liver HepG2 0.25 -2 0.01028 0.08403 DataSet_02_127
LHX1 SRSF9 shRNA Haematopoietic_and_lymphoid_tissue K562 0.375 -1.41504 0.04936 0.15473 DataSet_02_134
LHX1 PCBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.3125 -1.67807 0.01491 0.2076 DataSet_02_137
LHX1 RBM34 shRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.03336 0.22548 DataSet_02_141
LHX1 BCLAF1 shRNA Haematopoietic_and_lymphoid_tissue K562 5 2.32193 0.78268 0.87498 DataSet_02_142
LHX1 RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.11445 0.31158 DataSet_02_151
LHX1 ILF2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.45575 0.7236 DataSet_02_152
LHX1 XRCC5 shRNA Haematopoietic_and_lymphoid_tissue K562 0.4 -1.32193 0.0587 0.63352 DataSet_02_159
LHX1 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 0.16667 -2.58496 0.02785 0.15455 DataSet_02_160
LHX1 MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.18151 1 DataSet_02_173
LHX1 LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.06987 1 DataSet_02_175
LHX1 CEBPZ siRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.07313 1 DataSet_02_176
LHX1 ZNF180 siRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.05791 1 DataSet_02_177
LHX1 STAT5A siRNA Haematopoietic_and_lymphoid_tissue K562 9 3.16993 0.02954 1 DataSet_02_182
LHX1 CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 3.14286 1.65208 0.0768 1 DataSet_02_187
LHX1 BACH1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.07415 1 DataSet_02_188
LHX1 LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.09548 1 DataSet_02_191
LHX1 LMNB1 siRNA Haematopoietic_and_lymphoid_tissue K562 11 3.45943 0.8226 1 DataSet_02_195
LHX1 E2F4 siRNA Haematopoietic_and_lymphoid_tissue K562 11 3.45943 0.0326 1 DataSet_02_200
LHX1 BRCA1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.06671 1 DataSet_02_202
LHX1 RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.06648 1 DataSet_02_204
LHX1 E2F6 siRNA Haematopoietic_and_lymphoid_tissue K562 0.25 -2 0.0665 1 DataSet_02_205
LHX1 ZFX siRNA Mammary_gland MCF7 1.6 0.67807 0.02475 0.14008 DataSet_02_206
LHX1 AR siRNA Prostate abl cells 0.489583 -1.03037 0.475085292354623 0.999852161656754 DataSet_03_004
LHX1 AR siRNA Prostate LNCaP 2.33333 1.22239 0.182480416859317 1 DataSet_03_005
LHX1 ASCL1 siRNA Lung DMS79 0.49375 -1.01815 0.359750519113885 0.883439245342898 DataSet_03_016
LHX1 ATF4 siRNA Skin A375 0.602754 -0.730359 0.2482231396559 0.775512819201899 DataSet_03_018
LHX1 BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.26071 -1.93948 0.10699105858654 0.764919186474744 DataSet_03_025
LHX1 BCL6 siRNA Lymph Pfeiffer DLBCL 2.37519 1.24804 0.331783709796124 0.763406505116852 DataSet_03_026
LHX1 CEBPB siRNA Embryo hESC 0.372319 -1.42539 0.232852012307839 0.613571409163956 DataSet_03_049
LHX1 FOXP1 siRNA Mammary_gland MCF7 1.64915 0.721718 0.00333759701414018 0.999975993110711 DataSet_03_099
LHX1 GATA4 siRNA Stomach KatoIII 0.666078 -0.586238 0.0197116382560446 0.807081144985167 DataSet_03_106
LHX1 GATA6 siRNA Stomach KatoIII 0.587131 -0.768246 0.130640675540012 0.654866627041424 DataSet_03_109
LHX1 GATA6 siRNA Stomach YCC3 1.98076 0.986051 0.246941376031745 0.820173181132601 DataSet_03_110
LHX1 HNF4a siRNA Liver HepG2 0.581818 -0.78136 0.583590140982415 0.934164416530664 DataSet_03_126
LHX1 IRF4 siRNA Skin Cutaneous T cell lymphoma HuT-102 cells 0.253764 -1.97844 0.109374178356911 0.970298169733267 DataSet_03_134
LHX1 KLF5 siRNA Stomach YCC3 2.80222 1.48657 0.275794388565296 0.641151635467685 DataSet_03_151
LHX1 MAFB siRNA Peripheral_blood Monocyte-derived M-CSF macrophages 0.604298 -0.726667 0.0463939641156484 1 DataSet_03_155
LHX1 MTA2 siRNA Stomach SGC-7901 1.6455 0.718529 - - DataSet_03_169
LHX1 MYB siRNA Cord_Blood CD34+ progenitor cells 1.59292 0.671672 - - DataSet_03_170
LHX1 MYC siRNA Colon HT29 0.446364 -1.16371 - - DataSet_03_177
LHX1 MYC siRNA Central_nervous_system DAOY M2.1 0.59578 -0.747149 0.000102083326501292 0.000359215865353505 DataSet_03_178
LHX1 MYC siRNA Mammary_gland MCF7 1.82047 0.864308 0.00128897558785203 0.999887767096734 DataSet_03_182
LHX1 PHB shRNA Embryo Embryonic stem cells (ESCs) 3.939 1.97783 0.0301859932850072 0.0757711469325179 DataSet_03_211
LHX1 SOX11 siRNA Lung_fibroblast NHLF 1.68876 0.755965 0.569537772151251 0.731847719566559 DataSet_03_237
LHX1 SOX2 siRNA Lung H520 2.2494 1.16954 - - DataSet_03_240
LHX1 SOX2 siRNA Embryo 2102Ep 3.76302 1.91189 1.4247615841319e-08 5.81927621757451e-06 DataSet_03_242
LHX1 SOX2 siRNA Embryo NTera-2 1.50912 0.593703 0.000186839328307543 0.0103075981097818 DataSet_03_243
LHX1 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 3.8 1.926 - - DataSet_03_246
LHX1 STAT3 CRISPR Embryo hESC 11.1356 3.4771 0.0348133188618256 0.105160216493104 DataSet_03_258
LHX1 STAT6 siRNA Umbilical_vein HUVEC 0.492958 -1.02046 0.0503029069452543 0.719345554770036 DataSet_03_264
LHX1 TFAP2C siRNA Mammary_gland MCF7 0.581911 -0.781131 0.313976554459106 0.641733220610408 DataSet_03_274
LHX1 YBX1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.564103 -0.825971 0.526847398223029 0.784448484043084 DataSet_04_022
LHX1 CNOT7 CRISPR Liver HepG2 0.6 -0.736966 0.754362348111841 0.856451296514468 DataSet_04_045
LHX1 RIOK2 CRISPR Liver HepG2 2 1 0.797454793894669 1 DataSet_04_070
LHX1 CCAR1 shRNA Liver HepG2 0.5 -1 0.867149216901006 0.93263778837766 DataSet_04_054
LHX1 DDX17 CRISPR Haematopoietic_and_lymphoid_tissue K562 2 1 0.906826311370114 0.98976397934186 DataSet_04_047
LHX1 CITED2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.243902 -2.03562 0.225881602402053 0.49187672503592 DataSet_02_38
LHX1 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.512195 -0.965235 0.477672736853715 0.639340946333753 DataSet_02_14
LHX1 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.439024 -1.18763 0.408428415926284 0.586550907156921 DataSet_02_34
LHX1 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.205128 -2.2854 0.230409793524939 0.623973042139069 DataSet_02_75
LHX1 HMGN3 CRISPRi Haematopoietic_and_lymphoid_tissue K562 2.73171 1.4498 0.46837700838576 0.829186750815706 DataSet_02_45
LHX1 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.268293 -1.89812 0.20168687922904 0.484249093246782 DataSet_02_32
LHX1 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.121951 -3.03562 0.154040634725386 0.280251164241868 DataSet_02_47
LHX1 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.341463 -1.5502 0.272485763025708 0.422007467380148 DataSet_02_33
LHX1 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 0.285714 -1.80735 0.753884012242901 0.846670700693972 DataSet_04_059
LHX1 PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 4.6 2.20163 0.440521422707997 0.77359426814529 DataSet_04_065
LHX1 EZH2 shRNA Colon SW480 0.636984 -0.650671 - - DataSet_03_298
LHX1 ELF3 CRISPR Bile_duct HBDEC2 6.7052 2.74528 7.001685e-09 2.357111e-05 DataSet_03_304
LHX1 ELF3 knockdown Bile_duct HBDEC2 0.646612 -0.629028 3.056999e-04 1.160394e-02 DataSet_03_305
LHX1 PRMT1 shRNA Lung A549 1.64611 0.719063 - - DataSet_03_342
LHX1 EZH2 knockdown Colon HCT116 2.78719 1.47881 0.071439121 0.8488990 DataSet_03_334
LHX1 ETV5 knockdown Colon HT29 1.53333 0.616671 1.274947e-01 0.382094885 DataSet_03_353
LHX1 NCOA2 siRNA Uterus endometrial stromal cells 3 1.58496 0.4153242407 1 DataSet_03_360
LHX1 EP300 shRNA Mammary_gland MCF10AT 2.55556 1.35364 9.188173e-02 0.264363796 DataSet_03_364
LHX1 TP53 knockout Stomach SNU1 1.6308 0.705575 0.9773458062 1.0000000 DataSet_03_365
LHX1 ZNF148 shRNA Mammary_gland MDA-MB-231 4.47384 2.16151 3.548873e-01 0.583231522 DataSet_03_366
LHX1 DNMT3A knockout Embryo_kidney HEK293T 0.50719 -0.979402 - - DataSet_03_369
LHX1 GLI1 siRNA Skeletal_muscle RMS13 2.20032 1.13771 2.131011e-02 0.116779823 DataSet_03_375
LHX1 ZNF213 siRNA Mammary_gland MCF7 12.7167 3.66865 2.165966e-01 6.592819e-01 DataSet_03_376
LHX1 EZH2 CRISPR Ovary SKOV3 3.07196 1.61916 1.758040e-03 0.0280785263 DataSet_03_378
LHX1 ZBTB7A siRNA Stomach BGC823 0.472143 -1.0827 - - DataSet_03_380
LHX1 TRIM8 siRNA Mammary_gland MCF7 0.654472 -0.611598 1.212581e-01 0.2866491864 DataSet_03_388
LHX1 BMI1 shRNA Bile_duct QBC-939 0.45156 -1.14701 3.876988e-04 0.0042106753 DataSet_03_395
LHX1 TLE4 CRISPR Lymph CAR T Cell 0.43702 -1.19423 3.972215e-01 0.70009647 DataSet_03_398
LHX1 RELA CRISPR Brain T30 0.17786 -2.49118 0.6863345796 0.9129652 DataSet_03_399
LHX1 HMGA1 shRNA Bile_duct HUCCT1 0.587302 -0.767827 3.524536e-01 0.568676640 DataSet_03_400
LHX1 EHF shRNA Stomach MKN7 0.000399404 -11.2899 - - DataSet_03_402
LHX1 CDK7 shRNA Bone_marrow D458 11 3.45943 2.034749e-01 0.55623487 DataSet_03_404
LHX1 TFAP2A knockout Embryo H9 137.6 7.10434 1.144446e-05 0.01552045 DataSet_03_405
LHX1 STRAP knockout Nerve SK-N-AS 1.96701 0.976006 - - DataSet_03_409
LHX1 SIRT1 siRNA Pancreas PANC1 0.26828 -1.89819 1.828222e-04 0.011958447 DataSet_03_410
LHX1 ZKSCAN3 CRISPR Colon HCT116 0.62963 -0.667425 1.691947e-01 0.596803845 DataSet_03_415
LHX1 RUNX2 shRNA Cord_blood Natural Killer Cell 2.41304 1.27085 1.584443e-01 0.793390621 DataSet_03_416
LHX1 FOXK2 shRNA Ovary OVCAR-5 7.88043 2.97828 1.998848e-03 0.08266460 DataSet_03_419
LHX1 FOXQ1 CRISPR Lymph Primary CD4+ T cells 4.06667 2.02385 - - DataSet_03_422
LHX1 FOXP3 CRISPR Peripheral_blood Naive Treg 1.67606 0.745071 1.971004e-01 0.552103356 DataSet_03_427
LHX1 LHX2 shRNA Bone_marrow ES-derived RPE cells 2.83898 1.50537 1.920607e-02 1.000000e+00 DataSet_03_428
LHX1 USP7 shRNA Skin xenograft cells 0.377522 -1.40537 0.25946925 0.4348960 DataSet_03_431
LHX1 POU2AF1 CRISPR Lymph SUDHL4 0.5 -1 6.700480e-01 0.751518661 DataSet_03_435
LHX1 CAMTA1 knockout Embryo_kidney HEK293T 3.43333 1.77961 2.857923e-03 0.07479261 DataSet_03_448
LHX1 RELB CRISPR Colon SW480 0.2 -2.32193 1.495396e-02 9.712105e-02 DataSet_03_449
LHX1 CBX2 siRNA Mammary_gland MDA-MB-231 0.462724 -1.11178 4.631235e-01 6.792184e-01 DataSet_03_450
LHX1 CBX2 siRNA Mammary_gland MCF7 1.51566 0.599942 5.479235e-02 0.1167994668 DataSet_03_451
LHX1 SMARCA2 shRNA Lung HCC2302 0.632007 -0.661987 4.110329e-05 7.847208e-05 DataSet_03_455
LHX1 SOX9 knockout Liver HuH7 0.0769231 -3.70044 7.415533e-04 7.400067e-03 DataSet_03_463
LHX1 STAT3 shRNA Liver HepG2 1.64706 0.719892 6.959431e-02 0.3967514505 DataSet_03_465
LHX1 SMARCA1 Cas13 Embryo_kidney HEK293T 0.521739 -0.938599 - - DataSet_03_466
Regulation Region
 
T(co)Fs that significantly regulate TFAP2A by the evidences of both expression and ChIP-seq/motif
Expression Atlas of LHX1
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines