Gene Overview
Target Gene: SPDEF
NCBI Official Symbol: SPDEF
Entrez ID: 25803
Ensembl ID: ENSG00000124664
Gene Full Name: SAM pointed domain containing ETS transcription factor
Strand: -
Gene Locus: 6p21.31
External Links:

SPDEF Significantly Regulated by These T(co)Fs

T(co)Fs that Activate SPDEF   
T(co)Fs that Repress SPDEF
The Intensity of the Gene Regulated by T(co)Fs:
SPDEF-T(co)F Pairs
Target
Gene		 T(co)F Knock
-Method		 Tissue Type Biosample
Name		 Fold
Change		 Log2FC P-value Corrected
_P		 Dataset ID
SPDEF FOXA1 siRNA Prostate LNCaP 0.63916 -0.64575 - - DataSet_01_104
SPDEF FOXA1 shRNA Prostate 22RV1 0.25304 -1.98253 - - DataSet_01_105
SPDEF SPDEF shRNA Mammary_gland MCF7 1.63041 0.70523 0.84374 0.99999 DataSet_01_107
SPDEF HOXA1 siRNA Lung_fibroblast IMR-90 1.89058 0.91883 0.22786 0.51136 DataSet_01_110
SPDEF TCF3 shRNA Mammary_gland MDA-MB468 0.63878 -0.64661 0.00021 0.00413 DataSet_01_116
SPDEF GATA3 siRNA Mammary_gland MCF7 1.82793 0.87021 0.00013 0.0035 DataSet_01_120
SPDEF SPDEF shRNA Mammary_gland MCF7 0.48588 -1.04132 2.10299e-05 0.00712 DataSet_01_135
SPDEF ETS2 siRNA Lung H441 1.60214 0.68 4.72114e-08 2e-04 DataSet_01_149
SPDEF TFAP2C shRNA Mammary_gland MCF7 0.03062 -5.02921 1.54046e-19 2.50807e-16 DataSet_01_150
SPDEF ELK1 siRNA Peripheral_blood CD4+ T cells 1.52713 0.61082 0.10334 0.2492 DataSet_01_162
SPDEF GATA3 siRNA Peripheral_blood CD4+ T cells 1.71413 0.77748 0.02716 0.27219 DataSet_01_163
SPDEF NFKB1 siRNA Peripheral_blood CD4+ T cells 1.5529 0.63497 0.0849 0.67337 DataSet_01_167
SPDEF STAT3 siRNA Peripheral_blood CD4+ T cells 0.65514 -0.61013 0.16956 0.99183 DataSet_01_168
SPDEF SPDEF siRNA Mammary_gland MCF7 0.35378 -1.49909 0.00093 0.06963 DataSet_01_189
SPDEF CREB1 shRNA Parotid_gland HSY 2.08277 1.0585 0.06238 0.62791 DataSet_01_195
SPDEF HIC1 shRNA Mammary_gland HBL100 0.59254 -0.75502 - - DataSet_01_205
SPDEF FOXP1 siRNA Haematopoietic_and_lymphoid_tissue OCI-Ly1 1.63141 0.70612 - - DataSet_01_209
SPDEF TAL1 shRNA Haematopoietic_and_lymphoid_tissue HEL 2.90219 1.53714 0.18312 0.36006 DataSet_01_217
SPDEF ATM shRNA Mammary_gland MCF10A 0.60868 -0.71624 0.00018 0.00152 DataSet_01_219
SPDEF IRX1 shRNA Bone_marrow 143B 0.22962 -2.1227 0.39637 0.64051 DataSet_01_227
SPDEF FOXA1 siRNA Prostate LNCaP 0.18179 -2.45964 0.01267 0.18897 DataSet_01_233
SPDEF GATA6 siRNA Colon HT29 2.42879 1.28024 - - DataSet_01_247
SPDEF YBX1 shRNA Mammary_gland MDA 2.47012 1.30458 5.67104e-11 1.49821e-08 DataSet_01_255
SPDEF YBX1 shRNA Mammary_gland MDA-LM2 0.53166 -0.91142 2.45632e-07 7.89758e-05 DataSet_01_256
SPDEF YBX1 shRNA Mammary_gland MDA 3.13772 1.64972 1.49694e-05 0.00058 DataSet_01_257
SPDEF SOX4 shRNA Mammary_gland MDA-MB-231 0.41519 -1.26816 7.60137e-06 0.00234 DataSet_01_260
SPDEF AR shRNA Prostate CWR22Pc 0.27048 -1.8864 1.05906e-05 0.00254 DataSet_01_278
SPDEF STAT5 shRNA Prostate CWR22Pc 0.63381 -0.65788 0.00342 0.0284 DataSet_01_279
SPDEF NFYA shRNA Lung H322 0.55011 -0.86222 1.3045e-05 0.00054 DataSet_01_288
SPDEF SNAI2 siRNA Mammary_gland MCFDCIS 3.63499 1.86195 0.00463 0.39968 DataSet_01_292
SPDEF POSTN shRNA Brain GSC272 2.00534 1.00385 0.37888 0.69583 DataSet_01_293
SPDEF TFAP4 siRNA Brain BE(2)-C 0.16156 -2.6299 0.29513 0.51625 DataSet_01_295
SPDEF TFAP2C siRNA Lung NCI-H292 0.50884 -0.97472 - - DataSet_01_312
SPDEF ARNT siRNA Upper_aerodigestive_tract HSC3 3.04492 1.6064 - - DataSet_01_315
SPDEF MYC siRNA Colon HCT116 1.53044 0.61395 0.01309 0.02604 DataSet_01_324
SPDEF SMAD2 siRNA Pancreas BxPC-3 1.52365 0.60753 - - DataSet_01_351
SPDEF GTF2B siRNA Cervix HeLa 0.13127 -2.92944 - - DataSet_01_362
SPDEF FIP1L1 shRNA Liver HepG2 3.5 1.80735 0.46203 0.56592 DataSet_02_103
SPDEF SSB shRNA Liver HepG2 1.83333 0.87447 0.1748 0.23724 DataSet_02_107
SPDEF TARDBP shRNA Liver HepG2 0.5 -1 1 1 DataSet_02_116
SPDEF RBM25 shRNA Liver HepG2 4.5 2.16993 0.02593 0.06827 DataSet_02_119
SPDEF PTBP1 shRNA Liver HepG2 9.5 3.24793 0.47207 0.52758 DataSet_02_120
SPDEF PRPF4 shRNA Liver HepG2 1.66667 0.73697 0.09369 0.18942 DataSet_02_128
SPDEF TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 13.6667 3.77259 0.0442 0.3058 DataSet_02_129
SPDEF SRSF7 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 1 1 DataSet_02_133
SPDEF PCBP2 shRNA Haematopoietic_and_lymphoid_tissue K562 2.33333 1.22239 0.06171 0.18113 DataSet_02_135
SPDEF PCBP1 shRNA Haematopoietic_and_lymphoid_tissue K562 6 2.58496 0.1245 0.35554 DataSet_02_137
SPDEF RBM17 shRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.01654 0.26029 DataSet_02_138
SPDEF RBM34 shRNA Haematopoietic_and_lymphoid_tissue K562 3.66667 1.87447 0.21938 0.43768 DataSet_02_141
SPDEF BCLAF1 shRNA Haematopoietic_and_lymphoid_tissue K562 8.66667 3.11548 0.00423 0.09142 DataSet_02_142
SPDEF RBM15 shRNA Haematopoietic_and_lymphoid_tissue K562 2.75 1.45943 0.9542 0.97415 DataSet_02_143
SPDEF FIP1L1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.05698 0.16414 DataSet_02_147
SPDEF NONO shRNA Haematopoietic_and_lymphoid_tissue K562 3.5 1.80735 0.01559 0.1947 DataSet_02_149
SPDEF RBM39 shRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.77057 0.86578 DataSet_02_151
SPDEF PSIP1 shRNA Haematopoietic_and_lymphoid_tissue K562 2.71429 1.44057 0.99223 1 DataSet_02_158
SPDEF HNRNPL shRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.30314 0.48724 DataSet_02_160
SPDEF EWSR1 shRNA Haematopoietic_and_lymphoid_tissue K562 0.65385 -0.61298 0.99347 1 DataSet_02_167
SPDEF TARDBP shRNA Haematopoietic_and_lymphoid_tissue K562 8 3 0.10617 0.18817 DataSet_02_169
SPDEF MXI1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.40909 -1.28951 0.21185 1 DataSet_02_173
SPDEF NFE2L2 siRNA Haematopoietic_and_lymphoid_tissue K562 0.3 -1.73697 0.24324 1 DataSet_02_174
SPDEF LMNA siRNA Haematopoietic_and_lymphoid_tissue K562 2.7 1.43296 0.02497 1 DataSet_02_175
SPDEF ZNF180 siRNA Haematopoietic_and_lymphoid_tissue K562 0.5 -1 0.32464 1 DataSet_02_177
SPDEF TBL1XR1 siRNA Haematopoietic_and_lymphoid_tissue K562 2.75 1.45943 0.31042 1 DataSet_02_178
SPDEF ATF3 siRNA Haematopoietic_and_lymphoid_tissue K562 0.3 -1.73697 0.23185 1 DataSet_02_180
SPDEF ZMIZ1 siRNA Haematopoietic_and_lymphoid_tissue K562 7.66667 2.9386 0.22055 1 DataSet_02_181
SPDEF MAFK siRNA Haematopoietic_and_lymphoid_tissue K562 0.63636 -0.65208 0.39121 1 DataSet_02_183
SPDEF CTCF siRNA Haematopoietic_and_lymphoid_tissue K562 2.2 1.1375 0.9849 1 DataSet_02_185
SPDEF CHD1 siRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.27206 1 DataSet_02_187
SPDEF MAFG siRNA Haematopoietic_and_lymphoid_tissue K562 0.30769 -1.70044 0.26636 1 DataSet_02_189
SPDEF LMNB2 siRNA Haematopoietic_and_lymphoid_tissue K562 2 1 0.03474 1 DataSet_02_191
SPDEF MAX siRNA Haematopoietic_and_lymphoid_tissue K562 0.38462 -1.37851 0.53296 1 DataSet_02_192
SPDEF ARID3A siRNA Haematopoietic_and_lymphoid_tissue K562 1.66667 0.73697 0.32368 1 DataSet_02_193
SPDEF LMNB1 siRNA Haematopoietic_and_lymphoid_tissue K562 0.38462 -1.37851 0.53984 1 DataSet_02_195
SPDEF CDAN1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.53846 0.62149 0.19814 1 DataSet_02_197
SPDEF UBTF siRNA Haematopoietic_and_lymphoid_tissue K562 3 1.58496 0.49044 1 DataSet_02_198
SPDEF TAL1 siRNA Haematopoietic_and_lymphoid_tissue K562 1.8 0.848 0.78487 1 DataSet_02_201
SPDEF RCOR1 siRNA Haematopoietic_and_lymphoid_tissue K562 3.8 1.926 0.74898 1 DataSet_02_204
SPDEF AR siRNA Prostate abl cells 1.51266 0.597088 0.176160629715735 0.999852161656754 DataSet_03_004
SPDEF AR siRNA Prostate LNCaP 0.443666 -1.17245 0.0606790335802109 0.0783940534509436 DataSet_03_011
SPDEF EP300 siRNA Prostate LNCaP 0.452451 -1.14417 0.113170542029323 0.223057979597045 DataSet_03_065
SPDEF FOXA1 siRNA Mammary_gland MCF7 0.211699 -2.23991 2.55772446217185e-10 3.85062907604956e-07 DataSet_03_080
SPDEF FOXA1 siRNA Mammary_gland MCF7 0.199349 -2.32663 5.35839239911425e-16 4.40224343320752e-13 DataSet_03_081
SPDEF FOXA1 siRNA Mammary_gland MCF7 0.199349 -2.32663 5.35839239911425e-16 4.40224343320752e-13 DataSet_03_082
SPDEF GATA6 siRNA Stomach KatoIII 2.05878 1.04179 0.0530618564417053 0.561679629563911 DataSet_03_109
SPDEF GATA6 siRNA Stomach YCC3 1.73971 0.798847 0.0302318999185112 0.555748550709134 DataSet_03_110
SPDEF HMGA2 siRNA Mammary_gland MDA-MB-231 1.87936 0.910243 0.0064163361042918 0.49573909169184 DataSet_03_125
SPDEF HNF4a siRNA Liver HepG2 1.62619 0.701498 0.0515094312303164 0.639786177932759 DataSet_03_126
SPDEF MEF2D siRNA Liver HuH7 1.5031 0.587944 - - DataSet_03_163
SPDEF MITF siRNA Skin SK-MEL-5 0.536601 -0.898079 7.57416582212367e-05 0.000446962627055163 DataSet_03_168
SPDEF MYB siRNA Cord_Blood CD34+ progenitor cells 1.57707 0.657248 - - DataSet_03_170
SPDEF SMARCA4 siRNA Prostate LNCaP 1.85478 0.891249 0.318894954770743 0.837934672500428 DataSet_03_235
SPDEF SOX4 siRNA Haematopoietic_and_lymphoid_tissue ST1 0.503658 -0.989482 - - DataSet_03_246
SPDEF SOX4 siRNA Mammary_gland MDA-LM2 1.91546 0.937691 5.28747635167823e-05 0.106295907471686 DataSet_03_247
SPDEF SP1 siRNA Mammary_gland MDA-MB-231 0.532394 -0.909434 0.165524376467783 0.413972819854456 DataSet_03_250
SPDEF STAT3 CRISPR Embryo hESC 0.417301 -1.26084 0.0178599901713515 0.0798596383285129 DataSet_03_258
SPDEF TFAP2C siRNA Mammary_gland MCF7 0.348911 -1.51907 0.00248478817487613 0.199661266024629 DataSet_03_274
SPDEF CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 3.16667 1.66297 0.0244865302601628 0.0889534308895046 DataSet_04_002
SPDEF NKRF shRNA Haematopoietic_and_lymphoid_tissue K562 7.23661 2.85531 0.620269603674624 0.733358365899822 DataSet_04_014
SPDEF RPS3 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.207797990266847 0.61295683424676 DataSet_04_017
SPDEF YBX1 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.526316 -0.925999 0.153608881912027 0.566415313392388 DataSet_04_022
SPDEF ZNF574 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.529412 -0.917538 0.0728755640286464 0.202523824680143 DataSet_04_023
SPDEF SMAD5 CRISPR Liver HepG2 1.75 0.807355 0.193217350320514 0.586798378491902 DataSet_04_036
SPDEF ZNF574 CRISPR Liver HepG2 0.5 -1 0.289193656459572 0.431876337776761 DataSet_04_041
SPDEF CNOT7 CRISPR Liver HepG2 0.25 -2 0.653532154037625 0.788456584391607 DataSet_04_045
SPDEF CCAR1 shRNA Liver HepG2 0.25 -2 0.619883330608231 0.759975030040779 DataSet_04_054
SPDEF ACTN4 CRISPR Haematopoietic_and_lymphoid_tissue K562 2.5 1.32193 0.514350843423968 0.711719731305105 DataSet_04_048
SPDEF DDX17 CRISPR Haematopoietic_and_lymphoid_tissue K562 1.66667 0.736966 0.649607951700448 0.938774490829947 DataSet_04_047
SPDEF NPM1 CRISPR Haematopoietic_and_lymphoid_tissue K562 3.5 1.80735 0.54549414576807 0.72431046651092 DataSet_04_046
SPDEF RIOK2 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.363636 -1.45943 0.334798611232559 0.788744129108784 DataSet_04_076
SPDEF SEPT11 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.468736229744249 1 DataSet_04_077
SPDEF SMG7 CRISPR Haematopoietic_and_lymphoid_tissue K562 0.333333 -1.58496 0.49449638503006 0.792904131043738 DataSet_04_075
SPDEF DPF2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.410714 -1.28379 0.0110458942785138 0.0403107083458622 DataSet_02_14
SPDEF ERF CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.223214 -2.1635 0.00645562194769408 0.035127674272155 DataSet_02_34
SPDEF LDB1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.339286 -1.55943 0.0309368269594989 0.0872975169047451 DataSet_02_35
SPDEF SMARCA4 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.535714 -0.900464 0.0219828217502755 0.0658670791219771 DataSet_02_47
SPDEF SNW1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.16129 -2.63227 0.403685499727089 0.779758992784304 DataSet_02_49
SPDEF TBL1XR1 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.205357 -2.28379 0.0027125486452442 0.027283726198787 DataSet_02_43
SPDEF TEAD2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.241071 -2.05247 0.00584523069665252 0.0242404695924353 DataSet_02_33
SPDEF TLE2 CRISPRi Haematopoietic_and_lymphoid_tissue K562 0.491071 -1.026 0.0132414769281306 0.0625594259482079 DataSet_02_53
SPDEF ELF3 knockdown Bile_duct HBDEC2 0.571618 -0.806878 7.789215e-04 1.806076e-02 DataSet_03_305
SPDEF TET1 CRISPR Mammary_gland MDA-MB-231 12.0215 3.58754 2.983925e-01 5.173702e-01 DataSet_03_347
SPDEF EZH2 shRNA Mammary_gland LM2 0.391549 -1.35273 1.325473e-03 6.706474e-02 DataSet_03_350
SPDEF ESR1 siRNA Mammary_gland MCF7 0.497292 -1.00783 4.626705e-05 0.0071727504 DataSet_03_352
SPDEF TET1 CRISPR Mammary_gland Hs578T 2.55024 1.35063 7.028604e-01 8.342743e-01 DataSet_03_355
SPDEF RUNX1 shRNA Haematopoietic_and_lymphoid_tissue OCI-AML5 1.90583 0.93042 7.666924e-01 8.997364e-01 DataSet_03_359
SPDEF NCOA2 siRNA Uterus endometrial stromal cells 0.2 -2.32193 0.1507747914 1 DataSet_03_360
SPDEF ARID2 shRNA Haematopoietic_and_lymphoid_tissue MM.1S 1.63933 0.713109 2.679590e-01 3.803046e-01 DataSet_03_362
SPDEF DNMT3A knockout Embryo_kidney HEK293T 0.0073731 -7.08351 - - DataSet_03_369
SPDEF E2F1 siRNA Nasopharynx HK1 2.71429 1.44057 1.163065e-01 5.714929e-01 DataSet_03_373
SPDEF SMARCA2 shRNA Lung NCI-H1944 0.632588 -0.660662 2.139327e-02 2.905320e-01 DataSet_03_377
SPDEF NFKB2 siRNA Bone_marrow U2OS 0.538462 -0.893085 7.012183e-02 0.32883079 DataSet_03_381
SPDEF TCF19 CRISPR Oral_squamous CAL27 8.29213 3.05174 1.247172e-01 0.3750963333 DataSet_03_383
SPDEF TRIM8 siRNA Mammary_gland MCF7 0.594979 -0.74909 8.667548e-05 0.0038400854 DataSet_03_388
SPDEF NFKBIA shRNA Bone_marrow U2OS 0.123818 -3.01371 1.804137e-01 0.87005461 DataSet_03_389
SPDEF KDM5A CRISPR Lung GLC16 3.40715 1.76857 1.785012e-02 0.060994488 DataSet_03_392
SPDEF JAZF1 siRNA Cervix HeLa Kyoto 0.272932 -1.87339 1.765573e-01 0.766122791 DataSet_03_396
SPDEF IKZF2 CRISPR Lymph CAR T Cell 1.94313 0.958384 8.219011e-01 0.972686791 DataSet_03_397
SPDEF HMGA1 shRNA Bile_duct HUCCT1 4.75 2.24793 5.453229e-02 0.279655011 DataSet_03_400
SPDEF CDK7 shRNA Bone_marrow D458 0.577778 -0.791413 6.152127e-01 0.80300206 DataSet_03_404
SPDEF SIRT1 siRNA Pancreas PANC1 0.206349 -2.27684 2.123021e-02 0.078590962 DataSet_03_410
SPDEF ZKSCAN3 CRISPR Colon HCT116 2 1 7.306335e-02 0.439951759 DataSet_03_415
SPDEF FOXK2 shRNA Ovary OVCAR-5 0.109091 -3.1964 7.303578e-03 0.09472980 DataSet_03_419
SPDEF BRD4 CRISPR Lymph CD8+ T cells 0.4 -1.32193 - - DataSet_03_420
SPDEF PRDM1 CRISPR Lymph CD8+ T cells 2.2 1.1375 - - DataSet_03_421
SPDEF FOXQ1 CRISPR Lymph Primary CD4+ T cells 1.9 0.925999 - - DataSet_03_422
SPDEF STAT5B CRISPR Embryo_kidney HEK293 3 1.58496 3.163280e-01 0.672365079 DataSet_03_424
SPDEF USP7 shRNA Skin xenograft cells 0.259259 -1.94753 0.12298533 0.4348960 DataSet_03_431
SPDEF POU2AF1 CRISPR Haematopoietic_and_lymphoid_tissue OCI-Ly7 1.52758 0.61125 1.641111e-01 0.528983766 DataSet_03_434
SPDEF POU2AF1 CRISPR Lymph SUDHL4 0.533333 -0.906891 2.254292e-01 0.399499548 DataSet_03_435
SPDEF DAXX shRNA Mammary_gland MDA-MB-231 0.296325 -1.75475 4.815021e-04 0.04149262 DataSet_03_441
SPDEF HMG20A siRNA Mammary_gland MDA-MB-231 0.562835 -0.829215 0.0050040607 0.1533333 DataSet_03_442
SPDEF CBX2 siRNA Mammary_gland MDA-MB-231 0.628628 -0.669721 8.483219e-02 2.185706e-01 DataSet_03_450
SPDEF CBX2 siRNA Mammary_gland MCF7 0.364711 -1.45517 1.890216e-04 0.0019661168 DataSet_03_451
SPDEF OGT siRNA Embryo BeWo cells 1.75 0.807355 4.901418e-01 0.79052522 DataSet_03_453
SPDEF PPARG siRNA Aortic_valve Valvular endothelial cell 0.285714 -1.80736 5.108562e-01 8.237723e-01 DataSet_03_456
SPDEF ARID1A shRNA Bile_duct MMNK1 4.87116 2.28427 9.892691e-03 0.097104466 DataSet_03_458
SPDEF PARP1 knockout Embryo_kidney HEK293a 2.26 1.17632 2.342091e-03 9.490079e-03 DataSet_03_464
SPDEF STAT3 shRNA Liver HepG2 2 1 2.681122e-01 0.5909364897 DataSet_03_465
SPDEF SMARCA1 CRISPR-Csm Embryo_kidney HEK293T 33.5 5.06609 - - DataSet_03_467
SPDEF APTX CRISPR Haematopoietic_and_lymphoid_tissue K562 5.66667 2.5025 0.2300514 0.6802229 DataSet_04_072
SPDEF CDC5L CRISPR Haematopoietic_and_lymphoid_tissue K562 3.16667 1.66297 0.2202198 0.368458095 DataSet_04_074
Regulation Region
 
T(co)Fs that significantly regulate SPDEF by the evidences of both expression and ChIP-seq/motif
Expression Atlas of SPDEF
Gene Expression in Human Normal Tissues (GTEx) Gene Expression in Cancer Cell Lines (CCLE)
Gene Expression in Human Cancers (TCGA) Gene Expression in Encode Cell Lines