Gene Overview
Target Gene: SIGLEC9
NCBI Official Symbol: SIGLEC9
Entrez ID: 27180
Ensembl ID: ENSG00000129450
Gene Full Name: sialic acid binding Ig like lectin 9
Strand: +
Gene Locus: 19q13.41
External Links:

SIGLEC9 Significantly Regulated by These T(co)Fs

T(co)Fs that Activate SIGLEC9   
T(co)Fs that Repress SIGLEC9
The Intensity of the Gene Regulated by T(co)Fs:
SIGLEC9-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
SIGLEC9 ID1 siRNA Lung A549 0.51726 -0.95104 0.26985 0.50518 DataSet_01_117
SIGLEC9 ZIC2 siRNA Pancreas PANC1 1.67494 0.74411 - - DataSet_01_121
SIGLEC9 POLR3A siRNA Mammary_gland MCF7 2.92771 1.54977 - - DataSet_01_139
SIGLEC9 GATA3 siRNA Peripheral_blood CD4+ T cells 0.46717 -1.09799 0.05454 0.36539 DataSet_01_163
SIGLEC9 NFATC3 siRNA Peripheral_blood CD4+ T cells 2.23159 1.15807 0.01099 0.09644 DataSet_01_166
SIGLEC9 HOXB7 siRNA Pancreas Capan-1 0.59712 -0.74392 0.09099 0.56934 DataSet_01_170
SIGLEC9 CREB1 shRNA Parotid_gland HSY 0.50573 -0.98356 0.46263 0.98082 DataSet_01_195
SIGLEC9 TP63 siRNA Head_and_neck SCC-1 0.45425 -1.13845 - - DataSet_01_198
SIGLEC9 TP63 siRNA Head_and_neck SCC-6 5.35556 2.42104 - - DataSet_01_202
SIGLEC9 HIC1 shRNA Mammary_gland HBL100 0.33906 -1.56038 - - DataSet_01_205
SIGLEC9 FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly7 0.48831 -1.03414 - - DataSet_01_210
SIGLEC9 REST siRNA Prostate LNCaP 2.00299 1.00216 0.16185 0.44545 DataSet_01_211
SIGLEC9 LIN28A siRNA Embryo H9 1.97816 0.98416 0.00348 0.02598 DataSet_01_215
SIGLEC9 SNAI2 shRNA Skin Primary human keratinocytes 0.3749 -1.41542 0.11052 0.22273 DataSet_01_225
SIGLEC9 ESRRA shRNA Embryo_kidney 293T 0.38201 -1.38831 0.40338 0.85112 DataSet_01_280
SIGLEC9 MSX1 siRNA Tooth Dental Pulp Cells 1.85832 0.894 0.05133 0.11088 DataSet_01_281
SIGLEC9 TFAP4 siRNA Brain BE(2)-C 0.22266 -2.16706 0.38437 0.51625 DataSet_01_295
SIGLEC9 PTEN shRNA Skin A431 1.60733 0.68466 0.21472 0.41018 DataSet_01_301
SIGLEC9 PTEN shRNA Lung HCC827 0.64996 -0.62157 0.02326 0.50245 DataSet_01_302
SIGLEC9 PTEN shRNA Mammary_gland SKBR3 3.4285 1.77758 0.42576 0.78842 DataSet_01_303
SIGLEC9 SOX9 siRNA Prostate VCaP 0.54286 -0.88136 0.06323 0.9316 DataSet_01_308
SIGLEC9 SOX9 siRNA Prostate VCaP 0.54286 -0.88136 0.06323 0.9316 DataSet_01_309
SIGLEC9 ELK1 siRNA Mammary_gland MDA-MB-231 0.45142 -1.14745 - - DataSet_01_354
SIGLEC9 NFYA siRNA Mammary_gland MDA-MB-231 0.5391 -0.89138 - - DataSet_01_355
SIGLEC9 SRSF3 shRNA Liver HepG2 3 1.58496 0.0439 0.14765 DataSet_02_127
SIGLEC9 POLR2G shRNA Haematopoietic_and_lymphoid_tissue K562 0.47368 -1.078 0.10135 0.72262 DataSet_02_130
SIGLEC9 PCBP2 shRNA Haematopoietic_and_lymphoid_tissue K562 0.64286 -0.63743 0.13236 0.27375 DataSet_02_135
SIGLEC9 HNRNPK shRNA Haematopoietic_and_lymphoid_tissue K562 4.07143 2.02554 0.00905 0.15175 DataSet_02_136
SIGLEC9 RBM17 shRNA Haematopoietic_and_lymphoid_tissue K562 3.75 1.90689 0.02241 0.26453 DataSet_02_138
SIGLEC9 RBFOX2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.83333 1.5025 0.63186 0.82777 DataSet_02_139
SIGLEC9 RBM34 shRNA Haematopoietic_and_lymphoid_tissue K562 1.92857 0.94753 0.70695 0.83508 DataSet_02_141
SIGLEC9 DROSHA shRNA Haematopoietic_and_lymphoid_tissue K562 2.2 1.1375 0.05548 0.51061 DataSet_02_145
SIGLEC9 ILF3 shRNA Haematopoietic_and_lymphoid_tissue K562 1.83333 0.87447 0.57454 0.77781 DataSet_02_148
SIGLEC9 SRSF4 shRNA Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.80527 0.91328 DataSet_02_154
SIGLEC9 HNRNPUL1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.6 -0.73697 0.51385 0.75295 DataSet_02_156
SIGLEC9 GTF2F1 shRNA Haematopoietic_and_lymphoid_tissue K562 12.25 3.61471 0.00166 0.71632 DataSet_02_157
SIGLEC9 PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 5.5 2.45943 0.01121 0.08543 DataSet_02_158
SIGLEC9 XRCC5 shRNA Haematopoietic_and_lymphoid_tissue K562 2.75 1.45943 0.47223 0.85889 DataSet_02_159
SIGLEC9 HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 8 3 0.00153 0.11467 DataSet_02_160
SIGLEC9 SUB1 shRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.46961 0.89363 DataSet_02_161
SIGLEC9 U2AF1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.33333 -1.58496 0.05005 0.19919 DataSet_02_165
SIGLEC9 EWSR1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.48756 0.68248 DataSet_02_167
SIGLEC9 RBM22 shRNA Haematopoietic_and_lymphoid_tissue K562 3.64286 1.86507 0.02155 0.09405 DataSet_02_168
SIGLEC9 TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 1.85714 0.89308 0.51904 0.61279 DataSet_02_169
SIGLEC9 ZFX siRNA Prostate C4-2B 2.15385 1.10692 0.35831 0.47499 DataSet_02_172
SIGLEC9 NFE2L2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.2069 -2.27302 0.13045 1 DataSet_02_174
SIGLEC9 CEBPZ siRNA Haematopoietic_and_lymphoid_tissue K562 0.5303 -0.91511 0.44088 1 DataSet_02_176
SIGLEC9 TBL1XR1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.4375 1.2854 0.4199 1 DataSet_02_178
SIGLEC9 VEZF1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.33884 -1.56131 0.15417 1 DataSet_02_179
SIGLEC9 KAT2B siRNA Haematopoietic_and_lymphoid_tissue K562 0.54167 -0.88452 0.07922 1 DataSet_02_184
SIGLEC9 CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.25455 1.17284 0.75828 1 DataSet_02_187
SIGLEC9 ARID3A siRNA Haematopoietic_and_lymphoid_tissue K562 0.37383 -1.41954 0.1507 1 DataSet_02_193
SIGLEC9 TCP1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.33803 -1.56478 0.84202 1 DataSet_02_194
SIGLEC9 LMNB1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.59091 -0.75899 0.5595 1 DataSet_02_195
SIGLEC9 CDAN1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.62121 0.69707 0.75533 1 DataSet_02_197
SIGLEC9 UBTF siRNA Haematopoietic_and_lymphoid_tissue K562 0.60417 -0.72698 0.95568 1 DataSet_02_198
SIGLEC9 ZNF384 siRNA Haematopoietic_and_lymphoid_tissue K562 1.625 0.70044 0.04442 1 DataSet_02_203
SIGLEC9 RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.4 1.26303 0.06798 1 DataSet_02_204
SIGLEC9 E2F6 siRNA Haematopoietic_and_lymphoid_tissue K562 0.57576 -0.79647 0.50155 1 DataSet_02_205
SIGLEC9 AR siRNA Prostate abl cells 2.61905 1.38904 0.0977224460392818 0.999852161656754 DataSet_03_004
SIGLEC9 AR siRNA Prostate LNCaP 0.6 -0.736966 0.264820955408844 1 DataSet_03_005
SIGLEC9 ASCL1 siRNA Lung DMS79 0.479339 -1.06088 0.111156210049194 0.774660548659394 DataSet_03_016
SIGLEC9 ATF4 siRNA Skin A375 0.599344 -0.738543 0.124735184545757 0.775512819201899 DataSet_03_018
SIGLEC9 BCL6 siRNA Lymph OCI-Ly7 DLBCL 0.636987 -0.650664 0.254764029302754 0.836527944954955 DataSet_03_025
SIGLEC9 FLI1 siRNA Haematopoietic_and_lymphoid_tissue THP-1 0.654017 -0.612599 0.00359230166817042 0.150346849233654 DataSet_03_078
SIGLEC9 FOXF2 siRNA Mammary_gland MDA-MB-231 0.658244 -0.603305 - - DataSet_03_087
SIGLEC9 FOXO1 siRNA Skin primary human dermal lymphatic endothelial cells 0.605314 -0.724243 - - DataSet_03_096
SIGLEC9 GATA2 siRNA Uterus Decidual stromal cells 0.462669 -1.11195 0.085291839127985 0.714202969163864 DataSet_03_100
SIGLEC9 GATA4 siRNA Stomach AGS 1.87959 0.91042 0.199685132661328 0.8308557747058 DataSet_03_105
SIGLEC9 GATA4 siRNA Stomach YCC3 0.466777 -1.0992 0.104304113388298 0.651773953159009 DataSet_03_107
SIGLEC9 GATA6 siRNA Stomach AGS 2.93899 1.55532 0.119971883922998 0.613227102652247 DataSet_03_108
SIGLEC9 GATA6 siRNA Stomach KatoIII 0.533456 -0.906559 0.168271246104093 0.685813175628916 DataSet_03_109
SIGLEC9 GATA6 siRNA Stomach YCC3 0.610179 -0.712697 0.0871081159214303 0.706990020994719 DataSet_03_110
SIGLEC9 HNF4a siRNA Liver HepG2 3.03774 1.603 0.0273120026313076 0.588240992911483 DataSet_03_126
SIGLEC9 KLF5 siRNA Stomach AGS 2.57434 1.3642 0.0586508379334156 0.513550338757579 DataSet_03_149
SIGLEC9 KLF5 siRNA Stomach YCC3 0.302119 -1.72681 0.0640509399978563 0.368889123844036 DataSet_03_151
SIGLEC9 MEF2D shRNA Liver HuH7 2.17157 1.11873 - - DataSet_03_162
SIGLEC9 MEF2D siRNA Liver HuH7 0.560833 -0.834357 - - DataSet_03_163
SIGLEC9 MTA2 siRNA Stomach SGC-7901 1.65496 0.726798 - - DataSet_03_169
SIGLEC9 MYB siRNA Cord_Blood CD34+ progenitor cells 3.9405 1.97838 - - DataSet_03_170
SIGLEC9 MYC siRNA Colon HT29 0.281392 -1.82935 - - DataSet_03_177
SIGLEC9 SOX11 siRNA Lung_fibroblast NHLF 1.91608 0.938156 0.178403333521328 0.579152611295886 DataSet_03_237
SIGLEC9 SOX11 siRNA Lung_fibroblast NHLF 1.90628 0.930756 0.224735247927607 0.596946342541898 DataSet_03_238
SIGLEC9 SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 1.91667 0.9386 - - DataSet_03_246
SIGLEC9 SP1 siRNA Mammary_gland MDA-MB-231 0.227772 -2.13434 0.141117066067923 0.413972819854456 DataSet_03_250
SIGLEC9 STAT6 siRNA Umbilical_vein HUVEC 2.525 1.33628 0.642705448993487 0.950030911463146 DataSet_03_264
SIGLEC9 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.0208007798512359 0.0821655956215536 DataSet_04_002
SIGLEC9 DDX59 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.555556 -0.847997 0.170090115374966 0.579412769954808 DataSet_04_006
SIGLEC9 E4F1 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.6087 0.685891 0.244032588773802 0.656283651970605 DataSet_04_007
SIGLEC9 EIF2AK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.91892 0.940294 0.292585497828526 0.626272817517807 DataSet_04_008
SIGLEC9 MARK2 shRNA Haematopoietic_and_lymphoid_tissue K562 6 2.58496 0.000681914036529831 0.0116202262215363 DataSet_04_012
SIGLEC9 MECP2 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.85714 1.51457 0.0436217986129661 0.743078800258175 DataSet_04_013
SIGLEC9 NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 21.969 4.4574 0.0539179557932648 0.143900566177479 DataSet_04_014
SIGLEC9 NUP35 shRNA Haematopoietic_and_lymphoid_tissue K562 2.14286 1.09954 0.374012518739908 0.462239281670786 DataSet_04_015
SIGLEC9 RPS3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.578947 -0.788496 0.31267528774332 0.685701371970822 DataSet_04_017
SIGLEC9 SMAD5 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.17391 1.12029 0.0508167280580505 0.422780518771425 DataSet_04_020
SIGLEC9 ANXA2 CRISPR Liver HepG2 1.85714 0.893085 0.622368166899253 0.888002513062728 DataSet_04_024
SIGLEC9 APTX CRISPR Liver HepG2 1.65217 0.724366 0.110923493479869 0.523855019686248 DataSet_04_025
SIGLEC9 DDX17 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.277778 -1.848 0.186331323542284 0.704382110058098 DataSet_04_047
SIGLEC9 DDX20 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.444444 -1.16992 0.321515545817518 0.69143348882707 DataSet_04_050
SIGLEC9 NPM1 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.28571 1.19265 0.324467666346592 0.517826518762071 DataSet_04_046
SIGLEC9 SEPT11 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.615385 -0.70044 0.650540276908151 1 DataSet_04_077
SIGLEC9 SMG7 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.307692 -1.70044 0.451500813392826 0.763208395169552 DataSet_04_075
SIGLEC9 SNW1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.461538 -1.11548 0.510969329172072 0.67588366316016 DataSet_04_049
SIGLEC9 DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.21875 -2.19265 0.149927965998004 0.27485042680503 DataSet_02_14
SIGLEC9 ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.0625 -4 0.0887502806570038 0.196805916381062 DataSet_02_34
SIGLEC9 HMGA1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 5.92308 2.56635 0.0240659275286175 0.3937702583054 DataSet_02_75
SIGLEC9 LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.359375 -1.47644 0.22697033982367 0.3857738893835 DataSet_02_35
SIGLEC9 NFE2L1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 1.875 0.906891 0.45512852867411 0.67885774252489 DataSet_02_32
SIGLEC9 SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.515625 -0.955606 0.424025141337714 0.584931784188574 DataSet_02_47
SIGLEC9 TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.5625 -0.830075 0.418145598713589 0.607297075241662 DataSet_02_43
SIGLEC9 TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.361599982903618 0.51916724876881 DataSet_02_33
SIGLEC9 CCAR1 shRNA Haematopoietic_and_lymphoid_tissue K562 3.66667 1.87447 0.49054362720868 0.668151668890627 DataSet_04_064
SIGLEC9 CNOT7 shRNA Haematopoietic_and_lymphoid_tissue K562 2.14286 1.09954 0.571460061547614 0.747557620338777 DataSet_04_061
SIGLEC9 DDX1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.16667 1.11548 0.749738986900769 0.943878475450676 DataSet_04_063
SIGLEC9 HDGF shRNA Haematopoietic_and_lymphoid_tissue K562 1.57143 0.652077 0.791900076202972 0.874396407370452 DataSet_04_059
SIGLEC9 PRPF6 shRNA Haematopoietic_and_lymphoid_tissue K562 2.75 1.45943 0.614109162236659 0.874741965415598 DataSet_04_065
SIGLEC9 CNOT3 shRNA Lung A549 1.71437 0.777674 8.061774e-02 0.8830540 DataSet_03_340
SIGLEC9 SNAI2 shRNA Pancreas KLM1 0.620067 -0.689505 1.692292e-01 0.52098029 DataSet_03_307
SIGLEC9 EZH2 knockdown Colon HCT116 0.468737 -1.09315 0.024122464 0.8488990 DataSet_03_334
SIGLEC9 SKI CRISPR Blood HL60 12.25 3.61471 1.462930e-03 0.090535755 DataSet_03_351
SIGLEC9 TET1 CRISPR Mammary_gland Hs578T 2.04635 1.03305 6.854757e-01 8.228059e-01 DataSet_03_355
SIGLEC9 RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 1.55552 0.637396 9.499534e-02 3.071866e-01 DataSet_03_359
SIGLEC9 TP53 knockout Stomach SNU1 1.6053 0.682847 0.6402941013 0.9735747 DataSet_03_365
SIGLEC9 TPR shRNA Bone_marrow U2OS 2.22265 1.15228 1.335911e-04 1.000113e-02 DataSet_03_370
SIGLEC9 E2F1 siRNA Nasopharynx HK1 0.1875 -2.41504 1.417639e-01 6.387457e-01 DataSet_03_373
SIGLEC9 SMARCA2 shRNA Lung NCI-H1944 0.307692 -1.70044 2.876209e-01 6.547888e-01 DataSet_03_377
SIGLEC9 NFKB2 siRNA Bone_marrow U2OS 2 1 5.634095e-01 0.76755447 DataSet_03_381
SIGLEC9 DNMT1 siRNA Skin Human melanoma cells 1.58171 0.661484 1.218148e-01 1.899709e-01 DataSet_03_382
SIGLEC9 KAT6A CRISPR Haematopoietic_and_lymphoid_tissue MOLM-13 1.6263 0.701596 0.2121695470 0.8388073 DataSet_03_387
SIGLEC9 NFKBIA shRNA Bone_marrow U2OS 0.022093 -5.50027 8.490170e-01 0.93628645 DataSet_03_389
SIGLEC9 ILF2 siRNA Stomach SGC-7901 5 2.32193 0.8057311035 0.86596822 DataSet_03_393
SIGLEC9 IKZF2 CRISPR Lymph CAR T Cell 2.98931 1.57981 1.894154e-02 0.331951080 DataSet_03_397
SIGLEC9 TLE4 CRISPR Lymph CAR T Cell 2.02038 1.01462 1.744466e-01 0.49431292 DataSet_03_398
SIGLEC9 RELA CRISPR Brain T30 3.41759 1.77298 0.1359922781 0.8400824 DataSet_03_399
SIGLEC9 JARID2 siRNA Adipose_tissue human adipose tissue derived stem cells 2 1 2.848003e-02 0.3239928 DataSet_03_403
SIGLEC9 NFATC2 shRNA Haematopoietic_and_lymphoid_tissue THP-1 0.428571 -1.22239 1.015051e-01 0.263707911 DataSet_03_418
SIGLEC9 FOXP3 CRISPR Peripheral_blood Naive Treg 0.25 -2 1.964839e-01 0.552103356 DataSet_03_427
SIGLEC9 USP7 shRNA Skin xenograft cells 0.367347 -1.44478 0.41838444 0.5411335 DataSet_03_431
SIGLEC9 CIC knockout Brain Immortalized Astrocyte Cells 1.5625 0.643856 6.287809e-01 8.699246e-01 DataSet_03_438
SIGLEC9 FOXA2 CRISPR Liver iPSCs-derived progenitors and mature hepatocytes 12.5556 3.65025 1.887467e-02 0.63872149 DataSet_03_439
SIGLEC9 PPARG siRNA Aortic_valve Valvular endothelial cell 1.75 0.807355 5.746352e-01 8.511567e-01 DataSet_03_456
SIGLEC9 HAND1 siRNA Placenta HPMVEC 0.375 -1.41504 1.627815e-02 0.9463341 DataSet_03_459
SIGLEC9 TXNIP shRNA Cord_Blood CD34+ cells 22 4.45943 - - DataSet_03_461
SIGLEC9 PARP1 knockout Embryo_kidney HEK293a 2.46575 1.30203 9.464897e-04 4.456910e-03 DataSet_03_464
SIGLEC9 CHCHD3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.3179248 0.9053673 DataSet_04_071
SIGLEC9 CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.2402278 0.393300132 DataSet_04_074
Regulation Region
 
T(co)Fs that significantly regulate SOX2 by the evidences of both expression and ChIP-seq/motif
Expression Atlas of SIGLEC9
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines